Zinc Patents (Class 514/494)
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Patent number: 11566260Abstract: Disclosed is a method for preventing, controlling or treating a fungal infection on a plant. The method includes applying to such plant organ a non-fungicidal amount or a potentiating amount of a composition including a potentiating agent of a plant defense molecule, in association with a phytopharmaceutical vehicle.Type: GrantFiled: September 9, 2019Date of Patent: January 31, 2023Assignee: UNIVERSITE D'ANGERSInventors: Philippe Simoneau, Thomas Guillemette, Pascal Richomme, Jean-Jacques Helesbeux
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Patent number: 11471432Abstract: The invention relates to a combination therapy for the prevention and/or treatment of immune-mediated chronic inflammatory and autoimmune diseases comprising a combination of one or more C3-C8 carboxylic acids, physiologically acceptable salts and/or esters thereof, and one or more fumaric acid esters and/or salts thereof. The combination being particularly useful in the treatment of psoriasis and multiple sclerosis.Type: GrantFiled: June 29, 2020Date of Patent: October 18, 2022Assignee: Flexopharm Brain GMBH & Co. KGInventors: Ralf Gold, Aiden Haghikia, Ulrich Matthes
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Patent number: 11453142Abstract: Methods for treating cellulosic materials comprising introducing a liquid treating composition into the cellulosic material, the treating composition comprising a solution prepared from at least: (i) one or more of a copper amine complex or copper ammine complex, such as copper tetraamine carbonate, (ii) one or more of ammonia or a water-soluble amine and (iii) water; and exposing the cellulosic material provided thereby to carbon dioxide and/or carbonic acid to provide treated cellulosic material, and treated cellulosic materials prepared thereby.Type: GrantFiled: September 28, 2020Date of Patent: September 27, 2022Assignee: American Chemet CorporationInventor: Daniel Brimhall
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Patent number: 11396453Abstract: The present invention relates to a metal phase transformation compound and a method for preparing the same.Type: GrantFiled: March 10, 2021Date of Patent: July 26, 2022Assignee: WEBIOTREE CO.. LTDInventors: Ho Jun Kim, Ki Yeok Kim
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Patent number: 11147778Abstract: The present technology provides siderophore-polymer conjugates that enhance the sensitivity of bacteria to antibiotics, e.g., Pseudomonas, P. aeruginosa, Acinetobacter, and A. baumannii. Methods of preparing and using such conjugates to treat bacterial infections are disclosed.Type: GrantFiled: May 9, 2019Date of Patent: October 19, 2021Assignee: Wisconsin Alumni Research FoundationInventors: May Xiong, Max Purro
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Patent number: 11123406Abstract: The invention is a composition of human insulin or insulin analog that includes specific concentrations of citrate, chloride, in some cases including the addition of sodium chloride, zinc and, optionally, magnesium chloride and/or surfactant, and that has faster pharmacokinetic and/or pharmacodynamic action than commercial formulations of existing insulin analog products.Type: GrantFiled: May 14, 2018Date of Patent: September 21, 2021Assignee: Eli Lilly and CompanyInventors: Michael Patrick Akers, Chi A. Nguyen, Chad D. Paavola, Virender Kumar Sarin, Nanette Elizabeth Schulte, Ranajoy Majumdar
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Patent number: 11110120Abstract: Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The cinnamaldehyde is supplemented by zinc, and the combination can be effective to increase at least one of energy expenditure, sympathetic nervous system activity, or fat oxidation. The composition comprising the combination of cinnamaldehyde and zinc can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treating obesity or overweight. The composition can improve one or more of insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood or memory.Type: GrantFiled: May 24, 2016Date of Patent: September 7, 2021Assignee: Societe des Produits Nestle S.A.Inventors: Susana Camacho, Stephanie Michlig Gonzalez, Lucas Actis Goretta, Jenny Meylan Merlini, Johannes Le Coutre
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Patent number: 11058718Abstract: Provided is a method for treating non-alcoholic steatohepatitis (NASH), the method includes administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition and the pharmaceutical composition contains polaprezinc as zinc preparation and sodium selenite as selenium preparation.Type: GrantFiled: June 4, 2020Date of Patent: July 13, 2021Assignee: MEDICO CONSL CO., LTD.Inventors: Satoru Kubota, Toru Kono
