With An Additional Active Ingredient Patents (Class 514/515)
  • Patent number: 10111851
    Abstract: A method for treating eczema including the steps of applying an isothiocyanate functional surfactant to an area affected by eczema, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: October 30, 2018
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Patent number: 9332761
    Abstract: A synergistic antimicrobial composition containing chlorotoluron and zinc pyrithione is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 10, 2016
    Assignees: Rohm and Haas Company, Dow Global Technologies LLC
    Inventors: Kenneth M. Donnelly, Pierre Marie Lenoir, Lukas Thomas Johannes Villiger
  • Patent number: 9326512
    Abstract: A synergistic antimicrobial composition containing flurochloridone and zinc pyrithione is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 3, 2016
    Assignees: Rohm and Haas Company, Dow Global Technologies LLC
    Inventors: Kenneth M. Donnelly, Pierre Marie Lenoir, Lukas Thomas Johannes Villiger
  • Patent number: 9326517
    Abstract: A synergistic antimicrobial composition containing chlorotoluron and 3-Iodo-2-propynyl butylcarbamate is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 3, 2016
    Assignees: Rohm and Haas Company, Dow Global Technologies LLC
    Inventors: Kenneth M. Donnelly, Pierre Marie Lenoir, Lukas Thomas Johannes Villiger
  • Patent number: 9326518
    Abstract: A synergistic antimicrobial composition containing chlorotoluron and 2-n-octyl-4-isothiazolin-3-one is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: May 3, 2016
    Assignees: Rohm and Haas Company, Dow Global Technologies LLC
    Inventors: Kenneth M. Donnelly, Pierre Marie Lenoir, Lukas Thomas Johannes Villiger
  • Publication number: 20150132405
    Abstract: The present invention provides synergistic combinations of monochlorourea with other biocides for controlling microbial growth in aqueous systems. It also provides synergistic combinations of dimethyl monochlorourea with other biocides for controlling growth in aqueous systems. The synergistic combinations of monochlorourea and dimethyl monochlorourea with other biocides allows for the reduced use of total biocides to provide control of microbial growth in aqueous systems.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 14, 2015
    Applicant: HERCULES INCORPORATED
    Inventor: John S Chapman
  • Publication number: 20150126437
    Abstract: The disclosure provides compounds useful as insect repellents, compositions comprising such repellents, and methods of repelling an arthropod using such compounds and compositions. The disclosure further provides insect traps and method for identifying ligands and cognates for biological molecules.
    Type: Application
    Filed: October 17, 2012
    Publication date: May 7, 2015
    Applicant: The Regents of the University of California
    Inventors: Anandasankar Ray, Sean Michael Boyle
  • Publication number: 20150110863
    Abstract: The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.
    Type: Application
    Filed: March 6, 2013
    Publication date: April 23, 2015
    Applicants: Univerversidad De Sevilla, Consejo Superior De Investigaciones CientÍficas (CSIC)
    Inventors: Noureddine Khiar El Wahabi, Inmaculada Fernández Fernández, Rocío Recio Jiménez
  • Patent number: 8758990
    Abstract: The present invention relates to compositions and methods for detecting Mycobacterium genus (Mycobacterium sp.) bacteria (e.g., M. tuberculosis) and M. avium complex (MAC; M. avium, M. scrofulaceum and M. intracellulaire) in a clinical sample or culture. The present invention also relates to differentiating cultures or samples comprising (Mycobacterium sp.) bacteria (e.g., M. tuberculosis) from cultures or samples comprising M. avium complex (MAC; M. avium, M. scrofulaceum and M. intracellulaire).
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: June 24, 2014
    Assignee: ID-Fish Technology, Inc.
    Inventors: Jyotsna S. Shah, Helena Weltman
  • Patent number: 8632963
    Abstract: The present invention provides a method for allowing foreign particles to penetrate, very efficiently, the cell wall, cell membrane, organelle membrane and/or nuclear membrane of a cell and hybridizing or binding to the complimentary target in the cell. The cells may be from a culture or from specimens obtained from a patient. The foreign particle can be a probe consisting of, for example, either individually or in any combination of two or more of the following: DNA, RNA, peptide nucleic acids (PNA), glycopeptides, lipopeptides, glycolipids or prions. The target is a cell, a cell component or, preferably, a pathogen or pathogen component. The pathogen can be, for example, bacteria, fungi, yeast or viruses.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: January 21, 2014
    Assignee: ID-FISH Technology Inc.
