Benzene Ring Nonionically Bonded Patents (Class 514/567)
-
Publication number: 20140179784Abstract: A pharmaceutical composition comprising thyroxine and carrageenan. The pharmaceutical composition has an improved shelf life compared to other pharmaceutical compositions containing thyroxine. In one embodiment, the composition additionally comprises sucrose, microcrystalline cellulose, and mannitol. The pharmaceutical composition may be used for treating thyroid disorders by orally administering the composition to a patient in need thereof.Type: ApplicationFiled: December 21, 2012Publication date: June 26, 2014Applicant: Mylan Inc.Inventors: John Kirsch, Ramakrishna Nallamothu, Baris E. Polat
-
Publication number: 20140179717Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.Type: ApplicationFiled: December 13, 2013Publication date: June 26, 2014Applicant: OMEROS CORPORATIONInventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George A. Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
-
Publication number: 20140179786Abstract: A method is disclosed of reducing the level of tau protein in a subject's brain for the treatment of tau tangles. The method includes administrating an effective dose of drug that reduced Sp1 levels to the subject to lower tau mRNA and protein levels, CDK5 mRNA and protein levels, as well phosphorylated tau in the brain.Type: ApplicationFiled: December 20, 2013Publication date: June 26, 2014Applicant: Board of Governors for Higher Education, State of Rhode Island and Providence PlantationsInventor: Nasser Zawia
-
Publication number: 20140178449Abstract: Methods for restoring normal patterns of activity in a subject suffering from Parkinson's Disease are disclosed that include administering an effective steady state concentration of a dopamine modulating compound continuously for a prolonged period of time such that normal patterns of activity are substantially restored in the subject.Type: ApplicationFiled: October 30, 2013Publication date: June 26, 2014Applicant: NuPathe, Inc.Inventors: Terri B. Sebree, Steven J. Siegel
-
Publication number: 20140178468Abstract: The present invention relates to a multiparticulate extended-release pharmaceutical composition of mesalamine comprising a) an inert core, b) an active ingredient layer and one or more pharmaceutically acceptable excipients, c) an inner coating layer comprising a water-insoluble cellulose derivative, and d) an outer coating layer comprising an enteric polymer.Type: ApplicationFiled: December 23, 2013Publication date: June 26, 2014Applicant: RANBAXY LABORATORIES LIMITEDInventors: Rajesh S. SHEAR, Abhishank SINGH, Girish MITTAL, Sumit MADAN, Vinod Kumar ARORA
-
Publication number: 20140179722Abstract: The present application relates to personal care compositions comprising perfumes and non-sulfur-based perfume raw materials, and methods for making and using the personal care compositions to resist consumer fragrance habituation.Type: ApplicationFiled: December 13, 2013Publication date: June 26, 2014Applicant: The Procter & Gamble CompanyInventors: Jonathan Robert CETTI, Zerlina Guzdar DUBOIS, Virginia Tzung-Hwei HUTCHINS, Michael Wayne KINSEY
-
Publication number: 20140171448Abstract: The invention concerns the use of a nicotinic acetylcholine receptor alpha 7 activators for the treatment, prevention or delay of progression of a Movement Disorder selected from Dystonia, Dyskinesia, Chorea, Restless Legs Syndrome, Tics, Tremor, Myoclonus, Startle, Stiff Person Syndrome, Gait Disorder, Parkinson's Disease and Symptomatic Parkinsonism.Type: ApplicationFiled: January 20, 2012Publication date: June 19, 2014Applicant: NOVARTIS AGInventors: Dominik Feuerbach, Baltazar Gomez-Mancilla, Cristina Lopez-Lopez, Donald Johns, Thérése Di Paolo
-
Publication number: 20140170112Abstract: In alternative embodiments the invention provides compositions, e.g., pharmaceutical compositions and preparations, formulations, kits and other products of manufacture, e.g., exemplary drug combinations packaged together or separately in blister packs, lidded blisters or blister cards, or wrapped in paper, plastic or cellophane wrappers (e.g., a shrink wrap), comprising a combination regimen of at least two active ingredients designed to diminish systemic inflammation by targeting (inhibiting) two different, but convergent, signaling pathways, i.e., the sympathetic nervous system and the lipid-derived autacoid system; and methods for making and using these compositions. In alternative embodiments, the compositions of the invention (e.g., the combination of drugs) are used to ameliorate, diminish, treat, block or prevent an inflammatory response secondary to an infection, e.g., a viral infection and/or a reactivation.Type: ApplicationFiled: March 8, 2012Publication date: June 19, 2014Applicant: VICUS THERAPEUTICS, LLCInventors: John Maki, Newell Bascomb, Timothy J. Turner, Fredric Young
-