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Patent number: 10933091Abstract: A method of treating type I diabetes comprising administering a therapeutically effective amount of 64Zn-enriched zinc.Type: GrantFiled: December 20, 2019Date of Patent: March 2, 2021Assignee: Vector Vitale IP LLCInventors: Peter Novak, Maxim Temnikov, Oleksandr Balakin
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Patent number: 10821093Abstract: The present invention relates to a microelement organic O-chelate or N-chelate complex compound, for the inhibition of facultative pathogenic bacteria. The present invention further relates to a composition, feed additive or feed comprising the compounds, as well as methods for the preparation thereof, and for the use thereof in animal stock farming.Type: GrantFiled: July 16, 2018Date of Patent: November 3, 2020Assignee: Dr. Bata Zrt.Inventors: Árpád Bata, József Kutasi
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Patent number: 10709731Abstract: Provided is a hyaluronic acid (HA) composition for use in treating or preventing mucosa related disorders or diseases including a mixture of HAs having different average molecular weights and different rheological, isolation, tissue scaffold and degradation properties. The resulting formulation demonstrates an optimal balance between adhesion, tissue scaffold and treating time on the treatment and prevention of mucosa related disorders or diseases including conjunctivitis, otitis, allergic rhinitis, gingivitis, oral ulcer, bronchitis, gastroesophageal reflux disease (GERD), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), urethritis, cystitis and vaginitis.Type: GrantFiled: August 26, 2016Date of Patent: July 14, 2020Assignee: AIHOL CORPORATIONInventor: Shyh-Shyan Lin
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Patent number: 10632089Abstract: A tyrosinase activity inhibitor is prepared by combining (A) a metal (zinc, cobalt or iron) chelate compound of ?-lipoyl amino acid or its pharmaceutically acceptable salt with (B-1) a human manganese SOD or (B-2) an ascorbic acid compound such as ascorbic acid and ascorbyl glucoside. A ratio (R1) of the (B-1) component content to the (A) component content is preferably 0.001 to 1,500, when R1 is defined as R1=[Unit concentration of (B-1) component (unit/mL)/Concentration of (A) component (?g/mL)], and a ratio (R2) of the (A) component content to the (B-2) component content is preferably 0.0001 to 1,000, when R2 is defined as R2=[Concentration of (A) component (m/mL)/Concentration of (B-1) component (mg/mL)]. An external preparation for skin contains the (A) component and the (B-1) component or the (B-2) component as effective ingredients for inhibiting tyrosinase activity.Type: GrantFiled: April 7, 2016Date of Patent: April 28, 2020Assignee: JO Cosmetics Co., Ltd.Inventors: Kanako Wada, Katsura Adachi
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Patent number: 10524997Abstract: Several embodiments disclosed herein relate to formulations having antimicrobial and/or sanitizing effects, and uses of the same. In particular, the formulations and methods of using same provide, in several embodiments, an immediate and a persistent antimicrobial effect against a broad spectrum of microorganisms.Type: GrantFiled: June 18, 2018Date of Patent: January 7, 2020Inventors: Jesse Cozean, Colette Cozean, Susan Goldsberry
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Patent number: 10405550Abstract: A method for preventing, controlling or treating a fungal infection on a plant organ includes applying to the plant organ a non-fungicidal amount or a potentiating amount of a composition including a potentiating agent of a plant defense molecule, in association with a phytopharmaceutical vehicle.Type: GrantFiled: June 27, 2013Date of Patent: September 10, 2019Assignee: UNIVERSITE D'ANGERSInventors: Philippe Simoneau, Thomas Guillemette, Pascal Richomme, Jean-Jacques Helesbeux
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Patent number: 9993407Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.Type: GrantFiled: January 20, 2017Date of Patent: June 12, 2018Assignee: Colgate-Palmolive CompanyInventors: Zhiqiang Liu, Long Pan, Shaotang Yuan, Jairajh Mattai, James G. Masters
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Patent number: 9775799Abstract: Disclosed is a microneedle coating composition comprising a physiologically active substance (excluding Japanese encephalitis vaccine antigen), a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.Type: GrantFiled: February 12, 2014Date of Patent: October 3, 2017Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takuya Sugahara, Kazuya Machida
