Z Radical Contains Carbon To Carbon Unsaturation Patents (Class 514/549)
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Publication number: 20140127146Abstract: Linoleic or Linolenic acid esters of resveratrol and topical compositions containing the esters.Type: ApplicationFiled: April 16, 2013Publication date: May 8, 2014Inventors: Daniel H. Maes, Fatemeh Mohammadi, Lisa Qu, Anna Czarnota, Thomas Mammone, Julius R. Zecchino, Lieve Deckercq
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Publication number: 20140128465Abstract: The present invention includes methods for producing and purifying esters of polyunsaturated fatty acids that include reacting a composition having triglycerides with polyunsaturated fatty acid residues in the presence of an alcohol and a base to produce an ester of a polyunsaturated fatty acid from the triglycerides. The composition can be a polyunsaturated fatty acid-containing composition that has not been conventionally processed. The reacted composition can be further processed by distillation.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Inventors: Krishna Raman, Jung Lee, Neil Leininger, Chris Luigart
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Patent number: 8710041Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.Type: GrantFiled: February 23, 2012Date of Patent: April 29, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Patent number: 8709475Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: May 17, 2013Date of Patent: April 29, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20140113884Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.Type: ApplicationFiled: April 4, 2012Publication date: April 24, 2014Inventors: John David Imig, William B. Campell, John Russell Falck
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Patent number: 8703829Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.Type: GrantFiled: May 23, 2012Date of Patent: April 22, 2014Assignee: University of Louisville Research Foundation, Inc.Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
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Patent number: 8703185Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: May 17, 2013Date of Patent: April 22, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20140107198Abstract: Orally administrable composition comprising fatty acids, wherein at least 50% by weight of the fatty acids comprise omega-3-fatty acids, salts or derivatives thereof, wherein the omega-3 fatty acids comprise eicosapentaenoic acid (EPA; C20:5-n3), docosapentaenoic acid (DPA; C22:5-n3), and docosahexaenoic acid (DHA; C22:6-n3), wherein the ratio of DHA to EPA (DHA:EPA) is less than 1:20, and wherein the ratio of DHA to DPA (DHA:DPA) is less than 2:1 are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, CNS, inflammatory, and other diseases/conditions or risk factors therefore.Type: ApplicationFiled: December 9, 2013Publication date: April 17, 2014Applicant: Matinas BioPharma, Inc.Inventors: George BOBOTAS, Abdel Aziz Fawzy
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Publication number: 20140107199Abstract: Orally administrable composition comprising fatty acids comprising omega-3-fatty acids, salts or derivatives thereof are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, CNS, inflammatory, and other diseases/conditions or risk factors therefore.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: Matinas BioPharma, Inc.Inventors: Abdel Aziz FAWZY, George BOBOTAS, Roelof RONGEN
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Publication number: 20140107200Abstract: Orally administrable composition comprising fatty acids comprising omega-3-fatty adds, salts or derivatives thereof are provided. These compositions can be used for the treatment or prophylaxis of dyslipidemic, cardiovascular, CNS, inflammatory, and other diseases/conditions or risk factors therefore.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: MATINAS BIOPHARMA, INC.Inventors: ABDEL AZIZ FAWZY, GEORGE BOBOTAS, IHOR TERLECKYJ
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Patent number: 8697630Abstract: Disclosed is a method and composition for nutritionally improving glucose and insulin balance in an individual. The invention further provides a method for treating a comorbidity of diabetes. In one embodiment, the invention provides a nutritional formulation comprising: a protein source; a fat source; and a carbohydrate source, wherein the protein source, the fat source, and the carbohydrate source are in a ratio of about 1:1:1, each comprising about one third of the total calories of the composition.Type: GrantFiled: July 22, 2011Date of Patent: April 15, 2014Assignee: Nestec S.A.Inventors: Kenneth C. Hayes, Norman Alan Greenberg, John P. Troup, Anne L. Falk, Gianni Biolo
