Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.

Abstract: The present invention provides a fungicidal fertilizer composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form of a dry blend formulation remains non-caking and free-flowing under storage conditions. Illustrative of an invention fungicide composition is a formulation which has a content of sodium bicarbonate, potassium bicarbonate, potassium oleate, xanthan gum and a fertilizer-effective content of nitrogen, phosphorus and potassium elements. The combination of potassium oleate and xanthan gum functions as an effective spreader-sticker and film-forming medium when the composition is diluted with water for agricultural applications. When the aqueous medium is hard water, calcium oleate is formed which enhances the sticker properties of the aqueous fungicide composition in agricultural applications.

Abstract: Animal feed or human food which contains added conjugated linoleic acids (CLA) can enhance growth and prevent anorexia and weight loss due to immune stimulation (e.g., endotoxin exposure) and the adverse effects of catabolic hormones (i.e., IL-1). Methods of treatment using CLA also are disclosed.

Abstract: This invention provides a high purity particulate fatty acid salt product, which is a calcium salt derivative of a fatty acid mixture such as those obtained from vegetable oil and animal tallow sources.In a preferred embodiment, the invention fatty acid calcium salt product is substantially free of glyceride ingredient and odorant impurities, and optionally contains a flavor and aroma enhancing additive.

Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.

Abstract: Cosmetic compositions are described wherein .alpha.-hydroxyacids, .alpha.-ketoacids and related compounds are formed into amine salts through neutralization with a multi-amine functionalized polymer. Particularly preferred are glycolic acid and lactic acid salts of poly(ethylenimine).

Abstract: The present invention provides a method for controlling fungal disease in plants with a fungicidal fertilizer composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. Illustrative of an invention composition is an aqueous solution which has a content of two alkali metal bicarbonate salts, an alkali metal fatty acid salt, and a water-soluble thickener such as xanthan gum. The combination of fatty acid salt and thickener functions as an effective spreader-sticker medium.

Abstract: Disclosed herein are compositions comprisinga) at least one 3-isothiazolone of the formula (I) ##STR1## wherein Y is an unsubstituted or substituted (C.sub.1 -C.sub.18) alkyl, an unsubstituted or substituted (C.sub.3 -C.sub.12) cycloalkyl, an unsubstituted or halogen-substituted (C.sub.2 -C.sub.8) alkenyl or alkynyl, an unsubstituted or substituted (C.sub.7 -C.sub.10) aralkyl, or an unsubstituted or substituted aryl; andR and R.sup.1 is each independently H, halogen or (C.sub.1 -C.sub.4) alkyl; andb) a carbonyl compound selected from the group consisting of (C.sub.2 -C.sub.6) aldehydes, (C.sub.7 -C.sub.10) aromatic aldehydes or acids, (C.sub.2 -C.sub.4) dialdehydes, (C.sub.1 -C.sub.12) acids, (C.sub.2 -C.sub.8) diacids, triacids or tetracids, (C.sub.3 -C.sub.10) .alpha.,.beta. unsaturated carbonyls, (C.sub.1 -C.sub.6) haloamides of the formula ##STR2## where R.sub.1 =phenyl or (C.sub.1 -C.sub.4)alkyl, substituted phenyl,R.sub.2 =(C.sub.1 -C.sub.7)alkyl, (C.sub.1 -C.sub.7)alkoxylalkyl, or (C.sub.1 -C.sub.

Abstract: The present invention pertains to reducing milk fat levels optionally to enhancing overall milk yields in ruminants by administration of trans-fatty acids, trans-fatty acid salts, amides, and triglycerides containing trans-fatty acid substituents. The invention also pertains to a method of identifying those trans-fatty acids, trans-fatty acid salts, amides, and triglycerides containing trans-fatty acid substituents which reduce milk fat levels and may also enhance milk yields, and designing ruminant diets containing such trans-fatty acids, salts, or triglycerides.

Abstract: The present invention provides an aqueous antimicrobial composition containing one or more essential oils which exhibit antimicrobial properties and which can be combined with a water carrier and a solubilizing or dispersing agent to form a solution or a dispersion of the essential oil in the water carrier, said essential oil exhibiting antimicrobial properties when incorporated in said water carrier.

Abstract: A wood preservative composition including a mixture of two or more metallic soaps of long chain unsaturated fatty acids, which soaps have a metallic component selected from the group consisting of copper, zinc, chromium, iron, antimony, tin, cobalt, nickel, arsenic, boron, lead, magnesium, potassium and sodium, and a fatty acid component selected from two or more of the group consisting of oleic acid, linoleic acid, and linolenic acid, the composition being such that the ratio by mass of metallic soap of oleic acid:metallic soap of linoleic acid:metallic soap of linolenic acid is about 20-29:15-70:0-47.

