Compound Contains Two Or More C(=o)o Groups Patents (Class 514/547)
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Publication number: 20110177061Abstract: The disclosure relates to methods of treating or preventing neurological disorders using docosahexaenoic acid.Type: ApplicationFiled: July 9, 2010Publication date: July 21, 2011Applicant: MARTEK BIOSCIENCES CORPORATIONInventors: Paul S. AISEN, Joseph F. Quinn, Karin Yurko-Mauro
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Publication number: 20110171152Abstract: The present invention provides a cosmetic composition having a gloss of at least about 85 gloss units (gu), as well as sufficient shape retention properties for forming a stick-shaped cosmetic product. Specifically, the cosmetic composition contains: (a) a high viscosity oil component; (b) a medium viscosity oil component; (c) a low viscosity oil component; and (d) an oily gelling agent comprising an ester of glycerol or polyglycerin with an aliphatic or hydroxyl aliphatic acid and a dibasic acid. A stick-shaped cosmetic product formed by the cosmetic composition of the present invention exhibits a high-shine that is not available in conventional stick-shaped cosmetic products and yet retains the high make-up coverage typically provided by conventional stick-shaped cosmetic products.Type: ApplicationFiled: January 11, 2010Publication date: July 14, 2011Inventors: Tatyana R. Tabakman, George J. Stepniewski, John R. Castro, Cecilla D. Benedicto, Kathleen McKerlie, Anne T. Carullo
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Publication number: 20110172240Abstract: The invention relates to Fatty Acid Fumarate Derivatives; compositions comprising an effective amount of a Fatty Acid Fumarate Derivative; and methods for treating or preventing cancer, a metabolic disorder or neurodegenerative disorder comprising the administration of an effective amount of a Fatty Acid Fumarate Derivative.Type: ApplicationFiled: January 7, 2011Publication date: July 14, 2011Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu
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Patent number: 7977498Abstract: A process for the removal of sterols, specifically cholesterol, from a triglyceride oil, preferably a marine triglyceride oil, said process comprising contacting an oil with an absorbent, specifically TRIS YL™, clay or a mixture thereof, heating the mixture to 100° C. to 210° C., preferably 150° C. to 170° C., preferably for a time period of greater than one minute and optionally at a pressure less than 133 Pa, preferably less than 1.33 Pa.Type: GrantFiled: July 30, 2010Date of Patent: July 12, 2011Assignee: Ocean Nutrition Canada LimitedInventor: Weijie Wang
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Publication number: 20110166224Abstract: Disclosed is a fat or oil useful for cooking applications which includes from 10 to 90% by weight diacylglycerols, and has a SFI of at least 15% at room temperature. In particular embodiments, the fat or oil is derived from palm oil, palm kernel oil, coconut oil, sunflower oil, soybean oil, corn oil, rapeseed oil, grape seed oil, rice bran oil, sesame oil, and peanut oil, or any combination thereof. In some cases, the fat or oil exhibits health benefits including lowered serum LDL, raised serum HDL, lowered total serum cholesterol, reduced risk of metabolic syndrome, reduced risk of diabetes mellitus, enhanced fetal health, enhanced insulin sensitivity, reduced risk of hypertension, and enhanced resistance to obesity per unit of consumption. Food compositions and methods of health enhancement utilizing the fats and oils of the invention are also disclosed.Type: ApplicationFiled: December 29, 2010Publication date: July 7, 2011Inventors: Ganesh M. Kishore, Riccardo G. Locascio
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Patent number: 7973006Abstract: The present invention relates to an antibacterial composition based on a combination of fatty acid ester of fatty acid and hydroxy carboxylic acid with an antibacterial agent selected from polylysine, protamine, their salts and mixtures hereof. The hydroxy carboxylic acid may be present as acid in its free form, in its salt form and/or in its ester form. The present invention further is directed to the use of said composition as antibacterial agent against gram-negative bacteria in various products, applications and methods. Furthermore, the present invention is related to products comprising said antibacterial agent.Type: GrantFiled: September 17, 2008Date of Patent: July 5, 2011Assignee: Purac Biochem B.V.Inventors: Roel Otto, Aldana Mariel Ramirez, Diderik Reinder Kremer