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Publication number: 20140100274Abstract: The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol, non-HDL cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.Type: ApplicationFiled: December 9, 2013Publication date: April 10, 2014Applicant: Matinas BioPharma, Inc.Inventors: George BOBOTAS, Abdel Aziz Fawzy
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Publication number: 20140100275Abstract: The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol, non-HDL cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.Type: ApplicationFiled: December 9, 2013Publication date: April 10, 2014Applicant: Matinas BioPharma, Inc.Inventors: George BOBOTAS, Abdel Aziz FAWZY
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Publication number: 20140100272Abstract: The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol, non-HDL cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.Type: ApplicationFiled: December 9, 2013Publication date: April 10, 2014Applicant: Matinas BioPharma, Inc.Inventors: George BOBOTAS, Abdel Aziz Fawzy
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Publication number: 20140100273Abstract: The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol, non-HDL cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.Type: ApplicationFiled: December 9, 2013Publication date: April 10, 2014Applicant: MATINAS BIOPHARMA, INC.Inventors: George BOBOTAS, ABDEL AZIZ FAWZY
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Publication number: 20140099364Abstract: The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.Type: ApplicationFiled: October 7, 2005Publication date: April 10, 2014Applicant: Forward Pharma A/SInventors: Henrik NILSSON, Florian SCHOENHARTING, Bernd W. MUELLER, Joseph R. ROBINSON
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Patent number: 8691871Abstract: The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.Type: GrantFiled: May 20, 2013Date of Patent: April 8, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Patent number: 8686037Abstract: The invention is related to the new application of selected derivatives of 2-pyrrolidone to inhibition of protein glycation and to prevention and treatment of diabetes complications, such as atherosclerosis, nephropathy, retinopathy, cataract or neuropathy.Type: GrantFiled: October 23, 2010Date of Patent: April 1, 2014Assignee: Uniwersytet JagiellonskiInventors: Rafal Olszanecki, Beata Bujak-Giżycka, Ryszard Korbut, Mariusz Gajda
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Publication number: 20140088011Abstract: A softgel of NLKJ for the treatment of prostate diseases, comprising 0.05-1.0 g of NLKJ and 0.05-1.5 mg of an antioxidant, said NLKJ having the following physicochemical parameter: acid value<0.56, iodine value 95.0-107.00, saponification value 185.00-195.00, specific gravity 0.914-0.918 (20° C.), and refractive index 1.470-1.475 (20° C.). The inhibition of the softgel of NLKJ on the growth of prostate cancer in combination with the injection of Lupron is stronger than that of each of them used alone.Type: ApplicationFiled: September 21, 2012Publication date: March 27, 2014Inventor: Dapeng Li
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Patent number: 8680144Abstract: The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.Type: GrantFiled: May 20, 2013Date of Patent: March 25, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Patent number: 8673819Abstract: The present invention teaches a surfactant blend composition of at least one nonionic alkoxylate and at least one sugar-based surfactant, and its use as an adjuvant for pesticides. The pesticidal composition employing the surfactant blend composition of the invention realizes an efficacy that is unexpectedly superior to similar pesticidal compositions which employ only the individual surfactant components. The composition of the present invention is useful as a tank side additive, or as a component in herbicidal formulations. In addition the compositions of the present invention are useful as adjuvants for other pesticides, such as, fungicides, insecticides, plant growth regulators, acaracides and the like.Type: GrantFiled: July 3, 2009Date of Patent: March 18, 2014Assignee: Akzo Nobel N.V.Inventor: Jinxia Susan Sun
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Patent number: 8673881Abstract: The invention relates to novel resolvin compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel resolvin compounds of the invention.Type: GrantFiled: April 13, 2010Date of Patent: March 18, 2014Assignee: A.T. Resolve SarlInventors: Per Gjorstrup, C. Eric Schwartz
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Publication number: 20140073692Abstract: A pharmaceutical preparation comprising EPA in an appropriately assimilable form where of all the fatty acids present in the preparation at least 90%, and preferably at least 95%, is in the form of EPA and where less than 5%, and preferably less than 3%, is in the form of DHA is provided.Type: ApplicationFiled: September 16, 2013Publication date: March 13, 2014Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Malcolm Peet, Krishna S. Vaddadi
