Polycarboxylic Acid Patents (Class 514/566)
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Patent number: 6083498Abstract: Compositions and lures are described which provide vapor blends of acetic acid and one or more compounds selected from the group consisting of isobutanol, racemic 2-methyl-1-butanol, S-(-)-2-methyl-1-butanol, 2-methyl-2-propanol, heptyl butyrate, and butyl butyrate which function as highly effective attractants for yellowjacket wasps and paper wasps. By attracting wasps to traps or baits, the chemical attractants provide a means for detecting, surveying, monitoring, and controlling the wasps.Type: GrantFiled: March 10, 1998Date of Patent: July 4, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventor: Peter J. Landolt
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Patent number: 6063797Abstract: The use of a combination of an alpha RAR receptor-specific agonist ligand and a gamma RAR receptor-specific antagonist ligand to reduce the rate of apoptosis is disclosed.Type: GrantFiled: July 15, 1998Date of Patent: May 16, 2000Assignee: C.I.R.D. GaldermaInventors: Laszlo Fesus, Zsuzsa Szondy, Uwe Reichert
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Patent number: 6051605Abstract: This invention relates to compounds that are antagonists of dopamine D4 receptors, and to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4 receptors.Type: GrantFiled: January 29, 1999Date of Patent: April 18, 2000Assignee: Warner-Lambert CompanyInventors: Thomas Capiris, David Thomas Connor, Steven Robert Miller, Paul Charles Unangst, Lawrence David Wise
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Patent number: 6015828Abstract: This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride channels of the lung and other epithelia using genetic or chemical modification. These methods relate to the treatment of epithelia with compounds which cause activation of the channel as measured by increased probability (Po) of opening of the channel at physiologically relevant holding potentials. These methods also relate to the treatment of epithelia with gene therapy to introduce chloride channels genes with site mutations which cause activation of the channel as measured by increased probability (Po) of opening of the channel at physiologically relevant holding potentials. These treatments will reduce life-threatening complications frequently found in diseases such as cystic fibrosis. These methods of activation of chloride channels also comprise treatment of chloride channels with amidation reactions.Type: GrantFiled: May 23, 1997Date of Patent: January 18, 2000Inventor: John Cuppoletti
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Patent number: 6015792Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.Type: GrantFiled: March 13, 1998Date of Patent: January 18, 2000Assignee: Bioresearch, Inc.Inventors: Robert J. Kurtz, William D. Fuller
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Patent number: 6013660Abstract: Methods and associated compositions are provided for the effective treatment of mammalian disease conditions associated with infection by pathogenic organisms through the identification of extracellular enzymes necessary for the growth or survival of the pathogenic organism and the subsequent interference with the functional activity of the identified extracellular enzyme to an extent sufficient to significantly inhibit the growth or survival of the pathogenic organism.Type: GrantFiled: October 2, 1996Date of Patent: January 11, 2000Assignee: The Regents of the University of CaliforniaInventors: Marcus A. Horwitz, Gunter Harth
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Patent number: 6005006Abstract: Human skin is depigmented or bleached by applying thereto a compound of formula (1): ##STR1## wherein X represents COOH or the ring: ##STR2## wherein Z.sub.1, Z.sub.2 and Z.sub.3, independently of each other, are H, OR or R, R representing an optionally substituted saturated or unsaturated, linear or branched C.sub.4 -C.sub.8 -alkyl radical, or a salt, a metal complex or an ester of the compound.Type: GrantFiled: September 18, 1998Date of Patent: December 21, 1999Assignee: L'OrealInventors: Jean-Baptiste Galey, Laurent Marrot, Catherine Causse
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Patent number: 6001877Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B.sub.4.Type: GrantFiled: May 20, 1998Date of Patent: December 14, 1999Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Mitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