    Inventors: Jyotsna Shah, Helena Weltman
  • Patent number: 8628788
    Abstract: Novel formulations containing a non-oxidative biocide, such as DBNPA, and a source of an in situ produced active biocide, such as a concentrated aqueous solution of an inorganic halide salt, are disclosed. These novel formulations are particularly effective in the treatment of water, and are characterized by high stability, desirable rheological properties and an excellent biocidal activity.
    Type: Grant
    Filed: February 25, 2007
    Date of Patent: January 14, 2014
    Assignee: Bromine Compounds, Ltd.
    Inventors: David Feldman, Michel Adda, Raymond J. Roccon
  • Publication number: 20130295203
    Abstract: Methods and compositions are disclosed to treat neuropsychiatric disorders based upon a new framework of diagnosis. Axis I biomarkers include genes related to prefrontal dopamine synthesis and/or dopamine degradation. Axis II includes genes related to re uptake of dopamine, norepinephrine and serotonin and autonomic hyperactivity. Axis III includes genes relates to impairments in inflammatory pathways, glutamate neurotransmission and/or neurotrophic factors. Axis IV includes genes related to glutamate reuptake and predisposition to addictive behavior, and obsessive compulsions.
    Type: Application
    Filed: July 8, 2013
    Publication date: November 7, 2013
    Inventor: Jay L. LOMBARD
  • Publication number: 20130288985
    Abstract: This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 31, 2013
    Applicant: The Schepens Eye Research Institute Inc.
    Inventor: Ula V. Jurkunas
  • Publication number: 20130287918
    Abstract: The present invention provides a composition comprising (a) allyl isothiocyanate; and (b) an organic acid selected from acetic acid, propionic acid and mixtures thereof and optionally further comprising (c) green tea [Camellia sinensis] extract.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 31, 2013
    Applicant: DUPONT NUTRITION DIOSCIENCES APS
    Inventors: Jana Theresa Fischer, Brett Wesley Thompson
  • Publication number: 20130237423
    Abstract: An agricultural chemical composition comprises a solvent having the general formula CO(ORa)(Rb), wherein Ra is a linear or branched alkyl group of one to eight carbon atoms and Rb is an aromatic group. Active agricultural components are dissolved in the solvent to produce a solution usable for distributing the active components.
    Type: Application
    Filed: November 29, 2011
    Publication date: September 12, 2013
    Applicant: Hunstman Petrochemical LLC
    Inventor: Dave C. Ferguson
  • Publication number: 20130231387
    Abstract: The invention concerns the role of Glo 1 in the prevention and reversal of proteomic and genomic damage by carbonyl substrates thereof and, in particular, therapeutics that promote Glo 1 production.
    Type: Application
    Filed: June 20, 2011
    Publication date: September 5, 2013
    Applicant: THE UNIVERSITY OF WARWICK
    Inventors: Mingzhan Xue, Paul Thornalley, Naila Rabbani
  • Publication number: 20130184341
    Abstract: A biocidal composition comprising 2,2-dibromomalonamide and an electrophile containing biocide, and its use for the control of microorganisms in aqueous and water-containing systems.
    Type: Application
    Filed: September 30, 2010
    Publication date: July 18, 2013
    Applicant: DOW GLOBAL TECHNOLOGIES INC.
    Inventors: Bei Yin, Freddie L. Singleton
  • Publication number: 20130184340
    Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 18, 2013
    Inventor: The Penn State Research Foundation
  • Publication number: 20130184339
    Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 18, 2013
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventor: The Penn State Research Foundation
  • Publication number: 20130158111
    Abstract: The invention is directed towards methods of treating abnormal tissues in a subject or sensitizing an abnormal tissue to a chemotherapeutic agent. The methods comprise screening at least a portion of an abnormal tissue for at least one mutant form of p53 protein, and administering at least one isothiocyanate (ITC) to the subject or abnormal tissue if the abnormal tissue is positive for the at least one mutant form of p53.
