Nickel Or Cobalt Patents (Class 514/501)
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Patent number: 5824706Abstract: Respiratory viral infections may be effectively prevented or treated by administering an aerosol spray comprising a polyoxometalate to the lungs.Type: GrantFiled: March 3, 1995Date of Patent: October 20, 1998Inventors: Raymond F. Schinazi, Craig L. Hill
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Patent number: 5795374Abstract: A coating composition comprising a rosin compound, a polymer containing organosilyl ester groups, and an antifoulant as essential components is disclosed. This rosin-based coating composition gives a coating film which forms no residue layer on the surface thereof over long-term immersion, is hence free from physical defects such as cracks and peeling and capable of maintaining a sufficiently high rate of film erosion and preventing the attachment of marine organisms over a long period of time has satisfactory suitability for recoating, and has the satisfactory ability to prevent marine-organism attachment over the out-fitting period.Type: GrantFiled: April 15, 1997Date of Patent: August 18, 1998Assignee: NOF CorporationInventors: Masayasu Itoh, Shigeo Fukuda, Yoshihisa Kawakami, Yoshiro Matsubara, Yasushi Kawamura, Shigeru Masuoka, Yoshihiro Honda
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Patent number: 5756540Abstract: In accordance with the present invention, there are provided methods for the in vivo reduction of nitric oxide levels in a mammalian subject. In contrast to the inhibitory approach described in the prior art (i.e., wherein the function of the enzymes responsible for nitric oxide production is inhibited), the present invention employs a scavenging approach whereby overproduced nitric oxide is bound in vivo to a suitable nitric oxide scavenger. The resulting complex renders the nitric oxide harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods. An exemplary nitric oxide scavenger contemplated for use in the practice of the present invention is a dithiocarbamate-ferrous iron complex. The present invention relates to methods for reducing in vivo levels of .multidot.NO as a means of treating subjects afflicted with inflammatory and/or infectious disease.Type: GrantFiled: June 2, 1995Date of Patent: May 26, 1998Assignee: MCW Research Foundation, Inc.Inventor: Ching-San Lai
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Patent number: 5753698Abstract: A method of treating a subject having a condition associated with the presence of cyanide in quantities sufficient to cause undesirable symptoms which comprises administering to the subject a compound in an amount effective to alleviate the undesirable symptoms, the compound having the structure: ##STR1## wherein R.sup.1 and R.sup.1' are the same or different and each is an alkyl group, a phenyl group or a substituted derivative of a phenyl group;R.sup.2 and R.sup.2' are the same or different and each is hydrogen, an unbranched alkyl group, a halide or a group having the structure ##STR2## wherein R is hydrogen, an alkoxide group, and alkyl group or OH; R.sup.3 and R.sup.3' are the same or different and each is hydrogen or an alkyl group;X and X' are the same or different and each is a water-soluble group having weak to intermediate field strength; andQ.sup.-- is a soluble, pharmaceutically acceptable negative ion.Type: GrantFiled: October 4, 1996Date of Patent: May 19, 1998Assignee: Redox Pharmaceutical CorporationInventors: David Gershon, Uri Taitelman
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Patent number: 5741815Abstract: The present invention employs a scavenging approach whereby overproduced nitric oxide is bound in vivo to a suitable nitric oxide scavenger. The resulting complex renders the nitric oxide harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods. An exemplary nitric oxide scavenger contemplated for use in the practice of the present invention is a dithiocarbamate-ferrous iron complex. This complex binds to .NO, forming a stable, water-soluble dithiocarbamate-iron-NO complex having a characteristic three-line spectrum (indicative of a mononitrosyl-Fe complex) which can readily be detected at ambient temperatures by electron paramagnetic resonance (EPR) spectroscopy. The present invention relates to methods for reducing in vivo levels of .NO as a means of treating subjects afflicted with inflammatory and/or infectious disease.Type: GrantFiled: November 6, 1995Date of Patent: April 21, 1998Inventor: Ching-San Lai