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Patent number: 5998475Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellant is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.Type: GrantFiled: March 20, 1997Date of Patent: December 7, 1999Inventors: Lynn Sue James, Michael A. Siedman
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Patent number: 5993863Abstract: The present invention aims at providing an alimentative infusion liquid which has improved stability and preservability and can be administered through a peripheral vein. The infusion liquid contains sugars, amino acids, electrolytes and a fat emulsion at a specific mixing ratio and has a specific pH value and a titratable acidity. The alimentative infusion liquid of the present invention containing the above-described components has good preservability without suffering from precipitation, denaturation and the like problems. Further, since the pH value is adjusted to a specific level and the titratable acidity is retained low, administration of the infusion liquid through a peripheral vein does not cause troubles such as angialiga.Type: GrantFiled: October 7, 1997Date of Patent: November 30, 1999Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Masahiro Kikuchi, Yoshihiko Okutani, Tadaaki Inoue, Ryoichiro Murashima, Shunichi Abe, Hiroshi Koshiba, Hiroshi Shibata, Shunichiro Ishii, Yoshiyasu Kawabata, Kazumasa Yokoyama
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Patent number: 5993864Abstract: A novel chelate complex allows the formation of stable solutions of molecular chlorine dioxide. The chelate complexes are composed of the electron-deficient chlorine dioxide molecule, which can accept an electron, and a chelating agent, which can contribute its available electrons to the accepting orbital of the chlorine dioxide molecule. Both active and passive methods of releasing the chlorine dioxide from such chelates by competitive displacement with selected metal cations are presented. In this manner a stabilized solution of molecular chlorine dioxide can be stored until needed and the chlorine dioxide released at time of use for cleaning, disinfection or other uses.Type: GrantFiled: July 11, 1997Date of Patent: November 30, 1999Inventor: Robert D. Kross
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Patent number: 5968980Abstract: The present invention relates to compounds represented by the formula [I] and salts thereof, wherein R.sup.1 and R.sup.5 each represents carboxyl, phosphonic or a derivative thereof; R.sup.2 represents hydrogen, lower alkyl, (substituted) phenyl lower alkyl, lower alkoxy or (substituted) phenyl lower alkoxy; R.sup.3 represents lower alkyl or (substituted) phenyl lower alkyl; and R.sup.4 represents a group represented by the formula [XI], [XII] or [XIII]. The compounds of the present invention have endopeptidase 24.11 inhibitory activity and are useful for treating cardiovascular diseases such as heart failure and hypertension, renal diseases such as renal failure, gastroenteric disorders such as diarrhea and hyperchlorhydria, endocrine and metabolic diseases such as obesity, and autoimmune diseases such as rheumatic disease, and for mitigating myosalgia, migraine, etc.Type: GrantFiled: June 3, 1997Date of Patent: October 19, 1999Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Yoichi Kawashima, Ken-ichi Fujimura, Hiroshi Suhara, Noriyoshi Yamamoto, Hiromi Matsumoto, Nobuaki Miyawaki, Yuko Fujita
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Patent number: 5952314Abstract: An enteral nutritional product for a person having ulcerative colitis contains in combination (a) an oil blend which contains eicosapentaenoic acid (20:5n3) and/or docosahexaenoic acid (22:6n3), and (b) a source of indigestible carbohydrate which is metabolized to short chain fatty acids by microorganisms present in the human colon. Preferably the nutritional product also contains one or more nutrients which act as antioxidants.Type: GrantFiled: May 22, 1998Date of Patent: September 14, 1999Inventors: Stephen Joseph DeMichele, Keith Allen Garleb, John William McEwen, Martha Kay Fuller