    Type: Application
    Filed: December 20, 2012
    Publication date: June 20, 2013
    Applicant: Georgetown University
    Inventor: Georgetown University
  • Publication number: 20130072554
    Abstract: Provided is a composition that contains a mixture of broccoli seed and mustard seed. Before mixing the broccoli seed with the mustard seed, the broccoli seed is subjected to baking and a pressurized heat treatment. The broccoli seed is baked at a temperature of at least 200 degrees Fahrenheit for at least 60 minutes, and is subjected to a pressurized heat treatment of at least 200 degrees Fahrenheit at a pressure of at least 10 pounds/square inch for at least 5 minutes. Also provided is a method for therapy and/or prophylaxis of bladder cancer in an individual. The method entails administering orally to the individual a composition that contains an isothiocyanate (ITC) or a derivative thereof such that the administration inhibits the growth and/or recurrence of bladder cancer. Nutraceutical compositions are also provided.
    Type: Application
    Filed: September 11, 2012
    Publication date: March 21, 2013
    Applicant: HEALTH RESEARCH, INC.
    Inventors: Yuesheng Zhang, Arup Bhattacharya, Li Tang, Yun Li, Joseph D. Paonessa, Feng Geng, Yi Ding
  • Publication number: 20130071347
    Abstract: Antimicrobial compositions that include at least one aliphatic aldehyde component and allyl isothiocyanate are provided. Methods of reducing bacterial activity using the instantly disclosed compositions are also provided.
    Type: Application
    Filed: November 15, 2012
    Publication date: March 21, 2013
    Applicant: Takasago International Corporation
    Inventor: Takasago International Corporation
  • Publication number: 20130039928
    Abstract: The present invention features methods for reversing corticosteroid resistance, as well as for the treatment of respiratory infections, particularly those associated with chronic obstructive pulmonary disease. In one embodiment, the method increases Nrf2 biological activity or expression.
    Type: Application
    Filed: January 28, 2011
    Publication date: February 14, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shyam Biswal, Rajesh K. Thimmulappa
  • Publication number: 20120276198
    Abstract: A pharmaceutical composition used to treat Parkinson's disease contains levodopa, carbidopa and entacapone or pharmaceutically acceptable salt thereof, and at least one kind of pharmaceutically acceptable excipients. Entacapone is not mixed with levodopa or carbidopa in the pharmaceutical composition. The preparation method of the pharmaceutical composition includes making the first particles with levodopa and carbidopa, making the second particles with entacapone, and then pressing the two kinds of particles into tablets.
    Type: Application
    Filed: December 25, 2009
    Publication date: November 1, 2012
    Applicant: INNOPHARMAX INC.
    Inventors: Weihua Hao, Jongjing Wang, Huiyun Chen
  • Patent number: 8278352
    Abstract: New pesticide compositions comprising an alkyl formate and an isothiocyanic ester are described, as are methods of delivering fumigants and methods of pest control using a combination of fumigants.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: October 2, 2012
    Assignee: Commonwealth Scientific & Industrial Research Organisation
    Inventors: YongLin Ren, Colin Waterford, ByungHo Lee
  • Publication number: 20110245213
    Abstract: The present invention concerns compositions that may be used in the prevention or treatment of medical conditions characterised by having an inflammatory component. The compositions comprise a therapeutically effective amount of an isothiocyanate (ITC). The composition may comprise further anti-inflammatory agents (e.g. plant-derived polyphenols).
    Type: Application
    Filed: June 25, 2009
    Publication date: October 6, 2011
    Applicants: PROVEXIS NATURAL PRODUCTS LIMITED, PLANT BIOSCIENCE LIMITED
    Inventors: Niamh O'Kennedy, Richard Mithen
  • Publication number: 20110082099
    Abstract: The present invention relates to methods and compositions to treat subjects having cystic fibrosis. These compositions comprise the class of isothiocyanates. Isothiocyanates, absorbed by a cell are conjugated with glutathione GSH by glutathione-s-tranferase (GST). The conjugates are substrates of the multi-drug resistance associated (MRP)/multi-drug resistance (MDR) proteins. These proteins are functionally redundant to the cystic fibrosis transmembrane conductance regulator (CFTR), allowing for the substrate conjugates to be exported from the cell. The export of GSH conjugates restores intracellular and extracellular levels of GSH to normal levels. Normalizing both extracellular and intracellular GSH via the increased conjugation of isothiocyanates with GSH, and subsequent export, can significantly rectify numerous enzymatic processes and correct the pathologies that are typical of patients suffering from cystic fibrosis.
