Containing Casein Patents (Class 514/5.7)
  • Patent number: 10369174
    Abstract: The present disclosure relates to a composition for preventing or treating metabolic diseases, in which the composition includes Bacteroides acidifaciens as an active ingredient. In addition, the present disclosure relates to a composition for oxidizing fat or inhibiting DPP-4, in which the composition includes Bacteroides acidifaciens as an active ingredient. In addition, the present disclosure relates to a transformant expressing a lean phenotype, in which an Atg7 gene is deleted in dendritic cells.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: August 6, 2019
    Assignee: GI BIOME
    Inventors: Mi Na Kweon, Jin Young Yang
  • Publication number: 20150093459
    Abstract: A bioactive complex composition having enhanced oxidative stability, emulsion stability, mineral rich transparent beverages and a wide range of functional health benefits. The composition may include as a base composition individual ingredients or a synergistic blend of mineral salts, Omega-3 rich oils, phospholipids, chitosan, and alpha-casein, beta-casein, kappa-casein or protein fragments, glycopeptides, phosphopeptides. The composition may optionally be further utilized for the prevention of hypercholesterolemia, bone (and teeth) mineral loss, treatment of mental health diseases, heart health, additional nutritional supplementation, and treatment of additional medical conditions.
    Type: Application
    Filed: October 9, 2014
    Publication date: April 2, 2015
    Inventors: Adela Mora-Gutierrez, Michael H. Gurin
  • Patent number: 8987196
    Abstract: The present invention concerns an improved balance of the essential branched chain amino acids leucine, isoleucine and valine in infant formula.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: March 24, 2015
    Assignee: N.V. Nutricia
    Inventors: Johannes Bernard Van Goudoever, Eline Marleen Van Der Beek, Marieke Abrahamse-Berkeveld, Günther Boehm
  • Patent number: 8975222
    Abstract: The present invention provides a ketogenic diet in the form of a sterile shelf stable ready to use formula, in particular a tube feed, comprising casein and dietary fiber.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: March 10, 2015
    Assignee: N.V. Nutricia
    Inventors: Andrew Sean Lynch, Simon Anders, Paul Ronald
  • Publication number: 20150045294
    Abstract: The object of the present invention is to provide a liquid enteral composition for providing nutrition, either as a supplement, or as a complete nutrition, comprising a high protein content, in particular micellar casein as major protein source, in a small volume of liquid, in particular 6 to 20 g protein per 100 ml of the liquid composition, the composition further comprising lactic acid and having a pH in the range of 6 to 8. It is also an object of the invention to provide an improved manufacturing process for such liquid enteral compositions.
    Type: Application
    Filed: February 28, 2013
    Publication date: February 12, 2015
    Inventors: Esther Jacqueline Petra De Kort, Isabela Botelho Dutra
  • Publication number: 20150011468
    Abstract: Casein compositions for increasing the rate of gastric emptying following ingestion of the composition, increasing the digestibility of a protein composition, or increasing the rate of delivery of amino acids to the blood, or for increasing the blood serum concentration of free leucine in a subject, preferably to substantially the same level as whey protein, the casein being about 10 to about 100% calcium depleted, having a degree of hydrolysis less than about 1% and having an unmodified phosphorylation pattern.
    Type: Application
    Filed: March 11, 2013
    Publication date: January 8, 2015
    Applicant: FONTERRA CO-OPERATIVE GROUP LIMITED
    Inventors: Aaron Calvin FANNING, Hasmukh Ambalal PATEL, Johannes SCHALK, Ramon Stafford HALL, Roger Richard SCHWARZENBACH, Sergey Yevgenievich UKRAINTSEV
  • Patent number: 8921310
    Abstract: The present invention relates to an agent for improving lipid metabolism, a food/drink, and a feed, containing ?s-casein as an active ingredient thereof. In addition, the present invention relates to an agent for suppressing body weight gain, an agent for reducing body fat, and an agent for reducing blood lipid, containing the agent for improving lipid metabolism.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: December 30, 2014
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Yuuki Somoto, Masayuki Ikeda
  • Publication number: 20140370117
    Abstract: The present invention provides an enteral nutritional composition with which the labor of administering water between meals can be saved. The enteral nutritional composition comprises proteins, carbohydrates and lipids, with the calories per ml of the composition being less than 1 kcal and the moisture content being 30 percent by mass or more.