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Patent number: 5932229Abstract: Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin conditions using these compounds and compositions. ##STR1## wherein R.sub.4 is (CR.sub.5 R.sub.6 --CR.sub.7 R.sub.8 --X.sub.1).sub.n --CR.sub.9 R.sub.10 --C(.dbd.X.sub.2)X.sub.3 R.sub.11, n is an integer from 1 to 18; R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11, are independently, hydrogen or non-hydrogen substituents; and X, X.sub.1, X.sub.2, X.sub.3, Y and Z are independently, O, NH, or S.Type: GrantFiled: May 2, 1997Date of Patent: August 3, 1999Assignee: Avon Products, Inc.Inventors: Dmitri Ptchelintsev, Neil Scancarella, Robert Kalafsky
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Patent number: 5929112Abstract: The derivatives of N,N'-di(aralkyl)-N,N'-di(carboxyalkyl) alkylene di- or triamine and N-(aralkyl)-N'-(carboxyalkyl)-N'N'-di(carboxyalkyl) alkylene di- or triamine of the formula: ##STR1## and the salts and metallic complexes thereof are disclosed. Use in pharmaceutical or cosmetic compositions used to protect the organism from oxidizing stress situations linked to certain pathological states.Type: GrantFiled: July 23, 1996Date of Patent: July 27, 1999Assignee: L'OrealInventors: Jean-Baptiste Galey, Sylvie Genard
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Patent number: 5925678Abstract: The use of N-acyl derivatives of aminoalcohols with mono- and di-carboxylic acids for the prevention and treatment of diseases connected with hyper and prolonged excitation by excitatory amino acids is described.Type: GrantFiled: September 23, 1996Date of Patent: July 20, 1999Assignee: Lifegroup S.P.A.Inventors: Francesco Della Valle, Alberta Leon, Silvana Lorenzi
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Patent number: 5922766Abstract: This invention relates to a palatable elemental nutritional formula that is nutritionally complete for humans with specialized dietary needs. The nutritional of the present invention uses specific free amino acids to provide the source of amino nitrogen (protein equivalents) and a special blend of fats that provides 38 to 50% of the total Calories in a pleasant tasting formula. The nutritionally complete formula of this invention is useful for children having multiple protein allergies, short gut syndrome, sick gut, diarrhea and the like. More specifically, the nutritional product, in accordance with this invention, utilizes L-asparagine monohydrochloride and L-glutamine in place of L-aspartic acid and L-glutamic acid, respectively. In addition, the source of fat comprises soy, fractionated coconut oil (medium chain triglycerides), high oleic safflower oil and esterified glycerol emulsifiers.Type: GrantFiled: July 2, 1997Date of Patent: July 13, 1999Inventors: Phyllis J. B. Acosta, Marlene W. Borschel, Patricia A. Reynolds, Christopher T. Cordle, Geralyn O. Duska-McEwen
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Patent number: 5877212Abstract: Compositions comprising an alpha hydroxyacid or related acid and organic complexing agent having a molecular weight ranging preferably between about 100 and about 600 can form a control-release molecular complex. Such complexing agent preferably possesses one or more amino group in addition to other groups with unshared electrons such as hydroxyl, carbonyl, amido, ester and alkoxyl groups in the same molecule. Such functional groups are capable of forming multiple intermolecular hydrogen bonds with the hydroxyl groups of a free alpha hydroxyacid or related acid. The complexing agents include amino acid esters, non-amphoteric amino acid amides, aminosaccharides, aminoalditols and aminocyclitols.Type: GrantFiled: April 16, 1997Date of Patent: March 2, 1999Inventors: Ruey J. Yu, Eugene J. Van Scott
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Patent number: 5861431Abstract: The present invention provides a method of treating incontinence in a patient that has a bladder and a urethra. The urethra forms a lumen for draining the bladder. The method comprises the steps of delivering an agent into the lumen and passing the agent from the lumen to internal body tissue. The agent increases restriction of the lumen thereby providing increased control over urine flow from the bladder.Type: GrantFiled: June 7, 1995Date of Patent: January 19, 1999Assignee: Iotek, Inc.Inventors: Keith R. Hildebrand, Jan Ellen O. Fowler, Dezso K. Levius
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Patent number: 5834518Abstract: Human skin is depigmented or bleached by applying thereto a compound of formula (1): ##STR1## wherein X represents COOH or the ring: ##STR2## wherein Z.sub.1, Z.sub.2 and Z.sub.3, independently of each other, are H, OR or R, R representing an optionally substituted saturated or unsaturated, linear or branched C.sub.1 -C.sub.8 -alkyl radical, or a salt, a metal complex or an ester of the compound.Type: GrantFiled: July 24, 1997Date of Patent: November 10, 1998Assignee: L'OrealInventors: Jean-Baptiste Galey, Laurent Marrot, Catherine Causse
