Z Radical Contains Carbon To Carbon Unsaturation Patents (Class 514/549)
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Publication number: 20130137768Abstract: The present invention relates to the docosahexaenoatepanthenyl of the following formula: It also relates to a method for preparing same and to a pharmaceutical composition comprising same and to the use of same in the treatment or the prevention of cardiovascular diseases, in particular atrial fibrillation.Type: ApplicationFiled: August 11, 2011Publication date: May 30, 2013Applicant: PIERRE FABRE MEDICAMENTInventors: Frédérique Lantoine-Adam, Robert Letienne, Elisabeth Dupont-Passelaigue
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Publication number: 20130137767Abstract: The present invention is directed to methods and compositions for treating arthritis in a subject, comprising administering about 430 mg to about 12.4 g of docosahexaenoic acid (DHA) per day in a dosage form to the subject in need thereof, wherein the dosage form is substantially free of eicosapentaenoic acid (EPA) and substantially free of non-alpha tocopherol.Type: ApplicationFiled: February 2, 2011Publication date: May 30, 2013Applicant: DSM IP ASSETS B.V.Inventors: Julie Nauroth, Melissa Olson, Norman Salem, John Paul Zimmer
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Publication number: 20130131170Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: ApplicationFiled: November 7, 2012Publication date: May 23, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventor: AMARIN PHARMACEUTICALS IRELAND LIMITE
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Publication number: 20130131171Abstract: A jojoba formulation has been developed for administration to the meibomian gland, for treatment of the symptoms of dry eye, and/or for drug delivery to the meibomian gland. The formulation incorporates the natural product jojoba wax, or components thereof, to enhance the spreading of the artificial tear as well as stabilize the tear film. The jojoba wax tear relieves irritation and discomfort as well as sharpens the blurred vision. Jojoba, because of its close chemical and physical properties to meibomian gland secretions, is effective upon topical application to penetrate the lid margin to reach the gland tissues where it may exert a therapeutic effect with or without an adjunctive agent.Type: ApplicationFiled: January 17, 2013Publication date: May 23, 2013Applicant: MELBJ HOLDINGS, LLCInventor: MELBJ Holdings, LLC
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Patent number: 8445013Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: GrantFiled: September 13, 2012Date of Patent: May 21, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8445003Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular related diseases.Type: GrantFiled: April 27, 2012Date of Patent: May 21, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8440650Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: December 11, 2012Date of Patent: May 14, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Breackman, Paresh Soni
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Patent number: 8435643Abstract: The present invention provides antisapstain compositions comprising a haloalkynyl compound, an azole and an unsaturated carboxylic or sulphonic acid. The compositions of the invention are surprisingly effective at protecting wood and other cellulosic substrates, in particular at providing antisapstain activity. The invention also provides methods for treating wood and other cellulosic substrates with said compositions.Type: GrantFiled: October 28, 2010Date of Patent: May 7, 2013Assignee: Arch Timber Protection LimitedInventors: Paul Stuart Warburton, Lee Mason, Andrew Stewart Hughes
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Patent number: 8436196Abstract: The present invention aims to provide a novel type I natural ceramide derivative having a structure more similar to that of a type I natural ceramide composed of sphingosine and an ?-acyloxy long-chain carboxylic acid; and a method for producing the same. The derivative is provided by reacting an ?-acyloxy long-chain fatty acid derivative with dihydrosphingosine or a salt thereof. The thus produced novel type I natural ceramide derivative, when combined with other ceramides, can significantly improve the compatibility of ceramides, which facilitates preparation of a composition containing ceramides, such as a moisturizer or a cosmetic, and also increases the storage stability of the composition.Type: GrantFiled: September 30, 2009Date of Patent: May 7, 2013Assignee: Kaneka CorporationInventors: Tatsuyoshi Tanaka, Kazumi Okuro
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Publication number: 20130108564Abstract: The present invention relates to compounds having general formula (I): CH3—(CH?CH)n—R??(I) where: n=3, 5, 7; R is chosen from —CH2—O—CO—R?, —CO—OR? or —CO—O(?), R? is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.Type: ApplicationFiled: July 15, 2011Publication date: May 2, 2013Applicant: GIULIANI S.P.A.Inventors: Giammaria Giuliani, Ralf Paus, Yuval Ramot, Astrid Becker, Sergio Baroni
