Acyclic Patents (Class 514/526)
  • Patent number: 10751316
    Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: August 25, 2020
    Assignee: Olatec Therapeutics LLC
    Inventors: Joseph St. Laurent, Gerald S. Jones, David M. Bresse
  • Patent number: 9918452
    Abstract: A method and apparatus is provided for controlling the location in which herbivore fowl populations congregate by altering the behavior of the fowl through the combination of providing a strong disincentive to populate areas where the presence of the fowl is not desired and a strong incentive to populate a proximate area where the presence of fowl can be tolerated. For herbivore waterfowl, and in particular Canada geese, the adjacent area also provides the waterfowl with a means of egress to water as an escape from predators and other perceived threats. The method uses a deterrent in the form of adulterated feed to dissuade the herbivore fowl from congregating in areas in which their presence is not desired and the use of an attractant in the form of non-adulterated feed to encourage the herbivore fowl to congregate in a proximate area in which their presence can be tolerated.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: March 20, 2018
    Assignee: 2345422 Ontario Inc.
    Inventor: Dan Erlich
  • Patent number: 9622955
    Abstract: The present application relates to use of a Midkine family protein for growing hair on a mammal, or in the manufacture of a medicament for growing hair on a mammal, especially for treatment or prevention of different forms of alopecia.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: April 18, 2017
    Assignee: Advangen International Pty Ltd
    Inventors: Sadatoshi Sakuma, Maria Halasz, Darren Jones
  • Patent number: 9474734
    Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ?-(methylthio)alkylnitriles such as 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: October 25, 2016
    Assignee: OLATEC THERAPEUTICS LLC
    Inventors: Joseph P. St. Laurent, Gerald S. Jones, David M. Bresse
  • Patent number: 9278082
    Abstract: The present invention is directed to a method for treating skin inflammatory diseases such as dermatitis, psoriasis, and acne, and rosacea, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. The method alleviates the symptoms of the disease treated. The active compound can be administered by a systemic route or topical route. Topical administration is a preferred route of administration.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: March 8, 2016
    Assignee: OLATEC INDUSTRIES LLC
    Inventor: Joseph P. St. Laurent
  • Patent number: 9114122
    Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ?-(methylthio)alkylnitriles such as 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: August 25, 2015
    Assignee: Olatec Industries LLC
    Inventors: Joseph P. St. Laurent, Gerald S. Jones, David M. Bresse
  • Patent number: 9018254
    Abstract: A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein said sterilized cyanoacrylate adhesive composition does not cure upon sterilization, and wherein the composition when cured to form a film on a patient's tissue has water vapor transmission rate from about 950 to about 3000 g/m2/day.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: April 28, 2015
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr., Max Azevedo
  • Publication number: 20150094366
    Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ?-(methylthio)alkylnitriles such as 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 2, 2015
    Inventors: Joseph P. ST. LAURENT, Gerald S. JONES, David M. BRESSE
  • Publication number: 20150087702
    Abstract: The present invention comprises methods and compositions for reducing ethanol toxicity due to accumulation of acetaldehyde in a cell. A method comprises administering to a cell a composition comprising a compound that increases the expression, the amount of, and/or the activity of at least one member of the aldehyde dehydrogenase superfamily.
    Type: Application
    Filed: November 21, 2012
    Publication date: March 26, 2015
    Inventors: Paul Talalay, Yusuke Ushida
  • Patent number: 8980947
    Abstract: A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: March 17, 2015
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr., Max Azevedo
  • Patent number: 8975297
    Abstract: The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: March 10, 2015
    Assignee: Olatec Industries LLC
    Inventor: Joseph St. Laurent
  • Patent number: 8927603
    Abstract: The invention provides a method of preparing a sterile, liquid adhesive composition in a sealed container using X-ray irradiation. The liquid adhesive compositions maintain their stability after sterilization and have an extended shelf life, making them particularly useful in the medical field.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: January 6, 2015
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr.