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Patent number: 5834513Abstract: Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions, compositions containing these compounds, and methods of treating skin conditions using these compounds and compositions. ##STR1## wherein, R.sub.4 is (CR.sub.5 R.sub.6 --CR.sub.7 R.sub.8 --X.sub.1).sub.n --CR.sub.9 R.sub.10 --C(.dbd.X.sub.2)X.sub.3 R.sub.11, with n being an integer from 1 to 18; R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are independently, hydrogen or non-hydrogen substituents; and X, X.sub.1, X.sub.2, X.sub.3, Y and Z are independently, O, NH or S.Type: GrantFiled: April 25, 1996Date of Patent: November 10, 1998Assignee: Avon Products, Inc.Inventors: Dmitri Ptchelintsev, Neil Scancarella, Robert Kalafsky
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Patent number: 5821265Abstract: The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.Type: GrantFiled: June 11, 1997Date of Patent: October 13, 1998Assignee: Barnes-Jewish HospitalInventors: Paul H. Schlesinger, Steven L. Teitelbaum, Harry C. Blair
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Patent number: 5780508Abstract: The invention concerns pharmaceutical preparations for stimulation of the immune system which comprise a cystine derivative as active ingredient.Type: GrantFiled: June 1, 1995Date of Patent: July 14, 1998Assignee: Astra AktiebolagInventors: Carl-Magnus Alexander Andersson, H.ang.kan Sten Axel Bergstrand, Anders Rudolf Hallberg, Bengt Olof Sarnstrand, Anders Per Sigvard Tunek
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Patent number: 5780451Abstract: An enteral nutritional product for a person having ulcerative colitis contains in combination (a) an oil blend which contains eicosapentaenoic acid (20:5n3) and/or docosahexaenoic acid (22:6n3), and (b) a source of indigestible carbohydrate which is metabolized to short chain fatty acids by microorganisms present in the human colon. Preferably the nutritional product also contains one or more nutrients which act as antioxidants.Type: GrantFiled: April 1, 1994Date of Patent: July 14, 1998Assignee: Abbott LaboratoriesInventors: Stephen Joseph DeMichele, Keith Allen Garleb, John William McEwen, Martha Kay Fuller
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Patent number: 5776983Abstract: Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH.sub.2).sub.n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R.sup.9)R.sup.9' or --CO.sub.2 R.sup.7 ;R.sup.1 is lower alkyl, aryl or arylalkyl;R.sup.2 is hydrogen, hydroxy, alkoxy, --CH.sub.2 OH, cyano, --C(O)OR.sup.7, --CO.sub.2 H, --CONH.sub.2, tetrazole, --CH.sub.2 NH.sub.2 or halogen; ##STR2## R.sup.3 is hydrogen, alkyl, heterocycle or R.sup.4 is hydrogen, alkyl or B;R.sup.5, R.sup.5', R.sup.8, R.sup.8' or R.sup.8" are independently hydrogen, alkoxy, lower alkyl, halogen, --OH, --CN, --(CH.sub.2).sub.n NR.sup.6 COR.sup.7, --CON(R.sup.6)R.sup.6', --CON(R.sup.6)OR.sup.6', --CO.sub.2 R.sup.6, --SR.sup.7, --SOR.sup.7, --SO.sub.2 R.sup.7, --N(R.sup.6)SO.sub.2 R.sup.1, --N(R.sup.6)R.sup.6', --NR.sup.6 COR.sup.7, --OCH.sub.2 CON(R.sup.6)R.sup.6', --OCH.sub.2 CO.sub.2 R.sup.7 or aryl; orR.sup.5 and R.sup.5' or R.sup.8 and R.sup.Type: GrantFiled: December 2, 1994Date of Patent: July 7, 1998Assignee: Bristol-Myers Squibb CompanyInventors: William N. Washburn, Ravindar N. Girotra, Philip M. Sher, Amarendra B. Mikkilineni, Kathleen M. Poss, Arvind Mathur, Gregory S. Bisacchi, Ashvinikumar V. Gavai
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Patent number: 5763486Abstract: The object of the present invention is a physiological composition for the treatment of thermal and chemical burns comprising an efficient amount of Al(OH)Y complex formed between the aluminum ion Al.sup.3+ and an ethylenediamine-tetraacetic ligand (ligand Y).Type: GrantFiled: October 11, 1996Date of Patent: June 9, 1998Assignee: Marie-Claude Blomet Epouse MeyerInventors: Joel Blomet, Marie-Claude Blomet epouse Meyer, Dominique Friard epouse Jahan