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Patent number: 8431560Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: December 11, 2012Date of Patent: April 30, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8426399Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: September 10, 2012Date of Patent: April 23, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8415335Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: January 12, 2012Date of Patent: April 9, 2013Assignee: Amarin Pharmaceutical Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8410086Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.Type: GrantFiled: October 13, 2011Date of Patent: April 2, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Publication number: 20130079293Abstract: Isolated compounds from adelostemma gracillimum refined fractions and compositions containing the compounds are provided by the present invention. Adelostemma gracillimum refined fractions and the extraction process thereof are also provided by the present invention. The uses of the compounds and the adelostemma gracillimum refined fractions for inhibiting the activities of NMDA receptor or amyloid-beta peptide, for improving memory, and for treating neurodegenerative diseases, neuropathological conditions or epilepsy are further provided by the present invention.Type: ApplicationFiled: March 18, 2011Publication date: March 28, 2013Applicant: BIOTECHNOLOGY RESEARCH CORPORATION LIMITEDInventors: Nancy Yuk-yu Ip, Fanny Chui-Fun Ip, Shengjun Guo
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Patent number: 8399446Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: September 11, 2012Date of Patent: March 19, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8399514Abstract: Provided are certain methods of screening, identifying, and evaluating neuroprotective compounds useful for treatment of neurological diseases, such as, e.g., multiple sclerosis (MS). The compounds described upregulate the cellular cytoprotective pathway regulated by Nrf2. Also provided are certain methods of utilizing such compounds in therapy for neurological disease, particularly, for slowing or reducing demyelination, axonal loss, or neuronal and oligodendrocyte death.Type: GrantFiled: February 13, 2012Date of Patent: March 19, 2013Assignee: Biogen Idec MA Inc.Inventors: Matvey E. Lukashev, Gilmore O'Neill
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Publication number: 20130065956Abstract: Provided are composition and/or methods useful in preventing onset and/or recurrence of cardiovascular events, especially in patients who have escaped the unstable period after cardiovascular angioplasty or in hyperlipidemia patients who have been treated with HMG-CoA RI.Type: ApplicationFiled: November 8, 2012Publication date: March 14, 2013Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventor: MOCHIDA PHARMACEUTICAL CO., LTD.
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Publication number: 20130059911Abstract: There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.Type: ApplicationFiled: November 1, 2012Publication date: March 7, 2013Applicant: Centre de Recherche sur les Biotechnologies MarinesInventor: Centre de Recherche sur les Biotechnologies Mari
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Publication number: 20130058882Abstract: A personal care composition which has an ethylenic monomer having a molecular weight of 500 g/mole or less and a compound selected from the group consisting of 2-tert-butyl-4-hydroxy-anisole, 3-tert-butyl-4-hydroxy-anisole, and mixtures thereof. The compound is present in the personal care composition in an amount of from about 1 milligram to about 1000 milligram per kilogram of the ethylenic monomer.Type: ApplicationFiled: August 30, 2012Publication date: March 7, 2013Inventors: Andreas FLOHR, Thomas Kripp, Curtis Bobby Motley
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Publication number: 20130053441Abstract: A compound represented by the following formula (I?) wherein X1 is a methylene group, an ethylene group, a trimethylene group or a vinylene group, X2 is a divalent group represented by the following formula A or B, Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=0 to 8, R1 and R2 are each independently a hydrogen atom, a methyl group or an ethyl group, provided that when X1 is a methylene group, then X2 is not a divalent group represented by the formula A, and when X1 is a vinylene group, then X2 is not a divalent group represented by the formula A. The compound is a stable capsinoid derivative, and is useful as an active ingredient of an external blood circulation enhancer or a cosmetic composition, a pharmaceutical composition, or a food composition.Type: ApplicationFiled: June 26, 2012Publication date: February 28, 2013Applicant: AJINOMOTO CO., INC.Inventors: YUSUKE AMINO, YOSHINOBU TAKINO
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Patent number: 8383678Abstract: A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterized in that the capsule comprises gelatin extracted by an extraction process comprising acid pre-treatment of a collagen source. One advantage of the present invention over a soft gelatin capsule containing the same formulation but comprising gelatin extracted by an extraction process comprising alkali pre-treatment of the collagen source is that the present invention does not harden significantly over time and thus has a longer shelf life.Type: GrantFiled: January 5, 2011Date of Patent: February 26, 2013Assignee: Chrysalis Pharma AGInventors: Jean-Pierre Sachetto, Roly Bufton, Thomas Buser
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Patent number: 8383677Abstract: A nerve-regenerating agent comprising, as an active ingredient, arachidonic acid and/or a compound containing arachidonic acid as a constituent fatty acid.Type: GrantFiled: December 27, 2007Date of Patent: February 26, 2013Assignees: Suntory Holdings Limited, Tohoku UniversityInventors: Masanori Kontani, Yoshiyuki Ishikura, Noriko Oosumi, Motoko Maekawa
