Compound Contains Two Or More C(=o)o Groups Patents (Class 514/547)
  • Publication number: 20090304790
    Abstract: The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.
    Type: Application
    Filed: October 7, 2005
    Publication date: December 10, 2009
    Applicant: ADITECH PHARMA AB
    Inventors: Henrik Nilsson, Florian Schoenharting, Bernd W. Mueller, Joseph R. Robinson, Bonna Robinson
  • Publication number: 20090304618
    Abstract: The presently described technology relates to acyl lactylate containing compositions having improved stability and multifunctional performance characteristics (e.g., pH stability, phase stability, hydrolytic stability (e.g., aqueous stability), cleansing, foaming, skin softness and skin moisturization) that may be utilized in rinse-out and leave-on skin and hair applications. The acyl lactylate compositions of the present technology may be delivered to the skin or hair via a conventional delivery vehicle such as a body wash, a shampoo, a bubble bath, a skin cream, or a lotion.
    Type: Application
    Filed: February 27, 2007
    Publication date: December 10, 2009
    Applicant: Stepan Company
    Inventors: Irene Shapiro, Gregory Dado, David Allen, Branko Sajic
  • Publication number: 20090306205
    Abstract: The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to donate electrons to free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients.
    Type: Application
    Filed: February 14, 2007
    Publication date: December 10, 2009
    Applicant: Eastern Virginia Medical School
    Inventors: Karl A. Schellenberg, Frank A. Lattanzio, James Shaeffer
  • Patent number: 7629383
    Abstract: The invention provides acyloxymethyl esters of C6-14 alkane-dicarboxylic acids, or physiologically tolerable salts or esters thereof, for use in medicine as therapeutic or prophylactic agents.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: December 8, 2009
    Assignee: Drug Discovery Laboratory AS
    Inventor: Jo Klaveness
  • Publication number: 20090298937
    Abstract: The present invention is directed to a method for inhibiting the growth of pathogenic bacteria in an infant formula comprising supplementing the infant formula with at least one diglyceride antimicrobial agent.
    Type: Application
    Filed: April 24, 2009
    Publication date: December 3, 2009
    Applicant: MEAD JOHNSON NUTRITION COMPANY
    Inventor: Bryon W. Petschow
  • Publication number: 20090298936
    Abstract: The present invention relates to a method for energizing a human being and to administering an energizing (personal care) composition to human beings wherein said composition contains one or more fragrance materials of group (a) of the present invention.
    Type: Application
    Filed: May 29, 2008
    Publication date: December 3, 2009
    Applicant: SYMRISE GmbH & Co. KG
    Inventors: James G. Clothier, JR., Keith McDermott, Patrice Bellon
  • Publication number: 20090286877
    Abstract: A pesticidal/ovicidal composition comprising (a) 50-99.9 parts by mass of a triglyceride containing not less than 50% of oleic acid as a fatty acid component; (b) 0.1-20 parts by mass of a nonionic surface active agent; and (c) 0-30 parts by mass of a glycerin derivative. The composition according to the invention has not only a pesticidal activity but also an ovicidal activity on crop pests, and provides a safe and high pesticidal/ovicidal effect.
    Type: Application
    Filed: April 9, 2007
    Publication date: November 19, 2009
    Applicant: Riken
    Inventors: Yutaka Arimoto, Kenichi Tanaka
  • Patent number: 7619001
    Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: November 17, 2009
    Assignee: Biogen IDEC International GmbH
    Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel
  • Publication number: 20090281109
    Abstract: The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs and methods of using the prodrugs and compositions for treatment of schizophrenia and drug addiction.
    Type: Application
    Filed: February 9, 2009
    Publication date: November 12, 2009
    Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
  • Publication number: 20090281062
    Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
    Type: Application
    Filed: May 7, 2009
    Publication date: November 12, 2009
    Inventors: Lisa M. Frost, Stephen M. Courtney, Frederick A. Brookfield, Vincent J. Kalish
  • Patent number: 7612111
    Abstract: The invention is directed to compositions comprising lecithin, olive oil, esterified fatty acids and mixed tocophenols for use in the treatment and prevention of various types of arthritis and other inflammatory joint conditions, periodontal diseases and psoriasis, which avoid many of the side effects associated with known treatments. The compositions of the present invention have the advantage of increased stability, a reduction of arachidonic acid in cells, a reduction in eicosanoid production and enhanced cell regulation and communication. Also disclosed are methods for using the compositions for treatment and prevention.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: November 3, 2009
    Assignee: Imagenetix, Inc.
