Abstract: This invention provides a novel class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are tissue-selective androgen receptor modulators (SARM), which are useful for oral testosterone replacement therapy, male contraception, maintaining sexual desire in women, treating prostate cancer and imaging prostate cancer. These agents have an unexpected in-vivo activity for an androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. These agents may be active alone or in combination with progestins or estrogens. The invention further provides a novel class of non-steroidal agonist compounds. The invention further provides compositions containing the selective androgen modulator compounds or the non-steroidal agonist compounds and methods of binding an androgen receptor, modulating spermatogenesis, treating and imaging prostate cancer, and providing hormonal therapy for androgen-dependent conditions.

Abstract: Novel methods are provided for the manufacture of 117mSn(Sn4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to 117mSn(Sn4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.

Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.

Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are selective androgen receptor modulators (SARM) useful for oral testosterone replacement therapy. Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. In one embodiment, the SARM compounds bind irreversibly to the androgen receptor. In another embodiment, the SARM compounds bind reversibly to the androgen receptor.

Abstract: Novel methods are provided for the manufacture of 117mSn(Sn4+) DTPA. The method allows the use of DTPA, a toxic chelating agent, in an approximately 1:1 ratio to 117mSn(Sn4+) via either aqueous conditions, or using various organic solvents, such as methylene chloride. A pharmaceutical composition manufactured by the novel method is also provided, as well as methods for treatment of bone tumors and pain associated with bone cancer using the pharmaceutical composition of the invention.

Abstract: A pharmaceutical composition is provided for systemically treating a living mammal or avian. The composition preferably comprises an alkyl-dimethyl-benzyl-ammonium chloride, an alkyl-dimethyl-ethylbenzyl-ammonium chloride, and an organotin compound in a vehicle suitable for systemically treating a living mammal or avian of viral, bacterial, fungal infections and diseases, including HIV in humans.

Abstract: A pharmaceutical composition is provided for systemically treating a living mammal or avian. The composition preferably comprises an alkyl-dimethyl-benzyl-ammonium chloride, an alkyl-dimethyl-ethylbenzyl-ammonium chloride, and an organotin compound in a vehicle suitable for systemically treating a living mammal or avian of viral, bacterial, fungal infections and diseases, including HIV in humans.

Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.

Abstract: A pharmaceutical composition is provided for systemically treating a living mammal or avian. The composition preferably comprises an alkyl-dimethyl-benzyl-ammonium chloride, an alkyl-dimethyl-ethylbenzyl-ammonium chloride, and an organotin compound in a vehicle suitable for systemically treating a living mammal or avian of viral, bacterial, fungal infections and diseases, including HIV in humans.

Abstract: Disclosed are novel methods for a protecting or preserving wood, wood composites and other cellulosic materials, and in addition, disrupting the feeding behavior and growth cycle of termites, wood-borers and other insects, by applying certain compositions thereto which contain azadirachtin carried in neem tree extracts. Disclosed are novel neem extract compositions for coating, penetrating, treating, and curing said cellulosic materials which are non-toxic and provide long active lifetimes. The compositions contain the neem extracts in combination with binding and bittering agents which enhance the effectiveness of the extracts.

Abstract: Method for controlling harmful organisms in genetically modified cotton plants which contain a gene derived from Bacillus thuringiensis which encodes and expresses an insecticidally active protein, which comprises applying an insecticisally effective amount of one or more compounds from the following groups and a-f, described herein, to the plants, to their seeds or propagation stock and/or to the area in which they are cultivated. The method according to the invention makes it possible to reduce the application rate of crop protection agents which act synergistically with the transgenic plants, and also to increase and widen the efficacy of the transgenic plants, and therefore offers both economical and ecological advantages.

Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula 1

Abstract: The invention relates to novel targeting drug agents that are targeted for entry into the mitochondria. More specifically, the agents are cisplatin derivatives called mitoplatins which are useful as anti-tumor agents. Mitoplatins are named for their targeting to the mitochondrial DNA via the carnitine-acylcarnitine translocase system. The invention also relates to methods of synthesizing mitoplatins, compositions of matter containing mitoplatins and methods of using the mitoplatins.

Abstract: Tin polyaalkanecarboxylates having the formula [(R1pR2qSn)rOs]t wherein R1 represents C1-C6 alkyl, branched or straight, substituted or not by one or more hydroxyl groups or halogen atoms, or a phenyl group, substituted or not by one or more hydroxyl groups or halogen atoms, R2 is carboxylic residue selected from (I), (II), (III) or (IV); and p, q, r, s and t have the following meanings: P=3, q=1, r=1, s=) and t=1, p=2, q=2, r=1, s=0, and t=1, p=2, q=1, r=2, s=1 and t=2, have anti-tumor activity.

Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.

Abstract: The present invention relates to heavy metal chelate compositions, which are used as fungicides and bactericides, and methods of using the compositions. In particular, the present invention relates to a chelate, that is an EDDHA (copper-ethylenediamine-di-o-hydroxyphenylacetic acid), combined with a heavy metal, including iron, tin, zinc, manganese, copper, and combinations thereof.

Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.

Abstract: Fungicidal mixtures, comprisinga.sub.1) a carbamate of the formula I ##STR1## where T is CH or N, n is 0, 1 or 2 and R is halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -haloalkyl, it being possible for the radicals R to be different when n is 2, and/ora.sub.2) an oxime ether of the formula II ##STR2## where the substituents have the following meaning: X is oxygen or amino (NH);Y is CH or N;Z is oxygen, sulfur, amino (NH) or C.sub.1 -C.sub.4 -alkylamino (N--C.sub.1 -C.sub.4 -alkyl);R' is C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -haloalkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.3 -C.sub.6 -haloalkynyl, C.sub.3 -C.sub.6 -cycloalkyl-methyl, or benzyl which may be partially or fully halogenated and/or may carry one to three of the following radicals: cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy and C.sub.1 -C.sub.

Abstract: The present invention relates to compositions and methods of production of stress proteins using tin or zinc metal ions. The invention relates to methods of protecting a mammal against injury caused by a noxious condition by administering to the mammal tin or zinc metal ions in sufficient quantity and under appropriate conditions to induce production of stress proteins at sufficient levels to provide partial or complete protection against injury caused by a noxious condition which occurs subsequent to stress protein production. The invention also relates to methods of inducing stress protein production in a mammal by administering tin or zinc metal ions in sufficient quantity and under appropriate conditions to induce production of stress proteins to protect the mammal against injury caused by a noxious condition.

Abstract: This invention provides a novel fungicide composition which has a bicarbonate-containing inorganic salt ingredient which enhances the efficacy of a fungicide ingredient for the treatment of cultivated crops. An invention fungicide composition also contains a surfactant ingredient, and a water-soluble organic compound which functions as a compatibility enhancing ingredient in aqueous formulations, and the ingredients improve the spreadability and adhesiveness of the composition when applied to foliage. An invention fungicide composition also contains a fertilizer-effective ratio of nitrogen, phosphorus and potassium.

Abstract: This invention relates to preservative compositions which comprise a biocidal metal compound and an fungicidal compound containing a triazole group. Methods of treating wood with the composition are also described.

Abstract: A therapeutic composition and method of using the same for the palliation or relief of pain in patients having diseases which affect the bone and bone joints including metastatic bone cancer, arthritis, and other inflammatory arthropathies. The therapeutic composition comprises as the active agent a complex formed of non-radioactive metal ions and organic phosphonic acid ligands, or pharmaceutically acceptable salts thereof.

Abstract: Fine metallic particles-containing fibers with various fine metallic particles therein, which have fiber properties to such degree that they can be processed and worked, and which can exhibit various functions of the fine metallic particles, such as antibacterial deodorizing and electroconductive properties are provided, as well as a method for producing the same.

Abstract: Methods are provided for preparing compositions suitable for protecting irritated or damaged skin from further oxidative and biochemical damage and thus permitting natural healing processes to progress, for accelerating the rate of healing of burns and surgical wounds, and for increasing the size of hair follicles and the rate of hair growth. The compositions generally comprise precipitates formed by the complexation of starch of various plants with ionic transition metals, such as copper(II) and tin(II) salts.

Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying dihydropyridazinone and pyridazinone compounds onto or into the marine structure. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.

Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying diphenyldiones. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.

Abstract: A compound and method for controlling Take-all disease of plants are disclosed by applying a fungicide of the formula: ##STR1## wherein Z.sub.1 and Z.sub.2 are carbons of a benzene ring; A is selected from the group consisting of --C(X)-amine wherein the amine is substituted with a first and a second amine substituent or with an alkylaminocarbonyl and a hydrogen, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 ; Q is Si, Ge, or Sn; W is --C(R.sub.3).sub.p H.sub.(2-p) --; n is 0, 1, 2, or 3; m is 0 or 1; p is 0, 1, or 2;or an agronomic salt thereof;the first and second amine substituents and R, R.sub.2, R.sub.3, R.sub.4, and R.sub.7 are defined herein.

Abstract: The subject invention concerns a novel process for controlling methicillin-resistant Staphylococcus aureus (MRSA) microbes. The process comprises the use of organostannane-modified poly(vinyl alcohol) and naturally occurring small and large oxygen and/or nitrogen containing compounds, also referred to herein as modified tin-containing polymer (MTP) materials, to control MRSA microbes.

Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying onto or into the marine structure a phenylamide compound. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.

Abstract: The invention relates to thixotropic aqueous suspension concentrates of plant protection agents. The invention furthermore relates to the use of these agents in plant protection and the use of saponites as auxiliaries in the preparation of plant protection agent suspensions by wet grinding of the solid constituents.

Abstract: Disclosed are methods for treatment of herpes virus infections in a human or lower animal subject comprising administering to the subject stannous salt and one or more pharmaceutically acceptable carriers suitable for topical administration. The stannous salt may be one or more stannous carboxylates, a stannous halide selected from the groups consisting of stannous bromide, stannous iodide, and stannous chloride dihydrate, two or more stannous halides, or one or more stannous halides and one or more stannous carboxylates. Another therapeutic agent, such as an anesthetic, analgesic, or antibiotic, may also be administered. Also disclosed are compositions effective in treating herpes virus infections in a human or lower animal subject comprising stannous fluoride, one or more therapeutic agents, and one or more pharmaceutically acceptable carriers suitable for topical administration.

Abstract: Disclosed are methods for treatment of herpes virus infections in a human or lower animal subject comprising administering to the subject stannous salt and one or more pharmaceutically acceptable carriers suitable for topical administration. The stannous salt may be one or more stannous carboxylates, a stannous halide selected from the groups consisting of stannous bromide, stannous iodide, and stannous chloride dihydrate, two or more stannous halides, or one or more stannous halides and one or more stannous carboxylates. Another therapeutic agent, such as an anesthetic, analgesic, or antibiotic, may also be administered. Also disclosed are compositions effective in treating herpes virus infections in a human or lower animal subject comprising stannous fluoride, one or more therapeutic agents, and one or more pharmaceutically acceptable carriers suitable for topical administration.

Abstract: Disclosed are methods for treatment of herpes virus infections in a human or lower animal subject comprising administering to the subject stannous salt and one or more pharmaceutically acceptable carriers suitable for topical administration. The stannous salt may be one or more stannous carboxylates, a stannous halide selected from the groups consisting of stannous bromide, stannous iodide, and stannous chloride dihydrate, two or more stannous halides, or one or more stannous halides and one or more stannous carboxylates. Another therapeutic agent, such as an anesthetic, analgesic, or antibiotic, may also be administered. Also disclosed are compositions effective in treating herpes virus infections in a human or lower animal subject comprising stannous fluoride, one or more therapeutic agents, and one or more pharmaceutically acceptable carriers suitable for topical administration.

Abstract: A method of treating skeletal muscle fibrosis in mammals. The novel method is effective for reducing the extent of skeletal muscle fibrosis in an individual who suffers from a disorder which targets skeletal muscle tissue, such as Duchenne's and Becker's muscular dystrophy and denervation atrophy induced by either trauma or neuromuscular disease. The treatment includes administering to the individual an effective amount of a metalloporphyrin compound, especially hemin, heme arginate, cobalt protoporphyrin IX chloride and cobalt protoporphyrin IX arginate.

Abstract: Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.

Abstract: Kits comprising an agricultural chemical composition which can be safely applied to crops without causing any chemical damage; comprising a mixture, which exerts excellent potentiating effects on various agricultural chemicals, of compounds represented by the following general formula (I) and having (n1+n2+n3) and (n4+n5+n6) each being a number of 0 to 100 on the average, and an agricultural chemical, wherein the weight ratio of the mixture to the agricultural chemical ranges from 0.1 to 50: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group having from 1 to 30 carbon atoms.

Abstract: This invention provides novel Sn compounds, i.e. di-n.butyltindihydroxybenzoates, which exhibit excellent activities against varies tumors. This invention also provides pharmaceutical compositions which contain said novel Sn compounds in combination with a suitable carrier, in particular aqueous solutions which are suitable for injection.

Abstract: The invention relates to novel aromatic fluorine-containing organotin compounds of the formula {(F.sub.5 C.sub.6 RCO.sub.2 SnBu.sub.2).sub.2 O}.sub.2 and {(F.sub.5 C.sub.6 RCO.sub.2).sub.2 SnBu.sub.2 } wherein R is CH.sub.2, CH.dbd.CH or a single bond between the phenyl ring and the CO.sub.2 group, and Bu is a butyl group; as well as to anti-tumour compositions containing as an active ingredient one or more of these compounds.

Abstract: A method for enhancing an efficacy of an agricultural chemical which comprises incorporating a quaternary ammonium enhancer into a diluted solution of the agricultural chemical.

