Nickel Or Cobalt Patents (Class 514/501)
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Patent number: 11548184Abstract: Fire retardant composition for treatment of various wood products, method of producing the same and uses thereof. The compositions comprise an aqueous solution of bisphosphonate selected from 1-hydroxyethane 1,1-diphosphonic acid, an alkanol amine, and optionally an alkaline agent, the composition having a pH in the range of 4.0 to 7.0. The composition can be produced by mixing together 30 to 50 parts by weight of 1-hydroxyethane 1,1-diphosphonic acid; 1 to 10 parts by weight of an alkanol amine or mixture thereof, said alkanol amine being added in free form; and optionally 0.1 to 40 part by weight of an alkaline agent; and water. The compositions can be used for protecting wood not only against fire but also against mould, rot, blue stain, insect such as termite attacks on wood, dimensional changes, or a combination thereof due to environmental influence.Type: GrantFiled: March 9, 2018Date of Patent: January 10, 2023Assignee: Palonot OyInventors: Jari Kukkonen, Timo Nissinen
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Patent number: 8952057Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.Type: GrantFiled: June 16, 2011Date of Patent: February 10, 2015Assignee: JR Chem, LLCInventor: José E. Ramirez
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Publication number: 20150031758Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: ApplicationFiled: August 8, 2014Publication date: January 29, 2015Inventors: Masazumi Nagai, Jianhua Shen
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Patent number: 8802725Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: GrantFiled: May 24, 2013Date of Patent: August 12, 2014Assignee: Synta Pharmaceuticals Corp.Inventors: Masazumi Nagai, Jianhua Shen
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Publication number: 20140206635Abstract: A metal-salen complex compound, which exhibits excellent noninvasiveness and can be efficiently transferred to an affected site, a local anesthetic containing this metal-salen complex compound, and an antineoplastic drug containing this metal-salen complex compound are provided. Regarding the metal-salen complex compound, a metal atom part in each of two molecules of a metal-salen complex or a derivative of the metal-salen complex is dimerized via water, and the metal-salen complex compound is mixed with a base to produce an ointment.Type: ApplicationFiled: May 10, 2012Publication date: July 24, 2014Applicants: IHI CORPORATIONInventors: Yoshihiro Ishikawa, Haruki Eguchi
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Patent number: 8779175Abstract: A coordination complex having a physiologically acceptable pKa includes a metal and a biologically active agent. The pKa of the coordination complex is less than the pKa of the biologically active agent. A pharmaceutical solution for treating a patient includes a coordination complex and water, wherein the coordination complex is at least partially soluble in the water at physiological pH and in a therapeutically efficacious concentration. A method for treating a patient includes administering a pharmaceutical solution including a coordination complex and water to a patient in need of a biologically active agent.Type: GrantFiled: May 26, 2010Date of Patent: July 15, 2014Assignee: Synthonics, Inc.Inventors: Thomas Piccariello, John D. Price, Robert A. Oberlender, Michaela E. Mulhare, Mary C. Spencer, Scott B. Palmer
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Publication number: 20140011864Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: ApplicationFiled: May 24, 2013Publication date: January 9, 2014Inventors: Masazumi Nagai, Jianhua Shen
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Patent number: 8575212Abstract: Embodiments of the invention relate to a method of making a mineral product. The method includes contacting a carboxylic acid and an inorganic mineral compound sufficient to form a solution, reacting the solution over a period of time sufficient to provide a mineral chelated compound, transferring the mineral chelated compound to one or more molds prior to the compound substantially solidifying and reducing the size of the mineral chelated compound sufficient to provide a rapidly soluble mineral chelated product.Type: GrantFiled: July 13, 2010Date of Patent: November 5, 2013Assignee: Ralco Nutrition, Inc.Inventors: Brian Jon Knochenmus, Jon Kent Knochenmus, Richard Dale Lamb, Myrra Arlene Lamb
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Publication number: 20130251641Abstract: The present disclosure provides compositions comprising 2-deoxyglucose-functionalized magnetic nanoparticles. The compositions are useful in various applications, which are also provided.Type: ApplicationFiled: March 4, 2013Publication date: September 26, 2013Applicant: The Regents of the Universtiy of CaliforniaInventors: MASSOUD AKHTARI, JEROME ENGEL