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Patent number: 9655924Abstract: Disclosed herein are compositions for treatment of ear infection (such as bacterial and/or yeast infection) in human or veterinary subjects. In some embodiments the compositions include silver microparticles, for example about 0.1% silver microparticles, about 0.2% silver microparticles, or about 0.4% silver microparticles. Also disclosed are methods for treating ear infection in a subject utilizing one or more of the disclosed compositions, for example sequential application of compositions including about 0.1% silver microparticles, about 0.2% silver microparticles, and about 0.4% silver microparticles to the ear canal of the subject. In some examples, one or more of the disclosed compositions are provided in a kit.Type: GrantFiled: April 8, 2015Date of Patent: May 23, 2017Assignee: BioMedtrix, LLCInventors: Christopher G. Sidebotham, Alan Mundell
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Patent number: 9414599Abstract: A process is described for the preparation of a composition comprising a metal complex in an oily organic matrix, the latter being at the same time able to promote the formation of the complex. Said process also envisages that the complex, once formed, is not separated from said oily organic matrix, but the resulting composition is used as such, as having observed that the performances of the complex present therein is thus improved.Type: GrantFiled: June 7, 2012Date of Patent: August 16, 2016Assignee: Volare & Connecting, LLCInventor: Giuliano Leonardi
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Patent number: 9174935Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I), or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. In one embodiment, the compound is represented by Structural Formula (II), or a prodrug, isomer, ester, salt, hydrate, solvate or polymorph thereof. The present invention also provides a pharmaceutical composition comprising the compound of the invention and method of use thereof.Type: GrantFiled: October 21, 2009Date of Patent: November 3, 2015Assignee: Synta Pharmaceuticals Corp.Inventors: Masazumi Nagai, Jianhua Shen
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Patent number: 9149042Abstract: The present invention relates to a stable antiseptic solution comprising: a di(4-chlorophenyldiguanido) compound or a pharmaceutically acceptable salt thereof, wherein said di(4-chlorophenyldiguanido) compound or a pharmaceutically acceptable salt thereof is a compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to a process for preparing said antiseptic solution.Type: GrantFiled: March 14, 2012Date of Patent: October 6, 2015Assignee: Medichem, S.A.Inventors: Marina Puigvert Colomer, Sergio Lloret Perez
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Patent number: 9051335Abstract: An antipruritic against pruritus caused by multiple sclerosis is disclosed.Type: GrantFiled: March 9, 2006Date of Patent: June 9, 2015Assignee: TORAY INDUSTRIES, INC.Inventors: Hideo Umeuchi, Koki Ueno, Hiroshi Miyakawa
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Publication number: 20150148413Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.Type: ApplicationFiled: January 27, 2015Publication date: May 28, 2015Inventors: Mordechai Chevion, Vladimir Vinokur, Eduard Berenshtein, Ron Eliashar, Baruch Bulvik
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Publication number: 20150141504Abstract: The invention relates to the field of medicine, and specifically to preparations for treating skin lesions, in particular viral, benign, precancerous and cancerous, non-metastasizing, dysplastic and inflammatory lesions of the visible mucous membranes, and also viral and fungal skin and nail lesions, and for correcting wrinkles and senile pigment blemishes, said preparations comprising solutions of complex compounds of salts of zinc and alpha-chlorocarboxylic acids of general formula [Zn(RCH2?xClxCOOH) (H2O)4?n]+2 .2[RCH2?x ClxCOO]?, where R=alkyl, H or Cl, x=1-2 and n=0-4, in a corresponding alpha-chlorocarboxylic acid, wherein the content of zinc in the solution is 0.25-10.0% and the content of acid is 10-90%. The preparation may additionally contain an additive perfume, for example an ethyl ester of the corresponding alpha-chlorocarboxylic acid. The treatment method consists in that 2-5 doses of the preparation, which has been precooled to 10-15° C.Type: ApplicationFiled: November 14, 2011Publication date: May 21, 2015Applicant: OBSCHESTVO S OGRANITCHENNOI OTVETSTVENNOSTJU "OXYGON"Inventors: Shalva Iosifovitch Mardi, Lev Aleksandrovich Ustynyuk
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Patent number: 9034393Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.Type: GrantFiled: September 14, 2012Date of Patent: May 19, 2015Assignee: SCIESSENT LLCInventor: Joseph J. Crudden