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Patent number: 5716646Abstract: Arthritic conditions treated by oral administration of inorganic nickel compound(s), with or without bromide(s). In an especially preferred embodiment, the nickel compound used to treat these conditions is NiBr.sub.2.Type: GrantFiled: April 25, 1996Date of Patent: February 10, 1998Inventors: Steven A. Smith, Lorraine J. Smith
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Patent number: 5696109Abstract: The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical administration to treat a disease associated with cell or tissue damage produced by free radicals such as superoxide, and cosmetic and free radical quenching formulations of salen metal compounds.Type: GrantFiled: June 7, 1995Date of Patent: December 9, 1997Assignee: Eukarion, Inc.Inventors: Bernard Malfroy-Camine, Susan Robin Doctrow
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Patent number: 5681593Abstract: Psoriasis, seborrheic dermatitis and eczema are treated by oral administration of inorganic nickel compound(s), with or without inorganic bromide(s). In an especially preferred embodiment, the nickel compound used to treat these diseases is NiBr.sub.2.Type: GrantFiled: July 18, 1995Date of Patent: October 28, 1997Inventors: Steven A. Smith, Lorraine J. Smith
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Patent number: 5676923Abstract: Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.Type: GrantFiled: June 7, 1995Date of Patent: October 14, 1997Assignee: Schering AktiengesellschaftInventors: Johannes Platzek, Ulrich Niedballa, Peter Mareski, Bernd Raduchel, Hanns-Joachim Weinmann, Andreas Muhler, Bernd Misselwitz
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Patent number: 5604199Abstract: A method of treating skeletal muscle fibrosis in mammals. The novel method is effective for reducing the extent of skeletal muscle fibrosis in an individual who suffers from a disorder which targets skeletal muscle tissue, such as Duchenne's and Becker's muscular dystrophy and denervation atrophy induced by either trauma or neuromuscular disease. The treatment includes administering to the individual an effective amount of a metalloporphyrin compound, especially hemin, heme arginate, cobalt protoporphyrin IX chloride and cobalt protoporphyrin IX arginate.Type: GrantFiled: October 16, 1995Date of Patent: February 18, 1997Assignee: The Nemours FoundationInventor: Vicky L. Funanage
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Patent number: 5597809Abstract: Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.Type: GrantFiled: June 23, 1994Date of Patent: January 28, 1997Assignee: Massachusetts Eye & Ear InfirmaryInventor: Evan B. Dreyer
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Patent number: 5596016Abstract: Mineral absorption is promoted in warm-blooded animals by means of a class of 1,2-disubstituted aromatic mineral chelates wherein the 1 and 2 substituents each donates a pair of electrons to a metal ion for formation of a five-member chelate ring. 2-Alkoxyphenols are particularly preferred. The chelates contain from one to three alkoxyphenol ligands, with two ligands being preferred. A preferred alkoxyphenol is vanillin, and the minerals are selected from the group consisting of Mg, Ca, Cr, Mn, Fe, Co, Cu, Zn, Mo, and Se. Vanillin metal chelates have a slight to neutral taste, and are absorbed more readily than inorganic mineral salts.Type: GrantFiled: August 19, 1994Date of Patent: January 21, 1997Assignee: Albion International, Inc.Inventors: Stephen Ashmead, Harvey H. Ashmead
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Patent number: 5587395Abstract: The present invention provides a complex compound having the structure: ##STR1## wherein R.sub.1 and R.sub.1' are the same or different and each is an alkyl group, a phenyl group or a substituted derivative of a phenyl group;wherein R.sub.2 and R.sub.2' are the same or different and each is hydrogen, an unbranched alkyl group, a halide or a group having the structure ##STR2## wherein R is hydrogen, an alkoxide group, an alkyl group, or OH; wherein R.sub.3 and R.sub.3' are the same or different and each is hydrogen or an alkyl group;wherein X and X' are the same or different and each is a water soluble group having weak to intermediate ligand field strength; andQ is a soluble, pharmaceutically acceptable negative ion.The invention also provides a method of treating a subject having a condition associated with the presence of free radicals in quantities sufficient to cause undesirable symptoms.Type: GrantFiled: April 25, 1995Date of Patent: December 24, 1996Assignee: Chai-Tech CorporationInventors: Zvi Dori, David Gershon