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Patent number: 5733539Abstract: The invention discloses a bait for fishes and shellfishes characterized in that the bait comprises a matrix material containing a microorganically fermented product of a plant residue obtained by separating from a plant at least one liquid selected from the group consisting of vegetable juice, fruit juice, plant essential oil, juice extracted from a processed plant product, plant milk and mixtures thereof, or disintegrated product of said microorganically fermented product, wherein the matrix material has incorporated therein (A) an amino acid having 2 or 3 carbon atoms, and (B) amino acid having at least 4 carbon atoms in an (A)/(B) molar ratio of 1:1 to 40:1.Type: GrantFiled: July 13, 1997Date of Patent: March 31, 1998Assignee: Research Institute for Production DevelopmentInventors: Hisao Kitano, Masahiro Matsuda, Yasushi Ifuku, Hisao Maeda, Yoshifumi Matsuda
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Patent number: 5731355Abstract: Pharmaceutical compositions containing 2,6-diisopropylphenol (propofol) are described for use as anaesthetics.A method for their preparation is described, as their use in producing anaesthesia including induction and maintenance of general anaesthesia and sedation.Type: GrantFiled: February 18, 1997Date of Patent: March 24, 1998Assignee: Zeneca LimitedInventors: Christopher Buchan Jones, John Henry Platt
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Patent number: 5731356Abstract: Pharmaceutical compositions containing 2,6-diisopropylphenol (propofol) are described for use as anaesthetics.A method for their preparation is described, as their use in producing anaesthesia including induction and maintenance of general anaesthesia and sedation.Type: GrantFiled: February 18, 1997Date of Patent: March 24, 1998Assignee: Zeneca LimitedInventors: Christopher Buchan Jones, John Henry Platt
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Patent number: 5717109Abstract: The present invention provides compounds of formula ##STR1## in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists of one or more of the actions of L-glutamate at metabotropic excitatory amino acid receptors.Type: GrantFiled: July 10, 1995Date of Patent: February 10, 1998Assignee: Eli Lilly and CompanyInventors: M. Brian Arnold, Thomas J. Bleisch, David R. Helton, Mary Jeanne Kallman, Paul L. Ornstein, Darryle D. Schoepp, Joseph P. Tizzano
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Patent number: 5703095Abstract: N-arylmethylene ethylenediaminetriacetate, N-arylmethylene iminodiacetate or N,N'-diarylmethylene ethylenediaminediacetate type compounds and their use in combatting oxidative stress, and pharmaceutical and cosmetic compositions comprising said compounds. The invention also concerns a process for the preparation of said compounds.Type: GrantFiled: June 27, 1995Date of Patent: December 30, 1997Assignee: L'OrealInventors: Jean Baptiste Galey, Jacqueline Dumats
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Patent number: 5688516Abstract: Compositions and methods of employing compositions in flushing and coating medical devices are disclosed. The compositions include selected combinations of a chelating agent, anticoagulant, or antithrombotic agent, with an non-glycopeptide antimicrobial agent, such as the tetracycline antibiotics. Methods of using these compositions for coating a medical device and for inhibiting catheter infection are also disclosed. Particular combinations of the claimed combinations include minocycline or other non-glycopeptide antimicrobial agent together with EDTA, EGTA, DTPA, TTH, heparin and/or hirudin in a pharmaceutically acceptable diluent.Type: GrantFiled: October 3, 1994Date of Patent: November 18, 1997Assignees: Board of Regents, The University of Texas System, Baylor College of Medicine, Wake Forest UniversityInventors: Isaam Raad, Robert Sherertz
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Patent number: 5681578Abstract: A composition for relieving stress, anxiety, grief, and depression includes GABA (gamma amino butyric acid), glutamine, glycine, magnesium, passion flower, primula officinalis, and vitamin B-6.Type: GrantFiled: January 22, 1996Date of Patent: October 28, 1997Inventor: Billie J. Sahley
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Patent number: 5658945Abstract: The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.Type: GrantFiled: May 25, 1995Date of Patent: August 19, 1997Assignee: American Cyanamid CompanyInventors: Semiramis Ayral-Kaloustian, Steven R. Schow, Mila T. Du, James J. Gibbons, Jr.