  • Patent number: 8912230
    Abstract: The invention relates to the use of a molecule selected from the group which consists of geranyl acetate, geraniol, isomenthone, limonene or a mixture of at least two of the above, for preparing a drug for treating or preventing vascular endothelial cell senescence and subjacent tissue degeneration induced by repeated inflammatory episodes. Specifically, the drug is useful for treating vascular endothelial cell senescence and tissue degeneration induced by repeated inflammatory episodes resulting from the presence of cancer cells.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: December 16, 2014
    Assignee: Aisa Therapeutics
    Inventor: Patrizia D'Alessio
  • Patent number: 8901170
    Abstract: Compounds of formula (I) wherein the symbols have the meaning given in the specification, as well as processes for preparing the compounds (I), pesticidal compositions and synergistic mixtures comprising compounds (I), methods for the control of insects, acarids or nematodes by contacting the pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of compounds formula (I), and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a parasiticidally effective amount of compounds of formula (I).
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: December 2, 2014
    Assignee: BASF SE
    Inventors: Matthias Pohlman, Michael Hofmann, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Hassan Oloumi-Sadeghi, Takeo Hokama, Christopher Palmer
  • Patent number: 8865792
    Abstract: This invention relates to medicine, more specifically, to surgical devices, and can be used for gluing soft body tissues. The medical glue comprises 3-methacryloxysulpholane, N-butyl-2-cyanoacrylate and at least one stabilizer.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: October 21, 2014
    Inventor: Gennady Leplianin
  • Patent number: 8846569
    Abstract: The present invention provides bis-organosulfur compounds of formulae (I) and (II) and compositions comprising the compounds that are effective against animal pests, including parasites. The compounds and compositions may be used for combating parasites in or on birds and mammals and for combating pests that damage crops, plants and plant propagation material. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
    Type: Grant
    Filed: December 5, 2010
    Date of Patent: September 30, 2014
    Assignees: Merial Limited, BASF SE
    Inventors: Charles Q. Meng, Matthias Pohlman, Henricus Maria Martinus Bastiaans, Ralph Paulini, Sebastian Soergel
  • Patent number: 8829046
    Abstract: The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: September 9, 2014
    Assignee: Olatec Industries LLC
    Inventor: Joseph St. Laurent
  • Publication number: 20140235712
    Abstract: The disclosed conformable coating provides a highly durable and resilient film useful for protecting and repairing surfaces such as skin and mucous membranes. A conformable coating composition comprises an elastomer, a volatile liquid, wherein the volatile liquid is at least 40% wt. of the total composition and the composition has a viscosity less than 1,000 cps. Disclosed is a conformable film that comprises an elastomer on a substrate, wherein the coating weight is from 1 to 30 mg/in2, and wherein the film has less than 75% failure at 100% elongation.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 21, 2014
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Robert A. Asmus, Hae-Seung Lee, John D. Dell, Deena M. Conrad-Vlasak
  • Publication number: 20140228433
    Abstract: The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Application
    Filed: March 17, 2014
    Publication date: August 14, 2014
    Applicant: Olatec Industries LLC
    Inventor: Joseph St. Laurent
  • Patent number: 8729121
    Abstract: A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: May 20, 2014
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Max Azevedo, Rafael Ruiz, Sr.
  • Patent number: 8652510
    Abstract: Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: February 18, 2014
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr.
  • Patent number: 8609128
    Abstract: The invention relates to methods of using compositions for forming microbial sealant drapes. In particular, the invention relates to the use of compositions of combinations of cyanoacrylates for the in situ formation of drapes that can be used in surgery to protect patients from surgical site infections.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: December 17, 2013
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz
  • Publication number: 20130324603
    Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Application
    Filed: June 4, 2013
    Publication date: December 5, 2013
    Inventors: Joseph ST. LAURENT, Gerald S. JONES, David M. BRESSE
  • Publication number: 20130310755
    Abstract: Cyanoacrylate adhesive compositions comprise a mixture of two cyanoacrylate monomers, including 2-octyl cyanoacrylate and n-butyl cyanoacrylate. The monomers are stabilized and sterilized by irradiation, and do not substantially increase in viscosity after sterilization or after two years of shelf storage. These compositions have anti-microbial properties, and may be used to close wounds as well as secure catheters inserted into the body in place.
    Type: Application
    Filed: July 29, 2013
    Publication date: November 21, 2013
    Applicant: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, SR.