Abstract: A coating composition for application to tree wounds, such as pruning wounds of living trees is provided. The composition is non-phytotoxic and provides extended protection against fungal pathogens. The coating composition comprises a liquid carrier together with a fatty acid metal salt active ingredient. Exemplary fatty acid metal salts include those prepared from alpha monocarboxylic acids having from 4 to 18 carbon atoms and a compound containing a metal selected from the group consisting of calcium, copper, iron, magnesium, and zinc. Various additives can be included within the composition, including gum-like substances and binders suitable to facilitate the adhesion of the active ingredient to the tree surface, as well as defoaming agents and other formulation enhancing agents.

Abstract: Synthetically prepared pheromone compositions, prepared from various mixtures of (Z)-3,3-dimethyl-.DELTA..sup.1,.beta. -cyclohexane ethanol, (E)-3,3-dimethyl .DELTA..sup.1,.beta. -cyclohexane ethanol, (Z)-3,3-dimethyl-.DELTA..sup.1,.alpha. -cyclohexane acetaldehyde, (E)-3,3-dimethyl-.DELTA..sup.1,.alpha. -cyclohexane acetaldehyde, (E)-3,7-dimethyl-2,6-octadienoic acid, and (E)-3,7-dimethyl-2,6-octadien-1-ol were found to be attractive to both male and female pepper weevils. The compositions will greatly enhance pepper growers' ability to control these destructive pests.

Abstract: Fatty acid sanitizer concentrates and diluted final solutions are provided which include individual amounts of germicidally effective fatty acid, hydrotrope, strong acid selected from the group consisting of phosphoric and sulphuric acid sufficient to lower the pH of the final solutions to about 1-5, and a concentrate stabilizing weak acid component selected from the group consisting of propionic, butyric and valeric acids and mixtures thereof. The concentrate stabilizing component enhances the room and low temperature phase stability of the concentrates, even when used at very low levels typically ranging from 3.5%-15% by weight. Preferably, the fatty acid is a mixture of nonanoic and decanoic acids, whereas the strong acid is selected from the group consisting of orthophosphoric, sulfuric and mixtures thereof. Alternately, stable concentrates and use dilutions can be provided using undecylenic acid, either alone or in combination with other fatty acids.

Abstract: Bathing preparations comprising a soluble aluminum carboxylate exhibit excellent dissolvability into bath water, and give a refreshing sensation to users during bathing and after bathing.

Abstract: Described herein is the use of a substantially pure form of an oxidized polyamine, and especially spermine dialdehyde, in the treatment of tissue grafts or other organs for transplantation. The compounds and treatment are especially useful in treating grafts for bone marrow transplants, whether they be allogeneic or autograft transplants.

Abstract: The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.

Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.

Abstract: This invention is a burn remedial composition which is produced by mixing powder of the high heated abalone shells with sesame oil extracted from sesame, and its production method wherein it is characteristic that the grinding process of abalone shells heated at a temperature higher than 3000.degree. C. and the mixing process of the ground abalone shell powder and sesame oil are not performed in a stone or metallic vessel, but in a wooden vessel. A pharmaceutical additive can be added to aid the formation of a pharmaceutical type of burn remedial composition. When the burn remedial composition of the invention is applied to every degree of heat burn and fire burn for which there are few curing agents, especially to severe burns, the analgesic and antiphlogistic effects happen at that moment, the toxic materials in the injured region are eliminated within 24 hours and the injury is completely cured within 3-5 days.

Abstract: The present invention provides a tracheobronchodilator comprising 15-keto-PGEs, reduced in stimuli against bronchi and other side effects.

Abstract: A biocide composition comprising(A) 1 to 50% by weight of a biocide, and(B) 0.005-60% by weight of a biocide activator having the specific formula is provided. The biocide effect of a biocide can be enhanced with the use of an effective amount of a biocide activator.

Abstract: Storage-stable pesticide compositions comprising azadirachtin or an azadirachtin derivative as the active ingredient and an epoxide as the stabilizing agent.

Abstract: This invention provides a novel pesticide composition having a bicarbonate-containing inorganic salt ingredient which exhibits fungicidal activity, and which enhances the efficacy of a C.sub.8 -C.sub.22 fatty acid insecticidal ingredient for the treatment of agricultural and horticultural plants. An invention pesticide composition also can contain a water-soluble organic compound which functions as a compatibility enhancing agent for the active ingredients, and improves the spreadability and adhesiveness of the composition ingredients when applied to foliage as an aqueous pesticide formulation.