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Publication number: 20150105461Abstract: The present invention relates to metal complexes, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of conditions in which metal delivery can prevent, alleviate or ameliorate the condition. There are a number of clinical conditions which are caused by or associated with abnormal levels of metals (typically low metal levels). Conditions in of this type include cancer and conditions characterised by or associated with oxidative damage, more specifically neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease or Huntington's disease. The invention also relates to ligands useful in the preparation of metal complexes of this type.Type: ApplicationFiled: December 16, 2014Publication date: April 16, 2015Applicant: The University of MelbourneInventors: Kevin J. Barnham, Paul S. Donnelly, Anthony R. White
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Publication number: 20150099635Abstract: An agricultural oil-based suspension formulation comprising an active ingredient suspended in finely divided form in an oil and at least one unsaturated rubber-type copolymer or a mixture thereof, wherein the rubber-type copolymer comprises at least styrene as a residue.Type: ApplicationFiled: June 8, 2012Publication date: April 9, 2015Inventors: Andrew David Holliday, Dilek Saylik, Rowan Brown, Karen Vab Der Sande, Andrew F. Kirby, Robert E. Bohun
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Patent number: 8987244Abstract: Methods are provided for reducing copper values for, by way of example, treating, preventing or ameliorating tissue damage such as, for example, tissue damage that may be caused by (i) disorders of the heart muscle (for example, cardiomyopathy or myocarditis) such as idiopathic cardiomyopathy, metabolic cardiomyopathy which includes diabetic cardiomyopathy, alcoholic cardiomyopathy, drug-induced cardiomyopathy, ischemic cardiomyopathy, and hypertensive cardiomyopathy, (ii) atheromatous disorders of the major blood vessels (macrovascular disease) such as the aorta, the coronary arteries, the carotid arteries, the cerebrovascular arteries, the renal arteries, the iliac arteries, the femoral arteries, and the popliteal arteries, (iii) drug induced, and metabolic (including hypertensive and/or diabetic disorders of small blood vessels (microvascular disease) such as the retinal arterioles, the glomerular arterioles, the vasa nervorum, cardiac arterioles, and associated capillary beds of the eye, the kidney, the hType: GrantFiled: September 18, 2013Date of Patent: March 24, 2015Assignee: PhilERA New Zealand LimitedInventors: Garth J. S. Cooper, John R. Baker
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Patent number: 8986741Abstract: A sunscreen composition for application for plants comprises Titanium Dioxide (TiO2), Zinc Oxide (ZnO), Silicon Dioxide (SiO2), a surfactant, wetting agent, dispersant (SWD) and water. The composition forms a suspension concentrate when combined that when diluted in water provides a solution that provides uniform coverage using convention spraying equipment. A method of protecting plants including turfgrass from ultraviolet radiation, heat stress and/or sunburn comprises combining TiO2, ZnO, SiO2, SWD and water to form a suspension concentrate. The suspension concentrate is then diluted in water and applied to an area in which sun protection is desired.Type: GrantFiled: October 15, 2013Date of Patent: March 24, 2015Inventor: Scott May
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Patent number: 8975294Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.Type: GrantFiled: August 19, 2010Date of Patent: March 10, 2015Assignees: Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Mordechai Chevion, Vladimir Vinokur, Eduard Berenshtein, Ron Eliashar, Baruch Bulvik
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Patent number: 8975295Abstract: Methods of altering properties of tissues, by providing an effective modifying amount of zinc, which may be in the form of zinc ions. This is accomplished through the use of topical compositions containing one or more zinc-containing components such as salts and/or other zinc compounds or complexes, particularly zinc acetate. Altering properties of tissues includes increasing or decreasing fatty tissue, increasing or decreasing epidermal thickness, increasing elastin content, and preventing or treating gum regression or atrophy. Also disclosed is the provision of a contact lens coated with a zinc-containing material, to improve vision by increasing elastin content of the lens of the eye through release of zinc ions.Type: GrantFiled: October 22, 2003Date of Patent: March 10, 2015Assignee: Precision Dermatology, Inc.Inventor: Jacob M. Waugh
