Cyano Or Isocyano Bonded Directly To Carbon Patents (Class 514/519)
  • Patent number: 10105372
    Abstract: The present invention relates to methods of treating and/or preventing obesity comprising the administration of antioxidant inflammation modulators described herein, including for example bardoxolone methyl.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: October 23, 2018
    Assignee: REATA PHARMACEUTICALS, INC.
    Inventors: Colin J. Meyer, Warren Huff
  • Patent number: 9475766
    Abstract: Compounds of formula II are described: wherein D, n, Ra, Rb, and Rc are as herein defined, along with pharmaceutical compositions and methods of using compounds of formula II for treating or reducing the risk of peritoneal carcinomatosis in a patient.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: October 25, 2016
    Assignees: Cephalon, Inc., University of Utah Research Foundation, University of Hawaii
    Inventors: Bruce D. Dorsey, Scott K. Kuwada, Jay P. Theroff, Craig A. Zificsak
  • Patent number: 9095505
    Abstract: The present invention relates to the use of a pharmaceutical composition comprising a pyrethroid compound for inhibiting unwanted eye movement and for treating eye movement disorders, such as, but not limited to, nystagmus. The invention is directed to methods for treating unwanted eye movement and eye movement disorders by administering a pharmaceutical composition comprising a pyrethroid compound that is lambda cyhalothrin or an analog thereof, through topical administration of the composition or incorporation of the composition into a contact lens or an ocular device for implantation into the eye. It further provides for pharmaceutical compositions for the treatment of eye movement disorders and methods of preparing them.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: August 4, 2015
    Assignee: RBG Group, LTD.
    Inventor: Richard W. Hertle
  • Publication number: 20140377235
    Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Nanjoo Suh, Damian Medici, Pamela Gehron Robey
  • Patent number: 8901170
    Abstract: Compounds of formula (I) wherein the symbols have the meaning given in the specification, as well as processes for preparing the compounds (I), pesticidal compositions and synergistic mixtures comprising compounds (I), methods for the control of insects, acarids or nematodes by contacting the pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of compounds formula (I), and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a parasiticidally effective amount of compounds of formula (I).
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: December 2, 2014
    Assignee: BASF SE
    Inventors: Matthias Pohlman, Michael Hofmann, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Hassan Oloumi-Sadeghi, Takeo Hokama, Christopher Palmer
  • Publication number: 20140328809
    Abstract: The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies). The present invention also relates to methods of treatment comprising establishing a population of chondrocytes from a population of mesenchymal stem cells, which have been induced to differentiate with a synthetic triterpenoid, and administering the population of cells to a patient.
    Type: Application
    Filed: November 14, 2012
    Publication date: November 6, 2014
    Inventors: Gordon W. Gribble, Damian Medici, Pamela Gehron Robey, Karen T. Liby, Michael B. Sporn, Nanjoo Suh
  • Publication number: 20140315997
    Abstract: The present invention relates to polymorphic forms of the compound of Formula I (i.e., ethyl 2-cyano-3,12-dioxoIeana-1,9(11)-dien-28-oate (CDDO ethyl ester)) and methods of using them for treating a variety of disease states such as cancer and condisitons associated with inflammation.
    Type: Application
    Filed: December 6, 2012
    Publication date: October 23, 2014
    Inventors: Xiaohong Zhang, Lv Song, Wendong Sun, Kaiyang Liu, Chunlei Han
  • Publication number: 20140296223
    Abstract: This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia Transcription Factor (MITF) to the subject who is in need of regulation of skin pigmentation.
    Type: Application
    Filed: August 31, 2012
    Publication date: October 2, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: David E. Fisher, Rizwan Haq, Hans Ragnar Valdemar Widlund
  • Publication number: 20140288026
    Abstract: A one pack aqueous insecticidal architectural coating composition comprising an aqueous dispersion of polymer particles as binder and further comprising, based on the total liquid paint formulation, i) from 0.1 to 4.0 wt % insecticide; ii) from 0.5 to 6.5 wt % dibasic ester solvent wherein the insecticide is located in the polymer particles and the polymer particles are film forming at ambient temperatures.