Publication number: 20140171507Abstract: The invention relates to compounds, to compositions comprising the same and uses thereof for the prevention or treatment of pain, e.g neuropathic pain while having neutral or beneficial effect on metabolic parameters.Type: ApplicationFiled: September 6, 2013Publication date: June 19, 2014Inventors: Xianqi KONG, Nigel LEVENS, Serge LAMOTHE, Mohammed ATFANI, Stephane CIBLAT, Lucie JETTE
-
Patent number: 8754066Abstract: The present invention relates to novel phenoxy derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.Type: GrantFiled: February 20, 2013Date of Patent: June 17, 2014Assignee: Allergan, Inc.Inventors: Wenkui K. Fang, Liming Wang, Ken Chow, Evelyn G. Corpuz, Wha-Bin Im
-
Publication number: 20140162987Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a severe pain in an individual using such pharmaceutical compositions.Type: ApplicationFiled: January 14, 2014Publication date: June 12, 2014Applicant: BIOCOPEA LIMITEDInventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
-
Publication number: 20140163072Abstract: Methods, compositions and kits for treating a headache in a human patient are provided. The methods comprise intranasally administering to the patient a composition comprising a short-acting local anesthetic, a long-acting local anesthetic and a non-steroidal anti-inflammatory drug. A composition useful for practicing the methods of the disclosure is described which comprises a short-acting local anesthetic, a long-acting local anesthetic and a non-steroidal anti-inflammatory drug, wherein the composition is formulated for intranasal delivery. A kit comprising the composition and an intranasal applicator and a method of systemically delivering the composition to a human patient is also included in the disclosure. The headache-treating effectiveness of a local anesthetic in a Sphenopalatine Ganglion Block (SFGB) is significantly enhanced by coadministering diclofenac.Type: ApplicationFiled: December 6, 2012Publication date: June 12, 2014Inventor: Jose Carlos Romon-de-Jesus
-
Publication number: 20140163105Abstract: A composition for pain relief including synergistically effective amounts of an amino benzoate local anesthetic, methylsulfonylmethane (MSM), and ethoxydiglycol. A method of treating pain, by applying the composition to skin in an area of pain, and blocking nerve signals. A method of improving range of motion in an individual, by applying the composition to skin, relieving pain, and allowing the individual to have an improved range of motion at an area of pain.Type: ApplicationFiled: December 6, 2013Publication date: June 12, 2014Inventor: Michael Harvey Greenspan
-
Publication number: 20140162988Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.Type: ApplicationFiled: January 14, 2014Publication date: June 12, 2014Applicant: BIOCOPEA LIMITEDInventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
-
Patent number: 8748414Abstract: The present invention relates to a complex made up of at least one molecule of statin or a derivative thereof, covalently bonded to at least one hydrocarbon radical including at least 18 carbon atoms and containing at least one 2-methyl-buta-2-ene unit, to nanoparticles of such a complex, and to a method for preparing same, said complex and/or said nanoparticles optionally being in the form of a lyophilizate. The present invention also relates to a pharmaceutical composition including at least one complex and/or nanoparticles such as previously defined. The invention finally relates to said complex and/or to said nanoparticles for the treatment and/or prevention of hyperlipemia and hypercholesterolemia.Type: GrantFiled: October 28, 2009Date of Patent: June 10, 2014Inventors: Patrick Couvreur, Didier Desmaele, Fat'ma Zouhiri, Reddy Harivardhan Lakkireddy
-
Patent number: 8748485Abstract: Provided is a levodopa prodrug that overcomes the problems attributed to the blood kinetics of levodopa such as large number of doses and the incidence of side effects due to frequent dosing. (2S)-2-Amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid, a salt thereof, or a solvate thereof is a levodopa prodrug, and provides a flat blood concentration-time profile of levodopa through oral administration, and therefore is useful as a preventive and/or therapeutic agent for Parkinson's disease and/or Parkinson's syndrome that overcomes the problems associated with pharmaceutical preparations of levodopa.Type: GrantFiled: December 1, 2011Date of Patent: June 10, 2014Assignee: Ono Pharmaceuticals Co., Ltd.Inventors: Masaya Kokubo, Koji Yano
-
Patent number: 8747912Abstract: A drug delivery system for the controlled release of a pharmaceutically-active compound by oral route comprises an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group. A preferred layered double hydroxide is one that has layers which comprise [LiAl2(OH)6]+. The drug delivery system has use in the delivery of drugs such as 4-biphenylacetic acid, Diclofenac, Gemfibrozil, Ibuprofen, Naproxen, 2-Propylpentanoic acid and Tolfenamic acid.Type: GrantFiled: January 28, 2008Date of Patent: June 10, 2014Assignee: Isis Innovation LimitedInventor: Dermot Michael O'Hare