    Type: Application
    Filed: June 14, 2010
    Publication date: April 7, 2011
    Inventor: Melanie Childers
  • Publication number: 20100260737
    Abstract: A combination between levodopa and an extract derived from a vegetable of the Cruciferae family or Brassica genus, this extract containing sulforaphane (4-(methylsulfinyl)butyl isothiocyanate), is disclosed. This combination is useful for the treatment of Parkinson's disease and in particular, for on-off and wearing-off episodes.
    Type: Application
    Filed: December 17, 2008
    Publication date: October 14, 2010
    Inventors: Andrea Tarozzi, Fabiana Morroni, Giorgio Cantelli Forti, Patrizia Hrelia
  • Patent number: 7785573
    Abstract: An active or functional organic compound is solubilized by an ester of an aryl alcohol, e.g., phenethyl, benzyl or substituted benzyl alcohol, and an alkyl or cycloalkyl carboxylic acid, or by a carbonate of said aryl alcohol and an alkyl or cycloalkyl carbonic acid.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: August 31, 2010
    Assignee: ISP Investments Inc.
    Inventors: Steven H. Bertz, Ilya Makarovsky, Donna N. Laura
  • Publication number: 20100204319
    Abstract: A method and composition for the treatment for bladder outlet obstruction, particularly benign prostatic hyperplasia (BPH), which includes administering to the mammal a therapeutically effective amount of a synergistic combination of Capsicum plants and aqueous extract from cruciferous vegetables.
    Type: Application
    Filed: October 17, 2007
    Publication date: August 12, 2010
    Applicant: Summa Development Limited
    Inventor: David Archibald
  • Patent number: 7772156
    Abstract: Microbicidal compositions including (a) cyanodithiocarbimate and (b) an N-alkyl heterocyclic compound; a triazole compound or salt thereof or metal complex thereof; a microbicide with an activated halogen atom or a formaldehyde releasing compound; 1,4-bis(bromoacetoxy)-2-butene; 2-(thiocyanomethylthio)benzothiazole; a methylene-bis(thiocyanate); a halogenated acetophenone; a halopropynl compound; an iodosulfone; a phenol; a halocyanoacetamide compound and/or a quaternary ammonium compound are described. Components (a) and (b) can be present in a synergistically effective amount to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms with the compositions are also disclosed.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: August 10, 2010
    Assignee: Buckman Laboratories International, Inc.
    Inventor: Stephen D. Bryant
  • Patent number: 7705046
    Abstract: Disclosed are two new crystalline forms, ? and ?, of perindopril erbumine. Those forms are suitable as therapeutic active substances for medicaments for the treatment of cardio-vascular diseases, especially high blood pressure and heart failure. The ? crystalline form is obtained in the crystallization of perindopril erbumine at from 30 to 45° C., preferably from 34 to 45° C., from MTBE containing from 1.5 to 2.5% (v/v) water; the crystallization is advantageously carried out with stirring. If the water is then removed, advantageously by azeotropic distillation, preferably at from 35 to 37° C., and stirring is then continued for at least 15 h at from 30 to 45° C., preferably from 35 to 37° C., the ? crystalline form is converted to the ? crystalline form. The ? crystalline form can also be obtained by stirring the ? or ? crystalline form at from 33 to 38° C. in tert.-butyl methyl ether containing from 0.9 to 1.4% (v/v) water with seeding with the ? crystalline form.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: April 27, 2010
    Assignee: Les Laboratoires Servier
    Inventors: Christoph Strassler, Vit Lellek, Roger Fassler
  • Publication number: 20090117202
    Abstract: Novel formulations containing a non-oxidative biocide, such as DBNPA, and a source of an in situ produced active biocide, such as a concentrated aqueous solution of an inorganic halide salt, are disclosed. These novel formulations are particularly effective in the treatment of water, and are characterized by high stability, desirable rheological properties and an excellent biocidal activity.
    Type: Application
    Filed: February 25, 2007
    Publication date: May 7, 2009
    Applicant: BROMINE COMPOUNDS LTD.