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Publication number: 20110159074Abstract: A wipe article comprising a composition comprising omega-6 fatty acid. A method of improving skin barrier function of semi-occluded skin comprising the step of contacting the semi-occluded skin with a wipe comprising an omega-6 fatty acid.Type: ApplicationFiled: December 22, 2010Publication date: June 30, 2011Inventors: Raphael Warren, Thomas James Klofta, Randall Glenn Marsh
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Publication number: 20110160305Abstract: Nutritional supplements such as acetyl glutathione with malodor treated to remove the malodor associated with it. Acetyl glutathione, glutathione, esters of glutathione, derivatives of glutathione, and precursors of glutathione and other thiol compounds that may have a strong malodor based on their sulfur content. These compounds are treated with tartaric acid and other products to remove this malodor.Type: ApplicationFiled: May 1, 2007Publication date: June 30, 2011Inventor: Marty Jones
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Publication number: 20110159017Abstract: The unexpected expression of tryptophan 2,3-dioxygenase (TDO2) in cancer cells and tumors has been established. Methods for diagnosing cancer based on the expression of TDO2 are provided, as are methods for treating cancer and inhibiting the growth of cancer cells by inhibiting TDO2, as well as pharmaceutical compositions.Type: ApplicationFiled: April 10, 2009Publication date: June 30, 2011Applicant: Ludwig Institute for Cancer Research Ltd.Inventors: Benoit Van Den Eynde, Luc Pilotte, Etienne De Plaen
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Publication number: 20110135711Abstract: The present invention provides kits, methods and compositions for the treatment of diseases such as cancers. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues.Type: ApplicationFiled: May 31, 2010Publication date: June 9, 2011Inventors: Ru Chih C. Huang, Richard Park, Chih-Chuan Chang, Yu-Chuan Liang, David Mold, Elaine Lin, Jonathan Heller, Neil Frazer
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Patent number: 7956090Abstract: A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one ?-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.Type: GrantFiled: July 8, 2009Date of Patent: June 7, 2011Inventors: Michele Molino, Joseph MacDougall
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Publication number: 20110130456Abstract: A hair growth regulating agent containing, as an active ingredient, a compound represented by the following formula (I): [wherein R1 represents a substituted or unsubstituted, linear or branched C2 to C25 alkyl group; a group represented by the following formula (II): (wherein R1? represents a substituted or unsubstituted, linear or branched C2 to C20 alkylene group, or —(CH2)n-{O—(CH2)m}o-O—(CH2)p- in which each of n, m, o, and p is an integer from 1 to 6; X? represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y? represents a substituted or unsubstituted C1 to C4 alkylene group; R2? represents a hydrogen atom or a C1 to C4 alkyl group; R3? represents a C1 to C4 alkyl group; and when R2? and R3? each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other); or a group represented by the following formula (III): (wherein R1?, X?, and Y? have the same meanings as defined above; R4?, R5?, and R6?, which may be identical to or different from one another,Type: ApplicationFiled: August 4, 2009Publication date: June 2, 2011Applicant: Kao CorporationInventors: Yasuto Suzuki, Naoko Morisaki, Michiyo Sasajima
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Publication number: 20110130327Abstract: Multi-arm amine compounds and compositions for enhancing intracellular, in vitro, and in vivo delivery of drug, active, and therapeutic substances including ribonucleic acids. This disclosure provides novel compounds and compositions for making and using delivery materials and carriers which increase the efficiency of delivery of biologically active and pharmacologically active molecules. Embodiments of this disclosure may further provide delivery of various therapeutic agents including nucleic acid therapeutics such as regulatory RNA, interfering RNA, and agents for RNAi, as well as other protein and peptide therapeutics. In some aspects, this disclosure provides multi-arm amine compounds and compositions which can enhance permeation of a drug substance.Type: ApplicationFiled: November 26, 2010Publication date: June 2, 2011Applicant: MARINA BIOTECH, INC.Inventors: MICHAEL E. HOUSTON, JR., ROGER C. ADAMI, STEVEN C. QUAY, PHUONG NGUYEN, HARRY C. WANG, DIANE E. FRANK