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Patent number: 8968791Abstract: The present invention provides a dietary supplement that promote the growth, repair, and maintenance of mammalian bone and joint connective tissue. In particular, the dietary supplement comprises a combination of at least one metal chelate and at least one chondroprotective agent.Type: GrantFiled: May 30, 2008Date of Patent: March 3, 2015Assignee: Novus International, Inc.Inventors: Jeremy D. Moore, Thomas R. Hampton, Robert Harrell
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Publication number: 20150057345Abstract: Method for improving the feed efficiency in poultry husbandry wherein poultry is provided with a compound directly upon hatching, the compound being selected from a lactylate in accordance with formula 1, or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof, R2-COO—[—CH(CH3)-COO]n-R1??Formula 1 a glycolylate of formula 2, or a Na, K, Ca, Mg, Fe(II), Zn, NH4, or Cu(II) salt thereof. R2-COO—[—CH2-COO]n-R1??Formula 2: a lactate ester of formula 3, HO—CH(CH3)-COO—R2??Formula 3: and/or a glycolic acid ester of formula 4, HO—CH2-COO—R2??Formula 4: In the above formulas R1 is selected from H, n stands for an integer with value of 1-10, and R2 stands for C1-C35 alkyl or alkenyl chain, which may be branched or unbranched. The effective compound provided to poultry is dosed level in a first part of their life-span higher than the dose level in other part of their life span.Type: ApplicationFiled: April 3, 2013Publication date: February 26, 2015Applicant: PURAC BIOCHEM BVInventors: Bart Jan Boomsma, Anne Cazemier
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Patent number: 8952057Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.Type: GrantFiled: June 16, 2011Date of Patent: February 10, 2015Assignee: JR Chem, LLCInventor: José E. Ramirez
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Publication number: 20150038577Abstract: A nutritional supplement for a human, the supplement having a chelate comprised of an N-acetyl-L-cysteine ligand bonded to a metal to form a chelate ring. A method for preparing a chelate comprised of N-acetyl-L-cysteine ligand and a metal having the steps of: dissolving an amount of N-acetyl-L-cysteine in an aqueous solution, adding a metal to the aqueous solution, stifling and heating the aqueous solution, and removing the solvent under reduced pressure. A method of treating a human for one or more of oxidative stress, cardiovascular disease, cerebrovascular disease, neurodegenerative diseases, Alzheimer's disease, ADHD, bipolar, schizophrenia, autism, dementia, and HIV in a human comprising administering an effective amount of a composition having N-acetyl-L-cysteine in a chelate formation with a metal. A compound having a chelate formulation with a metal being chelated by an N-acetyl-L-cysteine ligand.Type: ApplicationFiled: December 27, 2013Publication date: February 5, 2015Inventors: Xueju Xie, Rhett Sean Daniels, Patricia Gahan
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Publication number: 20140364491Abstract: An orally deliverable dosage system comprises (a) iron in a form of one or more physiologically acceptable iron grades, compounds and/or complexes; and (b) an agent to mitigate one or more gastrointestinal adverse effects of unabsorbed iron, said agent comprising one or both of a zinc component and a chelator component, said zinc component if present comprising one or more physiologically acceptable zinc compounds and/or complexes, and said chelator component if present comprising an ion-chelating compound formulated for release distal to the primary site of iron absorption in the duodenum.Type: ApplicationFiled: May 28, 2014Publication date: December 11, 2014Applicant: AMIP, LLCInventor: Jonathan David Bortz
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Publication number: 20140350099Abstract: Compounds for use in the treatment or prophylaxis of pain, including acute and chronic pain (e.g., nociceptive pain, neuropathic pain, headaches, migraine), represented by general formula I: in which: the dotted line represents a single or a double bond; and R5 and R5? are independently —H, —OH or —OR6, where R6 is a linear or branched C1-C4 alkyl; X is —CH2O—; Z is —CH2CH2O—, —CH(CH3)CH2O— or —CH2CH(CH3)O—; m is 1; and n is an integer of 1-5. The compounds of the invention are also effective for reducing inflammation and may be used alone or in combination with other analgesics.Type: ApplicationFiled: July 21, 2014Publication date: November 27, 2014Inventor: Eliahu Kaplan