    Inventors: David Feldman, Michel Adda, Raymond J. Roccon
  • Publication number: 20090022824
    Abstract: The present invention discloses formulations that are effective for controlling pests. More particularly, the present invention discloses the use of at least one phenol and at least one isothiocyanate in methods and formulations for increasing the mortality or decreasing the growth of pests or for repelling pests.
    Type: Application
    Filed: May 3, 2006
    Publication date: January 22, 2009
    Applicant: Akhil Technologies Pty Ltd
    Inventor: Prem Chand Akhil
  • Publication number: 20090012158
    Abstract: New pesticide compositions comprising an alkyl formate and an isothiocyanic ester are described, as are methods of delivering fumigants and methods of pest control using a combination of fumigants.
    Type: Application
    Filed: May 25, 2005
    Publication date: January 8, 2009
    Applicant: Commonwealth Scientific and Industrial Research Organisation
    Inventors: YongLin Ren, Colin Waterford, ByungHo Lee
  • Publication number: 20080293676
    Abstract: Insecticidal compositions characterized by an effective amount of an active ingredient combination comprising (a) one or more compounds selected from the group of acetylcholinesterase inhibitors, sodium channel modulators, chitin biosynthesis inhibitors, juvenile hormone mimetics, chloride channel activators, ecdysone agonists, GABA-controlled chloride channel antagonists or acaricides, and (b) at least one crop plant tolerance promoter compound from the group of compounds specified in the description, which are used for controlling arthropods, and also methods of controlling arthropods through the treatment of plants and their seed with these compositions.
    Type: Application
    Filed: July 18, 2005
    Publication date: November 27, 2008
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Reiner Fischer, Wolfram Andersch, Heike Hungenberg, Wolfgang Thielert, Lothar Willms
  • Publication number: 20080269325
    Abstract: The invention is directed to a method of providing pain relief to a patient by administering to the patient an effective amount of a compound of Formula (I), which is represented by as RC(O)—NH—(CH2)n—CH?CH2, wherein R represents C1-20 alkyl, C2-20 alkenyl or C2-20 alkynyl; and n is an integer from 0 to 3.
    Type: Application
    Filed: February 18, 2005
    Publication date: October 30, 2008
    Applicant: Imperial Innovations Limited
    Inventors: Andrew Sven Cracroft Rice, Severine Vandvoorde, Didier Michel Lambert
  • Patent number: 7148209
    Abstract: The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: December 12, 2006
    Assignee: Ecole Polytechnique
    Inventors: Caroline D. Hoemann, Michael D. Buschmann, Marc D. McKee
  • Patent number: 6913761
    Abstract: A pharmaceutical and/or veterinary formulation comprising about 2-30% (w/w) (on an active basis) of at least one active agent, about 0.5-20.0% (w/w) of a pore-foaming agent and the balance stearin. Such formulations provided release of the at least one active agent in humans and other animals for periods of 7 days up to about 2 years.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: July 5, 2005
    Assignee: Peptech Limited
    Inventors: Timothy Elliot Trigg, John Desmond Walsh, Deborah Ann Rathjen
  • Patent number: 6872713
    Abstract: Saponins of formula (I), a stereoisomeric form thereof or a pharmaceutically acceptable addition salt thereof, wherein R1 to R12 have the meaning given in the description, can be isolated from plants of the family Myrsinaceae and used, to decrease the infectiousness of and reduce the mortality associated with protozoan parasites of the genus Leishmania which are responsible for a group of conditions known as leishmaniases.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: March 29, 2005
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Louis Jules Roger Marie Maes, Nils Albert Gilbert Germonprez, Luc Emiel Mathilde Van Puyvelde, Norbert G. M. De Kimpe, Tran Ngoc Ninh
  • Patent number: 6866869
    Abstract: A liquid antimicrobial composition comprises: (1) a mixture of iodide anions and thiocyanate anions; (2) periodic acid or an alkali metal salt thereof; and (3) optionally, a peroxidase. The composition may be used as a microbicide, disinfectant or for suppressing or killing viruses or spores.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: March 15, 2005
    Assignee: BASF Aktiengesellschaft
    Inventors: Walter Graham Guthrie, Mohammed Shoaib Qureshi, Lawrence Alan Staniforth, Darren Michael Hodgkinson, David Wilson Ashworth
  • Patent number: 6762202
    Abstract: The present invention describes rapid noninvasive methods for measuring vasodilation or changes in blood flow in a patient following administration of at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one vasoactive agent. The method comprises the administration of at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one vasoactive agent to the patient followed by monitoring the temperature change of an area of interest using infrared thermography.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: July 13, 2004
    Assignee: NitroMed, Inc.