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Publication number: 20110124729Abstract: The present invention relates to compositions which comprise highly branched polyesters, to the use of these highly branched polyesters in cosmetics and dermatology and to substituted highly branched polyesters.Type: ApplicationFiled: November 23, 2010Publication date: May 26, 2011Applicant: BASF SEInventors: Volker Wendel, Matthias Laubender, Jean-Fracois Stumbe, Bernd Bruchmann
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Publication number: 20110124728Abstract: The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70° C. and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.Type: ApplicationFiled: November 19, 2010Publication date: May 26, 2011Inventors: Florence MARCIACQ, Mathieu Soulayres, Bernard Freiss
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Publication number: 20110124615Abstract: According to a first aspect the invention relates to the use of fumaric acid derivatives selected from the group consisting of dialkyl fumarates, monoalkyl hydrogen fumarates, fumaric acid monoalkyl ester salts, fumaric acid monoamides, monoamido fumaric acid salts, fumaric acid diamides, monoalkyl monoamido fumarates, carbocyclic and oxacarbocyclic oligomers of these compounds and mixtures thereof for preparing a drug for the treatment or prevention of cardiac insufficiency, in particular left ventricular insufficiency, myocardial infarction and angina pectoris.Type: ApplicationFiled: September 17, 2010Publication date: May 26, 2011Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel, Christian Zaugg, Michael Tamm
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Patent number: 7947736Abstract: Method for the synthesis of a compound of formula H(OCH[CH3]CH2C[O])3—O-A-O—R wherein A is the residue of 1,3-butandiol and R is H or H(OCH[CH3]CH2C[O]3—. The method comprises reacting a cyclic oligomer of (R)-3-hydroxybutyrate consisting of (R)-3-hydroxybutyrate moieties with a 1,3-butandiol in an organic solvent in the presence of Candida antarctica lipase type B in a furan or pyran solvent.Type: GrantFiled: July 15, 2005Date of Patent: May 24, 2011Assignee: BTG International LimitedInventor: Richard A. Gross
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Publication number: 20110118217Abstract: Short chain fatty acids (SCFAs) and glycerol esters of SCFAs not previously used for that purpose are provided for use as a medicament for treating, preventing or counteracting microbial infections in animals, including humans, by stimulating the innate antimicrobial peptide defense system. Preferred compounds include phenyl substituted short chain fatty acids (SCFAs) derivatives and. Also provided are methods and compositions for treating, preventing or counteracting microbial infections, including bacterial, viral, fungal, and parasitic infections, by administration of medicaments comprising a secretagogue-effective amount of the compounds of the invention.Type: ApplicationFiled: December 11, 2008Publication date: May 19, 2011Applicant: Akthelia PharmaceuticalsInventors: Gudmundur Hrafn Gudmundsson, Birgitta Agerberth, Eirikur Steingrimsson, Roger Stromberg, Raqib Rubhana
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Publication number: 20110118265Abstract: Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.Type: ApplicationFiled: November 12, 2010Publication date: May 19, 2011Inventors: Jeffry B. Stock, Maxwell Stock
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Publication number: 20110097410Abstract: Nanoparticles of PX compounds in the size range of 10 to 1000 nanometers are incorporated into formulations that are safe for intravenous administration and used to treat disease conditions caused by phospholipase A2 (PLA2) such as ischemia-reperfusion injury.Type: ApplicationFiled: August 21, 2008Publication date: April 28, 2011Inventor: Richard L. Berney