Abstract: Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.

Abstract: Fatty acid sanitizer concentrates and diluted final solutions are provided which include individual amounts of germicidally effective fatty acid, hydrotrope, strong acid sufficient to lower the pH of the final solutions to about 1-5, and a concentrate stabilizing weak acid component selected from the group consisting of propionic, butyric and valeric acids and mixtures thereof. The concentrate stabilizing component enhances the room and low temperature phase stability of the concentrates, even when used at very low levels typically ranging from 2.5%-15% by weight. Preferably, the fatty acid is a mixture of nonanoic and decanoic acids, whereas the strong acid is selected from the group consisting of orthophosphoric, sulfuric and mixtures thereof.

Abstract: A natural or synthetic glycerol oil which comprises at least 20% by weight, preferably at least 25% of di-linoleoyl-mono-gamma-linolenyl-glycerol (DLMG), is used to supplement foods, nutritional compositions and in skin and hair care compositions.

Abstract: Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reported group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for each detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any change of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance.

Abstract: Reduction of urinary calcium excretion in humans or animals by the administration of GLA or DGLA as much or in salt or other pharmacologically acceptable form, optionally in association with EPA, DHA or other EFA in similar forms, is also useful in the treatment of nephrocalcinosis, renal stones and osteoporosis.

Abstract: A composition is disclosed containing non-esterified fatty acids having 14-18 carbon atoms, monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms, lysophosphatidylcholine in which the fatty acid moiety has 14-18 carbon atoms and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable fats and as particles for topical application to the skin. A method of making these particles is also described.

Abstract: A peroxyacid antimicrobial concentrate and use composition is provided comprising a C.sub.1 to C.sub.4 peroxycarboxylic acid, and a C.sub.6 to C.sub.18 peroxyacid. The combination of these acids produces a synergistic effect, providing a much more potent biocide than can be obtained by using these components separately. Other components can be added to the composition such as hydrotrope coupling agents, stabilizers, etc. An effective antimicrobial use solution is formed at low concentrations when the concentrate composition is diluted with water to a pH in the range of about 2 to 8. Sanitizing of substantially fixed, "in-place" processing lines in dairies, breweries, and other food processing operations is one utility of the composition.

Abstract: Compounds and a method useful for protection of tissue cells in a mammalian body from irreversible damages due to lactic acidosis caused by oxygen deficiency. The protection is achieved by administering a compound having a cell membrane permeability and/or ability to cross the blood brain barrier and being able to provide a buffering action to prevent an increase in a hydrogen ion concentration over the physiologically acceptable levels.

Abstract: A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.

Abstract: A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying an admixture of a charged phospholipid and a non-polar oil over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters.

Abstract: A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives of linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable is utilized in a nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C-.sub.8-18 saturated fatty acids, oleic acid and derivatives of these acids, in order to induce in a mammal (including humans) at least one physiological effect selected from memory enhancement, analgesia, sleep regulation and inhibition of the symptoms of senility.

Abstract: A decongestant composition and method are provided for treatment of symptoms associated with respiratory disorders. The composition in the form of an aqueous solution which comprises aloe vera, castor oil, sodium metasilicate and calcium chloride as the essential active components. The decongestant can be topically applied to the nasal or bronchial passages from dispensers containing spray means or inhalation mist means.

Abstract: The new compositions of the invention are formed by the total acid fraction obtained by alkali hydrolysis of the lipid extracts of the fruit of Sabal serrulata. Said compositions have an effective adrenergic antagonist action and a complementary antiinflammatory action, together with a high degree of innocuity and slight side effects, making its use highly effective for combatting prostate affections and, more particularly, benign hypertrophy of the prostate.

Abstract: Disclosed is a method for preventing the transmission of an ectoparasite-borne pathogen to a mammal exposed to predation by the ectoparasite, wherein a time delay exists between attachment of the ectoparasite to the mammal and transmission of the pathogen from the ectoparasite to the mammal. The method comprises applying to the mammal an ectoparacide to kill the ectoparasite in place on the mammal, without necessarily finding or mechanically detaching the ectoparasite, at a time after the exposure of the mammal to the ectoparasite, and within the time delay, thereby preventing transmission of the pathogen from the ectoparasite to the mammal.

Abstract: Methods for increasing the total fat and therefore energy content of mammalian and particularly human milk, the essential fatty acid content of that milk and the flow of that milk during lactation, or for preventing or reducing the normal decrease in milk fat content that occurs during prolonged lactation, by administering gamma linolenic acid, dihomo-gamma-linolenic acid or their mixture, alone or a physiologically acceptable diluent or carrier, in a form administrable to the lactating female.