    Type: Application
    Filed: June 24, 2014
    Publication date: December 18, 2014
    Applicant: NUTRI CO., LTD.
    Inventors: Susumu KAWAGUCHI, Yoshifumi INOUE
  • Publication number: 20140364361
    Abstract: The present invention relates in general to a shelf-stable liquid enteral composition for providing nutrition, either as a supplement, or as a complete nutrition, with a high protein content of a non-hydrolysed globular protein, in particular a whey protein.
    Type: Application
    Filed: July 21, 2014
    Publication date: December 11, 2014
    Applicant: N.V. Nutricia
    Inventors: Marcel MINOR, Koenraad Gerard Christoffel Weel, Natalie Elizabeth Hotrum
  • Publication number: 20140357553
    Abstract: A nutritional composition for promoting would healing comprises a protein source, a lipid source and a carbohydrate source wherein no more than 1.8% of the total calories of the composition derive from arginine and wherein the protein source includes praline in an amount of at least 3% of the total calories of the composition. The composition may be administered orally and is particularly suitable for the amelioration of pressure ulcers although it may also be used with advantage in the nutritional management of acute wounds including pre and post surgery.
    Type: Application
    Filed: August 20, 2014
    Publication date: December 4, 2014
    Inventors: Hans Smola, Gilberto Muceno
  • Patent number: 8846612
    Abstract: The use of a protein source comprising bovine casein proteins for the preparation of a nutrional composition for administration to an infant, young child or adult during or after a period of catch-up growth or weight recovery, following a period of growth restriction or weight lost, so as improve growth at early age and/or to reduce the risk of development of insulin resistance and/or Type 2 diabetes later in the life of the infant, young child or adult.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: September 30, 2014
    Assignee: Nestec S.A.
    Inventors: Olivier Aprikian, Florence Blancher, Catherine Mace, Yassaman Shahkhalili
  • Publication number: 20140271552
    Abstract: The present disclosure relates to nutritional compositions including a protein equivalent source including a peptide component comprising selected peptides from Tables 1 and 2 disclosed herein. The protein equivalent source may further include intact protein, hydrolyzed protein, including partially hydrolyzed protein, or combinations thereof. The disclosure further relates to methods of reducing the incidence of autoimmune disease and/or diabetes mellitus by providing said nutritional compositions to a target subject, which includes a pediatric subject.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Dirk Hondmann, Eric A.F. van Tol, Gabriele Gross, Marieke H. Schoemaker, Teartse Tim Lambers
  • Patent number: 8835383
    Abstract: This invention relates to the coagulation of protein containing nutritional compositions in the upper gastro-intestinal tract, more in particular in the stomach and provides a method for reducing suchcoagulation.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: September 16, 2014
    Assignee: N.V. Nutricia
    Inventors: Thomas Ludwig, Claudia Catharina Maria van den Braak, Marianne Klebach, Zandrie Hofman
  • Patent number: 8815797
    Abstract: The present invention relates in general to a shelf-stable liquid enteral composition for providing nutrition, either as a supplement, or as a complete nutrition, with a high protein content of a non-hydrolysed globular protein, in particular a whey protein.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: August 26, 2014
    Assignee: N.V. Nutricia
    Inventors: Marcel Minor, Koenraad Gerard Christoffel Weel, Natalie Elizabeth Hotrum
  • Patent number: 8791065
    Abstract: The present invention provides an enteral nutritional composition with which the labor of administering water between meals can be saved. The enteral nutritional composition comprises proteins, carbohydrates and lipids, with the calories per ml of the composition being less than 1 kcal and the moisture content being 30 percent by mass or more.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: July 29, 2014
    Assignee: Nutri Co., Ltd.
    Inventors: Susumu Kawaguchi, Yoshifumi Inoue
  • Patent number: 8735348
    Abstract: Biologically active peptides that are derived from or are similar to sequences identical with the N-terminus of the ?S1 fraction of milk casein. These peptides are capable of stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non-toxic and can be used to treat and prevent immune pathologies, hypercholesterolemia, hematological disorders and viral-related diseases, alone or in combination with other peptides or blood cell stimulating factors.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: May 27, 2014
    Assignee: Peptera Ltd.