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Publication number: 20130046016Abstract: The present invention relates to a method of lowering cholesterol in a patient in need thereof by administering to said patient a therapeutic effective amount of a compound selected from the group of Dihydroxyacetone phosphate (DHAP); 1-acyl-DHAP; 1-alkyl-DHAP; 1-alkyl-glyceraldehyde-3-phosphate (G3P); 1-alkyl, 2-acyl-G3P; 1-alkyl, 2-acyl-glycerol; 1-alkyl,2-acyl-glycerylphosphatidylethanolamine (GPE), 1-alkyl, diacyl glycerol (sn-1=16:0, sn-2=docosohexaenoic acid (DHA); sn-3=DHA) (sn-1 position has an alkyl ether bond, sn-2 and sn-3 positions have acyl bonds); 1-alkyl diacyl glycerol (sn-1=16:0, sn-2=18:1, sn-3=18:1) (sn-1 position has an alkyl ether bond, sn-2 and sn-3 positions have acyl bonds); triacyl glycerol (sn-1=16:0, sn-2=DHA, sn-3=DHA) (all three positions have acyl bonds); and triacyl glycerol (sn-1=16:0, sn-2=18:1, sn-3=18:1) (all three positions have acyl bonds) and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: June 18, 2012Publication date: February 21, 2013Applicant: PHENOMENOME DISCOVERIES INC.Inventor: Dayan Burke GOODENOWE
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Patent number: 8377920Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: September 20, 2012Date of Patent: February 19, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130039872Abstract: The present invention relates to a process for the preparation of an ester in a reactor, a device, a process for the preparation of a thermoplastic composition comprising the ester prepared according to the invention, a process for the production of a shaped article comprising the ester according to the invention or the thermoplastic composition according to the invention, a process for the production of a packed product, a process for the production of an at least partly coated object, and uses of the esters according to the invention as an additive in various compositions.Type: ApplicationFiled: December 30, 2010Publication date: February 14, 2013Inventors: Peter Daute, Wilhelm Reiners, Martin Schäfer, Udo Frerichs, Hinrich Hildebrandt, Joern Ellerbrake
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Publication number: 20130040913Abstract: The present invention provides a kit for the dietary management of cardiovascular patients with cardiovascular disease who are deficient in blood Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) levels, the kit including a diagnostic assay for determining blood levels of EPA, DHA and Docosapentaenoic acid (DPA) and a pharmaceutical grade prescription medical food omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight including a combination of EPA, DPA and DHA in a weight ratio of EPA:DHA of from 5.7 to 6.3, wherein the sum of the EPA, DHA and DPA are about 82% by weight of the total formulation and about 92% of the total omega 3 fatty acid content of the composition. The kit may further contain instructions for use of its components.Type: ApplicationFiled: August 13, 2012Publication date: February 14, 2013Applicant: PIVOTAL THERAPEUTICS INC.Inventors: George JACKOWSKI, Rachelle MACSWEENEY, Nisar SHAIKH, Jason YANTHA, Valerie SCHINI-KERTH
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Publication number: 20130034535Abstract: Combinations of one or more anti-obesity drugs with mixtures of an omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight comprised of a combination of Eicosapentaenoic acid (EPA), Docosapentaenoic acid (DPA) and Docosahexaenoic acid (DHA) in a weight ratio of EPA:DHA of from 5.7 to 6.3, wherein the sum of the EPA, DHA and DPA comprise about 82% by weight of the total formulation and about 92% of the total omega 3 fatty acid content of the composition for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics.Type: ApplicationFiled: August 13, 2012Publication date: February 7, 2013Applicant: PIVOTAL THERAPEUTICS INC.Inventors: George JACKOWSKI, Rachelle MACSWEENEY, Nisar SHAIKH, Jason YANTHA, Valerie SCHINI-KERTH
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Patent number: 8367652Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: September 11, 2012Date of Patent: February 5, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Patent number: 8357677Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: GrantFiled: September 10, 2012Date of Patent: January 22, 2013Assignee: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130017256Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: ApplicationFiled: September 20, 2012Publication date: January 17, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130011471Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: ApplicationFiled: September 13, 2012Publication date: January 10, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130011472Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: ApplicationFiled: September 13, 2012Publication date: January 10, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130011468Abstract: This invention relates to the use of a fatty acid composition comprising at least (all-Z omega-3)-4,7,10,13,16,19-docosahexaenoic acid (DHA), or derivatives thereof, and (all-Z omega-3)-5,8,11,14,17-eicosapentaenoic acid (EPA), or derivatives thereof for manufacturing of a medicinal product or a food stuff for the treatment and/or prevention of amyloidos-related diseases, such as Alzheimer's disease, as well as treatment/prevention of cognitive dysfunction.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Inventor: Morten BRYHN