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Patent number: 5554648Abstract: New cobalt complexes of nitrogen mustard alkylating agents which have been found to have hypoxia-selective antitumor properties and are thereby useful antitumor agents are described.Type: GrantFiled: June 22, 1994Date of Patent: September 10, 1996Assignee: Warner Lambert CompanyInventors: William A. Denny, Brian D. Palmer, David C. Ware, William R. Wilson
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Patent number: 5534542Abstract: Disclosed herein is a bi-metallic cross-linking reagent according to the following formula: ##STR1## where M.sub.1 is a metal ion species capable of forming a complex of coordination number four or coordination number six; wherein L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are each independently a halide, ammonia, dimethyl sulfoxide, carboxylate, thiolate, imidazole, a nucleobase, or an empty coordination site, provided that no more than two of L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are empty coordination sites; wherein M.sub.2 is a metal ion species capable of forming a complex of coordination number two with a first ligand that is a hydrocarbon moiety and a second ligand that is kinetically lablie; and wherein n is an integer from two to nine. Also disclosed are cross-linked species, methods of preparing the crosslinking reagents of the invention, and methods for their use in tissue-specific targeting of anti-tumor agents.Type: GrantFiled: January 24, 1994Date of Patent: July 9, 1996Assignee: Northwestern UniversityInventors: Thomas V. O'Halloran, Stephen P. Watton
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Patent number: 5504055Abstract: A water soluble metal amino acid chelate is prepared by adding a metal salt to deaerated water, mixing the salt solution with a mixture of an amino acid and an organic acid and adjusting the pH of the resulting composition to a range of from about 4.5 to about 8.5 to produce a clear solution. The resultant clear solution can then be applied to plants or it can be dried for storage. The water soluble metal amino acid chelate produced by the process, when applied to plants, results in increased metals assimilation and improved plant growth.Type: GrantFiled: March 15, 1994Date of Patent: April 2, 1996Assignee: J.H. Biotech, Inc.Inventor: Hsinhung J. Hsu
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Patent number: 5476644Abstract: The present invention provides compounds of the formula ##STR1## chelated with a paramagnetic metal ion wherein Z1 and Z2 each represent the atoms necessary to complete a monocyclic or polycyclic carbocyclic or heterocyclic ring system, said Z1 and Z2 independently optionally substituted with R.sup.6 and R.sup.7, respectively;R.sup.l, R.sup.2, R.sup.3 and R.sup.4 are independently carboxyalkyl (C.sub.1 -C.sub.2), --(CH.sub.2).sub.n --C(.dbd.O)--NH--R.sup.8, or --(CH.sub.2).sub.n --C(.dbd.O)--O--R.sup.8R.sup.5 is carboxyalkyl (C.sub.1 -C.sub.2);R.sup.6 and R.sup.7 are independently hydrogen, benzyl, or benzyloxy, said benzyl or benzyloxy optionally substituted with one, two or three substituents selected from the group consisting of amino, isocyanato (--N.dbd.C.dbd.O), isothiocyanato (--N.dbd.C.dbd.S), --NH--C(.dbd.O)--X or --NH--C(.dbd.S)--X;R.sup.8 is alkyl (C.sub.1 -C.sub.20), --(CH.sub.2).sub.m --Ar, or polyhydroxyalkyl (C.sub.1 -C.sub.Type: GrantFiled: April 13, 1994Date of Patent: December 19, 1995Assignee: Sterling Winthrop Inc.Inventors: Carl R. Illig, Thomas J. Caulfield, John L. Toner, Peng Guo, David L. Ladd
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Patent number: 5470586Abstract: A method of controlling the attachment of organisms to an underwater surface is disclosed. The method comprises contacting the organisms with a compound of Formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halogen, or hydroxyl. Antifouling coatings and cementitious compositions containing a compound of Formula I are also disclosed.Type: GrantFiled: April 11, 1994Date of Patent: November 28, 1995Assignee: Duke UniversityInventor: Donald J. Gerhart