    Inventor: Zvi Sidelman
  • Publication number: 20140051627
    Abstract: The invention provides a composition and method for providing nutritional support to obese patients. The composition has an energy density between 0.4 and 0.9 kcal/ml and comprises a protein source which comprises at least 30% by weight whey protein and provides at least 30% of the total calories of the composition. The composition may include a carbohydrate source and a lipid source. Preferably at least 50% by weight of the protein source is whey protein. The invention further extends to use of the composition in the preventin of treatment of malnutrition in obese patients.
    Type: Application
    Filed: October 14, 2013
    Publication date: February 20, 2014
    Applicant: NESTEC S.A.
    Inventor: Claudia Roessle
  • Publication number: 20140044685
    Abstract: Nutritional compositions for maximizing muscle protein synthesis while minimizing the catabolism of muscle proteins and methods of using same are provided. In this manner, the nutritional compositions may provide for retention of lean body mass, which helps to avoid loss of independence and functionality, as well as to improve quality of life especially in the elderly at risk of sarcopenia and frailty. The nutritional compositions include ?-hydroxyisocaproic acid and citrulline. The composition may include other functional ingredients such as, but not limited to whey protein including whey protein micelles, prebiotic fibers, ?-keto-glutarate, eicosapentaenoic acid, L-carnitine, nucleotides, and amino acids. Methods of administering such nutritional products to individuals in need of same are also provided.
    Type: Application
    Filed: April 18, 2012
    Publication date: February 13, 2014
    Applicant: NESTEC S.A.
    Inventors: Norman Alan Greenberg, Denis Breuille, Zamzam Kabiry (Fariba) Roughead, Doug Bolster, Jennifer Mager
  • Publication number: 20140045744
    Abstract: The present invention encompasses cultured collections of a gut microbial community, models comprising such cultures, and methods of use thereof.
    Type: Application
    Filed: September 9, 2013
    Publication date: February 13, 2014
    Inventors: Jeffrey I. Gordon, Jeremiah J. Faith, Nathan P. McNulty, Federico E. Rey, Andrew Goodman, George Kallstrom, Vanessa K. Ridaura
  • Publication number: 20140037602
    Abstract: Nutritional compositions for improving, treating and/or preventing various medical conditions and methods of using same are provided. The medical conditions may include allergies, autoimmune diseases, among others. The nutritional compositions include branched chain fatty acids and may include other functional ingredients such as, but not limited to probiotics, nucleotides and amino acids. Methods of administering such nutritional products to individuals in need of same are also provided.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 6, 2014
    Applicant: NESTEC S.A.
    Inventors: Doug Bolster, Norman Alan Greenberg, Jennifer Mager, Zamzam Kabiry (Fariba) Roughead
  • Patent number: 8642736
    Abstract: Complexes comprising resveratrol and a casein, a process for their manufacture, their uses and compositions comprising them.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: February 4, 2014
    Assignee: DSM IP Assets B. V.
    Inventor: Chyi-Cheng Chen
  • Publication number: 20140030241
    Abstract: Nutritional compositions having dietary nucleotides, ?-3 fatty acids and citrulline are provided. The nutritional compositions may be formulated to improve T cell function, increase arginine availability in vivo, regulate myeloid-derived suppressor cells (“MDSC”), and decrease the risk and/or severity of infection after surgery or trauma. Methods of making, using and administering such nutritional compositions to individuals in need of same are also provided. Methods for modulating the affects of MDSC's are also provided.
    Type: Application
    Filed: March 15, 2012
    Publication date: January 30, 2014
    Applicant: NESTEC S.A.
    Inventor: Norman Alan Greenberg
  • Publication number: 20140024581
    Abstract: The invention pertains to a liquid enteral nutritional composition with an energy density between 1.0 and 4.0 kcal/ml, a viscosity between 150 and 1800 mPas measured at a shear rate of 50/second at 20° C., comprising digestible carbohydrates and fat, wherein the composition further comprises at least one of (a1)) between 8-20 g protein per 100 ml of the composition, where micellar casein comprises at least 50 wt % of the total protein content of the composition, or (a2) between 16-45 en % protein, where micellar casein comprises at least 50% of the protein caloric content; and (b) anionic fibers capable of sequestering of calcium, and (c) carrageenan between 0.015 and 0.25 g per 100 ml of the composition, and its use for preventing/treating dysphagia, and/or treating/preventing malnourishment or undernourishment associated with dysphagia.