    Inventors: William P. Spencer, Patrick S. Millsap
  • Patent number: 7612110
    Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: November 3, 2009
    Assignee: Biogen Idec International AG
    Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel
  • Patent number: 7608254
    Abstract: The present invention relates to pheromone mixture comprising 2,9 diacetoxyundecane, 2,10-diacetoxyundecane and 2-acetoxyundecane, as a racemate or, biologically active stereoisomers thereof, as well as a method for monitoring and/or mating disruption of swede midge, Contarinia nasturtii, in Brassica vegetables, in particular Brussels sprouts, cauliflower and broccoli.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: October 27, 2009
    Assignee: Forskarpatent I Syd AB
    Inventors: Ylva Hillbur, Robert Baur, Stefan Rauscher
  • Publication number: 20090257958
    Abstract: The present disclosure relates to pesticidal compositions and to methods for controlling pests such as insects and other arthropods. More particularly, the disclosure relates to a pesticidal compositions containing mineral oil and one or more additional components which, when used in combination, act synergistically to control insect and pest populations.
    Type: Application
    Filed: April 3, 2009
    Publication date: October 15, 2009
    Applicant: Whitmire Micro-Gen Research Laboratories, Inc.
    Inventor: Steven R. Sims
  • Publication number: 20090253781
    Abstract: Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such as found in Alzheimer's and similar conditions. These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.
    Type: Application
    Filed: May 12, 2009
    Publication date: October 8, 2009
    Applicant: BTG International Limited
    Inventor: Richard L. Veech
  • Publication number: 20090247629
    Abstract: The present invention relates to a novel class of polymeric compounds having specific quaternized amine based upon a dimer acid reacted with an alkanolamine to make an ester quaternary compound. Dimer acid is a C-36 diacid having a cyclic structure and two amine groups that allow for the synthesis of a high molecular weight cationic compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications. These materials are dimethylaminopropyl amine free, which is highly desirable in personal care applications.
    Type: Application
    Filed: April 1, 2008
    Publication date: October 1, 2009
    Inventors: Kevin A. O'Lenick, Anthony J. O'Lenick, JR.
  • Publication number: 20090239830
    Abstract: Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.
    Type: Application
    Filed: June 2, 2008
    Publication date: September 24, 2009
    Inventors: Josh Munger, Bryson Bennett, Thomas Shenk, Joshua Rabinowitz
  • Patent number: 7592370
    Abstract: A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid compound or derivative thereof, wherein the compound or derivative thereof is able to readily enter the mitochondrion without special transport enzymes. A dietary formulation suitable for treatment of heart tissue in cardiac or surgical patients has been found which comprises a seven-carbon fatty acid chain, wherein the seven-carbon fatty acid chain is characterized by the ability to transverse the inner mitochondrial membrane by a transport mechanism which does not require carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, or carnitine/acylcarnitine translocase and the ability to undergo mitochondrial ?-oxidation, and wherein the compound is selected from the group consisting of n-heptanoic acid or a derivative thereof, a triglyceride comprising n-heptanoic acid or a derivative thereof, and triheptanoin or a derivative thereof.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: September 22, 2009
    Assignee: Baylor Research Institute
    Inventor: Charles R. Roe
  • Publication number: 20090227675
    Abstract: Antimicrobial compositions which are active against bacteria, yeast and mold spores are described. The compositions may be blends of (I) an acrylate/methacrylate copolymer having a hydrophobic network structure and (II) a preservative component comprising comprising (A) an isothiazolinone or (B)phenoxyethanol and either (i) a 1,2-diol or (ii) benzoic acid and dehydroacetic acid.