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Patent number: 5433954Abstract: Psoriasis, seborrheic dermatitis and eczema are treated by oral administration of inorganic nickel compound(s), with or without inorganic bromide(s). In an especially preferred embodiment, the nickel compound used to treat these diseases is NiBr.sub.2.Type: GrantFiled: December 3, 1992Date of Patent: July 18, 1995Inventors: Steven A. Smith, Lorraine J. Smith
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Patent number: 5409914Abstract: The present invention provides a pharmaceutical composition of a complex compound having the structure: ##STR1## wherein R.sub.1 and R.sub.1, are the same or different and each is an alkyl group, a phenyl group or a substituted derivative of a phenyl group;wherein R.sub.2 and R.sub.2, are the same or different and each is hydrogen, an unbranched alkyl group, a halide or a group having the structure ##STR2## wherein R is hydrogen, an alkoxide group, an alkyl group, or OH; wherein R.sub.3 and R.sub.3, are the same or different and each is hydrogen or an alkyl group;wherein X and X' are the same or different and each is a water soluble group having weak to intermediate ligand field strength; andQ is a soluble, pharmaceutically acceptable negative ion.Type: GrantFiled: November 1, 1993Date of Patent: April 25, 1995Assignee: Chai-Tech CorporationInventors: Zvi Dori, David Gershon
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Patent number: 5403576Abstract: Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.Type: GrantFiled: February 4, 1994Date of Patent: April 4, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Youlin Lin, Muthanadar P. Periasamy, Donald R. VanDeripe, William P. Cacheris
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Patent number: 5399190Abstract: A wood preservative composition including a mixture of two or more metallic soaps of long chain unsaturated fatty acids, which soaps have a metallic component selected from the group consisting of copper, zinc, chromium, iron, antimony, tin, cobalt, nickel, arsenic, boron, lead, magnesium, potassium and sodium, and a fatty acid component selected from two or more of the group consisting of oleic acid, linoleic acid, and linolenic acid, the composition being such that the ratio by mass of metallic soap of oleic acid:metallic soap of linoleic acid:metallic soap of linolenic acid is about 20-29:15-70:0-47.Type: GrantFiled: May 3, 1993Date of Patent: March 21, 1995Assignees: Shell South Africa (Pty.) Ltd., CSIR, Shell Research Ltd.Inventors: Wilhelm E. Conradie, Andrew J. Pendlebury, Antonio Pizzi, Denise Conradie
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Patent number: 5385724Abstract: Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize trifluoromethyl derivatives of iodinated X-ray contrast media. Typical magnetic resonance contrast media within the scope of the present invention include bis(trifluoromethyl)benzene derivatives, tris(trifluoromethyl)benzene derivatives, tetrakis(trifluoromethyl)benzene derivatives, and other related trifluoromethylated benzene derivatives.Type: GrantFiled: March 4, 1994Date of Patent: January 31, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: David H. White, Steven R. Woulfe, Youlin Lin, Mills T. Kneller
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Patent number: 5348977Abstract: New cobalt complexes of nitrogen mustard alkylating agents which have been found to have hypoxia-selective antitumour properties and are thereby useful antitumour agents are described.Type: GrantFiled: January 21, 1994Date of Patent: September 20, 1994Assignee: Warner Lambert CompanyInventors: William A. Denny, Brian D. Palmer, David C. Ware, William P. Wilson
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Patent number: 5324503Abstract: Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.Type: GrantFiled: February 6, 1992Date of Patent: June 28, 1994Assignee: Mallinckrodt Medical, Inc.Inventors: Youlin Lin, Muthanadar P. Periasamy, Donald R. VanDeripe