    Inventors: Przemyslaw A. Marek, Andzrej M. Trocha, Chia-En Lin, Ramani R. Ranatunga, Stewart K. Richardson
  • Patent number: 6737441
    Abstract: The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to methods of preventing or treating persistent chronic gastritis, ulcers and/or stomach cancer in subjects at risk for, or in need of treatment thereof.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: May 18, 2004
    Inventor: Jed W. Fahey
  • Patent number: 6638499
    Abstract: The present invention is directed to polymeric-prodrug transport forms of the formula: wherein: E1-4 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy, C1-6 heteroalkoxy, and at least one of E1-4 includes a B moiety, wherein B is a leaving group, OH, a residue of a hydroxyl-or amino-containing moiety or wherein J1 is the same as J, or another member of the group defining J and E5 is the same as E1-4, or another member of the group defining E1-4, Y1-2 are independently O, S or NR9; M is a heteroatom selected from either X or Q; wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(═Y2); R2-5 and R7-9 are independently selected fro
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: October 28, 2003
    Assignee: Enzon, Inc.
    Inventors: Anthony J. Martinez, Annapurna Pendri, Richard B. Greenwald, Yun H. Choe
  • Patent number: 6458834
    Abstract: The present invention relates to fuingicidally effective compositions containing at least one pentacyclic triterpene compound.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: October 1, 2002
    Assignee: Micro Flo Company
    Inventors: Jan Glinski, Keith L. Branly
  • Patent number: 6447811
    Abstract: A formulation comprising lactoperoxidase, thiocyanate and/or iodide and a hydrogen peroxide donor system, in particular glucose oxidase and glucose, is useful for controlling plant-pathogenic microorganisms such as fungi and bacteria. Preferably the formulation also contains an oil.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: September 10, 2002
    Assignees: Koppert B.V., Campina-Melkunie B.V.
    Inventors: Willem Jacobus Ravensberg, Richard Karel Van der Pas, Klaas Daniel Kussendrager, Johannes Antonius Maria Maas
  • Patent number: 6433010
    Abstract: The present invention relates to fungicidally effective compositions containing at least one pentacyclic triterpene compound.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: August 13, 2002
    Assignee: Micro Flo Company
    Inventors: Jan Glinski, Keith L. Branly
  • Patent number: 6423733
    Abstract: A fungicidal mixture comprises a) a phenyl benzyl ether derivative of the formula I.a, I.b or I.c,  and/or a carbamate of the formula Id where X is CH or N, n is 0, 1 or 2 and R is halogen, Cl-C4-alkyl or C1-C4-haloalkyl, it being possible for the radicals R to be different if n is 2, or a salt or adduct thereof, and b) a N-acetonylbenzamide of the formula II  where: R1 and R3 independently of one another are each halogen or C1-C4-alkyl; R2 is cyano, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl or C1-C4-alkoxy; R4 is hydrogen or C1-C4-alkyl; R5 is C2-C4-alkyl; R6 is thiocyano, isothiocyano or halogen, or a salt or adduct thereof, in a synergistically effective amount.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: July 23, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Schelberger, Maria Scherer, Hubert Sauter, Bernd Müller, Erich Birner, Joachim Leyendecker, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann, Reinhold Saur
  • Patent number: 6410265
    Abstract: This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an understanding of the mechanisms of solvent tolerance. The invention further provides a Pseudomonas mendocina strain deficient in this gene. This strain is unable to grow in the presence of chloramphenicol and, compared to the wildtype strain, grows slowly in the presence of high concentrations of PHBA.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: June 25, 2002
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Kevin Keqin Chen
  • Patent number: D913748
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: March 23, 2021
    Assignee: PACKED PARTY, INC.
    Inventor: Jordan Jones