    Type: Application
    Filed: February 25, 2009
    Publication date: September 10, 2009
    Inventors: Susan Lindstrom, John J. Merianos, Nancy Clements
  • Publication number: 20090227676
    Abstract: Pharmaceutical compositions and kits useful for the treatment of cancer include certain alkyl esters of cystine and certain alkyl-substituted cystamine derived esters, including, for example, cystine dimethyl ester and a di-alkyl peptidyl cystamine ester, among others. These compounds may be employed in methods of treating cancers or methods of determining sensitivity of certain cancer cells to apoptosis alone, or in combination with other chemotherapeutic, radiological or apoptotic agents.
    Type: Application
    Filed: April 28, 2009
    Publication date: September 10, 2009
    Applicant: The Administrators of the Tulane Educational Fund
    Inventor: Jess G. Theone
  • Patent number: 7585896
    Abstract: A composition is disclosed which is suitable for the prevention and treatment of kidney dysfunctions and diseases and which can therefore take the form of a food supplement or of an actual medicinal drug comprising a combination of acetyl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: September 8, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Claudio Cavazza
  • Publication number: 20090215891
    Abstract: A novel mixed salt of S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine is disclosed. The novel mixed salt, S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, may be produced to form crystals that may be arranged as generally orderly packed agglomerates, which are particularly useful in making pharmaceutical compositions. Such pharmaceutical compositions are also described, as well as methods to make crystalline S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride, and methods of treating conditions characterized by an overexpression on nitric oxide from the inducible isoform of nitric oxide synthase using the S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine maleate hydrochloride.
    Type: Application
    Filed: December 5, 2008
    Publication date: August 27, 2009
    Applicant: Pfizer, Inc.
    Inventors: Lyle Brostrom, Ann Czyzewski, Vahid Zia, Ahmad Sheikh
  • Publication number: 20090203634
    Abstract: Amooranin (AMR) has been found to cause tumor cell death through G2/M cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR compounds, including AMR analogs, can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.
    Type: Application
    Filed: April 14, 2006
    Publication date: August 13, 2009
    Applicant: Variety Children's Hospital d/b/a Miami Children's Hospital
    Inventors: Cheppail Ramachandran, P.K. Raveendran Nair, Steven J. Melnick
  • Publication number: 20090197950
    Abstract: This patent discloses the use of water-soluble substituted fullerenes as inhibitors of cell death. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fullerene core; (ii) from 1 to 18 —X3 groups bonded to the fullerene core; (iii) from 1 to 6 —X4— groups bonded to the fullerene core; or (iv) from 1 to 6 dendrons bonded to the fullerene core.
    Type: Application
    Filed: April 13, 2009
    Publication date: August 6, 2009
    Inventors: Russ Lebovitz, Michael Rosenblum
  • Publication number: 20090197951
    Abstract: This patent discloses a composition comprising a substituted fullerene, wherein the substituted fullerene comprises a fullerene core (Cn), wherein n is an even integer greater than or equal to 60, and at least one substituent group bonded to at least one carbon atom of the fullerene core, and at least one adjuvant, wherein the adjuvant is an absorption enhancer or bioavailability enhancer. It also discloses methods of using such compositions to ameliorate oxidative stress diseases or inhibit cell death.
    Type: Application
    Filed: April 13, 2009
    Publication date: August 6, 2009
    Inventors: Russ Lebovitz, My Phuong Lam
  • Patent number: 7569213
    Abstract: The invention relates to a compound which is an ester of 1,2,3-propanetriol with one or more C11 to C24 fatty acids, wherein at least one fatty acid has at least one double bond. The compound is useful in the treatment of chronic inflammatory disorders.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: August 4, 2009
    Assignee: Stanford Rook Limited
    Inventors: Laura Rosa Brunet, Graham Rook
  • Publication number: 20090186761
    Abstract: A method is described for treating soil to increase plant growth or improve the health of plants, wherein an aqueous solution of a bio-derived surfactant obtained from natural lipids has pesticidal effects. In some embodiments, the method can be used against soil pests such as at least one of nematodes, soil-dwelling insects, and weeds. The invention also pertains to methods for applying bio-derived surfactants to crops and other plants or to the soil used for such plants in order to reduce the need to apply environmentally unfriendly pesticides substances.