-
Publication number: 20140155355Abstract: The invention provides novel compounds of formulae I and II: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).Type: ApplicationFiled: April 29, 2013Publication date: June 5, 2014Inventor: Jenrin Discovery
-
Publication number: 20140154343Abstract: Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.Type: ApplicationFiled: December 9, 2013Publication date: June 5, 2014Applicant: Avon Products, Inc.Inventors: Siming W. Chen, Qian Zheng, Satish Parimoo
-
Patent number: 8741955Abstract: The present invention relates to pharmaceutical compositions comprising D-serine transporter inhibitors and therapeutic methods using such pharmaceutical compositions in methods for the treatment of central nervous system disorders.Type: GrantFiled: May 24, 2012Date of Patent: June 3, 2014Assignee: Allergan, Inc.Inventors: Alan C. Foster, Yong-Xin Li, Ursula Staubli, Veena Viswanath, Lauren Luhrs
-
Patent number: 8735450Abstract: The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac, medicaments produced using diclofenac in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of diclofenac administered by way of said medicaments.Type: GrantFiled: April 23, 2010Date of Patent: May 27, 2014Assignee: Iceutica Pty Ltd.Inventors: Aaron Dodd, Felix Meiser, Marck Norret, Adrian Russell, H William Bosch
-
Patent number: 8735451Abstract: The present invention relates to pharmaceutical compositions comprising D-serine transporter inhibitors and therapeutic methods using such pharmaceutical compositions in methods for the treatment of visual system disorders and the enhancement of the visual function.Type: GrantFiled: May 24, 2012Date of Patent: May 27, 2014Assignee: Allergan, Inc.Inventors: Alan C. Foster, Yong-Xin Li, Ursula V. Staubli, Veena Viswanath, Lauren M. Luhrs
-
Patent number: 8735382Abstract: An infusion or injection solution of Levodopa containing at least 10 mg/mL of Levodopa, or at least 5 mg/mL of Levodopa together with at least 0.5 mg/mL of at least one inhibitor of a Levodopa-metabolising enzyme is disclosed. The solution further contains a buffer, a physiologically acceptable sugar, such as glucose, a physiologically acceptable acid, such as hydrochloric acid, and optionally a stabilizer, and has a pH of lower than or equal to 6. There are also described a disposable syringe containing an infusion or injection solution of Levodopa, optionally together with a Levodopa-metabolising enzyme, and an infusion pump cassette containing an infusion or injection solution of Levodopa optionally together with a Levodopa-metabolising enzyme.Type: GrantFiled: August 12, 2011Date of Patent: May 27, 2014Assignee: Dizlin Medical Design ABInventor: Nil Dizdar Segrell
-
Publication number: 20140142182Abstract: An aqueous liquid composition comprising: (a) 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or hydrate; (b) a non-ionic surfactant; and (c) a preservative; wherein at least 90 percent of the original amount of said 2-amino-3-(4-bromobenzoyl)phenylacetic acid or pharmacologically acceptable salt or hydrate remains in the composition after storage at 60° C., for 4 weeks. The composition can satisfy the preservative efficacy of US Pharmacopeia 35 (2012). The composition is useful for the treatment of ocular or nasal inflammation of diverse etiology.Type: ApplicationFiled: November 18, 2013Publication date: May 22, 2014Applicant: BAUSCH & LOMB INCORPORATEDInventors: Angeliqueo E. Padilla, George A. Baklayan
-
Publication number: 20140142183Abstract: An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. Since even in the case where a preservative is incorporated into said aqueous liquid preparation, the preservative exhibits a sufficient preservative effect for a long time, said aqueous liquid preparation in the form of an eye drop is useful for the treatment of blepharitis, conjunctivitis, scleritis, and postoperative inflammation. Also, the aqueous liquid preparation of the present invention in the form of a nasal drop is useful for the treatment of allergic rhinitis and inflammatory rhinitis (e.g. chronic rhinitis, hypertrophic rhinitis, nasal polyp, etc.).Type: ApplicationFiled: January 28, 2014Publication date: May 22, 2014Applicant: SENJU PHARMACEUTICAL CO., LTD.Inventors: Shirou SAWA, Shuhei FUJITA
-
Patent number: 8728547Abstract: The invention provides methods for increasing resting metabolic rate, reducing waist circumference, and weight control by administering a composition comprising dietary fiber, phenylalanine, tyrosine, tea blend, caffeine, and Lycium plants or Lycium plant extract preparations to the subject. The invention also provides a food or dietary supplement formulation which contains dietary fiber, phenylalanine, tyrosine, tea blend, caffeine, and Lycium plants or Lycium plant extract preparations.Type: GrantFiled: February 5, 2009Date of Patent: May 20, 2014Assignee: Freelife International, Inc.Inventors: Harunobu Amagase, Richard Handel
-