    Type: Application
    Filed: October 29, 2012
    Publication date: September 25, 2014
    Inventors: Kai Kang, Junbiao Lu, Daragh McLoughlin, Jørgen H. Olsen
  • Publication number: 20140256805
    Abstract: The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Inventor: Douglas Covey
  • Publication number: 20140235681
    Abstract: Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: ?-Blockers, Adrenergic Agonists, non-selective adrenergic agonists, ?2-selective adrenergic agonists, Carbonic Anhydrase Inhibitors, Cholinergic Agonists, direct acting cholinergic agonists, chlolinesterase inhibitors, Glutamate Antagonists, Ca2+ channel blockers, Prostamides, Prostaglandins, Cannabinoids, and combinations thereof. Compositions and medicaments containing a combination of these two active agents are also disclosed.
    Type: Application
    Filed: December 6, 2013
    Publication date: August 21, 2014
    Applicant: ALLERGAN, INC.
    Inventors: SCOTT M. WHITCUP, ROBERT M. BURK, DAVID W. OLD, YARIV DONDE, WHA-BIN IM, MARK A. HOLOBOSKI
  • Patent number: 8758738
    Abstract: The present invention relates to compositions of cyanoacrylate monomer, a method of improving the viscosity and the curing speed with a single additive and a process of providing sterilized cyanoacrylate adhesive compositions for application in the medical field.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: June 24, 2014
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz, Sr.
  • Publication number: 20140100227
    Abstract: Disclosed herein are novel C17-alkanediyl and alkenediyl derivatives of oleanolic acid, including those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds, for example, as antioxidant inflammation modulators, and compositions thereof are also provided.
    Type: Application
    Filed: September 10, 2013
    Publication date: April 10, 2014
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Christopher F. BENDER, Xin JIANG, Eric ANDERSON, Melean VISNICK
  • Publication number: 20140024635
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicant: The Trustees of The University Of Pennsylvania
    Inventors: WILLIAM F. DeGRADO, JUN WANG
  • Patent number: 8598084
    Abstract: An herbicide/insecticide composition containing (a) a pyridine carboxylic acid component and (b) an insecticide component provides synergistic control of selected weeds.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: December 3, 2013
    Assignee: Dow AgroSciences, LLC.
    Inventors: Norbert M. Satchivi, Paul R. Schmitzer
  • Patent number: 8569284
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Grant
    Filed: August 1, 2010
    Date of Patent: October 29, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang
  • Patent number: 8524634
    Abstract: A method of preventing damage to the seed and/or shoots and foliage of a plant by a pest includes treating the seed from which the plant grows with a composition that includes a combination of clothianidin and at least one pyrethrin or synthetic pyrethroid. The treatment is applied to the unsown seed. In another embodiment, the seed is a transgenic seed having at least one heterologous gene encoding for the expression of a protein having pesticidal activity against a first pest and the composition has activity against at least one second pest. Treated seeds are also provided.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: September 3, 2013
    Inventors: Jawed Asrar, Frank C. Kohn
  • Patent number: 8455544
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 4, 2013
    Assignees: Reata Pharmaecuticals, Inc., Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
  • Publication number: 20130089526
    Abstract: The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
    Type: Application
    Filed: May 8, 2012
    Publication date: April 11, 2013
    Applicants: Trustees of Dartmouth College, National Institute of Health, Beth Israel Deaconess Medical Center, Rutgers, The State University
    Inventors: Trustees of Dartmouth College, Beth Israel Deaconess Medical Center, National Institute of Health, Rutgers, The Sstate University
  • Publication number: 20130090381
    Abstract: An ester compound represented by formula (1): wherein R1 represents R1 represents 2-propenyl or 2-propynyl; R3 represents hydrogen or methyl, R4 represents hydrogen or C1-C4 alkyl, and R5 represents hydrogen or C1-C4 alkyl; has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.
    Type: Application
    Filed: March 18, 2011
    Publication date: April 11, 2013
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Noritada Matsuo
  • Patent number: 8389766
    Abstract: A compound of formula (I): wherein A1, A2, A3, A4, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: March 5, 2013
    Assignee: Syngenta Crop Protection LLC
    Inventors: Pierre Jung, Christopher Richard Syles Godfrey, William Lutz, Peter Maienfisch, Andre Stoller, Werner Zambach
  • Publication number: 20130040916
    Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Application
    Filed: October 12, 2012
    Publication date: February 14, 2013
    Applicant: ESPERION THERAPEUTICS, INC.
    Inventor: Esperion Therapeutics, Inc.