  • Publication number: 20130245062
    Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
    Type: Application
    Filed: November 27, 2012
    Publication date: September 19, 2013
    Applicant: CELLCEUTIX CORPORATION
    Inventor: KRISHNA MENON
  • Publication number: 20130184341
    Abstract: A biocidal composition comprising 2,2-dibromomalonamide and an electrophile containing biocide, and its use for the control of microorganisms in aqueous and water-containing systems.
    Type: Application
    Filed: September 30, 2010
    Publication date: July 18, 2013
    Applicant: DOW GLOBAL TECHNOLOGIES INC.
    Inventors: Bei Yin, Freddie L. Singleton
  • Publication number: 20130172410
    Abstract: The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Application
    Filed: February 5, 2013
    Publication date: July 4, 2013
    Applicant: OLATEC INDUSTRIES LLC
    Inventor: Olatec Industries LLC
  • Patent number: 8476316
    Abstract: The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: July 2, 2013
    Assignee: Olatec Industries LLC
    Inventor: Joseph St. Laurent
  • Publication number: 20130053439
    Abstract: The invention relates to a disinfectant composition (i) comprising a combination of citric acid or a physiologically acceptable salt thereof as component (A), and poly(hexamethylene-biguanide) (PHMB) or a physiologically acceptable salt thereof as component (B) and/or (ii) exhibiting a log reduction of staphylococcus aureus of at least 4.0 after a contact time of 5 minutes according to DIN EN 13727 and/or a growth inhibition of Candida and/or S. aureus and the use of said composition for the prevention and/or reduction and/or elimination and/or eradication of microbial contaminations in health care products.
    Type: Application
    Filed: November 23, 2010
    Publication date: February 28, 2013
    Inventor: Barbara Kirschner
  • Patent number: 8362051
    Abstract: Wallboard and facing paper that provides increased mold resistance at lower biocide loadings. The biocide is: (a) an n-alkyl isothiazolinone such as octylisothiazolinone (OIT), a monohalo and dihalo substituted n-alkylisothiazolinone such as chloromethylisothiazolinone (CMIT) or dichlorooctylisothiazolinone (DCOIT), 3-iodo-2-propynyl-butylcarbamate (IPBC), chlorothalonil, methylene-bis-thiocyanate, or mixtures of two or more thereof; or (b) carbendazim and a second biocide selected from 3-iodo-2-propynyl-butylcarbamate (IPBC), diiodomethyltolylsulfone (DIMTS), sodium pyrithione, octylisothiazolinone (OIT), dichlorooctylisothiazolinone (DCOIT), and chlorothalonil.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: January 29, 2013
    Assignee: Rohm and Haas Company
    Inventors: Sheila M. Tinetti, Paul Foley, Li Wang, Michael V. Enzien, Sanjay B. Bishnoi
  • Patent number: 8338454
    Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: December 25, 2012
    Assignee: Cellceutix Corporation
    Inventor: Krishna Menon
  • Publication number: 20120283094
    Abstract: The present invention provides bis-organosulfur compounds of formulae (I) and (II) and compositions comprising the compounds that are effective against animal pests, including parasites. The compounds and compositions may be used for combating parasites in or on birds and mammals and for combating pests that damage crops, plants and plant propagation material. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
    Type: Application
    Filed: December 5, 2010
    Publication date: November 8, 2012
    Inventors: Charles Q. Meng, Matthias Pohlman, Henricus Maria Martinus Bastiaans, Ralph Paulini, Sebastian Soergel
  • Patent number: 8293838
    Abstract: A stable and sterile adhesive composition with a controlled level of high viscosity is disclosed in the present invention. Adhesive compositions with different ranges of viscosity could be prepared by heating the adhesive monomer composition at mild temperature in the presence of pluronic polymer. The viscosity of the adhesive composition is able to be controlled to any desired level. A method of stabilizing the adhesive composition with a desired level of high viscosity is provided by using the combination of free radical and acid stabilizers. Methods for packaging, sterilizing and applying the adhesive in the medical field are also provided.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: October 23, 2012
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz
  • Publication number: 20120189537
    Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
    Type: Application
    Filed: November 22, 2011
    Publication date: July 26, 2012
    Inventor: Krishna Menon
  • Publication number: 20120184613
