Tin Patents (Class 514/493)
  • Patent number: 9950310
    Abstract: The present invention relates to a preparation method of a granular oxide adsorbent for water treatment in which a metal oxide is bound to the surface of polymer particles, and more specially, to a preparation method of a granular oxide adsorbent, comprising the following steps: putting polymer particles in an acidic solution; adding polymer particles to a metal oxide aqueous solution and adjusting a pH; and washing and drying the obtained product. Accordingly, a granular oxide adsorbent prepared by the preparation method is provided and is utilized in water treatment and the like.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: April 24, 2018
    Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
    Inventor: Kwang-Ho Choo
  • Patent number: 9144576
    Abstract: The disclosure provides antiviral pharmaceutical compositions comprising one or more antiviral compounds and 2-deoxy-D-glucose in the form of lip-balms, creams and ointments. A specific embodiment discloses a lip-balm composition comprising acyclovir and 2-deoxy-D-glucose.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: September 29, 2015
    Assignee: 3B Pharmaceuticals, Inc.
    Inventors: Darby C. Brown, Kristen A. Brown
  • Patent number: 9096620
    Abstract: A mercaptoalkylsilatrane derivative having protecting group and a method of manufacturing the same. The mercaptoalkylsilatrane derivative includes: mercaptoalkylsilatrane compound having a mercapto group; a protecting group bonding to sulfur of the mercapto group, wherein the protecting group is used to avoid the chemical reaction of the mercapto group with reactive chemical species, e.g., oxygen, ketone, and aldehyde, etc. Besides, the manufacturing method thereof includes the steps of: providing silane compound having the mercapto group; bonding the protecting group to the mercapto group of the silane compound; performing the chemical reaction of triethanolamine with the silane compound having the protecting group for manufacturing the mercaptoalkylsilatrane derivative having the protecting group.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: August 4, 2015
    Assignee: National Chung Cheng University
    Inventors: Wen-Hao Chen, Lai-Kwan Chau, Chao-Wen Chen, Yen-Ta Tseng
  • Patent number: 8952057
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 10, 2015
    Assignee: JR Chem, LLC
    Inventor: José E. Ramirez
  • Patent number: 8889729
    Abstract: Indole derivatives, compositions including same, and methods utilizing same for the treatment of amyloid associated diseases, such as type II diabetes mellitus, Alzheimer's dementia or diseases, systemic and localized amyloidosis, and prion-related encephalopathies are provided.
    Type: Grant
    Filed: June 6, 2010
    Date of Patent: November 18, 2014
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventors: Ehud Gazit, Tomer Cohen
  • Patent number: 8829045
    Abstract: An agrochemical composition comprising a propylene glycol fatty acid monoester and fenbutatin oxide in a proportion of 1:150 to 150:1 in terms of a mass ratio (propylene glycol fatty acid monoester:fenbutatin oxide) shows an excellent control effect on pests, hyposensitive mites having reduced sensitivity to chemicals, eggs of mites, and pests other than mites in all stages of growth, even when the composition is applied in a small amount. A pest control method comprising applying the propylene glycol fatty acid monoester and fenbutatin oxide in a proportion of 1:150 to 150:1 in terms of a mass ratio (propylene glycol fatty acid monoester:fenbutatin oxide) to pests or a habitat of the pests also shows an excellent control effect.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: September 9, 2014
    Assignee: Ishihara Sangyo Kaisha, Ltd.
    Inventors: Kohji Hirano, Kouichi Yamaguchi, Makiko Ohasa
  • Publication number: 20140147691
    Abstract: The present invention relates to a preservative formulation for use in treating wood or other cellulosic materials, said formulation comprising: at least one biocidal metal compound; at least one preservative; and an aqueous carrier, wherein the preservative formulation has an uptake in the sapwood of less than about 220 l/m3 yet achieves substantially full penetration of the sapwood. Preferably, the preservative formulation is copper/tebuconazole in a ratio of about 25/1 w/w; and the wood is around 25 mm in thickness—for instance, decking timber.