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Patent number: 8513303Abstract: The present invention provides a method of killing and/or inactivating microbes, the method comprising the step of placing the microbes in contact with a catalyst by means of a fluid medium, wherein the catalyst comprises a solid support, which solid support comprises one or more fibers, and a first metal cation fixed to the support. The fibers are keratinous fibers like wool fibers, or polyacrylonitrile (PAN) fibers. The first metal cation is selected from transition metal copper, silver and gold included. A second non-transition metal cation can be present. The catalyst is prepared by first treating the fibers with hydrazine and/or hydroxylamine salt in presence of a base, the modified fibers are then treated with an aqueous solution of containing the metal cations.Type: GrantFiled: August 22, 2008Date of Patent: August 20, 2013Assignee: De Montfort UniversityInventors: Katherine Huddersman, Susannah Elizabeth Walsh
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Publication number: 20130150440Abstract: Improved cancer treatments with bis[thiohydrazide amide] compounds such as elesclomol, in particular for identifying patient populations that would benefit from such treatments.Type: ApplicationFiled: April 20, 2011Publication date: June 13, 2013Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Masazumi Nagai, Ronald K. Blackman, Patricia E. Rao, Yumiko Wada, Keizo Koya
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Patent number: 8461199Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: GrantFiled: October 21, 2009Date of Patent: June 11, 2013Assignee: Synta Pharmaceuticals Corp.Inventors: Nagai Masazumi, Jianhua Shen
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Publication number: 20130096090Abstract: The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.Type: ApplicationFiled: October 17, 2012Publication date: April 18, 2013Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.Inventor: Virginia Tech Intellectual Properties, Inc.
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Publication number: 20130035386Abstract: Certain bis[thio-hydrazide amide]-related compounds are found to be surprisingly effective at treating with leukemia, e.g., acute myeloid leukemia (AML). Methods of treating a subject with AML including administering bis[thio-hydrazide amide]-related compounds described herein, are disclosed.Type: ApplicationFiled: December 6, 2010Publication date: February 7, 2013Applicant: SYNTA PHARMACEUTICALS CORP.Inventors: Masazumi Nagai, Jianhua Shen
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Patent number: 8299285Abstract: A metal complex of formula (III) wherein: M is a transition metal and A1, A2, X, X?, Y, L1?, R1? and R2? are as defined herein, is useful in medical imaging and therapy.Type: GrantFiled: July 5, 2006Date of Patent: October 30, 2012Assignee: Isis Innovation LimitedInventors: Jonathan Robin Dilworth, Josephine Mary Peach, Julia May Heslop, Paul Stephen Donnelly
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Publication number: 20120177583Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.Type: ApplicationFiled: June 16, 2011Publication date: July 12, 2012Inventor: José E. Ramirez
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Publication number: 20110294877Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I), or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. In one embodiment, the compound is represented by Structural Formula (II), or a prodrug, isomer, ester, salt, hydrate, solvate or polymorph thereof. The present invention also provides a pharmaceutical composition comprising the compound of the invention and method of use thereof.Type: ApplicationFiled: October 21, 2009Publication date: December 1, 2011Applicant: SYNTA PHARMACEUTICAL CORP.Inventors: Nagai Masazumi, Jianhua Shen
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Publication number: 20110288162Abstract: The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thio-hydrazide amide] is represented by Structural Formula (I): or a prodrug, isomer, ester, salt, hydrate, solvate, polymorph or a deprotonated form thereof. The present invention also provides a pharmaceutical composition comprising a compound of the invention and method of use thereof.Type: ApplicationFiled: October 21, 2009Publication date: November 24, 2011Applicant: SYNTA PHARMACEUTICAL CORPInventors: Nagai Masazumi, Jianhua Shen
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Patent number: 7994142Abstract: The invention relates to agents that contain folic acid, vitamin B6 and vitamin B12, and to the use thereof in hyperhomocysteinemia for controlling homocysteine levels. The agents are mainly suitable for the preventive and acute treatment of vascular diseases, of pregnant women and neurodegenerative diseases and are particularly advantageous in cases where the homocysteine levels to be controlled are found in an individual suffering from renal failure or being treated with immune suppressors. The invention particularly relates to pharmaceutical agents and food supplements comprising a corresponding active ingredient combination and to agents in the form of commercial packages containing corresponding combination preparations or monopreparations for the combined use.Type: GrantFiled: January 11, 2006Date of Patent: August 9, 2011Assignee: Phrontier S.A.R.L.Inventor: Martin Goerne