    Abstract: There is provided a sulfur-containing compound having a controlling effect on arthropod pests represented by the formula (I): wherein m represents 1, 2 or 3; n represents 0, 1 or 2; A represents an optionally substituted C2-C10 fluoroalkyl group; R1 represents an optionally halogenated C1-C4 chain hydrocarbon group, a halogen atom, or a hydrogen atom; R2 represents an optionally halogenated C1-C4 chain hydrocarbon group, etc.; R3 and R4 independently represent an optionally halogenated C1-C4 chain hydrocarbon group, etc.; X represents an oxygen atom, a sulfur atom, —SO—, or —SO2—; R5 represents an optionally halogenated C1-C4 chain hydrocarbon group, etc.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 19, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Hiromasa Mitsudera
  • Publication number: 20120157524
    Abstract: The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
    Type: Application
    Filed: December 13, 2011
    Publication date: June 21, 2012
    Inventor: Joseph St. Laurent
  • Publication number: 20120148530
    Abstract: An inexpensive, easily available, and convenient method of treating or preventing a virus infection is provided. The present invention relates to a method for the treatment or prevention of virus infections using polybiguanide-based compounds administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof The invention relies on the unique biochemical reaction in which polybiguanide-based compounds interfere with the spread of virus within or between organisms. The compositions and formulations described in the present invention are effective means to reduce the infectivity of the human immunodeficiency virus type 1 (HIV-1), and human herpes simplex viruses, and also to kill the causative organisms of many other sexually transmitted diseases (STDs).
    Type: Application
    Filed: June 21, 2010
    Publication date: June 14, 2012
    Applicant: Novaflux Biosciences, Inc.
    Inventors: Mohammed E. Labib, Richard F. Stockel
  • Patent number: 8110563
    Abstract: The present invention features a composition for killing fire ants. In some embodiments, the composition comprises an insecticide and a triclosan composition. In some embodiments, the composition is a liquid composition.
    Type: Grant
    Filed: May 23, 2009
    Date of Patent: February 7, 2012
    Inventor: Harold V. Hutchins
  • Publication number: 20110293691
    Abstract: Provided herein are multimodal barrier materials useful for preventing adhesions in a subject, which may include a collagen, a collagen deposition inhibitor and/or a chitosan.
    Type: Application
    Filed: April 28, 2011
    Publication date: December 1, 2011
    Inventors: Kurt R. Weber, Steve J. Hodges, Scott A. Washburn
  • Publication number: 20110207787
    Abstract: What is described herein are antimicrobial compositions which are defined blends of a 1,2-diol and phenoxyethanol which show broad activity against bacteria, fungi and mold spores. This activity is potentiated by the addition thereto of small amounts of a co-biocide for which the blend acts as a delivery system for the otherwise water-insoluble co-biocide.
    Type: Application
    Filed: April 29, 2011
    Publication date: August 25, 2011
    Applicant: ISP INVESTMENTS INC.
    Inventors: John J. Merianos, Paul Garelick, Susan M. Lindstrom
  • Publication number: 20110182832
    Abstract: Perfume ingredients have been investigated and classified for their effectiveness in detaching biofilms from surfaces. Based on this classification, perfume compositions that are effective in assisting biofilm detachment can be formulated, whilst also allowing a degree of freedom in formulation that permits consideration of the hedonic properties of the composition. The compositions can be used in a wide range of perfumed consumer products, such as personal, domestic and industrial products, e.g. hard surface cleaning products, dental care products, and deodorant products.
    Type: Application
    Filed: April 13, 2006
    Publication date: July 28, 2011
    Applicant: QUEST INTERNATIONAL SERVICES B.V.
    Inventors: David Jonathan Bradshaw, Alan Forbes Provan, Christopher James Ioannou, John Martin Behan, Keith Douglas Perring
  • Patent number: 7973037
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: July 5, 2011
    Assignees: Axys Pharmaceuticals, Inc., Merck Canada Inc.
    Inventors: Christopher I. Bayly, Cameron Black, Serge Leger, Chun Sing Li, Dan McKay, Christophe Mellon, Jacques Yves Gauthier, Vouy-Linh Truong, Cheuk Lau, Michel Therien, Michael J. Green, Bernard L. Hirschbein, James William Janc, James T. Palmer, Chitra Baskaran
  • Publication number: 20100298374
    Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 25, 2010
    Applicant: CELLCEUTIX CORPORATION
    Inventor: Krishna MENON
  • Publication number: 20100297104
    Abstract: The present invention is in relation to a dendritic molecule having symmetrically sited branches having four or more generations of dendrimers wherein the branch points are tertiary amines linked together with oxygen atom of ether and the heteroatoms are separated by a substituted or non-substituted linear three methylene linker. In addition the invention also provides a process to prepare such dendritic macromolecules.