  • Patent number: 8338454
    Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: December 25, 2012
    Assignee: Cellceutix Corporation
    Inventor: Krishna Menon
  • Publication number: 20120322869
    Abstract: An ester compound represented by formula (1): wherein R1 represents 2-propenyl or 2-propynyl, and R2 represents C1-C4 alkyl, has an excellent pest control effect and is therefore useful as an active ingredient of a pest control agent.
    Type: Application
    Filed: February 18, 2011
    Publication date: December 20, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Noritada Matsuo
  • Publication number: 20120295886
    Abstract: The present disclosure provides compounds having affinity for the M2 proton channel, useful for the treatment of viral infections such as influenza, which are of the Formula (I): wherein R1, R2, and Y are as defined herein. Methods of preparing the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds in the treatment of viral infections such as influenza are also provided.
    Type: Application
    Filed: May 18, 2012
    Publication date: November 22, 2012
    Applicant: INFLUMEDIX, INC.
    Inventors: Jizhou Wang, Xiaodong Fan, Lidia Cristian
  • Patent number: 8293838
    Abstract: A stable and sterile adhesive composition with a controlled level of high viscosity is disclosed in the present invention. Adhesive compositions with different ranges of viscosity could be prepared by heating the adhesive monomer composition at mild temperature in the presence of pluronic polymer. The viscosity of the adhesive composition is able to be controlled to any desired level. A method of stabilizing the adhesive composition with a desired level of high viscosity is provided by using the combination of free radical and acid stabilizers. Methods for packaging, sterilizing and applying the adhesive in the medical field are also provided.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: October 23, 2012
    Assignee: Adhezion Biomedical, LLC
    Inventors: Sheng Zhang, Rafael Ruiz
  • Patent number: 8278352
    Abstract: New pesticide compositions comprising an alkyl formate and an isothiocyanic ester are described, as are methods of delivering fumigants and methods of pest control using a combination of fumigants.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: October 2, 2012
    Assignee: Commonwealth Scientific & Industrial Research Organisation
    Inventors: YongLin Ren, Colin Waterford, ByungHo Lee
  • Publication number: 20120245027
    Abstract: The present Invention deals with an alternative Interfacial polymerization process of microencapsulation, microcapsule's produced thereof, microencapsulated agrochemicals, pharmaceuticals, catalysts and phase transfer materials, and formulations thereof, by means of microcapsules and starting materials with the participation of acetylene carbamide derivatives in the final structure of the microcapsules' wall.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Inventors: Victor Casaña Giner, Miguel Gimeno Sierra, Barbara Gimeno Sierra
  • Publication number: 20120214814
    Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: January 23, 2012
    Publication date: August 23, 2012
    Inventors: Eric Anderson, Xin Jiang, Melean Visnick
  • Publication number: 20120190648
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, a stereoisomer or a mixture in all proportions of stereoisomers thereof, in particular a mixture of enantiomers, such as a racemic mixture, wherein R represents a (C1-C6)alkyl or (C1-C6)alkenyl group, optionally substituted by one or more groups chosen among an halogen atom, ORa, SRb, NRcRd, PO(ORe)(ORf), CO2Rg, SO2Rh SO3R1, P0(0H)(CH(0H)Rk), CN, N3 and NH—C(?NH)NH2, with Ra, Rb, Rc and Rd, representing, independently of each other, an hydrogen atom, a (C1-C6)alkyl group or a —CO—(C1-C6)alkyl group, Re, Rf, Rg, Rh and R1 representing, independently of each other, an hydrogen atom or a (C1-C6)alkyl group, and Rk representing an aryl or heteroaryl group, said group being optionally substituted by one or more groups selected from an halogen atom and NO2, as well as to the use thereof and to a process for preparing such a compound, to a pharmaceutical composition containing it and to synthesis intermediates.
    Type: Application
    Filed: July 23, 2010
    Publication date: July 26, 2012
    Inventors: Philippe Jubault, Jean-Charles Quirion, Gerald Lemonnier, Cedric Lion
  • Publication number: 20120189537
    Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
    Type: Application
    Filed: November 22, 2011
    Publication date: July 26, 2012
    Inventor: Krishna Menon
  • Patent number: 8182795
    Abstract: An oil-in-water emulsified sunscreen cosmetic which contains: (A) Containing the following three types of surfactants (A-1)-(A-3); (A-1) A POE stearic ester having a POE mole number of 20-120; (A-2) sorbitan tristearate; and (A-3) glyceryl stearate having a HLB of 5-8; (B) bis-ethylhexyloxyphenolmethoxyphenyltriazine and/or tert-butylmethoxybenzoylmethane, oil soluble ultraviolet absorbents, solid at room temperatures; (C) ethylhexyl methoxycinnamate and/or octocrylene, oil soluble ultraviolet absorbents, liquid at room temperature; (D) phenylbenzimidazolesulfonic acid, a water soluble ultraviolet absorbent; and (E) a higher alcohol having 14-24 carbon atoms.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: May 22, 2012
    Assignee: Shiseido Co., Ltd.