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Patent number: 5321030Abstract: The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, HSV-2, cytomegaloviruses, Varicella-Zoster virus) and adenovirus. The invention further relates to creatine analogs including four classes of creatine analogs selected as candidate antiviral compounds: (1) creatine analogs that can be phosphorylated by creatine kinase but differ in their phosphoryl group transfer potential, (2) bisubstrate inhibitors of creatine kinase comprising covalently linked structural analogs of adenosine triphosphate (ATP) and creatine, (3) creatine analogs which can act as irreversible inhibitors of creatine kinase, and (4) N-phosphorocreatine analogs bearing non-transferable moieties which mimic the N-phosphoryl group.Type: GrantFiled: December 20, 1991Date of Patent: June 14, 1994Assignee: Amira, Inc.Inventors: Rima Kaddurah-Daouk, James W. Lillie, Theodore S. Widlanski, Jonathan J. Burbaum, Craig J. Forsyth
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Patent number: 5294616Abstract: A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.Type: GrantFiled: March 25, 1992Date of Patent: March 15, 1994Assignee: Merck & Co., Inc.Inventors: Mark E. Duggan, Melissa S. Egbertson, Wasyl Halczenko, George D. Hartman, Laura M. Turchi, William L. Laswell
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Patent number: 5260272Abstract: Polypeptides of the formulapoly (X).sub.m (Y).sub.n,whereinX is selected from the group consisting of aspartate, glutamate, glutamine, asparagine, mixtures and block polymers thereof,Y is selected from the group consisting of phosphoserine, sulfoserine, phosphohomoserine, phosphotyrosine, phosphothreonine, phosphoglutamine, phosphoasparagine, serine, alanine, dehydroalanine and mixtures thereof,m=5-199 andn=1-10have been demonstrated to inhibit mineral deposition, and can be employed in the inhibition of mineral deposition in both in vitro and in vivo applications. Serine-containing polypeptides can be thermally synthesized by combining the necessary amino acid residues in a reaction vessel, eliminating oxygen to preclude charring, and heating said reaction vessel in a heating medium to a temperature of about 155.degree. C.Type: GrantFiled: March 29, 1991Date of Patent: November 9, 1993Assignee: University of South AlabamaInventors: Julie Donachy, Steven Sikes
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Patent number: 5258403Abstract: The present invention provides pharmaceutical compositions for the treatment of tumor cells in a subject of for the treating of undesirable symptoms associated with the presence of free radicals. The compositions comprising a complex compound having the structure: ##STR1## wherein R.sub.1 and R.sub.1, are the same or different and each is an alkyl group, a phenyl group or a substituted derivative of a phenyl group;wherein R.sub.2 and R.sub.2, are the same or different and each is hydrogen, an unbranched alkyl group, a halide or a group having the structure ##STR2## wherein R is hydrogen, an alkoxide group, an alkyl group, or OH; wherein R.sub.3 and R.sub.3, are the same or different and each is hydrogen or an alkyl group;wherein X and X' are the same or different and each is a water soluble group having weak to intermediate ligand field strength; andQ is a soluble, pharmaceutically acceptable negative ion and a pharmaceutically acceptable carrier.Type: GrantFiled: June 2, 1992Date of Patent: November 2, 1993Assignee: Chai-Tech CorporationInventors: Zvi Dori, David Gershon
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Patent number: 5210096Abstract: Compositions having significant activity as antiviral agent are disclosed containing, as an active component, a compound having the structural formula: ##STR1## wherein R.sub.1 and R.sub.1' are the same or different and each is an alkyl group, a phenyl group or a substituted derivative of a phenyl group;wherein R.sub.2 and R.sub.2' are the same or different and each is hydrogen, an unbranched alkyl group, a halide or a group having the structure ##STR2## wherein R is hydrogen, an alkoxide group, an alkyl group, or OH; wherein R.sub.3 and R.sub.3' are the same or different and each is hydrogen or an alkyl group;wherein X and X' are the same or different and each is a water soluble group having weak to intermediate ligand field strength; andQ.sup.- is a soluble, pharmaceutically acceptable negative ion.Methods of use of the inventive compositions are also disclosed.Type: GrantFiled: July 10, 1991Date of Patent: May 11, 1993Assignee: Chai-Tech CorporationInventor: David I. Scheer
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Patent number: 5187194Abstract: Wood preservatives which contain a mixture of an N-organyldiazeniumdioxy-metal salt and a complex-forming polymeric nitrogen compound are used for preserving wood.Type: GrantFiled: October 16, 1990Date of Patent: February 16, 1993Assignee: Dr. Wolman GmbHInventors: Reimer Goettsche, Wolfgang Reuther