    Type: Application
    Filed: July 9, 2013
    Publication date: January 23, 2014
    Inventors: Edward Lucian Sliwinski, Esther Jacqueline Petra De Kort, Christiaan Thedoor Van Ravesteijn, Audrey Claire Lilie Le Fur
  • Publication number: 20140024580
    Abstract: High energy and high protein liquid nutrition enteral compositions are provided that contain micellar casein and caseinate, an optionally a small amount of whey.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 23, 2014
    Applicant: N.V. Nutricia
    Inventor: N.V. Nutricia
  • Patent number: 8618047
    Abstract: The invention is directed to liquid enteral nutritional compositions comprising a protein fraction comprising more than 25 weight % and up to 80 weight % of a vegetable protein comprising at least a source of pea protein, and a fat fraction comprising (a) 8 to 15 weight % of linoleic acid; (b) 3.0 to 6.0 weight % of a combination of alpha-linolenic acid, docosahexaenoic acid and eicosapentaenoic acid, wherein the amount of ALA is >2.5 weight % and the combined amount of DHA and EPA is ?2.5 weight %; (c) 10 to 20 weight % of at least one medium-chain fatty acid; and (d) 35 to 79 weight % of at least one mono-unsaturated fatty acid. The compositions provide for a healthy and balanced diet, which is well-tolerated and minimises clinical complications that are frequently associated with the administration of enteral nutrition in patients using tube feeding, especially with respect to a reduced gastric emptying.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: December 31, 2013
    Assignee: N.V. Nutricia
    Inventors: Zandrie Hofman, Rogier Daniël van Anholt, Wynette Hermina Agnes Kiers, Marianne Klebach, Marloes Heleen van Beusekom
  • Patent number: 8603988
    Abstract: The present invention provides a phosphopeptide or phosphoprotein (PP) stabilized amorphous calcium phosphate or amorphous calcium fluoride phosphate complex having a calcium ion greater than about 30 moles of calcium per mole of PP.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: December 10, 2013
    Assignee: The University of Melbourne
    Inventor: Eric Charles Reynolds
  • Publication number: 20130224284
    Abstract: The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated.
    Type: Application
    Filed: April 1, 2013
    Publication date: August 29, 2013
    Inventors: Raphael J. Mannino, Sara L. Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Ruying Lu
  • Publication number: 20130210715
    Abstract: Nutritional compositions and methods of using the nutritional compositions are provided. In a general embodiment, the present disclosure provides a nutritional composition including one or more proteins, one or more amino acids and one or more exogenous nucleotides. The nutritional compositions can be specifically used to assist a patient in weaning from partial or total parenteral nutrition to enteral nutrition with improved tolerance.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 15, 2013
    Applicant: NESTEC S.A.
    Inventors: Norman Alan Greenberg, Claudia Roessle
  • Publication number: 20130203664
    Abstract: Nutritional compositions having reduced amounts of calories and high amounts of protein and methods of making and using the nutritional compositions are provided. The nutritional compositions may include a processed whole food component, a high amount of protein, and a reduced amount of calories in order to provide a patient with a pH-balanced formulation that includes the benefits of food bioactives beyond essential macro- and micronutrients without providing excessive energy. Methods of administering such nutritional compositions to patients in need of improved bone, muscle, neurological, immune, and/or overall health are also provided.
    Type: Application
    Filed: June 28, 2011
    Publication date: August 8, 2013
    Applicant: NESTEC S.A.
    Inventors: Doug Bolster, Zamzam Fariba Roughead, Norman Alan Greenberg, Jennifer Mager
  • Publication number: 20130157937
    Abstract: The present invention provides a ketogenic diet in the form of a sterile shelf stable ready to use formula, in particular a tube feed, comprising casein and dietary fibre.
    Type: Application
    Filed: June 6, 2011
    Publication date: June 20, 2013
    Applicant: N.V. Nutricia
    Inventors: Andrew Sean Lynch, Simon Anders, Paul Ronald
  • Publication number: 20130116174
    Abstract: Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch. The compositions include iodinated tyrosine-containing proteins, suitably iodinated casein, and carbohydrates.