    Type: Application
    Filed: June 29, 2012
    Publication date: May 29, 2014
    Applicant: ARCH WOOD PROTECTION PTY LTD
    Inventors: David Humphrey, Brett Skewes, Angelo Hrastov, Drago Bagaric, Peter Hausler, Shane McFarling, Greg Jensen, Steve Koch, Noel Koskela, Troy Justice
  • Publication number: 20120322765
    Abstract: The present invention provides a composition having an excellent controlling activity on plant disease. The composition comprising the compound represented by the formula (1) and one or more inorganic fungicidal compound selected from the group (A) shows an excellent controlling activity on a plant disease. group (A): a group consisting of fludioxonil, pencycuron, ametoctradin, chloroneb, chlorothalonil, oxine-copper, cyflufenamid, dichlofluanid, dicloran, diethofencarb, dinocap, dithianon, edifenphos, fenaminosulf, fentin, fluazinam, fluoroimide, flusulfamide, flutianil, fosetyl-Al, hydrargaphen, iprobenfos, metrafenon, milneb, penflufen, phosdiphen, phthalide, prothiocarb, pyrazophos, sedaxane, silthiofam, spiroxamine, tebufloquin, and tolyfluanid.
    Type: Application
    Filed: March 2, 2011
    Publication date: December 20, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: So Kiguchi, Soichi Tanaka, Mayuko Ozawa, Atsushi Iwata
  • Publication number: 20120177583
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Application
    Filed: June 16, 2011
    Publication date: July 12, 2012
    Inventor: José E. Ramirez
  • Publication number: 20120148651
    Abstract: According to one embodiment, a coagulant comprising calcium nitrate and an antimicrobial agent is disclosed. The coagulant may be used in the molding process to releasably bond the substrate material to the mold and to bond to the antimicrobial to the substrate material.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Applicant: MEDLINE INDUSTRIES INC.
    Inventors: Samuel T. Amdur, Min Yao
  • Publication number: 20120016022
    Abstract: The invention has as its object the provision of an agrochemical composition for pest control, by which an excellent control effect is achieved on pests, hyposensitive mites having reduced sensitivity to chemicals and eggs of the mites, and other pests of all stages of growth than the mites even when the composition is applied in a small amount, and a pest control method. The agrochemical composition for pest control comprises a propylene glycol fatty acid monoester and fenbutatin oxide in a proportion of 1:150 to 150:1 in terms of a mass ratio (propylene glycol fatty acid monoester:fenbutatin oxide). The pest control method comprises applying the propylene glycol fatty acid monoester and fenbutatin oxide in a proportion of 1:150 to 150:1 in terms of a mass ratio (propylene glycol fatty acid monoester:fenbutatin oxide) to pests or a habitat of the pests.
    Type: Application
    Filed: March 26, 2010
    Publication date: January 19, 2012
    Applicant: ISHIHARA SANGYO KAISHA, LTD
    Inventors: Kohji Hirano, Kouichi Yamaguchi, Makiko Ohasa
  • Patent number: 8088828
    Abstract: This invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of benign prostate hyperplasia in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein. This invention also provides a method of treating a subject suffering from hair loss, comprising the step of administering to the subject a therapeutically effective amount of a 5-? reductase enzyme type 1 and/or type 2 inhibitor, wherein said inhibitor is a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: January 3, 2012
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka, Wenqing Gao
  • Patent number: 8007771
    Abstract: The present invention relates to oral care compositions comprising stannous ions, a mint-type flavor oil, a protectant component that prevents generation of off odor and off taste in the composition, and orally acceptable carriers. The mint-type oils include peppermint, spearmint and corn mint. Suitable protectant components include copper salts and carbonyl compounds such as ascorbic acid; cis-jasmone; 2,5-dimethyl-4-hydroxy-3(2H)-furanone; 5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone; vanillin; ethyl vanillin; anisaldehyde; 3,4-methylenedioxybenzaldehyde; 3,4-dimethoxybenzaldehyde; 4-hydroxybenzaldehyde; 2-methyoxybenzaldehyde; 4-methoxybenzaldehyde; benzaldehyde; cinnamaldehyde (3-phenyl-2-propenal); hexyl cinnamaldehyde; ?-methyl cinnamaldehyde; ortho-methoxy cinnamaldehyde; ?-amyl cinnamaldehyde; and combinations thereof. The oral care composition may be a dentifrice.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: August 30, 2011