    Type: Application
    Filed: August 14, 2007
    Publication date: November 25, 2010
    Applicant: INDIAN INSTITUTE OF SCIENCE
    Inventors: Jayaraman Narayanaswamy, Jayamurugan Govindasamy
  • Publication number: 20100297215
    Abstract: Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course of cancer therapy or bone marrow transplant. These are based on the use of chemoprotective inducing agents that induce or increase production of cellular detoxification enzymes in target cell populations. The compositions and methods are useful to reduce or prevent hair loss, gastrointestinal distress and lesions of the skin and oral mucosa that commonly occur in patients undergoing cancer therapy. Also disclosed is a novel assay system for identifying new chemoprotective inducing agents.
    Type: Application
    Filed: May 11, 2009
    Publication date: November 25, 2010
    Inventors: William E. Fahl, Nalini Raghavachari, Ming Zhu, John A. Kink
  • Publication number: 20100239678
    Abstract: The present invention is directed to attaching drugs 11 and other functional groups to surfaces of nano-sized diamond particles (NDs) 20 to enhance their efficacy. The method involves hydrating a plurality of nanodiamond (ND) particles 20 having a plurality of carbon chain surface molecules 23 on its surface. Cations 40 are embedded within the lattice structure 21 of the surface molecules 23 of the ND particles 20. The embedded cations 40 attract anions that cause crystalline growth. The anion form of drug molecules 11 are then grown on the crystal to cause the NDs 20 to be coated such that the active sites of said drug molecules 11 point away from the ND particle 20 exposing them for enhanced activity and enhanced drug efficacy. The efficacy of antimicrobial drugs 11, as well as other drugs 11 are enhanced by their attachment to the NDs 20.
    Type: Application
    Filed: June 7, 2010
    Publication date: September 23, 2010
    Inventor: Ali RAZAVI
  • Publication number: 20100215777
    Abstract: Compounds of formula (I) wherein the symbols have the meaning given in the specification, as well as processes for preparing the compounds (I), pesticidal compositions and synergistic mixtures comprising compounds (I), methods for the control of insects, acarids or nematodes by contacting the pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of compounds formula (I), and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a parasiticidally effective amount of compounds of formula (I).
    Type: Application
    Filed: June 22, 2007
    Publication date: August 26, 2010
    Applicant: BASF SE
    Inventors: Matthias Pohlman, Michael Hofmann, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Hassan Oloumi-Sadeghi, Takeo Hokama, Christopher Palmer
  • Publication number: 20100160430
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods represented by the formula (I): wherein, R1 represents a C1-C5 haloalkyl group having at least one fluorine atom, R2 represents a C1-C4 alkyl group optionally substituted with at least one halogen atom or the like, R3 represents a hydrogen atom or the like, R4 represents a cyano group or the like, R5 represents a hydrogen atom or the like, m represents an integer of 1 to 4, and n represents 0, 1 or 2.
    Type: Application
    Filed: May 16, 2008
    Publication date: June 24, 2010
    Inventor: Hiroyuki Miyazaki
  • Publication number: 20100152289
    Abstract: There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods which is represented by formula (I): wherein R1 represents a C3-C6 haloalkyl group having at least one fluorine atom and at least one atom selected from group consisting of a chlorine atom, a bromine atom and an iodine atom, R2 represents a cyano group and the like, R3 represents a hydrogen atom, a halogen atom or a C1-C4 alkyl group, R4 represents a C1-C5 fluoroalkyl group, and n represents 0, 1 or 2.
    Type: Application
    Filed: May 18, 2008
    Publication date: June 17, 2010
    Inventor: Hiroyuki Miyazaki
  • Patent number: RE42377
    Abstract: A composition including 2-hexyl cyanoacrylate and gold is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: May 17, 2011
    Assignees: Stryker Corporation, Stryker NV Operations Limited
    Inventors: Robert E. Krall, Charles W. Kerber, Kimberly Knox