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Patent number: 8894978Abstract: A new skin care system includes day and night skin cream compositions comprising nutrients and antioxidants for use by children between six months and eighteen years of age. The day skin cream composition provides protection from UV radiation and the night skin cream composition contains no sun protection ingredients and elevated levels of nutrients and antioxidants. A child-friendly bottle for each composition can be used by young children without difficulty. A fragrance included in each composition is popular with children, and the bottle for the day composition has graphics indicating day-time use and the bottle for the night composition has graphics indicating night-time use. The day composition is applied topically each day to the face after tooth-brushing, and the night composition is applied topically to the face each night after tooth-brushing.Type: GrantFiled: April 25, 2014Date of Patent: November 25, 2014Inventor: William Scott Prendergast
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Publication number: 20140343140Abstract: [Problem] To provide an agent for preventing and/or treating veisalgia. [Solution] Provided is an agent for preventing and/or treating veisalgia, the agent including an ALA (5-aminolevulinic acid).Type: ApplicationFiled: November 30, 2012Publication date: November 20, 2014Inventors: Tohru Tanaka, Motowo Nakajima, Fuminori Abe, Satofumi Kawata
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Patent number: 8889038Abstract: This invention relates to wood preservatives containing copper complexes and calcium ions, zinc ions or calcium and zinc ions for protection of wood, cellulose, hemicellulose, lignocellulose, cellulosic materials and articles derived from cellulosic materials from decay caused by fungi. The calcium ions, zinc ions, or calcium and zinc ions improve the penetration of copper preservative agent into the interior of a treated material or article.Type: GrantFiled: December 18, 2008Date of Patent: November 18, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Albert Gordon Anderson, Mark A. Scialdone
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Patent number: 8865687Abstract: The present invention relates to a preparation suitable for the prevention and/or treatment of vascular disorders, comprising the following fractions: fraction a) consisting of long chain polyunsaturated fatty acids; fraction b) consisting of phospholipids, which fraction contains at least two different phospholipids selected from the group consisting of phosphatidylserine, phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine. fraction c) consisting of compounds which are a factor in methionine metabolism, which fraction contains at least one member selected from the group consisting of folic acid, vitamin B12, vitamin B6, magnesium and zinc.Type: GrantFiled: February 14, 2013Date of Patent: October 21, 2014Assignee: N.V. NutriciaInventors: Amanda Johanne Kiliaan, Robert Johan Joseph Hageman
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Patent number: 8858922Abstract: Disclosed is a new composition of matter that is a compound which also is presented as a dispersion with broad UVA and UVB spectral absorption stability, heat absorption, and insulation properties, anti-microbial, water resistance, and high SPF properties. The composition of matter is a zinc oxide complex that is provided with distilled water buffered to a pH of greater than 10 using ammonium hydroxide, L-arginine, or other buffering agents, and zinc oxide particles. The zinc oxide complex may be dried and rinsed to increase stability. An emollient, such as glycerine, and/or an emulsifier such as a combination of cetearyl alcohol and cetearyl glucoside and/or sodium stearoyl glutamate and/or cetearyl glucoside may also be added to the zinc oxide complex. The zinc oxide complex is made from natural-based, earth-derived, Ecocert® certified ingredients is non-toxic, and may be used or combined with any compound in which UVA/UVB stability is desired.Type: GrantFiled: November 22, 2010Date of Patent: October 14, 2014Assignee: 3rd Rock Sunblock, Inc.Inventor: Guerry L. Grune
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Publication number: 20140303081Abstract: Nanoparticles include a core and one or more targeting moieties, as well as one or more contrast agents or one or more therapeutic agents. The contrast agents or therapeutic agents may be contained or embedded within the core. If the nanoparticle includes therapeutic agents, the agents are preferably released from the core at a desired rate. The core may be biodegradable and may release the agents as the core is degraded or eroded. The targeting moieties preferably extend outwardly from the core so that they are available for interaction with cellular components, which interactions will target the nanoparticles to the appropriate cells, such as apoptotic cells; organelles, such as mitochondria; or the like. The targeting moieties may be tethered to the core or components that interact with the core.Type: ApplicationFiled: August 31, 2012Publication date: October 9, 2014Applicant: UNIVERSITY OF GEORGIA FOUNDATION, INC.Inventors: Shanta Dhar, Sean Marrache