    Assignee: The Procter & Gamble Company
    Inventors: Niranjan Ramji, Marc Hester, Steve Hoke, Robert Leslie Swaine, Jr., Gerhard Norbert Zehentbauer
  • Patent number: 8008348
    Abstract: This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or an analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, impurity or crystal of said SARM compound, or any combination thereof.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: August 30, 2011
    Assignee: University of Tennessee Research Foundation
    Inventors: Mitchell S. Steiner, Karen A. Veverka, James T. Dalton, Duane D. Miller
  • Publication number: 20110054019
    Abstract: The present invention is a glutamine analogue which enters the mitochondrion and is subsequently exposed to ionizing radiation. When exposed to ionizing radiation, the present invention damages mitochondrial (as well as other) substructures such as mtDNA, the outer membrane, the inner membrane, cristae, ribosomes, etc., and causes the effective destruction of such mitochondrion. Tumorigenic cells without mitochondria cannot produce the energy they need to subsist and replicate, effectively starving them of energy and causing their destruction.
    Type: Application
    Filed: September 1, 2009
    Publication date: March 3, 2011
    Inventor: Pedro Anastacio Serrano-Ojeda
  • Patent number: 7855229
    Abstract: This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or an analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, impurity or crystal of said SARM compound, or any combination thereof.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: December 21, 2010
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka
  • Patent number: 7803970
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: September 28, 2010
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka, Dong Jin Hwang, Jiyun Chen
  • Publication number: 20100175796
    Abstract: Anti fungal and anti-microbial protection for storage items and protective covers.
    Type: Application
    Filed: January 12, 2010
    Publication date: July 15, 2010
    Inventor: Johannes Blok
  • Patent number: 7732479
    Abstract: Indole derivatives, compositions including same, and methods utilizing same for the treatment of amyloid associated diseases, such as type II diabetes mellitus, Alzheimer's dementia or diseases, systemic and localized amyloidosis, and prion-related encephalopathies are provided.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: June 8, 2010
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventors: Ehud Gazit, Tomer Cohen
  • Patent number: 7547728
    Abstract: This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide or any combination thereof, as described herein.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: June 16, 2009
    Assignee: University of Tennessee Research Foundation
    Inventors: Mitchell S. Steiner, Karen A. Veverka, James T. Dalton, Duane D. Miller
  • Patent number: 7547444
    Abstract: The present invention includes compounds of pyridinium salts and methods of their use for agricultural purposes. The present invention also relates to methods of controlling fungi and/or bacteria.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: June 16, 2009
    Assignee: Mycosol, Inc.
    Inventors: Richard B. Klein, Jeffrey L. Selph, John J. Partridge, John Reinhard
  • Publication number: 20090098226
    Abstract: Composition in the form of a cosmetic formulation or dermatological medicament, suitable for maintaining skin cells at, or helping to restore skin cells to, their basal physiological state, enabling them to effect a regeneration of the dermis and the epidermis, comprising: —curcumin—a phosphosaccharide and possibly—a metal or basic oxide, or a biologically acceptable salt thereof, or a labile coordination compound thereof able to form, with at least one of said compounds: complexes, derivatives or associations which enhance their activity, in combination with excipients and/or diluents normally employed for cosmetic or pharmaceutical use.
    Type: Application
    Filed: March 13, 2007
    Publication date: April 16, 2009
    Applicant: SCHARPER S.P.A.
    Inventors: Laura Martelli, Mario Martelli
  • Publication number: 20080292674
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 27, 2008
    Inventor: Joseph J. Crudden
  • Publication number: 20080292673
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.