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Patent number: 8669287Abstract: An emulsifying preparation for an oil-soluble component, which is sensorily superior when applied to an aqueous phase, can maintain stability for a long time, and imposes less restriction for formulation or production is provided. The emulsifying preparation of the present invention contains (A) an oil phase component containing an oil-soluble component, (B) an aqueous phase component containing a polyol, and (C) an emulsifier containing polyglycerol fatty acid monoester having an average degree of polymerization of not less than 10, and having an HLB value of not less than 14 and not more than 18 or showing a transmittance of 1 wt % aqueous solution at 600 nm of not less than 80%.Type: GrantFiled: December 5, 2011Date of Patent: March 11, 2014Assignee: Ajinomoto Co., Inc.Inventors: Yoko Shimagami, Yasushi Ichimi
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Patent number: 8669245Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.Type: GrantFiled: June 3, 2013Date of Patent: March 11, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Publication number: 20140065192Abstract: The invention relates to an orally administrable, sour-tasting chewable composition in unit dosage form comprising an oil-in-water emulsion in which the aqueous phase is gelled and comprises at least one physiologically acceptable acid and at least one buffering agent and in which the oil phase comprises a physiologically tolerable unsaturated fatty acid ester.Type: ApplicationFiled: October 6, 2011Publication date: March 6, 2014Applicant: AYANDA GROUP ASInventor: Andrzej Siwek
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Patent number: 8663662Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: November 26, 2012Date of Patent: March 4, 2014Assignee: Amarin Pharma, Inc.Inventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20140057981Abstract: This invention provides a self-emulsifying composition comprising 50 to 95% by weight in total of at least one compound selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; and 5 to 50% by weight of an emulsifier having a hydrophilic lipophilic balance of at least 10. The composition has no or reduced ethanol content, and exhibits excellent self-emulsifying property, dispersibility in the composition, emulsion stability, and absorption property. The composition is adapted for use as a drug.Type: ApplicationFiled: November 1, 2013Publication date: February 27, 2014Applicant: MOCHIDA PHARMACEUTICAL CO., LTDInventors: Hirosato FUJII, Motoo YAMAGATA
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Patent number: 8658693Abstract: The present invention provides novel selective androgen receptor modulators and their salts and pharmaceutical compositions thereof.Type: GrantFiled: October 5, 2012Date of Patent: February 25, 2014Assignee: Eli Lilly and CompanyInventors: Jonathan Edward Green, Prabhakar Kondaji Jadhav, Venkatesh Krishnan, Donald Paul Matthews, Ashraf Saeed, Gregory Alan Stephenson
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Publication number: 20140050807Abstract: The invention provides compositions containing omega-3 oil and at least one anti-inflammatory agent and/or at least one gastrotoxic, nephrotoxic, or hepatotoxic pharmaceutical agent. The invention further provides kits containing these compositions and methods for decreasing pain or inflammation, decreasing the symptoms of an allergic condition, and/or the gastrotoxicity, nephrotoxicity, and hepatotoxicity of a pharmaceutical agent in a subject (e.g., a human) or companion animal requiring the administration of at least one composition containing omega-3 oil. The invention also provides methods for formulating an anti-inflammatory agent to increase its absorption rate requiring the mixing of omega-3 oil with the anti-inflammatory agent and methods of concentrating an omega-3 oil.Type: ApplicationFiled: September 15, 2011Publication date: February 20, 2014Inventor: Harry J. Leighton
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Publication number: 20140044693Abstract: Some aspects of the invention provide for a method of treating Wet and/or Dry Age-related Macular Degeneration, Retinitis Pigmentosa, Diabetic Retinopathy, cataracts, and/or Stargardt Disease using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: ApplicationFiled: April 24, 2012Publication date: February 13, 2014Applicant: RETROTOPE, INC.Inventor: Mikhail S. Shchepnov
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Publication number: 20140044692Abstract: Some aspects of the invention provide for a method of treating Impaired Energy Processing Disorders and Mitochondrial Deficiencies using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.Type: ApplicationFiled: April 24, 2012Publication date: February 13, 2014Applicant: RETROTOPE, INC.Inventor: Mikhail S. Shchepinov