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Patent number: 5631232Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.Type: GrantFiled: June 1, 1995Date of Patent: May 20, 1997Assignee: Bioresearch, Inc.Inventors: Robert J. Kurtz, William D. Fuller
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Patent number: 5626883Abstract: A vitamin C supplement comprising ascorbic acid, ascorbyl palmitate, niacinamide ascorbate, calcium ascorbate, magnesium ascorbate, potassium ascorbate, and sodium ascorbate which together can be administered to a human to avoid the transitory initial suppression of human NK cell activity which is present when ascorbic acid alone is administered. Also included is xylitol, lysine acetate, tetrasodium pyrophosphate, ribose, cysteine, and hesperidin which further prolongs the biological activity of ascorbic acid and promotes the uptake of ascorbic acid by human tissue.Type: GrantFiled: April 15, 1994Date of Patent: May 6, 1997Assignee: Metagenics, Inc.Inventor: Stephen M. Paul
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Patent number: 5618842Abstract: N-acyl derivatives of aminoalcohols with bicarboxylic or tricarboxylic acids able to modulate the degranulation process consequent to the mast cells activation in inflammatory processes caused by supramaximal stimuli of neurogenic and immunogenic origin.Type: GrantFiled: June 24, 1994Date of Patent: April 8, 1997Assignee: Lifegroup S.p.A.Inventors: Francesco Della Valle, Silvana Lorenzi, Gabriele Marcolongo
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Patent number: 5616612Abstract: The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.Type: GrantFiled: May 25, 1995Date of Patent: April 1, 1997Assignee: American Cyanamid CompanyInventors: Semiramis Ayral-Kaloustian, Steven R. Schow, Mila T. Du, James J. Gibbons, Jr.
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Patent number: 5587400Abstract: The object of the present invention is a physiological composition for the treatment of thermal and chemical burns comprising an efficient amount of an Al(OH)Y complex formed between the aluminum ion Al.sup.3+ and an ethylenediamine-tetraacetic ligand (ligand Y).Type: GrantFiled: April 14, 1994Date of Patent: December 24, 1996Assignee: Marie-Claude Blomet epouse MeyerInventors: Jo el Blomet, Marie-Claude Blomet epouse Meyer, Dominique F. Jahan
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Patent number: 5587399Abstract: The present invention involves a method of preparing a nutritional product in which a powder base containing fats, carbohydrates, vitamins, minerals and trace elements is mixed with specific amino acids to yield several different therapeutic products for use in the nutritional support of infants or toddlers having various inherited metabolic diseases.Type: GrantFiled: April 20, 1994Date of Patent: December 24, 1996Assignee: Abbott LaboratoriesInventors: Phyllis J. B. Acosta, Richard A. Grondalski, Jeffrey W. Liebrecht, Patricia A. Reynolds
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Patent number: 5576287Abstract: A nutritional composition and methods of using same for treating and preventing renal failure is provided. The nutritional composition includes a therapeutically effective amount of a source protein including meat proteins. Furthermore, the nutritional composition includes a therapeutically effective amount of specific amino acids, peptides, and/or polypeptides. The specific amino acids, peptides and polypeptides are selected such that they counteract a pathophysiologic mechanism contributing to the renal failure.Type: GrantFiled: April 29, 1994Date of Patent: November 19, 1996Assignee: Wake Forest UniversityInventors: Gary P. Zaloga, Pamela Roberts
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Patent number: 5550146Abstract: The present invention relates generally to a generic powder base rich in fats, carbohydrates, vitamins and minerals and trace elements which can be readily admixed with specific amino acids to yield several different therapeutic products for use in the nutritional support of various inherited metabolic diseases.Type: GrantFiled: April 18, 1995Date of Patent: August 27, 1996Assignee: Abbott LaboratoriesInventors: Phyllis J. B. Acosta, Richard A. Grondalski, Jeffrey W. Liebrecht, Patricia A. Reynolds
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Patent number: 5545662Abstract: The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.Type: GrantFiled: March 14, 1994Date of Patent: August 13, 1996Assignee: American Cyanamid CompanyInventors: Semiramis Ayral-Kaloustian, Steven R. Schow, Mila T. Du, James J. Gibbons, Jr