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Patent number: 7976876Abstract: The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and a quinone, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard.Type: GrantFiled: September 29, 2008Date of Patent: July 12, 2011Assignee: Well-Being Biochemical Corp.Inventors: Jih-ru Hwu, Shwu-chen Tsay
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Publication number: 20110152363Abstract: Embodiments of the invention relate to a method of making a mineral product. The method includes contacting a carboxylic acid and an inorganic mineral compound sufficient to form a solution, reacting the solution over a period of time sufficient to provide a mineral chelated compound, transferring the mineral chelated compound to one or more molds prior to the compound substantially solidifying and reducing the size of the mineral chelated compound sufficient to provide a rapidly soluble mineral chelated product.Type: ApplicationFiled: July 13, 2010Publication date: June 23, 2011Applicant: RALCO NUTRITION, INC.Inventors: Brian Jon Knochenmus, Jon Kent Knochenmus, Richard Dale Lamb, Myrra Arlene Lamb
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Publication number: 20110098353Abstract: A metal complex of formula (III) wherein: M is a transition metal and A1, A2, X, X?, Y, L1?, R1? and R2? are as defined herein, is useful in medical imaging and therapy.Type: ApplicationFiled: July 5, 2006Publication date: April 28, 2011Inventors: Jonathan Robin Dilworth, Josephine Mary Peach, Julia May Heslop, Paul Stephen Donnelly
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Publication number: 20110054019Abstract: The present invention is a glutamine analogue which enters the mitochondrion and is subsequently exposed to ionizing radiation. When exposed to ionizing radiation, the present invention damages mitochondrial (as well as other) substructures such as mtDNA, the outer membrane, the inner membrane, cristae, ribosomes, etc., and causes the effective destruction of such mitochondrion. Tumorigenic cells without mitochondria cannot produce the energy they need to subsist and replicate, effectively starving them of energy and causing their destruction.Type: ApplicationFiled: September 1, 2009Publication date: March 3, 2011Inventor: Pedro Anastacio Serrano-Ojeda
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Publication number: 20100267652Abstract: Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.Type: ApplicationFiled: November 5, 2008Publication date: October 21, 2010Inventors: Curtis J. Henrich, Heidi R. Bokesch, Susan E. Bates, Robert W. Robey, Suneet Shukla, Suresh V. Ambudkar, Michael C. Dean, James B. McMahon
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Patent number: 7812042Abstract: Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, N-acetyl-L-cysteinylcobalamin (NACCbl) to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as NACCbl, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.Type: GrantFiled: September 20, 2007Date of Patent: October 12, 2010Assignees: Kent State University, University of ChesterInventors: Nicola E. Brasch, Catherine Stephanie Birch, John Henry Howatson Williams
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Publication number: 20100240601Abstract: A coordination complex having a physiologically acceptable pKa includes a metal and a biologically active agent. The pKa of the coordination complex is less than the pKa of the biologically active agent. A pharmaceutical solution for treating a patient includes a coordination complex and water, wherein the coordination complex is at least partially soluble in the water at physiological pH and in a therapeutically efficacious concentration. A method for treating a patient includes administering a pharmaceutical solution including a coordination complex and water to a patient in need of a biologically active agent.Type: ApplicationFiled: May 26, 2010Publication date: September 23, 2010Inventors: Thomas Piccariello, John D. Price, Robert A. Oberlender, Michaela E. Mulhare, Mary C. Spencer, Scott B Palmer