    Type: Application
    Filed: July 11, 2011
    Publication date: May 9, 2013
    Applicant: The Board of Trustees of the University of Arkansas
    Inventors: Billy Hargis, Walter Bottje
  • Patent number: 8431531
    Abstract: A protein hydrolysate having a degree of hydrolysis between 1 and 40% and containing between 1 and 70 wt. % of peptides having a molecular weight of less than 500 Da and less than 55 wt. % of peptides or proteins having a molecular weight of more than 5000 Da, on the basis of the total proteinaceous material of the composition, is effective in stimulating secretion of glucagon-like peptide-1 (GLP-1). In addition, the hydrolysate may have DPP-IV inhibiting activity. The hydrolysate is suitable for the manufacture of a medicament, or food product for prophylaxis and/or treatment of a GLP-1 mediated condition, in particular obesity, type 2 diabetes mellitus and an immunological disorder.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: April 30, 2013
    Assignee: Campina Nederland Holding B.V.
    Inventor: Jan-Willem Pieter Boots
  • Publication number: 20130102529
    Abstract: The present invention refers to an iron (III) caseinsuccinylate characterised by a content of iron comprised between 4.5% and 7% by weight, and by a solubility in water approximately greater than 92%. The present invention further refers to a method for preparing iron (III) caseinsuccinylate.
    Type: Application
    Filed: June 30, 2010
    Publication date: April 25, 2013
    Applicant: ITALFARMACO S.P.A.
    Inventors: Andrea Stevenazzi, Lorenzo De Ferra, Barbara Pinto
  • Publication number: 20130065823
    Abstract: A protein and amino acid supplement for strengthening the muscles of a human, the supplement comprises of: a Creatine monohydrate; a vitamic C; a hydrolyzed collagen; and a hydrolyzed casein. The supplement may further comprise of L-glutamine, ribose, taurine, alpha lipoic acid, methyl sulfonyl methane. The supplement may further comprise of glucosamine sulfate and chondroitin sulfate.
    Type: Application
    Filed: September 14, 2011
    Publication date: March 14, 2013
    Inventor: Sergio Ammirata
  • Publication number: 20130065824
    Abstract: Medical dairy products are highly concentrated in proteins and minerals. Formulation of such products is challenging, since viscosities can easily increase during processing and storage. It was found that using one or more chelating agents selected from the group consisting of a phosphoric acid, citric acid, a soluble phosphate salt, a soluble citrate salt, or a mixture thereof, the viscosity and the transparency of an aqueous micellar casein composition, comprising 6 to 20 g/100 ml of micellar casein and having a pH of about 6 to 8 could be controlled independently of each other. It was found that products become more viscous after addition of phytate, citrate, or orthophosphate, and that the viscosity depends on concentration and type of phosphate. Addition of hexametaphosphate leads to gel formation. In contrast, high concentrations of uridine monophosphate can be added without significantly affecting the viscosity.
    Type: Application
    Filed: March 11, 2011
    Publication date: March 14, 2013
    Inventors: Esther Jacqueline De Kort, Marcel Minor
  • Publication number: 20130023468
    Abstract: The invention is directed to liquid enteral nutritional compositions comprising a protein fraction comprising more than 25 weight % and up to 80 weight % of a vegetable protein comprising at least a source of pea protein, and a fat fraction comprising (a) 8 to 15 weight % of linoleic acid; (b) 3.0 to 6.0 weight % of a combination of alpha-linolenic acid, docosahexaenoic acid and eicosapentaenoic acid, wherein the amount of ALA is >2.5 weight % and the combined amount of DHA and EPA is ?2.5 weight %; (c) 10 to 20 weight % of at least one medium-chain fatty acid; and (d) 35 to 79 weight % of at least one mono-unsaturated fatty acid. The compositions provide for a healthy and balanced diet, which is well-tolerated and minimises clinical complications that are frequently associated with the administration of enteral nutrition in patients using tube feeding, especially with respect to a reduced gastric emptying.
    Type: Application
    Filed: July 27, 2012
    Publication date: January 24, 2013
    Inventors: Zandrie HOFMAN, Rogier Daniël VAN ANHOLT, Wynette Hermina Agnes KIERS, Marianne KLEBACH, Marloes Helleen VAN BEUSEKOM
  • Publication number: 20120328585
    Abstract: The present invention is directed to a novel method for increasing the production of acetate, decreasing the production of butyrate, increasing the population and species of beneficial bacteria and slowing the rate of fermentation of prebiotics within the gut of a formula-fed infant. The method comprises administration of a therapeutically effective amount of PDX to the infant.