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Patent number: 5171581Abstract: Psoriasis molecules are treated by administering non-toxic pharmaceutically acceptable solutions (topically, orally or by I.V.) of a composition containing nickel with a bromide carrier.Type: GrantFiled: May 1, 1990Date of Patent: December 15, 1992Inventors: Steven A. Smith, Lorraine J. Smith
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Patent number: 5164380Abstract: A process for preparing complexes of piroxicam with cyclodextrins in which the two components in the powder state are premixed and then co-ground in a high energy mill in the presence of steam.The products obtained have technological, physical and biopharmacological characteristics which are advantageous compared with those of liquid-state complexes obtained by traditional methods, and are suitable for preparing pharmaceutical compositions for oral, rectal and topical use.Type: GrantFiled: March 27, 1991Date of Patent: November 17, 1992Assignee: Chiesi Farmaceutici S.p.A.Inventors: Fabio Carli, Paolo Chiesi
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Patent number: 5138040Abstract: Methods and compositions for enhancing magnetic resonance imaging in at least a portion of a warm-blooded animal.Type: GrantFiled: July 2, 1991Date of Patent: August 11, 1992Assignee: Mallinckrodt Medical, Inc.Inventors: Dennis A. Moore, Rebecca A. Wallace
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Patent number: 5116872Abstract: 1-Aminocyclohexanecarboxylic acid derivatives of the formula I ##STR1## or their acid addition salts or a metal complex can be employed for protecting plants from microorganisms. In the formula I, R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, benzyl, or an ammonium radical which is unsubstituted or substituted by hydrocarbon radicals having not more than 20 C atoms, or a metal ion equivalent.Compounds of the formula I can be employed in the form of crop protection agents using suitable carrier materials.Type: GrantFiled: January 22, 1991Date of Patent: May 26, 1992Assignees: Ciba-Geigy Corporation, Degussa AktiengesellschaftInventors: Peter Ackermann, Hanspeter Fischer, Rolf Vogel, Karlheinz Drauz, Hans-Albrecht Hasseberg, Hans-Jochen Hasselbach, Gunter Knaup, Hans-Peter Krimmer, Matthias Schafer
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Patent number: 5084482Abstract: This invention concerns novel methods employing compositions containing as an active antioxidant or antiinflammatory agent the amino acid methionine, and/or one or more related compounds including certain metabolic precursor compounds, for treating or inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response in a subject. The compounds include the methionine hydroxy analogs, as well as compounds having the structural formula I: ##STR1## and pharmaceutically acceptable N-(mono- and di-carboxylic acid) acyl derivatives and alkyl esters thereof, where n is an integer from 1 to 3.Type: GrantFiled: April 10, 1990Date of Patent: January 28, 1992Assignee: The Lithox CorporationInventors: Gerald P. Hirsch, Robert K. Bayless
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Patent number: 5030651Abstract: Methods for preventing and treating oxidative insult to the eye by the administration of transition metal complexes are disclosed.Type: GrantFiled: May 22, 1989Date of Patent: July 9, 1991Assignee: Alcon Laboratories. Inc.Inventors: Hans R. Moll, Mark T. DuPriest
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Patent number: 5010103Abstract: New compounds having utility for enhancing the activity of antifolates are disclosed of the formula: ##STR1## wherein X is selected from hydrogen ##STR2## and R" ; R' is selected from alkyl, alkenyl, alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heterocyclic aryl; R" is selected from ##STR3## and R'S; M is selected from OR and secondary amine; and R is selected from hydrogen, alkyl, acyloxymethyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclic aryl, amino cation and metal cation.Type: GrantFiled: January 17, 1990Date of Patent: April 23, 1991Assignee: The Research Foundation of State University of N.Y.Inventor: Thomas I. Kalman