    Inventors: Yoshihito Takakura, Kazuaki Suzuki, Takayuki Omura
  • Patent number: 8173701
    Abstract: A pesticidal composition containing: 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylate, a saturated hydrocarbon having an initial boiling point of 150 C or higher and a 95%-distillation temperature of 300 C or lower, and at least one alkyl carboxylate ester selected from the group consisting of the following esters (i) to (iii): (i) alkyl alkylcarboxylate esters having 12 to 20 carbon atoms, (ii) dialkyl dicarboxylate esters having 12 to 20 carbon atoms, and (iii) trialkyl acetylcitrate esters having 12 to 20 carbon atoms; has an excellent pesticidal activity.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: May 8, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masahiro Yamada, Yoshito Tanaka
  • Publication number: 20120095004
    Abstract: The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.
    Type: Application
    Filed: October 19, 2011
    Publication date: April 19, 2012
    Applicant: APOGEE BIOTECHNOLOGY CORPORATION
    Inventors: Charles D. Smith, Kevin J. French, Yan Zhuang
  • Publication number: 20120071528
    Abstract: The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.
    Type: Application
    Filed: September 20, 2011
    Publication date: March 22, 2012
    Applicant: KAREUS THERAPEUTICS, SA
    Inventors: Ish Khanna, Sivaram Pillarisetti
  • Patent number: 8138166
    Abstract: The present invention discloses a method to induce fatty liver in an animal. The steps of the method comprise: feeding an animal with a high calorie diet, and injecting a mitochondrial inhibitor into the animal to inhibit the mitochondrial activity of the animal, then resulting in fat accumulation and inflammation in the liver of the animal.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: March 20, 2012
    Assignee: Taipei Medical University
    Inventors: Rong-Hong Hsieh, Sheng-Mei Lin
  • Patent number: 8129429
    Abstract: The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: March 6, 2012
    Assignees: Reata Pharmaceuticals, Inc., Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Gordon W. Gribble, Tadashi Honda, Robert M. Kral, Colin J. Meyer
  • Publication number: 20120035141
    Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Application
    Filed: October 11, 2011
    Publication date: February 9, 2012
    Applicant: ESPERION THERAPEUTICS, INC.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Publication number: 20120028957
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Application
    Filed: August 1, 2010
    Publication date: February 2, 2012
    Inventors: William F. DeGrado, Jun Wang
  • Publication number: 20120022129
    Abstract: Methods for the treatment or prevention of diseases which are caused by the degradation of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by the methods of the invention include chronic obstructive pulmonary disease (COPD) and asthma. The invention provides methods for treating or preventing of diseases caused by the degradation of HDAC2 by providing to the subject in need of treatment or prevention a molecular compound capable of preventing the degradation of HDAC2. Such molecular compounds include protein kinase CK2 inhibitors, ubiquitination inhibitors, ubiquitin-proteosome inhibitors, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activators and MAPK phosphatase 1 activators. Methods are also provided for the treatment and prevention of diseases caused by the degredation of HDAC2 by interfering with the expression of protein kinase CK2 or by increasing expression of Nrf2.