Abstract: The present invention discloses unique methods employing mixtures of phospholipids and neutral lipids for surfactant replacement therapy in the treatment of the various forms of respiratory distress syndrome. These compositions are shown to greatly enhance the surfactant replacement efficiency of surface-active lipids. In this regard, experimental models have shown that both the surface-tension lowering effect and rate of phospholipid absorption to an air/liquid interface are accelerated by the addition of triglycerides and/or sterols to mixtures of saturated or unsaturated phospholipids. Such compositions are therefore theorized to give new and enhanced therapeutic value to the use of surface-active lipids for surfactant replacement therapy in a subject without risk of immunogenic response. The subject methods also comprise a simple, rapid and inexpensive means for the deposition of polar lipids to a variety of air/liquid interfaces.

Abstract: A series of cytotropic heterogeneous molecular lipids (CHML) and the method of preparation thereof are disclosed in the invention. CHML provided by this invention is in molecular type, it is an activated molecular carrier of functions with orientionally penetrating into membranes or walls of the cells. It possesses the active site for binding anti-carcinogenic drugs which is water soluble, lipid soluble or gas soluble and possesses the activated portion for binding structure of membrane of cancer cells also.CHML can synergetically injure the carcinoma cells and varius verus, at the same time it can enhance the immunity of the body. These are ascertained by the animal tests and in vitro tests.CHML in this invention can kill the sarcoma cell S-180 within 50 min. and the cells of human squamous cell carcinoma of esophagus within 40 min.The rate of DNA and RNA depolymerizations in cancer cells and mortality of cancer cells are attained to 100%. These are evidenced in the vitro test also.

Abstract: This invention relates to novel diaminoalkanoic acid derivatives that inhibit platelet aggregation and thrombus formation in mammalian blood thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease and disseminated intravascular coagulation, to pharmaceutical compositions including such compounds, and to their use in inhibiting thrombus formation and platelet aggregation in mammals.

Abstract: Nutritional supplements and methods of use of the supplements to maximally stimulate gallbladder contraction in patients undergoing rapid weight loss, to prevent the build up of bilary sludge and/or gallstones.

Abstract: An environmentally compatible, non-phytotoxic anti-fungal composition is provided having an active ingredient which comprises a fatty acid metal salt having from 4 to 18 carbon atoms. The metal salt may be formed from metals including calcium, copper, magnesium, and zinc. Additional formulation enhancing agents, such as dispersants, wetting agents and gums, are typically included within the composition. The composition is advantageous in that it exhibits a residual fungicidal effect lasting up to 2 months.

Abstract: A process for the production of 5,8,11,14,17 -eicosapentaenoic acid from filamentous fungi with lactose as a substrate. Preferred filamentous fungi include Pythium ultimum, Pythium debaryanum, Pythium sp, and Pythium irregulare, the preferred lactose source being whey.

Abstract: A topical preparation for aiding in the care of minor skin irritations, such as chapping, reddening, tenderness, and the like, has as its constituents a mixture of glycerin, stearic acid, cocoa butter and boric acid blended together in a creamy base.

Abstract: Pharmaceutical formulations and adhesive-coated sheet materials for the topical and/or transdermal delivery of 1-isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine, including creams, ointments and pressure-sensitive adhesive compositions. Pharmacological methods of using the formulations and the adhesive-coated sheet materials of the invention in the treatment of viral infections.

Abstract: This invention provides an improved process for the production of fatty acid metal salts. An essential feature of the process is the use of a combination of basic alkaline earth metal and alkali metal compounds as salt-forming reagents.A product of the invention process is a fatty acid salt dietary supplement composition which contains one or more additional biologically active nutrient or medicament ingredients.

Abstract: In one embodiment this invention provides an improved process for the production of fatty acid calcium salt. An important feature of the process is the utilization of a residual effluent byproduct stream from a sodium bicarbonate manufacturing plant as the aqueous medium of the fatty acid calcium salt-forming reaction process.A product of the invention process is a fatty acid salt dietary supplement composition which contains one or more additional biologically active nutrient or medicament ingredients.

Abstract: Lipids obtained from blackcurrant seed are used for reducing thrombogenicity of blood vessels in humans.

Abstract: The present invention relates to laxative compositions comprising psyllium and sennoside wherein sennoside is dispersed in a palatable food grade fat having a melting point within the range of from about 30.degree. C. to about 50.degree. C.