    Type: Application
    Filed: July 11, 2008
    Publication date: July 23, 2009
    Inventors: Stephen Craig Arbogast, Herbert Nicholas Nigg, Ronald A. Becton
  • Publication number: 20090181085
    Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
    Type: Application
    Filed: March 17, 2009
    Publication date: July 16, 2009
    Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel
  • Publication number: 20090182046
    Abstract: Esters of 2-propylheptanol with linear or branched, saturated or unsaturated C5-C36 carboxylic acids and C4-C36 dicarboxylic acids, compositions comprising these esters, and to the use of esters of 2-propylheptanol with linear or branched, saturated or unsaturated C5-C36-carboxylic acids and/or C4-C36-dicarboxylic acids in cosmetic and/or topical pharmaceutical preparations.
    Type: Application
    Filed: March 9, 2006
    Publication date: July 16, 2009
    Inventors: Markus Dierker, Catherine Weichold, Stefanie Althaus, Lars Zander, Daniela Prinz
  • Publication number: 20090182047
    Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
    Type: Application
    Filed: March 17, 2009
    Publication date: July 16, 2009
    Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel
  • Publication number: 20090163590
    Abstract: The present invention concerns a process for producing refined avocado oil rich in triglycerides. The invention also pertains to refined avocado oil rich in triglycerides obtainable by said process. Advantageously, the refined avocado oil of the invention contains a sterols-enriched unsaponifiable fraction. Advantageously, the refined avocado oil of the invention is substantially free of acetogenins and furanic lipids. The invention also concerns compositions containing said oil. The invention also pertains to such compositions for use as a medication, as a dermatological agent, as a cosmetic agent, or as a nutriceutical, for human or animal use.
    Type: Application
    Filed: February 27, 2009
    Publication date: June 25, 2009
    Inventors: Philippe MSIKA, Jacques Legrand
  • Publication number: 20090156562
    Abstract: The invention is directed to pharmaceutical compositions comprising colored solutions, colored emulsions, or colored powders of injectable pharmaceuticals wherein said pharmaceuticals are selected from the group consisting of muscle relaxants, hypnotics, induction agents, and anticholinergics. The formulations of the present invention may all be colored using fluorescein. Different colors may be achieved by either varying the concentration of fluorescein, or by combining fluorescein with another dye. The invention is also directed to methods involving the use of said pharmaceutical compositions.
    Type: Application
    Filed: November 13, 2006
    Publication date: June 18, 2009
    Inventor: Peter D. Winch
  • Publication number: 20090156638
    Abstract: Provided herein are methods for inhibiting proliferation of a microbe associated with a sexually transmitted disease (STD) or infection and for preventing transmission of one or more sexually transmitted diseases in a subject at-risk for acquiring the same, including an HIV positive subject at risk for acquiring another sexually transmitted disease. The methods comprise contacting a microbe or cell thereof associated with the STD or administering to the subject nordihydroguaiaretic acid or a derivative or analog thereof. In HIV positive at-risk subjects one or more anti-retroviral drugs are co-administered.
    Type: Application
    Filed: May 12, 2008
    Publication date: June 18, 2009
    Inventor: Niharika Khanna
  • Publication number: 20090124574
    Abstract: The presently described embodiments are directed to compositions that include one or more carotenoid analogs or derivatives for use in the treatment of a disorder associated with platelet aggregation. Certain embodiments provide for the use of said carotenoid analogs or derivatives in preparing compositions suitable for use in such treatments. Further embodiments provide for pharmaceutical compositions that include one or more carotenoid analogs or derivatives in combination with one or more additional compositions or medicaments suitable for the treatment of a disorder associated with platelet aggregation.
    Type: Application
    Filed: March 24, 2008
    Publication date: May 14, 2009
    Inventors: Samuel F. Lockwood, R. Preston Mason
  • Patent number: 7531676
    Abstract: Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: May 12, 2009
    Assignee: Celltech R & D Limited
    Inventors: Michael Anthony William Eaton, Timothy John Norman, David Parker, Terence Seward Baker, Andrew Neil Charles Weir, Catherine Fiona Catterall
  • Publication number: 20090110746
    Abstract: The subject invention relates to novel compositions containing a diffusion enhancing compound and their use in treating a variety of disorders.