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Publication number: 20100160429Abstract: The invention provides a pharmaceutical composition which comprises a pharmaceutical carrier and at least one compound selected from the group consisting of cobaltocene-octamethyl, stigmastan-3,5-diene, galoxolide, benzyl salicylate, eucalyptol, and ?-pinene. Also provided is a method of preparing a composition having antimicrobial activity comprising extracting a plant material in an organic solvent, contacting the extracted material to a chromatographic column, and eluting from the chromatographic column with a mobile polar phase to obtain a composition. The plant material is from Mammea Americana, Marchntia polymorpha, or Callistemon citrinus. Also provided is a method of inhibiting the growth of a mycobacterium, comprising administering a composition comprising a carrier and at least one compound selected from among cobaltocene-octamethyl, stigmastan, 3,5-diene, friedelin, galoxolide, benzyl salicylate, eucalyptol, and ?-pinene.Type: ApplicationFiled: December 9, 2009Publication date: June 24, 2010Inventor: Anne D. Frame
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Publication number: 20100069487Abstract: A method for the therapeutic treatment of psoriasis by the administration of an anti-psoriasis effective amount of Doxivir (CTC-96) is discloses.Type: ApplicationFiled: October 23, 2007Publication date: March 18, 2010Applicant: REDOX PHARMACEUTICAL CORPORATIONInventor: David Gershon
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Publication number: 20100004187Abstract: Disclosed herein is a method of: administering to a subject suspected of being infected with a bacterium, a composition of a cobalt (III) compound having the formula CoR1R2R3R4R5R6 or a salt thereof and an antibiotic compound. Each of R1, R2, R3, R4, and R5 is the same or different and includes an N-based ligand donor atom selected from the group consisting of ammonia, primary amine, or secondary amine, or salt thereof. R6 is a ligand. Also disclosed herein is a composition of the above cobalt (III) compound and an antibiotic compound.Type: ApplicationFiled: June 30, 2009Publication date: January 7, 2010Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Eddie L. Chang, Daniel Zabetakis, Andy Knight, Monique L. van Hoek
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Patent number: 7582786Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.Type: GrantFiled: February 23, 2006Date of Patent: September 1, 2009Assignee: Eukarion Inc.Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
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Patent number: 7563818Abstract: The present invention relates to self-assembly of a photosensitizer on a nanoparticle. The invention also provides methods for production of functionalized (eg. stabilized) nanoparticles. The nanoparticles may be used in Photodynamic Therapy (PDT). The invention can provide, for example, self-assembled phthalocyanine monolayers (SAMs), wherein the monolayer is formed on a metallic nanoparticle. The term “metallic” as used herein refers to metals, metal oxides and other metal-containing compositions. According to the invention a functionalized nanoparticle comprises: a metallic core; a photosensitizer monolayer chemically bonded to said core, said monolayer containing molecules capable of photo-excitation to produce a reactive oxygen species such as singlet oxygen, from oxygen molecules; and a phase transfer reagent.Type: GrantFiled: October 31, 2002Date of Patent: July 21, 2009Assignee: Cancer Research Technology LimitedInventors: David Andrew Russell, Duncan Christopher Hone
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Publication number: 20090182044Abstract: The present invention is directed to methods and compositions which include nitrate amino acid chelates that can increase the metabolic activity or metal concentration in animals and that can increase metabolic activity and nitrogen content in plants. In one embodiment, a nitrate-complexed amino acid composition can comprise a metal, an amino acid ligand, and a nitrate, wherein the amino acid ligand is chelated to the metal forming an amino acid chelate and the nitrate is complexed to the amino acid chelate. In another embodiment, a nitrate-chelated amino acid composition can comprise a metal, an amino acid ligand, and a nitrate, wherein the amino acid ligand and the nitrate are chelated to the metal forming a nitrate-chelated amino acid chelate.Type: ApplicationFiled: January 9, 2009Publication date: July 16, 2009Inventors: H. DeWayne Ashmed, Charlie Thompson
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Publication number: 20090176875Abstract: A method for manufacturing a stabilized metal nano particle solution is disclosed. This method manufactures a metal nano particle solution so as to make a metal substance such as silver, gold, copper, zinc or cobalt into ultra-capsular nano particles. That is to say, this new method is simple and suitable for mass production without requiring any separate reducer putting process at a room temperature while a transition metal nano particle solution is produced. In this method, an alcohol solution including a metal salt solution and a soluble polymer is mixed at a room temperature to make a nano metal particle solution with a particle size of 100 nm or less.Type: ApplicationFiled: January 9, 2008Publication date: July 9, 2009Inventors: Dong-Pyo Kim, Yoon-Hyuck Choi, Choong G. Row