    Type: Application
    Filed: February 18, 2011
    Publication date: January 26, 2012
    Inventor: Irfan Rahman
  • Patent number: 8101626
    Abstract: The present invention relates to the use of GPR119 receptor agonists for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. The present invention further relates to the use of a GPR119 receptor agonist in combination with a dipeptidyl peptidase IV (DPP-IV) inhibitor for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. A GPR119 receptor agonist and the combination of a GPR119 receptor agonist and a DPP-IV inhibitor promote bone formation in an individual.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: January 24, 2012
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Zhi-Liang Chu, James N. Leonard, Juerg Lehmann, Robert M. Jones
  • Publication number: 20120015933
    Abstract: The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
    Type: Application
    Filed: September 29, 2011
    Publication date: January 19, 2012
    Applicant: SANOFI-AVENTIS
    Inventors: Manfred SCHUDOK, Michael WAGNER, Armin BAUER, Anna KOHLMANN
  • Patent number: 8067465
    Abstract: Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral sclerosis, rheumatoid arthritis, inflammatory bowel disease, and all other diseases whose pathogenesis is believed to involve excessive production of either nitric oxide (NO) or prostaglandins or the overexpression of iNOS or COX-2 genes or gene products. Further, methods for the synthesis of the TBE compounds of the invention utilize cheap commercially available reagents and are highly cost effective and amenable to scale-up. Additional high efficiency synthetic methods that utilize novel intermediates as well as the synthesis of these intermediates are also provided. Furthermore, the invention also provides methods for designing novel and water-soluble TBEs.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: November 29, 2011
    Assignee: The Trustees of Dartmouth College
    Inventors: Tadashi Honda, Frank G. Favaloro, Gordon W. Gribble, Michael B. Sporn, Nanjoo Suh
  • Publication number: 20110245233
    Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: February 23, 2011
    Publication date: October 6, 2011
    Inventors: Eric Anderson, Xin Jiang, Xiaofeng Liu, Melean Visnick
  • Publication number: 20110224075
    Abstract: The present invention relates to pesticidal mixtures comprising as active compounds 1) at least one aminothiazoline compound I of formula I: wherein R1 is selected from hydrogen, COCH3, COCH2CH3 or COCH2C(CH3)3; R2 and R3 together with the carbon atoms of the phenyl ring to which they are attached form a ring which, depending on the tautomeric formula I a) or b) is depicted as: a benzene ring, a saturated 5-, 6-, or 7-membered carbocycle, a partially unsaturated 5-, 6-, or 7-membered carbocycle, a 5-, 6-, or 7-membered saturated heterocycle, a partially unsaturated 5-, 6-, or 7-membered heterocycle, which heterocycles contain 1, 2, or 3 heteroatoms selected from O, S and N as ring members, and a 5- or 6-membered heteroaromatic ring which contains 1, 2, or 3 heteroatoms selected from O, S and N as ring members, and wherein the ring is unsubstituted or may carry any combination of 1, 2, 3, or 4 radicals selected from the group consisting of halogen, CH3, CH2CH3, CF3, CH3O, cyano and (?O) (oxo); R4 is se
    Type: Application
    Filed: March 24, 2009
    Publication date: September 15, 2011
    Applicant: BASF SE
    Inventors: Markus Kordes, Ronan Le Vezouet, Jurgen Langewald, Ralph Paulini, Deborah L. Culbertson, Douglas D. Anspaugh, Luiz Antonio Jose, Hassan Oloumi-Sadeghi
  • Publication number: 20110200618
    Abstract: This invention relates to treatment of neuro-psychiatricdisorders. Specifically, the invention relates to the use of small molecule agent specific against erbB4, erbB3 or their combination, or fragments thereof in inhibiting the attachment of erbB4, erbB3 or their combination to NRG1.
    Type: Application
    Filed: February 17, 2009
    Publication date: August 18, 2011
    Inventor: Chang-Gyu Hahn
  • Patent number: 7989495
    Abstract: Disclosed are compositions and methods for inhibiting NF-?B mediated cellular proliferation and metastasis.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: August 2, 2011
    Assignee: University of Utah Research Foundation
    Inventor: Scott K. Kuwada
  • Publication number: 20110178045
    Abstract: The present invention discloses a method to induce fatty liver in an animal. The steps of the method comprise: feeding an animal with a high calorie diet, and injecting a mitochondrial inhibitor into the animal to inhibit the mitochondrial activity of the animal, then resulting in fat accumulation and inflammation in the liver of the animal.
    Type: Application
    Filed: July 8, 2010
    Publication date: July 21, 2011
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Rong-Hong Hsieh, Sheng-Mei Lin
  • Patent number: 7863327
    Abstract: Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: January 4, 2011
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Tadashi Honda, Michael B. Sporn, Nanjoo Suh
  • Publication number: 20100298374
    Abstract: Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also disclosed are processes for the preparation of such compounds, intermediates used in the preparation of such compounds, and the uses of such compounds in treating hyperproliferative diseases, inflammatory diseases and viral and bacterial infections and inducing apoptosis in cancer cells.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 25, 2010
    Applicant: CELLCEUTIX CORPORATION
    Inventor: Krishna MENON