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Patent number: 5006539Abstract: Novel compounds have a formula (I) ##STR1## wherein ##STR2## represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1]heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substituted at the 5-position by the group R.sup.1 and at the 6-position by the group ANR.sup.2 R, a 6,6-dimethyl-bicyclo [3,1,1] heptane substituted at the 2-position by the group R.sup.1 and at the 3-position by the group ANR.sup.2 R or at the 2-position by the group ANR.sup.2 R and at the 3-position by the group R.sup.1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R.sup.1 and at the 5-position by the group ANR.sup.2 R or a 1-hydroxyclopentane substituted at the 2-position by the group R.sup.1 and at the 2-position by the group ANR.sup.2 R, R.sup.Type: GrantFiled: March 6, 1989Date of Patent: April 9, 1991Assignee: National Research Development CorporationInventors: Robert L. Jones, Norman H. Wilson
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Patent number: 4985404Abstract: Prolonged parenteral release of a bioactive polypeptide at desirably effective levels can be achieved using novel compositions in which the polypeptide is present in a biocompatible oil in an unusually high proportion such as at least about 10% by weight. Also disclosed are certain metal-associated somatotropins that are useful for prolonged parenteral release of such somatotropins.Type: GrantFiled: June 29, 1988Date of Patent: January 15, 1991Assignee: Monsanto CompanyInventor: James W. Mitchell
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Patent number: 4952404Abstract: Healing of injured avascular tissue is promoted by applying angiogenic factor in proximity to the injured tissue.Type: GrantFiled: June 19, 1987Date of Patent: August 28, 1990Assignee: President and Fellows of Harvard CollegeInventors: Bert L. Vallee, Thomas V. King
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Patent number: 4866054Abstract: A method of treating an inflammatory condition in a mammalian subject, particularly arthritis, comprising the steps of administering an effective and nontoxic dose for an inflammation ameliorating period to the subject of at least one metallo-organic complex capable of in vivo superoxide anti-oxidant effects and wherein the metal of the complex is selected from the group which consists of cobalt and iron.Type: GrantFiled: January 25, 1988Date of Patent: September 12, 1989Assignee: Chai-Tech CorporationInventors: Zvi Dori, David Gershon
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Patent number: 4866053Abstract: A new method of treating a burn is disclosed wherein a cobalt-containing metallo-organic complex is applied to the burn site to promote epithelialization and in some cases hair follicle preservation as well.Type: GrantFiled: January 25, 1988Date of Patent: September 12, 1989Assignee: Chai-Tech CorporationInventors: Zvi Dori, David Gershon, Yehuda Scharf
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Patent number: 4863898Abstract: Amino acid chelates having a ligand to divalent metal mole ratio of at least 2:1 and having a molecular weight of not more than 1500 and preferably not more than 1000 and also having a stability constant of between about 10 and 10 are formulated for delivery to one or more specific tissue sites within a mammal. The ligand utilized in formulating the amino acid chelate is a naturally occuring amino acid or a dipeptide, tripeptide or quadrapeptide thereof. The selection of an appropriate ligand with which to form the chelate provides a product that, when entering the bloodstream of the mammal, either by mean of oral ingestion or injection, has a propensity to migrate to one or more targeted tissue sites within the mammal.Type: GrantFiled: February 6, 1986Date of Patent: September 5, 1989Assignee: Albion International, Inc.Inventors: Harvey H. Ashmead, H. Dewayne Ashmead, Darrell J. Graff
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Patent number: 4851430Abstract: Metallicenium salts of the general formula I[(.eta..sup.5 --C.sub.5 H.sub.-x R.sub.x)M(.eta..sup.5 --C.sub.5 H.sub.5-y R'.sub.y)].sub.a.sup.m+ [A].sub.b.sup.n- (I)in which M is Fe, Co, Ni, Ru or Os; C.sub.5 H.sub.5-x R.sub.x and C.sub.5 H.sub.5-y R'.sub.y denote cyclopendadienyl rings which, independently of one another, can be unsubstituted (x and y=0) or mono-, di-, tri-, tetra- or penta-substituted (x and y=1, 2, 3, 4 or 5), and in which R and R' independently of one another represent identical or different substituents and denote alkyl, cycloalkyl, hydroxyalkyl, aminoalkyl, halogenoalkyl, alkenyl, aryl, aralkyl, ferrocenyl, ferrocenylium, ferrocenylalkyl, acyl, halogenyl, trialkylsilyl, tricycloalkylsilyl, triarylsilyl, triaralkylsilyl or carboxyl, ester, amide or hydrazide groups, or R and R' together form an alkylene bridge with 2 to 4 bridge atoms; a, b, m and n are integers, and m has the value 1 or 2, n has the value 1, 2 or 3 and a.times.m=b.times.Type: GrantFiled: October 3, 1985Date of Patent: July 25, 1989Inventors: Petra Kopf-Maier, Hartmut Kopf, Eberhard W. Neuse