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Publication number: 20090098098Abstract: The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and quinones, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard.Type: ApplicationFiled: September 29, 2008Publication date: April 16, 2009Applicant: Well-Being Biochemical Corp.Inventors: Jih-Ru Hwu, Shwu-Chen Tsay
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Publication number: 20080176940Abstract: The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect.Type: ApplicationFiled: December 14, 2004Publication date: July 24, 2008Applicant: The Trustees of Columbia University in the City of New YorkInventors: Roberto Etchenique, Rafael Yuste, Luis Baraldo
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Patent number: 7335248Abstract: Disclosed are marine coating compositions that are useful to inhibit the fouling of a marine structure by a broad spectrum of organisms. Generally, the marine coating composition comprises an antifouling agent and an organic vehicle.Type: GrantFiled: September 1, 2006Date of Patent: February 26, 2008Assignee: Novus International, Inc.Inventor: Ibrahim Abou-Nemeh
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Patent number: 7326725Abstract: 1) Fungicidal compositions comprising: a) at least one pyridylmethylbenzamide derivative of formula (I), in which the various radicals are as defined in the description, and b) at least one compound (II) chosen from dithiocarbamates, preferably fungicidal dithiocarbamates, and, still more preferably from the following active agents: ferbam, mancopper, mancozeb, maneb, metiram, nabam, nickel bis(dimethyldithio-carbamate), propineb, zineb and mixtures thereof; and their agriculturally acceptable isomers and addition salts with an acid. 2) Method for the curative or preventive control of phytopathogenic fungi of crops using an effective and non-phytotoxic quantity of one of these fungicidal compositions.Type: GrantFiled: October 21, 2002Date of Patent: February 5, 2008Assignee: Bayer Cropscience S.A.Inventors: Richard Mercer, Thomas Wegmann
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Patent number: 7323452Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: December 20, 2004Date of Patent: January 29, 2008Assignee: Wardan, L.L.C.Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
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Publication number: 20070232693Abstract: The present invention provides compositions and methods for treating the infestation of plants or progeny of plants by phytopathogenic microorganisms. The anti-phytopathogenic microbial compositions are generally effective against of broad spectrum of microbes, such as fungi, yeast and bacteria. Because of their broad spectrum of efficacy, the anti-phytopathogenic microbial compositions may be utilized to treat or prevent pathogenic infestation of a multitude of plants.Type: ApplicationFiled: March 27, 2007Publication date: October 4, 2007Applicant: NOVUS INTERNATIONAL, INC.Inventor: Ibrahim Abou-Nemeh
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Patent number: 7244452Abstract: Disclosed is a member which is superior in anti-fungus property and anti-alga property, and is coated with a surface treatment coating comprising at least a layer having anti-fungus property and/or anti-alga property laminated between a topmost surface functional layer and a base, wherein the layer having anti-fungus property and/or anti-alga property comprises 80% or more of Ni, 0.1 to 10% of P, and 0.0001 to 1% of hydrogen, holes reaching the surface of the layer having anti-fungus property and/or anti-alga property are present in the topmost surface functional layer so as to penetrate the topmost surface functional layer, the opening area ratio thereof to the total area when the topmost surface functional layer is viewed in plan being from 0.001 to 10%, or the elution amount of Ni is from 0.1 to 50 ?g/cm2/week when the member is immersed in still water at 30° C.Type: GrantFiled: August 15, 2002Date of Patent: July 17, 2007Assignee: Kobe Steel, Ltd.Inventors: Wataru Urushihara, Takenori Nakayama, Sadako Yamada
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Patent number: 7220426Abstract: Neutral alpha amino diacid complexes of trace minerals and their use for animal nutrition.Type: GrantFiled: November 13, 2003Date of Patent: May 22, 2007Assignee: Zinpro CorporationInventors: Mahmoud M. Abdel-Monem, Michael D. Anderson
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Patent number: 7208519Abstract: The invention includes a pesticidal compound comprising at least one organic phenolic compound and at least one salt comprising a divalent cation. Preferably, the organic phenolic compound is chosen from Carvacrol, thymol or combinations thereof; and is derived from a natural source, preferably extracted from a member of the family Labiatae or Verbenacea. Preferably the divalent cation is a transition metal salt and more preferably is zinc chloride or zinc sulfate. The invention also includes methods of eradicating, repelling or preventing infestations of pests, including such pests as insects, mites, ova, fungus, or parasites. The methods comprise the steps of preparing a pesticidal compound, combining it with a carrier, and applying it to the affected area.Type: GrantFiled: November 18, 2004Date of Patent: April 24, 2007Assignee: Van Beek Natural Science, LLCInventor: Dusan Ninkov