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Publication number: 20140044661Abstract: Provided are polyglyceryl compositions comprising one or more polyglyceryl compounds having: (a) a node structure comprising at least three contiguous glyceryl remnant units; (b) one or more cationic groups each linked to the node structure by an independently selected linking group; and (c) one or more hydrophobic moieties each independently (i) linked to the node structure by a linking group, or (ii) constituting a portion of one of the one or more cationic groups, wherein the composition has an average degree of polymerization determined by hydroxyl value testing (DPOH) of from about 3 to about 20. Also provided are polyglyceryl compounds which may compose such compositions, and uses of the polyglyceryl compositions and compounds.Type: ApplicationFiled: October 23, 2013Publication date: February 13, 2014Applicant: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.Inventors: Michael J. Fevola, Frank C. Sun, Stacey E. York
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Patent number: 8648061Abstract: The use of polyunsaturated fatty acids of the ?-3 series such as eicosapentaenoic acid (EPA, C20:5 ?-3), docosahexaenoic acid (DHA, C22:6 ?-3), or their pharmaceutically acceptable derivatives is described for the primary prevention of major cardiovascular events in subjects who have not undergone previous infarct episodes.Type: GrantFiled: September 29, 2009Date of Patent: February 11, 2014Assignee: Pro Aparts Investimentos E. Consultoria LDA.Inventor: Hajime Shibuya
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Patent number: 8642077Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: February 15, 2013Date of Patent: February 4, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20140031426Abstract: The present invention relates generally to the field of lipids and in particular aims at improving lipid absorption, for example under conditions of lipid maldigestion or malabsorption. One embodiment of the present invention relates to a composition comprising sn-1(3) monoacylglycerols, wherein the sn-1 or sn-3 position is occupied by an acyl group such as a fatty acid and the sn-2 position remains unoccupied. The fatty acid may be one with anti-inflammatory properties.Type: ApplicationFiled: April 3, 2012Publication date: January 30, 2014Applicant: NESTEC S.A.Inventors: Frederic Destaillats, Cristina Cruz-Hernandez, Fabiola Dionisi, Isabelle Masserey-Elmelegy, Manuel Oliveira, Julie Moulin
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Patent number: 8637570Abstract: A pharmaceutical composition comprising a docusate; an osmotic laxative; and a benzoate.Type: GrantFiled: December 5, 2008Date of Patent: January 28, 2014Assignee: Ferring International Center S.A.Inventors: Klaus Jensen, Soren Halskov, Henning Lund
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Patent number: 8637056Abstract: Mixture comprising esters of saturated C16-C18 fatty acid and unsaturated C16-C18 fatty acids with 2-ethyl-hexyl alcohol, said esters being in an amount ranging from 90% to 100% by weight with respect to the total weight of the mixture. The cosmetic compositions containing such a mixture formulated in topical form have a moisturizing, emollient, elasticizing and skin compactness and smoothness improving action.Type: GrantFiled: October 15, 2009Date of Patent: January 28, 2014Assignee: Hallstar Italia S.R.L.Inventors: Sergio Amari, Edoardo Pallucca
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Patent number: 8632795Abstract: The present invention relates to a device in the form of a container made of a polymer material, which container has one or more sealed chambers, each of which comprise a liquid pheromone comprising 2-ethyl-1,6-dioxaspiro[4,4]nonane, methyl 2,4-decadiene-carboxylate and at least one alcohol selected among 2-methylbut-3-en-2-ol and 2-methylbut-3-yn-2-ol, where at least 50% of the area of the walls forming the chambers have a wall thickness in the range of from 0.1 to 1 mm and the polymer material which forms the chamber is at least in those areas an uncoated vinyl acetate/ethylene copolymer with a vinyl acetate content in the range of from 10 to 17% by weight. The invention also relates to a method of combating and for monitoring the swarming behavior of the species Pityogenes chalcographus, generally also referred to as spruce wood engraver or six-dentated bark beetle.Type: GrantFiled: November 30, 2005Date of Patent: January 21, 2014Assignee: BASF SEInventors: Thomas Zühlke, Jürgen Jentzsch, Ulf Baier, Hansjochen Schroeter