    Type: Application
    Filed: October 31, 2008
    Publication date: April 30, 2009
    Applicant: Diffusion Pharmaceuticals LLC
    Inventor: John L. Gainer
  • Publication number: 20090110755
    Abstract: The present invention relates to compositions and methods for preventing migraines. The migraine prophylaxis composition is a single dosage form comprising at least one form of elemental magnesium and at least one NSAID. The prophylaxis composition, comprising at least one form of elemental magnesium and a therapeutically effective concentration of acetylsalicylic acid may also provide cardiac protection and prevent cardiovascular diseases.
    Type: Application
    Filed: October 29, 2008
    Publication date: April 30, 2009
    Inventor: Alexander Mauskop
  • Publication number: 20090111875
    Abstract: Provided are compositions which are suitable for topical application to mammalian skin for cleansing and anti-microbial properties. In one embodiment, the compositions include a glyceryl monoazelate monolaurate ester. It is postulated that bacteria on or in the skin may cleave the ester linkage of a compound according to the present disclosure that is applied to the skin, which causes liberation of the acid moiety from the ester, which acid moiety then inhibits or kills the bacterium. Compositions according to the present disclosure may comprise skin creams, soaps, shampoos and lotions, and are especially effective in treating acne and acne-like skin ebullitions. The glyceryl portion of the molecules is believed to facilitate penetration of the ester into the skin prior to release of the azelate or laurate residue.
    Type: Application
    Filed: October 29, 2007
    Publication date: April 30, 2009
    Inventor: Christopher J. Whewell
  • Publication number: 20090105238
    Abstract: Amphoteric compounds are described, having a zwitterionic structure of the betainic type having general formula (I) and their use for the control of phytopathogen fungi and/or the mitigation of abiotic and biotic stress.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 23, 2009
    Applicant: ISAGRO RICERCA S.r.l
    Inventors: Lucio Filippini, Marilena Gusmeroli, Silvia Mormile, Gregorio Valea, Luigi Mirenna, Maria Gabriella Colucci, Fabio Apone
  • Patent number: 7521463
    Abstract: Compounds are described which modulate the tzrosine kinase activity of p56lck and signal transduction pathways in which this enzyme is involved. The invention also relates to compounds which have immunomodulatory activity, e.g., which have immunosuppressant or immunostimulatory activity, and/or which have an antineoplastic effect. The invention further relates to compositions comprising these compounds, and methods of using them. Compounds are described which modulate the tyrosine kinase activity of p56.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: April 21, 2009
    Assignee: University of Maryland, Baltimore
    Inventors: Jun Hayashi, Alexander Mackerell
  • Publication number: 20090099258
    Abstract: A method of imparting a physiological cooling effect to a consumer product is disclosed. The method comprises formulating into the consumer product a composition comprising at least one lactoyl ester of menthyl lactate. Also disclosed is a method of providing physiological cooling by contacting skin or mucous membranes with the lactoyl ester compositions. Coolants comprising the lactoyl esters and additional coolants are also disclosed. The lactoyl esters are conveniently prepared from menthol and lactic acid.
    Type: Application
    Filed: October 15, 2007
    Publication date: April 16, 2009
    Inventors: Mark B. Erman, Patrick J. Whelan, Joe W. Snow
  • Publication number: 20090092656
    Abstract: The present invention provides novel pharmaceutical compositions containing triphenylethylene derivative compounds, and methods of using the composition for treatment of symptoms associated with atrophic vaginitis. The pharmaceutical compositions are prepared for the vaginal administration of triphenylethylene derivative compounds in single or combination therapies. Preferably, the triphenylethylene derivative is tamoxifen.