    Type: Application
    Filed: September 4, 2012
    Publication date: December 27, 2012
    Inventors: Bryon W. Petschow, Robert J. McMahon, Glenn R. Gibson, Robert A. Rastall, Renia Gemmell, Maria Saarela, Anna-Marja Aura
  • Patent number: 8338363
    Abstract: The present invention relates to peptides derived from casein and their use in the management of lactating animals, particularly to methods for decreasing the length of the dry period of a lactating livestock animal, for increasing its milk yield and milk hygiene after parturition and for improving the livestock welfare. The present invention further relates to pharmaceutical compositions comprising peptides derived from casein in the form of a sterile solution, which compositions are clear and substantially devoid of micelles.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: December 25, 2012
    Assignees: Mileutis Ltd., State of Israel, Ministry of Agriculture & Rural Development, Agriculture Research Organization
    Inventors: Jose Mario Iscovich, Nissim Silanikove, Javier Iscovich
  • Publication number: 20120288573
    Abstract: A method is provided for preventing or treating bone or musculoskeletal metabolism disorders or kidney malfunction in humans. It comprises providing to a subject in need of that a calcium containing or calcium enriched diet combined with the administration of an efficient amount of a plant extract of Solatium glaucophyllum comprising from about 0.8 to about 2.2 weight % of a mixture of 1,25-dihydroxyvitamin D3 glycosides and quercetin glycosides present in a ratio of about 1:100 to 1:200 parts by weight. There are also provided food or dietary composition and food supplement designed for preventing or treating bone or musculoskeletal metabolism disorders or kidney malfunction in humans which comprises an efficient amount of the said plant extract of Solanum glaucophyllum and a source of calcium.
    Type: Application
    Filed: October 20, 2010
    Publication date: November 15, 2012
    Applicant: HERBONIS AG
    Inventors: Heinrich Bachmann, Sabrina Autzen
  • Publication number: 20120283180
    Abstract: This invention relates to a pea-based protein mixture and use thereof in a liquid nutritional composition, in particular suitable for tube feeding, and further relates to said liquid nutritional composition for providing long-term complete enteral nutrition to patients in need thereof. More specifically, the pea-based protein mixture and the liquid nutritional composition comprising said pea-based protein mixture comprises more than 25 weight % and up to 80 weight % of vegetable protein comprising a source of intact pea protein and a source of intact soy protein. The invention relates further to a method for long-term enteral nutrition of patients in need thereof comprising administering an effective amount of said liquid nutritional composition comprising said pea-based protein mixture, in particular comprising a defined amount of intact pea protein and a second vegetable intact protein, other than pea protein.
    Type: Application
    Filed: April 27, 2010
    Publication date: November 8, 2012
    Applicant: N.V. NUTRICIA
    Inventors: Zandrie Hofman, Rogier Daniël Van Anholt, Wynette Hermina Agnes Kiers, Thomas Ludwig, Claudia Catharina Maria Van Den Braak, Marianne Klebach
  • Patent number: 8273710
    Abstract: Disclosed is a protein hydrolysate having DPP-IV inhibiting activity, the hydrolysate being enriched in peptides having a length of 2-8 amino acids comprising at least one proline residue, an isolated peptide derivable from such a protein hydrolysate, or a mixture thereof, and the use of such protein hydrolysate or isolated peptide for the manufacture of a medicament, food supplement, beverage or food product for prophylaxis and/or treatment of a DPP-IV mediated condition, in particular chosen from the group of obesity, type 2 diabetes mellitus and an immunological disorder.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: September 25, 2012
    Assignee: Campina Nederland Holding B.V.
    Inventor: Jan-Willem Pieter Boots
  • Publication number: 20120142587
    Abstract: Heat-treated liquid enteral nutritional composition with a low monovalent metal ion content are provided that contain micellar casein and optionally caseinate, and in which the total amount of monovalent metal ions is less than 25 mg/g of protein. Also, heat-treated liquid enteral nutritional compositions are disclosed comprising 10 to 20 g of protein per 100 ml of the composition, in which all or a major part of said protein comprises micellar casein. Also, a method is disclosed for producing the composition according to the invention, comprising a step wherein an aqueous protein solution in which all or a major part of said protein comprises micellar casein, is subjected to an evaporation step.