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Patent number: 8632792Abstract: A cooling sensation agent composition with a prolonged cool sensation effect is provided comprising at least one compound selected from the group consisting of aceia or ketal derivatives of 3-(1-menthoxy)propan-1,2-diol represented by Formula (1), single or mixed carbonic esters ol one or two kinds ol alcohols represented by Formula (2), and carboxylic esters represented by Formula (4). A sensory stimulation agoni composition, a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent; and new compounds are also provided.Type: GrantFiled: April 1, 2009Date of Patent: January 21, 2014Assignee: Takasago International CorporationInventors: Kenya Ishida, Takashi Aida, Tetsuya Yamamoto
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Patent number: 8629180Abstract: A novel antiseptic agent composition which has a wide antimicrobial spectrum and excellent antiseptic properties is provided. An antiseptic agent composition A contains a glycerin hydroxy fatty acid monoester that is an ester of glycerin and a hydroxy fatty acid having 8 to 18 carbon atoms, and a specific antiseptic agent such as an alkanediol. An antiseptic agent composition B contains the glycerin hydroxy fatty acid monoester and an aromatic antiseptic agent. An antiseptic agent composition C contains the glycerin hydroxy fatty acid monoester and a chelating agent.Type: GrantFiled: January 18, 2010Date of Patent: January 14, 2014Assignee: Taiyo CorporationInventors: Shuji Kanatani, Soota Iwamoto
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Patent number: 8623916Abstract: The present invention relates to compounds of the following formula (I): where n is an integer between 1 and 15, m is 0, 1, 2 or 3, and R is the hydrocarbon chain of a polyunsaturated fatty acid selected from among omega 3 and omega 6, as well as to pharmaceutical or cosmetic compositions containing same, to a method for preparing and using same, in particular for treating acne and seborrhoeic dermatitis.Type: GrantFiled: December 21, 2009Date of Patent: January 7, 2014Assignee: Pierre Fabre Dermo-CosmetiqueInventors: Daniel Redoules, Sylvie Daunes-Marion, Marie-Françoise Aries
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Patent number: 8623406Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: February 15, 2013Date of Patent: January 7, 2014Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20140005264Abstract: In various embodiments, the present invention provides methods of treating and/or preventing pediatric metabolic syndrome comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: ApplicationFiled: June 27, 2013Publication date: January 2, 2014Inventor: Paresh Soni
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Publication number: 20140004183Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease in a statin-intolerant subject in need thereof and, in particular, a method of blood lipid therapy in a statin-intolerant subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: ApplicationFiled: June 27, 2013Publication date: January 2, 2014Inventors: Paresh Soni, Rene Braeckman, William Stirtan
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Patent number: 8618166Abstract: The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.Type: GrantFiled: July 2, 2012Date of Patent: December 31, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Patent number: 8617610Abstract: Disclosed are compositions including powdered green tea extract and a powdered preparation comprising polyunsaturated fatty acids. Also disclosed are methods of preparing the compositions and using the compositions in food products, as well as food products containing or that are prepared from the compositions.Type: GrantFiled: May 21, 2012Date of Patent: December 31, 2013Assignee: DSM Nutritional Products AGInventors: Amber Lynn Gareau, Sharon Ann Spurvey Pittman, Lariza Beristain Taboada
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Patent number: 8617594Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: February 26, 2013Date of Patent: December 31, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8617593Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: February 15, 2013Date of Patent: December 31, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8618165Abstract: Compounds of formula (I); wherein R1 and R2 are the same or different and may be selected from the group consisting of a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and X represents a carboxylic acid group, a carboxylate group, or a carboxamide group; or any pharmaceutically acceptable salt, solvate, complex or pro-drug thereof, with the provisos that the compound of formula (I) is not (all-Z)-4,7,10,13,16,19-docosahexaenoic acid (DHA), alpha-methyl DHA, alpha-methyl DHA methyl ester, alpha-methyl DHA ethyl ester or alpha-hydroxy DHA ethyl ester, are disclosed. A fatty acid composition and a pharmaceutical composition comprising such compounds are also disclosed.Type: GrantFiled: September 6, 2011Date of Patent: December 31, 2013Assignee: Pronova Biopharma Norge ASInventors: Morten Bryhn, Jan Kopecky, Anne Kristin Holmeide