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Publication number: 20110098229Abstract: Provided herein are methods of improving one or more symptoms of a dermatological condition in a patient. The methods comprise topically administering a topical composition to the patient comprising a branched chain amino acid, and an enzyme activator. Also provided are kits comprising the topical composition and optionally a topical steroid.Type: ApplicationFiled: October 28, 2009Publication date: April 28, 2011Inventor: Harbhajan S. Paul
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Patent number: 7931911Abstract: A pesticidal/ovicidal composition comprising: (a) 50-97.9 parts by mass of a triglyceride containing not less than 50% of oleic acid as a fatty acid component; (b) 0.1-20 parts by mass of a cationic surface active agent; and (c) 2-30 parts by mass of a glycerin derivative, and a pesticidal/ovicidal method using the same. The composition according to the invention has not only a pesticidal activity but also an ovicidal activity on crop pests, and provides a safe and high pesticidal/ovicidal effect.Type: GrantFiled: April 9, 2007Date of Patent: April 26, 2011Assignee: RikenInventor: Yutaka Arimoto
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Publication number: 20110091400Abstract: The invention relates to a cosmetic composition comprising a) sodium stearyl glutamate, b) a crosslinked polymer of vinylpyrrolidone and acrylic acid.Type: ApplicationFiled: August 1, 2008Publication date: April 21, 2011Applicant: BEIERSDORF AGInventors: Mirko Tesch, Kerstin Skubsch, Alexandra Blohm
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Publication number: 20110092447Abstract: Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such conditions are linked to genetically inherited mutations of crucial genes which predispose a person with this condition to develop the disease phenotype. Thus, such compounds can be used for a suppressive therapeutic approach—the SUPPRESSION THERAPY—in order to inhibit or delay the onset or progression of the genetically predisposed disorder. Furthermore, a clinically used medicament can be manufactured for the SUPPRESSION THERAPY of such inherited predisposing conditions.Type: ApplicationFiled: December 22, 2010Publication date: April 21, 2011Inventors: Bernd Hentsch, Alexander B. Maurer, Sascha Hovelmann, Monika Raab, Elke Martin
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Publication number: 20110087152Abstract: Compositions and method for augmenting tissue after delivery to localized area. The compositions include a hydrogel and a dermal filler. The hydrogel can polymerize and/or crosslink upon a first trigger event. The dermal filler can also optionally crosslink upon a second trigger event.Type: ApplicationFiled: May 7, 2010Publication date: April 14, 2011Inventors: Nathaniel E. David, Jennifer Elisseeff
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Publication number: 20110085997Abstract: The present invention relates to a cosmetic make-up or care composition comprising an oily phase comprising at least one liquid polyester obtained by condensation of unsaturated fatty acid dimer and/or trimer and diol, said composition being free from lipophilic gelling agent or comprising at the most 10 wt. % thereof, relative to the weight of the composition. The present invention also relates to a method of make-up of the face and body comprising the use of said composition.Type: ApplicationFiled: May 29, 2009Publication date: April 14, 2011Applicant: L'OREALInventor: Claudia Barba
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Publication number: 20110081330Abstract: The present invention relates to compositions containing plant gums and one or more fat-soluble active ingredients, wherein the composition comprises less than 40 weight-% oil, based on the total composition in dry matter. These compositions can be used for the enrichment, fortification and/or coloration of food beverages, animal feed, cosmetics or pharmaceutical compositions. The present invention also refers to the preparation of such compositions. The present invention furthermore refers to a process for the manufacture of a beverage by mixing the compositions with ingredients of beverages. The present invention also refers to beverages obtainable by this process.Type: ApplicationFiled: June 3, 2009Publication date: April 7, 2011Inventors: Andrea Hitzfeld, Bruno H. Leuenberger, Olivia Vidoni
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Patent number: 7919527Abstract: The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.Type: GrantFiled: January 25, 2010Date of Patent: April 5, 2011Assignee: Diffusion Pharmaceuticals LLCInventors: John L. Gainer, Raymond C. Grabiak