    Type: Application
    Filed: May 19, 2008
    Publication date: November 27, 2008
    Inventor: Joseph J. Crudden
  • Patent number: 7323452
    Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 29, 2008
    Assignee: Wardan, L.L.C.
    Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
  • Patent number: 7276534
    Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: October 2, 2007
    Assignee: Emisphere Technologies, Inc.
    Inventor: Sam J. Milstein
  • Patent number: 7252842
    Abstract: Microparticles and a method for their production is described. The process of the present invention provides a simple, quick, and efficient one-pot process for the production of microparticles containing a hydrophilic active agent of various and uniform morphologies, including microcapsules, microspheres, and microsponges. The microparticles are preferably used for pharmaceutical applications.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: August 7, 2007
    Assignee: Alrise Biosystems GmbH
    Inventor: Celal Albayrak
  • Patent number: 7008647
    Abstract: The invention relates to the use of one or more antimicrobial metals selected from silver, gold, platinum, and palladium but most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of a acne. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: March 7, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Hua Qing Yin
  • Patent number: 6989156
    Abstract: Therapeutic treatments using the direct application of selected structures of antimicrobial metals in free-standing powder form, solution form and/or suspension form in therapeutically effective amounts. The selected structures of antimicrobial metals serve as an antimicrobial agent, an anti-inflammatory agent, an immuno modulator agent, an enzyme modulator agent, and/or an anti-tumor agent, for human and/or animal use.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: January 24, 2006
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventor: Scott H. Gillis
  • Patent number: 6939568
    Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: September 6, 2005
    Assignee: Nucryst Pharmaceuticals Corp.
    Inventors: Robert Edward Burrell, Hua Qing Yin
  • Patent number: 6939566
    Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.
    Type: Grant
    Filed: January 17, 2001
    Date of Patent: September 6, 2005
    Inventors: Kareem I. Batarseh, Marwan Al-Kayed
  • Patent number: 6833362
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 21, 2004
    Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
  • Publication number: 20040167103
    Abstract: The present invention relates to a novel class of androgen receptor targeting agents (ARTA), which contain a haloacetamide or azide moiety and are alkylating agents.
    Type: Application
    Filed: July 10, 2003
    Publication date: August 26, 2004
    Inventors: James T. Dalton, Duane D. Miller, Huiping Xu, Vipin Nair
  • Patent number: 6770674
    Abstract: A mollusc repellent, which includes a substantially insoluble metal oxalate and a suitable carrier therefor, which exhibits prolonged efficacy. The mollusc repellent is environmentally friendly, being both non-phytotoxic and harmless to non-target animals, and is therefore suitable for use in sustainable agriculture, where the use of toxic chemicals is unacceptable. The mollusc repellent can be used in the form of a solid or as a coating composition.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: August 3, 2004
    Inventor: Colin Leslie Young
  • Patent number: 6764692
    Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: July 20, 2004
    Inventor: Carlos Cortelezzi
  • Publication number: 20040138244
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: October 14, 2003
    Publication date: July 15, 2004
    Inventors: James T. Dalton, Duane D. Miller
  • Publication number: 20040122087
    Abstract: Described are dermatological compositions for treating, protecting and re-epitheliazing cutaneous wounds and damaged skin, such compositions including about 21 to about 40% urea and trace amounts of zinc, copper and manganese in the form of their respective pharmaceutically acceptable salts.
    Type: Application
    Filed: December 23, 2002
    Publication date: June 24, 2004
    Applicant: Bradley Pharmaceuticals, Inc.
    Inventors: Bradley P. Glassman, Dileep Bhagwat, Daniel Glassman
  • Publication number: 20040087489
    Abstract: The invention relates to composition and methods for the treatment of Gram-positive bacterial infections. More specifically, the invention describes the use of ATP synthase and vacuolar ATPase inhibitors for the treatment of mycobacterial infections particularly tuberculosis.
    Type: Application
    Filed: September 11, 2003
    Publication date: May 6, 2004
    Inventors: Antonio Ruiz, Adonia Papathanassiu
  • Publication number: 20040087557
    Abstract: This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide or any combination thereof, as described herein.