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Patent number: 5523078Abstract: An aqueous composition for the treatment of hair and scalp which includes a chelating agent, gellan gum, a vitamin precursor, a preservative, biotin, a vitamin derivative, .gamma.-linolenic acid, menthol, a liposome, a conditioner, a solubilizer, a conditioner/humectant, folic acid, and a poly amino sugar condensate.Type: GrantFiled: February 3, 1995Date of Patent: June 4, 1996Assignee: Michael E. BaylinInventor: Michael E. Baylin
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Patent number: 5496856Abstract: The present invention relates to aspartame for its application as a therapeutically active substance. It has been demonstrated that this compound has a protective action against human and animal ochratoxicosis which is capable of being applied in therapeutics.Type: GrantFiled: November 1, 1994Date of Patent: March 5, 1996Inventor: Edmond Creppy
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Patent number: 5490992Abstract: The present invention is generally related to a product and a process to reduce the microbial contamination of processed meat and is particularly related to a product and a process to disinfect poultry carcasses using a disinfectant composition containing a fatty acid monoester, an acid or chelating agent, and a food grade surfactant. These components may be combined in either an aqueous or nonaqueous vehicle as desired. The present combination is effective against pathogenic and undesired bacteria. Advantageously, the present composition does not detrimentally alter the taste, texture, color, odor or appearance of the processed meat.Type: GrantFiled: March 22, 1995Date of Patent: February 13, 1996Assignee: Minnesota Mining and Manufacturing CompanyInventors: Jeffrey F. Andrews, Janet F. Munson
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Patent number: 5460833Abstract: The present invention is generally related to a product and a process to reduce the microbial contamination of processed meat and is particularly related to a product and a process to disinfect poultry carcasses using a disinfectant composition containing a fatty acid monoester, an acid or chelating agent, and a food grade surfactant. These components may be combined in either an aqueous or nonaqueous vehicle as desired. The present combination is effective against pathogenic and undesired bacteria. Advantageously, the present composition does not detrimentally alter the taste, texture, color, odor or appearance of the processed meat.Type: GrantFiled: March 22, 1995Date of Patent: October 24, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Jeffrey F. Andrews, Janet F. Munson
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Patent number: 5422366Abstract: Fungal nail infections are treated by depriving aerobic fungi of oxygen by forming an oxygen barrier over the exposed surface of an infected nail. Conveniently, the oxygen barriers are formed by applying a liquid film-forming carrier comprising an oxygen-scavenging substance, such as transition metal chelate or complex of salicylic acid or a salicylate, an oxidizable organic acid or alcohol in combination with a catalyzing agent, or a polycarboxylic acid chelate or complex of a transition metal or transition metal salt.Type: GrantFiled: December 13, 1993Date of Patent: June 6, 1995Assignee: Advanced Oxygen Technologies, Inc.Inventors: Medwin M. Mintzis, N. Ross Buckenham, Donald G. Rosellini
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Patent number: 5405620Abstract: The pharmaceutical composition according to the invention consists essentially of:i) one or more, pharmaceutically acceptable, water soluble compounds of boron, fluorine, magnesium, vanadium, manganese, iron, cobalt, nickel, copper, zinc and molybdenum, which compounds do not precipitate with each other or with the other components of the composition and exhibit a neutral or acidic pH in an aqueous medium;ii) glycine;iii) glycerol;iv) L-(+)-ascorbic acid;v) succinic acid;vi) a neutral or acidic and water-soluble, pharmaceutically acceptable salt of ethylenediamine tetraacetic acid;vii) potassium sodium tartrate; andviii) L-(+)-tartaric acid. The composition can be used for the treatment of mucoviscidosis and chronic pain syndromes deriving from locomotor diseases or accompanying diseases of tumorous origin.Type: GrantFiled: November 12, 1993Date of Patent: April 11, 1995Assignee: Beres Export-Import Rt.Inventors: Jozsef Beres, Jozsef Beres, Jr.
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Patent number: 5393545Abstract: This invention relates to a composition of food having animal and/or vegetable origin which contains lysozyme and a chelating agent in amounts that are effective at preventing contamination of the food by Clostridium botulinum.Type: GrantFiled: February 3, 1993Date of Patent: February 28, 1995Assignee: Solchem Italiana S.p.A.Inventors: Eric A. Johnson, Ernani Dell'Acqua