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Publication number: 20110077300Abstract: Sodium butyrate was chronically administrated through diet supplementation at 5% w/w in a high fat diet. Supplementation of butyrate prevented development of insulin resistance and obesity in C57BL/6J mice on a high fat diet, and in mice fed on a regular diet of tributyrin. Fasting blood glucose, insulin, and insulin tolerance were all reserved in the butyrate-treated mice. The body fat content was maintained at 10% without a reduction in food intake. Adaptive thermogenesis and fatty acid oxidation were enhanced. An increase in mitochondria function and biogenesis was observed in the skeletal muscle and brown fat, and Type 1 muscle fiber was enriched in the skeletal muscle. In genetically obese mice, supplementation of butyrate led to an increase in insulin sensitivity and reduction in adiposity. Dietary supplementation of butyrate can prevent and treat diet-induced insulin resistance.Type: ApplicationFiled: March 25, 2010Publication date: March 31, 2011Inventors: Jianping Ye, Zhangguo Gao
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Patent number: 7915450Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds lo prepare liposomes and other lipid aggregates suitable for iransfcclion or delivery of compounds to target cells, cither in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules. particularly polyanions such as nucleic acids. These compounds have the properly, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.Type: GrantFiled: December 15, 2009Date of Patent: March 29, 2011Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7915310Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.Type: GrantFiled: March 17, 2009Date of Patent: March 29, 2011Assignee: Biogen Idec International GmbHInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Publication number: 20110071218Abstract: The disclosure relates to novel compounds of the formula (I) R1NH—CH(R2)CH2—S—S—CH2—C(R3)(R4)—CONH—C(R5)(R6)—COOR7, in which R1 is a (acyloxy)alkyl carbamate-C(O)—O—C(R8)(R9)—OC(O)—R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle, R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The disclosure also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier.Type: ApplicationFiled: May 13, 2009Publication date: March 24, 2011Applicant: PHARMALEADSInventors: Marie-Claude Fournie-Zaluski, Hervé Poras, Bernard Roques
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Publication number: 20110059906Abstract: The present invention relates to a method of improving the energy status of an individual by enhancing the usage of lactate. Improved lactate usage is accomplished through a composition comprising lactate precursors, adrenergic receptor agonists and insulinotropic agents.Type: ApplicationFiled: July 2, 2010Publication date: March 10, 2011Applicant: Northern Innovations and Formulations Corp.Inventors: Jason Peters, Michele Molino
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Publication number: 20110052641Abstract: Halogenated aliphatic carboxylic acids, salts and/or oligomers or polymers thereof, which exhibit a devitalizing effect of neoplastic tissues, are disclosed. Methods and uses that utilize these compounds for the treatment of medical conditions associated with a neoplastic tissue are also disclosed. Further disclosed are methods and uses that utilize these compounds for reducing or abolishing blood and lymph as well local dissemination of malignant neoplastic cells during a surgical removal thereof, thereby preventing recurrences and distance metastases, and/or inducing immune response to potentially malignant, pre-malignant and/or malignant cells. Further disclosed are novel oligomeric forms of halogenated aliphatic carboxylic acids, pharmaceutical compositions containing same and uses thereof.Type: ApplicationFiled: June 9, 2010Publication date: March 3, 2011Applicant: Mardi Medicines Ltd.Inventors: Shalva Mardi, Rosa Mardi, Gymsher Mardi, Laura Mardi, Shimon Slavin