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Patent number: 8853265Abstract: An oral spray composition for preventing and/or reducing the symptoms of the common cold including a zinc formulation containing both zinc acetate and zinc gluconate to ensure sustained availability of increased amounts of ionizable zinc.Type: GrantFiled: July 13, 2010Date of Patent: October 7, 2014Assignee: Zicam, LLCInventor: Tim Clarot
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Publication number: 20140271760Abstract: Described are antimicrobial liquid products comprising one or more antimicrobial organometallic additives dispersed throughout an organic host liquid.Type: ApplicationFiled: May 14, 2014Publication date: September 18, 2014Applicant: DMR INTERNATIONAL, INC.Inventors: MARC CHASON, DANIEL ROMAN GAMOTA, RICK LATELLA
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Publication number: 20140248221Abstract: Compositions containing polymetal complexes useful in treating disorders of the oral mucosa, lips, and perioral regions are described.Type: ApplicationFiled: May 13, 2014Publication date: September 4, 2014Applicant: JR CHEM, LLCInventor: Jose E. Ramirez
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Patent number: 8822532Abstract: Certain bis[thio-hydrazide amide]-related compounds are found to be surprisingly effective at treating with leukemia, e.g., acute myeloid leukemia (AML). Methods of treating a subject with AML including administering bis[thio-hydrazide amide]-related compounds described herein, are disclosed.Type: GrantFiled: December 6, 2010Date of Patent: September 2, 2014Assignee: Synta Pharmaceuticals Corp.Inventors: Masazumi Nagai, Jianhua Shen
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Publication number: 20140242404Abstract: The present invention relates to a wood preservative formulation comprising a biocidal agent which is a copper or zinc ion complexed with an amino compound selected from the group consisting of ammonia, a water soluble amine or alkanolamine and an aminocarboxylic acid and a stabilizer, as well as to aqueous treatment solutions comprising such a formulation and methods of treating wood or other cellulosic material utilising said formulation.Type: ApplicationFiled: May 2, 2014Publication date: August 28, 2014Applicant: ARCH TIMBER PROTECTION LIMITEDInventors: Kevin HUGHES, Craig Andrew MARS, Andrew HUGHES
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Publication number: 20140242137Abstract: Compositions and methods for use in treating, in particular, lignocellulosic substrates such as lumber, are provided; wherein said compositions comprise a preservative or biocidal species, other than boron, in the form of a glycolate. The methods may be used for the purpose of, for example, preventing the growth of pest organisms, or for providing other specific properties to the substrate.Type: ApplicationFiled: July 27, 2012Publication date: August 28, 2014Applicant: Matterworks One LimitedInventor: Nigel Paul Maynard
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Patent number: 8815948Abstract: An alternative method of delivery of homeopathic medicines by targeting delivery to the MALT's, especially of the intestinal tract and in high volumes.Type: GrantFiled: February 10, 2005Date of Patent: August 26, 2014Inventors: Char Tara Albert, Floyd E. Taub
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Patent number: RE45435Abstract: The addition of low concentrations of combinations of water-soluble organic salts of zinc to gels, creams, lotions or ointments can increase the ability of these products to reduce or prevent exogenous irritants from causing irritation of the underlying substrate. The addition of low concentrations of combinations of water-soluble organic zinc salts to these gels, creams, lotions or ointments also can reduce the irritation of skin or mucous membranes caused by the addition of potentially-irritating substances such as spermicides, microbicides, fungicides or other therapeutic agents to the gel, cream, lotion or ointment. The advantages of this anti-irritant approach over others, which generally employ high concentrations of single zinc salts, are the reduced potential for zinc toxicity, the reduced potential for toxicity related to zinc itself, and the preservation of the desirable biological properties of potentially-irritating therapeutic substances added to the gel, cream, lotion or ointment.Type: GrantFiled: November 9, 2012Date of Patent: March 24, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Shanta M. Modak, Milind S. Shintre, Lauserpina Caraos, Trupti Gaonkar