Abstract: A method of controlling the attachment of organisms to an underwater surface is disclosed. The method comprises contacting the organisms with a compound of Formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halogen, or hydroxyl. Antifouling coatings and cementitious compositions containing a compound of Formula I are also disclosed.

Abstract: This invention provides a novel fungicide composition which has bicarbonate-containing inorganic salt ingredients which enhance the efficacy of a fungicide ingredient for the treatment of cultivated crops. The fungicide composition contains nitrogen, phosphorus and potassium fertilizer elements, and the inorganic salt ingredients contain at least two different alkali metal or ammonium cations.

Abstract: An agricultural chemical composition which can be safely applied to crops without causing any chemical damage; comprising a mixture, which exerts excellent potentiating effects on various agricultural chemicals, of compounds represented by the following general formula (I) and having (n1+n2+n3) and (n4+n5+n6) each being a number of 0 to 100 on the average, and an agricultural chemical, wherein the weight ratio of the mixture to the agricultural chemical ranges from 0.1 to 50: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group having from 1 to 30 carbon atoms.

Abstract: A carbon black system for manufacturing rubber comprises a pair of carbon blacks having the same structure, a fumed silica and a silane coupler. One of the pairs of carbon blacks has an Iodine Adsorption No. of less than 115 and the other pair of carbon blacks has an Iodine Adsorption No. of greater than 115. A rubber composition comprises a rubber selected from a group of polar and nonpolar rubbers, a carbon black system comprising a pair of furnace carbon blacks with both of the pairs of carbon blacks having the same structure, a fumed silica and silane coupler. One of the pairs of carbon blacks has an Iodine Adsorption No. of less than 115 and the other pair has an Iodine Adsorption No. of greater than 115. The carbon black system is from about 40 parts per hundred to about 80 parts per hundred of the rubber. The ratio of either pair of carbon blacks to the other in the rubber does not exceed 3:1.

Abstract: A wood preservative composition including a mixture of two or more metallic soaps of long chain unsaturated fatty acids, which soaps have a metallic component selected from the group consisting of copper, zinc, chromium, iron, antimony, tin, cobalt, nickel, arsenic, boron, lead, magnesium, potassium and sodium, and a fatty acid component selected from two or more of the group consisting of oleic acid, linoleic acid, and linolenic acid, the composition being such that the ratio by mass of metallic soap of oleic acid:metallic soap of linoleic acid:metallic soap of linolenic acid is about 20-29:15-70:0-47.

Abstract: The invention relates to anti-tumor compositions containing as an active ingredient one or more compounds of the formulaAr.sub.3 Sn--O--C(O)--C.sub.6 H.sub.2 XYZwherein X and Y are each H, OH, halogen or alkyl; and Z is halogen, amino, alkoxy, acyloxy, sulphonic acid or alkyl. A number of these compounds are novel compounds.

Abstract: A biocide composition comprising(A) 1 to 50% by weight of a biocide, and(B) 0.005-60% by weight of a biocide activator having the specific formula is provided. The biocide effect of a biocide can be enhanced with the use of an effective amount of a biocide activator.

Abstract: The present invention relates to the use of thiadiazoles of the type ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 =hydrogen,alkyl groups having 1-4 carbon atomssubstituted alkyl groups having 1-4 carbon atoms which are substituted by halogen, carboxyl, hydroxyl or nitro group,an alkoxyCN, halogen, NO.sub.2 orCOOR in which R=H or alkyl groups 1-4 carbon atoms,and the use of synergistic combinations of thiadiazoles with other biocidal substances as biocides for material protection. The compounds according to-the invention, which are distinguished by a broad, biocidal action spectrum, can be used in particular for wood preservation for preventing the destruction of wood by fungi or bacteria, for the biocidal treatment of plastics and as preservatives or disinfectants. The recommended concentrations for use are 0.01 to 15 percent by weight-preferably 0.1-3.0 percent by weight.

Abstract: A pesticidal organotin formulation is a water dispersible solid concentrate comprising at least one pesticidal organotin compound and polyvinylpyrrolidone. The formulation is prepared by dissolving the organotin compound and the polyvinylpyrrolidione in a solvent, followed by removal of the solvent, preferably by evaporation at a pressure below atmospheric pressure to yield the solid concentrate. The formulation may be dispersed in water, either with or without agitation, to yield an aqueous dispersion which may be applied to a locus to combat pests, especially acarids.

Abstract: 9.alpha.-Hydroxy-19,11.beta.-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R.sup.1, R.sup.2, G, Z, R.sup.4 --Y and R.sup.4' --Y' follows from the description. The steroids of general formula I have antigestagen and/or antiglucocorticoidal action and can be used for the production of pharmaceutical agents.

Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.