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Patent number: 7897641Abstract: A composition is disclosed which is suitable for the prevention and/or treatment of cell and tissue abnormalities of exogenous, toxic or metabolic origin and suitable for reducing the toxic effects of cyclosporin-A and other immunosuppressive agents, which may take the form of a food supplement or of an actual medicine, containing as its active ingredients in combination or separately packaged: (a) propionyl L-carnitine or one of its pharmacologically acceptable salts, and (b) an amino acid selected from the group consisting of glycine, serine, alanine and arginine, or mixtures thereof.Type: GrantFiled: February 20, 2001Date of Patent: March 1, 2011Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventor: Claudio Cavazza
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Patent number: 7897642Abstract: Compositions and methods to inhibit dry eye as well as other conditions are provided.Type: GrantFiled: June 18, 2003Date of Patent: March 1, 2011Inventor: Irvine Dubow
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Patent number: 7888083Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: April 27, 2010Date of Patent: February 15, 2011Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
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Publication number: 20110033413Abstract: The object of the present invention is a method for producing oil-in-water (O/W) emulsions from self-emulsifying gel concentrates without agitation, such as stirring, or in a laminar flow field.Type: ApplicationFiled: December 19, 2008Publication date: February 10, 2011Inventors: Klaus Kwetkat, Britta Jakobs, Gerd M. Dahms
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Publication number: 20110028438Abstract: The present invention relates to highly effective treatment of ischemic heart disease with 3-(2,2,2-trimethylhydrazinium) propionate hydrogen fumarate, and 3-(2,2,2-trimethylhydrazinium) propionate dihydrogen phosphate.Type: ApplicationFiled: December 3, 2008Publication date: February 3, 2011Inventors: Ivars Kalvinsh, Ilmars Stonans
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Publication number: 20110027327Abstract: A cosmetic or pharmaceutical composition, to be applied topically is described, which has a hydrophilic outer phase, at least one cosmetic and/or pharmaceutical active ingredient and at least one carrier substance for the active ingredient. The carrier substance here forms such structures, which comprises at least two lamellar double membrane layers arranged one over another in the manner of a sandwich, wherein between adjacent double membrane layers, aligned parallel to each other, a layer of an inner phase is respectively arranged.Type: ApplicationFiled: October 1, 2008Publication date: February 3, 2011Applicant: KUHS GMBHInventor: Martin Albrecht
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Publication number: 20110027326Abstract: An external composition for skin is provided, which gives good warmth without inducing irritation or pain and whose sustainability of warmth is good. The external composition for skin contains (A) an agent for giving warmth and (B) at least one member selected from the group consisting of fatty acid esters of aliphatic polyhydric alcohols and aromatic carboxylic acid esters of lower alcohols or aliphatic polyhydric alcohols.Type: ApplicationFiled: March 26, 2009Publication date: February 3, 2011Applicant: ROHTO PHARMACEUTICAL CO., LTD.Inventor: Yoshiyuki Hirayama
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Publication number: 20110020265Abstract: Use of the one or more oligomers of lactic acid with the following formula (I) wherein n is an integer from 2 to 25 such as, e.g., from 2 to 20, from 3 to 25, from 3 to 20, from 2 to 15, from 3 to 15, from 2 to 10, from 3 to 10, from 4 to 10, or from 4 to 9 or a lactic acid oligomeric product for the prophylaxis and/or treatment of a disease or condition that benefit of an acidic environment especially a gynaecological infection such as a bacterial infection, such as bacterial vaginosis, unspecific colpitis, senile colpitis, cervicitis, and urethritis, a fungal infection, such as candidosis (Candida albicans), cryptococcosis, actinomycosis, or a viral infection, such as Human Immunodefiency Virus (HIV), Herpes Simplex Virus (HSV), Human Papilloma Virus (HPV).Type: ApplicationFiled: March 28, 2009Publication date: January 27, 2011Applicant: LACCURE ABInventors: Greg Batcheller, Thomas Hedner, Jorgen Johnsson, Werner Schubert, Christer Sjogren, Olov Sterner, Malgorzat Aznitowska