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Patent number: 4826673Abstract: The disclosure is directed to compounds of the formula: ##STR1## wherein n=0, 1, 2, 3 or 4, and R.sub.1 and R.sub.2 may be the sam e or different and are selected from the group consisting of hydrogen and lower alkyl and hydroxy lower alkyl groups containing between 1 and 6 carbon atoms. Complexes of iron(II), iron(III), manganese(II), manganese(III), gadolinium(III), chromium(III), cobalt(II), and nickel(II) and such compounds are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative complexes include (N,N"-bis[N-(2,3-dihydroxypropyl) carbamoylmethyl]diethylenetriamine-N,N',N"-triaceto)-iron(III), (N,N"-bis[N-(2,3-dihydroxypropyl)carbamoylmethyl]diethylenetriamine-N,N',N "-triaceto)manganese(II), (N,N"-bis[N-(2,3-dihydroxypropyl) )carbamoylmethyl]diethylenetriamine-N,N',N"-triaceto)gadolinium(III) and (N,N'-bis[N-(2,3-dihydroxypropyl)-carbamoylmethyl]ethylenediamine-N,N'-dia ceto)manganese(II).Type: GrantFiled: January 9, 1985Date of Patent: May 2, 1989Assignee: Mallinckrodt, Inc.Inventors: Richard T. Dean, Youlin Lin, Robert W. Weber, David H. White
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Patent number: 4746507Abstract: Ethylene Diamine Hydroxy Phenylacetic Acid (EDHPA) type chelators strongly bind paramagnetic metal ions to provide excellent contrast agents for magnetic resonance (MR) imaging. The magnetic dipole generated by unpaired electrons within the paramagnetic (PM) atom, causes a local reduction in the bulk magnetic field of the MR system. The resulting shortening of the T1 (spin lattice) relaxation time in the hydrogen protons within the area of interest, causes an intense "free induction signal" and a corresponding modulation in the collected scanning data. The tissue of organ of interest appears on the MR display as a high intensity of white area. Background tissue is displayed as darker or lower intensity greys. Each member chelator EDHPA' of the EDHPA family of chelators, is a phenolic analog of EDTA, with variations in the para position radical (PR) of the phenol ring.Type: GrantFiled: April 2, 1985Date of Patent: May 24, 1988Assignee: Salutar, Inc.Inventor: Steven C. Quag
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Patent number: 4701448Abstract: A metal salt of an organic phosphate, having good stability and cholesterol-lowering activity, is produced by reacting a known compound ##STR1## wherein R.sub.4 and R.sub.5 are hydrogen or methyl, with a reaction agent such as metal hydroxide.Type: GrantFiled: January 29, 1986Date of Patent: October 20, 1987Assignee: Asahi Denka Kogyo Kabushiki KaishaInventors: Akira Endo, Haruyuki Yamashita
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Patent number: 4680309Abstract: A method of treating inflammation or arthritis with metal complexes that can traverse skin and animal cell membranes intact and effectively deliver and release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes have an aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of hydrogen ion concentration. This dissociation property enables the metal complexes to release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes can be effectively administered either topically or subcutaneously.Type: GrantFiled: February 3, 1986Date of Patent: July 14, 1987Assignee: National Research LaboratoriesInventor: Gerald L. Maurer
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Patent number: RE32909Abstract: Metal oxycarboxylates are made by reacting a metal, a carboxylic acid, and hydrogen peroxide in aqueous reaction mixture. The metal oxycarboxylate is precipitated and removed from the reaction mixture in high yield and with high purity. The compound is effective in supplying the metal to plants, animals and humans.Type: GrantFiled: June 18, 1984Date of Patent: April 18, 1989Assignee: BioSystems Research Inc.Inventors: Joseph E. Lionelle, Jeffrey A. Staffa