    Type: Application
    Filed: June 27, 2008
    Publication date: April 9, 2009
    Inventors: Bernadette KLAMERUS, Janet A. Chollet, Fred Mermelstein
  • Patent number: 7514574
    Abstract: Design of new, safe and effective biodegradable agents, which can cover a wide range of drug molecules in the transdermal permeation and other membranes absorption of physiologically active agents are disclosed. Biodegradable agents includes compounds having a multiple hydrophilic moiety groups which are water loving groups with general chemical structures provide for contributing the penetration enhancement characteristics such as glycolic group and N-alkyl substituted amino acidic group and a lipophilic moiety and also in contributing the balanced lipophilicity of the compounds such as long chain alkyl group are disclosed. More particularly, compounds with R1, and R2, as the steric hindered but can significantly affect the hydrolytic and enzymatic degradation or stability of the biodegradable enhancers.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: April 7, 2009
    Inventor: Ooi Wong
  • Patent number: 7514472
    Abstract: Described is a fat or oil composition which comprises at least 35 wt % of a diacylglycerol, the constituent fatty acids of said diacylglycerol satisfying the following equation: (an amount of a cis-form unsaturated fatty acid)/(an amount of a saturated fatty acid+an amount of a trans-form unsaturated fatty acid)?6, the usual intake of which as an edible oil makes it possible to reduce arteriosclerotic factors in blood, leading to the prevention of arteriosclerosis, and furthermore, various degenerative diseases.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: April 7, 2009
    Assignee: Kao Corporation
    Inventors: Kenji Masui, Yoshihisa Katsuragi, Tomoko Toi, Takuji Yasukawa
  • Publication number: 20090087419
    Abstract: This invention provides a highly concentrated licorice polyphenol preparation with high bioavailability. Further, this invention is intended to maintain high transparency of a composition without deterioration of the indigenous properties of an aqueous substance, even when such composition is added thereto. Such licorice polyphenol preparation comprises a hydrophobic licorice extract comprising licorice polyphenol as a primary component, medium-chain fatty acid triglyceride, and polyoxyethylene sorbitan fatty acid ester, and the ratio of the total weight of the hydrophobic licorice extract and medium-chain fatty acid triglyceride to the weight of polyoxyethylene sorbitan fatty acid ester is between 1:1 and 1:10.
    Type: Application
    Filed: April 12, 2007
    Publication date: April 2, 2009
    Applicant: Kaneka Corporation
    Inventors: Midori Sakai, Toshinori Ikehara
  • Publication number: 20090081177
    Abstract: A method of increasing pregnancy rate in a female subject is provided, the female subject or an oocyte for introduction into the female subject being fertilized by a sperm from a male subject. The method includes the steps of administering to the male subject prior to fertilization: (i) an effective amount of an anti-oxidant agent; and (ii) an effective amount of an agent that reduces inflammation in the male reproductive tract and/or an effective amount of an agent that increases testicular testosterone concentration.
    Type: Application
    Filed: July 5, 2006
    Publication date: March 26, 2009
    Applicant: FERTILITY TECHNOLOGIES PTY LTD
    Inventor: Kelton Paul Tremellen
  • Publication number: 20090082311
    Abstract: The present invention provides a novel compound having few side effects such as bradycardia and the like and having superior peripheral blood lymphocyte-decreasing effect.
    Type: Application
    Filed: April 27, 2007
    Publication date: March 26, 2009
    Applicant: Mitsubishi Tanabe Pharma Corporation
    Inventors: Masatoshi Kiuchi, Mitsuharu Nakamura, Maiko Hamada, Kunio Sugahara
  • Publication number: 20090076147
    Abstract: Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.
    Type: Application
    Filed: September 5, 2008
    Publication date: March 19, 2009
    Inventors: Bernd Jandeleit, Yunxiao Li, Mark A. Gallop, Noa Zerangue, Peter A. Virsik, Wolf-Nicolas Fischer
  • Publication number: 20090076146
    Abstract: The use of acetyl L-carnitine or one of its pharmaceutically acceptable salts is described for the preparation of a medicament and/or dietetic product for the treatment of fibromyalgic syndrome.
    Type: Application
    Filed: November 10, 2005
    Publication date: March 19, 2009
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventor: Aleardo Koverech
  • Publication number: 20090069423
    Abstract: Carnitines are nutraceuticals with indications in treating a variety of mental health disorders. A metabolomics-guided bioprocess method is presented to produce longer chain fatty acid esters of carnitines such as polyunsaturated fatty acid esters including eicosapentaenoyl-L-carnitine and/or docosahexaenyl-L-carnitine in germinating plant seeds. The resulting products from the plant seeds are used as a natural nutritional source of powerful human antioxidants.
    Type: Application
    Filed: July 31, 2008
    Publication date: March 12, 2009
    Inventors: Jay W. Pettegrew, Kanagasabai Panchalingam, Richard J. McClure