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Publication number: 20110021630Abstract: Disclosed herein are methods for treating wounds. In one embodiment, the method comprises: administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene of the formula Zm—F—Yn wherein F is a fullerene of formula Cp or X@Cp, the fullerene having two opposing poles and an equatorial region; Cp represents a fullerene cage having p carbon atoms, and X@CP represents such a fullerene cage having a chemical group X within the cage; Z and Y are positioned near respective opposite poles of Cp; m=1-5 and Z is a hydrophilic, lipophilic, or amphiphilic chemical moiety; n=1-5 and Y is a lipophilic chemical moiety; p=60-200 and p is an even number; and X, if present, represents one or more metal atoms within the fullerene (F), optionally in the form of a trinitride of formula Gi=1?3Hk=3?iN in which G and H are metal atoms.Type: ApplicationFiled: March 3, 2009Publication date: January 27, 2011Inventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou
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Publication number: 20110015268Abstract: A pharmaceutical composition comprising a docusate; an osmotic laxative; and a benzoate.Type: ApplicationFiled: December 5, 2008Publication date: January 20, 2011Applicant: FERRING INTERNATIONAL CENTER S.A.Inventors: Haijun Xu, Tiejun Diao
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Patent number: 7872046Abstract: A crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug and methods of preparing a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug, and methods of using a crystalline form of a (3S)-aminomethyl-5-hexanoic acid prodrug are provided.Type: GrantFiled: January 23, 2009Date of Patent: January 18, 2011Assignee: Xenoport, Inc.Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
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Patent number: 7868043Abstract: Mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs and methods of preparing and methods of using mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs are provided.Type: GrantFiled: January 23, 2009Date of Patent: January 11, 2011Assignee: Xenoport, Inc.Inventors: Fenmei Yao, Mark A. Gallop, Ronald W. Barrett, Peter A. Virsik
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Publication number: 20110003893Abstract: An aqueous loxoprofen-containing patch is provided, which has good stability and excellent transdermal absorption of loxoprofen. The aqueous patch includes loxoprofen or a salt thereof and triacetin. Specifically, the aqueous patch includes, based on the weight of the adhesive gel base, 0.1 to 5% by weight of loxoprofen or a salt thereof, 0.5 to 5% by weight of triacetin, 1 to 30% by weight of a water-soluble polymer, 0.01 to 5% by weight of a cross-linking agent, 10 to 90% by weight of purified water, and 0 to 20% by weight of an inorganic powder.Type: ApplicationFiled: December 11, 2008Publication date: January 6, 2011Applicant: TEIKOKU SEIYAKU CO., LTD.Inventors: Kazuha Tani, Mitsuji Akazawa
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Publication number: 20110003860Abstract: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.Type: ApplicationFiled: August 27, 2010Publication date: January 6, 2011Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Publication number: 20110002905Abstract: The present invention relates to compositions containing one or more proteins, one or more polysaccharides and one or more fat-soluble active ingredients and their use for the enrichment, fortification and/or coloration of food beverages, animal feed and/or cosmetics.Type: ApplicationFiled: February 23, 2010Publication date: January 6, 2011Applicants: DSM IP ASSETS B.V., FUDAN UNIVERSITYInventors: Chyi-Cheng CHEN, Ping Yao, Bruno H. Leuenberger, Gerhard Wagner, Keke Xu, Shi-Kchen Chen
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Patent number: 7863472Abstract: The present invention concerns a process for producing refined avocado oil rich in triglycerides. The invention also pertains to refined avocado oil rich in triglycerides obtainable by said process. Advantageously, the refined avocado oil of the invention contains a sterols-enriched unsaponifiable fraction. Advantageously, the refined avocado oil of the invention is substantially free of acetogenins and furanic lipids. The invention also concerns compositions containing said oil. The invention also pertains to such compositions for use as a medication, as a dermatological agent, as a cosmetic agent, or as a nutriceutical, for human or animal use.Type: GrantFiled: February 27, 2009Date of Patent: January 4, 2011Assignee: Laboratories ExpanscienceInventors: Philippe Msika, Jacques Legrand