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Patent number: 7011854Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.Type: GrantFiled: February 3, 2003Date of Patent: March 14, 2006Assignee: Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos LdaInventors: Werner Haas, Carlos Romao, Beatriz Roya, Ana Cristina Fernandes, Isabel Goncalves
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Patent number: 6939566Abstract: Microbicidal formulations are described which are preferably ecologically friendly and non-toxic to mammals, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having the formula R-M, wherein R is at least one organic chelating moiety and M is at least one metal ion which is microbicidal to at least one microorganism. These complexes can disrupt microorganism activities by penetrating the natural protecting bio-films of such microorganisms through the reaction of the R-group with the organic constituents of these microorganisms while releasing M into their intra-cellular media. Thus, this process exhibits its biocidal activities from the inside-out, contrary to other methods which rely on damaging the protective biofilms.Type: GrantFiled: January 17, 2001Date of Patent: September 6, 2005Inventors: Kareem I. Batarseh, Marwan Al-Kayed
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Patent number: 6841085Abstract: Methods for hydrogenolysis are described which use a Re-containing multimetallic catalyst for hydrogenolysis of both C—O and C—C bonds. Methods and compositions for reactions of hydrogen over a Re-containing catalyst with compositions containing a 6-carbon sugar, sugar alcohol, or glycerol are described. It has been surprisingly discovered that reaction with hydrogen over a Re-containing multimetallic catalyst resulted in superior conversion and selectivity to desired products such as propylene glycol.Type: GrantFiled: October 23, 2001Date of Patent: January 11, 2005Assignee: Battelle Memorial InstituteInventors: Todd A. Werpy, John G. Frye, Jr., Alan H. Zacher, Dennis J. Miller
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Patent number: 6833362Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: June 7, 2001Date of Patent: December 21, 2004Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
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Patent number: 6784319Abstract: Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods of preparing (±)-cis-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol, are disclosed herein. In one embodiment, the (±)-2-((dimethylamino)methyl)cyclohexanone and transition-metal salt are in the form of a (±)-2-((dimethylamino)methyl)cyclohexanone:transition-metal salt complex. In another embodimemt, aryl is 3-methoxyphenyl.Type: GrantFiled: September 15, 2003Date of Patent: August 31, 2004Assignee: Euro-Celtique, S.A.Inventors: Robert J. Kupper, Andreas Stumpf
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Patent number: 6780856Abstract: The invention relates to methods of stabilizing in an aqueous medium cobalt (III) Schiff base complexes and stabilized cobalt (III) Schiff base compounds therefrom.Type: GrantFiled: April 6, 2001Date of Patent: August 24, 2004Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Ofer Blum, Harry B. Gray
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Patent number: 6770674Abstract: A mollusc repellent, which includes a substantially insoluble metal oxalate and a suitable carrier therefor, which exhibits prolonged efficacy. The mollusc repellent is environmentally friendly, being both non-phytotoxic and harmless to non-target animals, and is therefore suitable for use in sustainable agriculture, where the use of toxic chemicals is unacceptable. The mollusc repellent can be used in the form of a solid or as a coating composition.Type: GrantFiled: February 9, 2001Date of Patent: August 3, 2004Inventor: Colin Leslie Young
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Patent number: 6764692Abstract: A method of treating laminitis in a horse is disclosed, comprising administering to the horse a naturally chelated trace mineral composition; promoting healthy skin, hair and hoof tissue. A method of reducing dietary intake is also disclosed, comprising administering to a horse in need thereof, effective amounts of a naturally chelated trace mineral composition. A method of preparing the chelated trace mineral composition from ocean seabed rock is further disclosed, as well as the chelated trace mineral composition.Type: GrantFiled: August 27, 2002Date of Patent: July 20, 2004Inventor: Carlos Cortelezzi