    Type: Application
    Filed: December 5, 2002
    Publication date: May 6, 2004
    Inventors: Mitchell S. Steiner, Karen A. Veverka, James T. Dalton, Duane D. Miller
  • Publication number: 20040067979
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: June 17, 2003
    Publication date: April 8, 2004
    Inventors: James T. Dalton, Duane D. Miller, Craig A. Marhefka, Wenqing Gao
  • Publication number: 20040029913
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: February 24, 2003
    Publication date: February 12, 2004
    Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka
  • Publication number: 20030232792
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: October 15, 2002
    Publication date: December 18, 2003
    Inventors: James T. Dalton, Duane D. Miller, Donghua Yin, Yali He
  • Publication number: 20030225040
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: October 16, 2002
    Publication date: December 4, 2003
    Inventors: James T. Dalton, Duane D. Miller, Yali He, Donghua Yin
  • Publication number: 20030213401
    Abstract: A material and method for treating timber. The material comprises a preservative and a carrier. The carrier is selected such that it remains mobile within the wood and provides for migration of the preservative within the treated wood. By providing a carrier which is mobile within the wood, the timber has a ‘self healing’ effect wherein the carrier/preservative migrates to any freshly cut or exposed surface of the wood to thereby redistribute and treat such a surface within the preservative and hence maintain integrity of a treatment envelope surrounding the wood.
    Type: Application
    Filed: June 13, 2003
    Publication date: November 20, 2003
    Applicant: Koppers-Hickson Timber Protection Pty Limited
    Inventor: Peter Ravnor Soundy Cobham
  • Patent number: 6638431
    Abstract: A formulation and method to treat and control microbial growth present in the water of climate control systems such as air conditioner air handlers, dehumidifiers, and humidifiers, which formulation can be entrained and dispersed into to living space air. Specifically, a formulation is provided in the form of a tablet or a spray for being applied onto a wetted surface element present in these systems which will effectively control the growth of microbes such as fungus, molds, bacteria, and virus present on the surface for an extended period of time. The formulations include at least two metals, at least two chelating agents, at least one surfactant, and at least one viscosity enhancing compound.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: October 28, 2003
    Assignee: Mainstream Engineering Corporation
    Inventors: Dwight D. Back, Robert P. Scaringe, John A. Meyer
  • Patent number: 6630172
    Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: October 7, 2003
    Inventor: Kareem I. Batarseh
  • Publication number: 20030162761
    Abstract: The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: October 15, 2002
    Publication date: August 28, 2003
    Inventors: Mitchell S. Steiner, Karen A. Veverka, James T. Dalton, Duane D. Miller
  • Patent number: 6569896
    Abstract: This invention provides a novel class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are tissue-selective androgen receptor modulators (SARM), which are useful for oral testosterone replacement therapy, male contraception, maintaining sexual desire in women, treating prostate cancer and imaging prostate cancer. These agents have an unexpected in-vivo activity for an androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. These agents may be active alone or in combination with progestins or estrogens. The invention further provides a novel class of non-steroidal agonist compounds. The invention further provides compositions containing the selective androgen modulator compounds or the non-steroidal agonist compounds and methods of binding an androgen receptor, modulating spermatogenesis, treating and imaging prostate cancer, and providing hormonal therapy for androgen-dependent conditions.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: May 27, 2003
    Assignee: The University of Tennessee Research Corporation
    Inventors: James T. Dalton, Duane D. Miller, Donghua Yin, Yali He
  • Patent number: 6541514
    Abstract: Novel methods are provided for the manufacture of 117mSn(Sn4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to 117mSn(Sn4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.
    Type: Grant
    Filed: May 2, 2001
    Date of Patent: April 1, 2003
    Assignee: Brookhaven Science Associates, LLC
    Inventors: Suresh C. Srivastava, Zizhong Li, George Meinken
  • Patent number: 6521265
    Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: February 18, 2003
    Assignee: Biolife, L.L.C.
    Inventor: James A. Patterson