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Publication number: 20130012580Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.Type: ApplicationFiled: January 26, 2012Publication date: January 10, 2013Applicant: AMARIN PHARMA, INC.Inventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Patent number: 8349896Abstract: Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with diseases, including ischemia.Type: GrantFiled: February 17, 2010Date of Patent: January 8, 2013Assignee: The Brigham and Womens's Hospital, Inc.Inventors: Charles N. Serhan, Clary B. Clish
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Publication number: 20130004567Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: ApplicationFiled: September 10, 2012Publication date: January 3, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130005805Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.Type: ApplicationFiled: June 13, 2012Publication date: January 3, 2013Inventors: Annabelle Gallois-Bernos, Frank F. Molock, JR., Carrie L. Davis, Kathrine Osborn Lorenz, James K. Young, Kristy L. Canavan, Fang Lu
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Publication number: 20130005757Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising EPA and one or more cardiovascular agents, and to therapeutic methods for treating various diseases and disorders using the same.Type: ApplicationFiled: July 2, 2012Publication date: January 3, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni, Mehar Manku
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Publication number: 20130005693Abstract: The subject invention concerns the reduction of protein aggregation in the neurons of a mammal through the use of a ketogenic treatment such as a ketogenic diet, a physical training regimen and/or administration of agents to increase fatty acid oxidation. Such ketogenic treatment can be useful in the reduction of certain aggregates including amyloid ? peptide, polyglutamine containing huntintin protein, polyglutamine containing androgen receptor, polyglutamine containing atrophin-1, polyglutamine containing ataxins, ?-synclein, prion protein, tau and superoxide dismutase 1 (SOD1).Type: ApplicationFiled: September 10, 2012Publication date: January 3, 2013Applicant: ACCERA, INC.Inventor: Samuel T. Henderson
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Publication number: 20130004566Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereofType: ApplicationFiled: September 10, 2012Publication date: January 3, 2013Applicant: Amarin Pharmaceuticals Ireland LimitedInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130004572Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.Type: ApplicationFiled: September 13, 2012Publication date: January 3, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130005691Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a polyol wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.Type: ApplicationFiled: June 13, 2012Publication date: January 3, 2013Inventor: Annabelle Gallois-Bernos
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Publication number: 20130004568Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: ApplicationFiled: September 11, 2012Publication date: January 3, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130005809Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.Type: ApplicationFiled: September 11, 2012Publication date: January 3, 2013Applicant: AMARIN PHARMACEUTICALS IRELAND LIMITEDInventors: Mehar Manku, Ian Osterloh, Pierre Wicker, Rene Braeckman, Paresh Soni
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Publication number: 20130004444Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.Type: ApplicationFiled: December 15, 2010Publication date: January 3, 2013Inventors: Caroline Baudouin, Philippe Msika
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Publication number: 20120329866Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.Type: ApplicationFiled: May 23, 2012Publication date: December 27, 2012Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATIONInventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
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Publication number: 20120329852Abstract: Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.Type: ApplicationFiled: September 5, 2012Publication date: December 27, 2012Inventors: Mitsuhiro YOKOYAMA, Hideki Origasa, Masunori Matsuzaki, Yuji Matsuzawa, Yasushi Saito
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Publication number: 20120316237Abstract: It is an object of the present invention to provide a pest control composition capable of exerting a high effect on pests such as spider mites and aphids even at low concentration using a food/food additive with high safety to the human body and the environment. The present inventors have intensively studied to solve the above problem and found that, among polyglycerol fatty acid esters widely used as a food additive, a composition containing a polyglycerol fatty acid ester which has an HLB of 5 or less and is liquid at ordinary temperature and also a nonionic surfactant has a high effect on pests even at low concentration, and that the possibility for pests to develop resistance to the composition is extremely low, and the present invention has been completed.Type: ApplicationFiled: February 22, 2011Publication date: December 13, 2012Applicant: Nippon Kayaku Kabushiki KaishaInventors: Takeshi Suzuki, Takaaki Miyake, Kazuteru Ogawa
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Patent number: 8329747Abstract: There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.Type: GrantFiled: August 4, 2009Date of Patent: December 11, 2012Assignee: Centro de Recherche sur les Biotechnologies MarinesInventor: Samuel Fortin