    Type: Application
    Filed: June 7, 2010
    Publication date: June 7, 2012
    Inventors: Marcel Minor, Suzanne van Steenis, Hilde Ruis
  • Publication number: 20120142588
    Abstract: The present invention relates to a method for suppression, prevention, delaying the onset or treatment of diabetes, by administering to an individual in need thereof a fragment of Hsp60 or analog thereof in conjunction with a low antigenicity diet. The invention is exemplified using DiaPep277™, an analog of residues 437-460 of human Hsp60 in combination with a hydrolyzed casein diet.
    Type: Application
    Filed: February 15, 2012
    Publication date: June 7, 2012
    Applicant: ANDROMEDA BIOTECH LTD.
    Inventors: Johannes Rozing, Dana Elias
  • Publication number: 20120094901
    Abstract: This invention relates to the coagulation of protein containing nutritional compositions in the upper gastro-intestinal tract, more in particular in the stomach and provides a method for reducing such coagulation.
    Type: Application
    Filed: April 27, 2010
    Publication date: April 19, 2012
    Inventors: Thomas Ludwig, Claudia Catharina Mari van den Braak, Marianne Klebach, Zandrie Hofman
  • Patent number: 8129337
    Abstract: The present invention describes a composition comprising EGCG and a protein hydrolysate.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: March 6, 2012
    Assignee: DSM IP Assets B.V.
    Inventor: Swen Wolfram
  • Publication number: 20120021977
    Abstract: The use of a protein source comprising bovine casein proteins for the preparation of a nutrional composition for administration to an infant, young child or adult during or after a period of catch-up growth or weight recovery, following a period of growth restriction or weight lost, so as improve growth at early age and/or to reduce the risk of development of insulin resistance and/or Type 2 diabetes later in the life of the infant, young child or adult.
    Type: Application
    Filed: March 26, 2010
    Publication date: January 26, 2012
    Applicant: NESTEC S.A.
    Inventors: Olivier Aprikian, Florence Blancher, Catherine Mace, Yassaman Shahkhalili
  • Publication number: 20110319318
    Abstract: The present invention relates to the field of complexes. Embodiments of the present invention relate to food-grade covalent complexes containing at least one milk protein and at least one ITC-compound and to the uses of such complexes, e.g., to reduce the perceived pungency of ITC-compounds, to produce antimicrobial effects and/or to form and stabilize emulsions and/or foams.
    Type: Application
    Filed: March 3, 2010
    Publication date: December 29, 2011
    Applicant: NESTEC S.A.
    Inventors: Koraljka Rade-Kukic, Christophe Joseph Etienne Schmitt
  • Publication number: 20110257089
    Abstract: The invention concerns nutritional compositions for persons with a (partially) functional gastrointestinal tract, who are unwilling and/or unable to consume sufficient quantities of conventional food to meet their nutritional requirements such as malnourished persons or persons at risk of becoming malnourished, and in need of liquid oral nutrition. The shelf-stable liquid nutritional compositions comprise at least non-micellar casein, a high amount of fat, and optionally a heat stabilisation system.
    Type: Application
    Filed: October 23, 2009
    Publication date: October 20, 2011
    Inventors: Ingmar Harald Huisman, Wynette Hermina Agnes Kiers, Edward Lucian Sliwinski, Sander Hougee, Marike Joanna Bernadette Molenaar-Groenendaal
  • Patent number: 8012509
    Abstract: The present invention pertains to nutritional and pharmaceutical compositions for treating and preventing cyclooxygenase-2 mediated diseases and to a process for increasing the cyclooxygenase-2 inhibiting activity of a product. In addition thereto, the present invention relates to the use of one ore more milk protein fractions and/or one ore more milk protein preparations for inhibiting the activity of cyclooxygenase-2 (COX-2), in particular for the preparation of a medicament or a functional food for treating and preventing cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: September 6, 2011
    Assignee: Nestec S.A.
    Inventors: Lionel Bovetto, Joerg Hau, Catherine Mace
  • Patent number: 7968513
    Abstract: The present invention relates to peptides derived from casein and their use in the management of lactating animals, particularly to methods for decreasing the length of the dry period of a lactating livestock animal, for increasing its milk yield and milk hygiene after parturition and for improving the livestock welfare. The present invention further relates to pharmaceutical compositions comprising peptides derived from casein in the form of a sterile solution, which compositions are clear and substantially devoid of micelles.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: June 28, 2011
    Assignees: Mileutis Ltd., State of Israel
    Inventors: Jose Mario Iscovich, Nissim Silanikove, Javier Iscovich