Publication number: 20140135397Abstract: The present invention provides compositions and methods for the targeted delivery, release and/or formation of a drug compound at a target site(s) within the body of an individual, such as a diseased and/or inflamed tissue in the body of the individual. These compositions may comprise a halogenated phenol ring cleavably linked to a core structure of a drug compound. Due to the variety of substituents that may be utilized in forming the different types of linkages, numerous examples of drug compounds linked to a halogenated phenol ring are proposed. The present invention further provides compositions comprising halogenated phenol starting compounds that do not undergo cleavage during a dehalogenation reaction to form a drug compound in a targeted tissue when administered to an individual. Methods of administering these non-cleaving compounds are further provided.Type: ApplicationFiled: January 21, 2014Publication date: May 15, 2014Inventor: Keith R. Latham
-
Publication number: 20140135299Abstract: Long term storage stable budesonide-containing solutions are disclosed. The solutions can include budesonide or a pharmaceutically acceptable salt thereof, cromolyn sodium, antioxidizing agent, benzoic acid, and a pharmaceutically acceptable fluid including propylene glycol and water. Kits including the long term storage stable budesonide-containing solutions and methods of treating ulcerative colitis are also disclosed.Type: ApplicationFiled: November 11, 2013Publication date: May 15, 2014Inventors: Nagesh R. PALEPU, Philip Christopher BUXTON
-
Patent number: 8722669Abstract: A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.Type: GrantFiled: June 8, 2012Date of Patent: May 13, 2014Assignee: Case Western Reserve UniversityInventors: Krzysztof Palczewski, Akiko Maeda, Marcin Golczak
-
Patent number: 8722923Abstract: A conjugate comprising L-DOPA covalently linked to at least one ?-aminobutyric acid (GABA) moiety, an ester and/or an addition salt thereof are disclosed, as well as uses thereof for treating a neurodegenerative disease or disorder.Type: GrantFiled: June 25, 2012Date of Patent: May 13, 2014Assignees: Ramot at Tel-Aviv University Ltd., Bar-Ilan UniversityInventors: Gideon Stein, Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
-
Patent number: 8722739Abstract: The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.Type: GrantFiled: October 29, 2008Date of Patent: May 13, 2014Assignee: Novaer Holdings, Inc.Inventors: Mitchell A. deLong, Jill Marie Sturdivant
-
Publication number: 20140128420Abstract: Dietary supplement compositions containing one or more compounds such as arginine, selenium, calcium, calcium sources, morphine precursors (e.g., reticuline), morphine, and morphine-6?-glucuronide are provided.Type: ApplicationFiled: January 10, 2014Publication date: May 8, 2014Applicant: The Research Foundation of State University of New YorkInventors: George B. Stefano, Patrick Cadet, Kirk J. Mantione, Wei Zhu
-
Publication number: 20140128354Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.Type: ApplicationFiled: January 14, 2014Publication date: May 8, 2014Applicant: BIOCOPEA LIMITEDInventors: Robin M. Bannister, John Brew
-
Publication number: 20140128472Abstract: The present invention relates to the field of treatment and prevention of conditions related to oxidative stress and hormone resistance. Preferably, insulin resistance, erythropoietin resistance and acetyl-choline resistance are in the focus. The invention also relates to the field of use of amino acids, in particular p-L-Tyrosine and a precursor thereof as a medicament or composition or formulation in the prevention or treatment of said conditions.Type: ApplicationFiled: June 25, 2012Publication date: May 8, 2014Inventors: István Wittmann, Gergö Attila Molnar, Judit Mohás-Cseh, István András Szijártó
-
Publication number: 20140128353Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.Type: ApplicationFiled: January 14, 2014Publication date: May 8, 2014Applicant: Biocopea LimitedInventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
-
Patent number: 8715701Abstract: Protein preparations containing biologically active compounds and the application of the protein preparations obtained, particularly as a component of medicinal and cosmetic preparations as protective substances or in the regeneration of cells and tissues of the human organism, and which can comprise a component of culture media for dermal or hepatic tissues, or for stem cells destined for use in the regeneration of cells and tissues in the human organism.Type: GrantFiled: November 20, 2007Date of Patent: May 6, 2014Assignee: Instytut Medycyny Doswiadczalnej I KlinicznejInventors: Andrzej Lipkowski, Anna Grabowska, Katarzyna Kurzepa, Aleksandra Szczucinska
-
Patent number: 8716340Abstract: The invention relates to beneficial topical pharmaceutical compositions comprising the diclofenac sodium salt in unusually low amounts. The compositions represent opaque emulsion-gels, in which diclofenac is kept fully dissolved.Type: GrantFiled: October 14, 2013Date of Patent: May 6, 2014Assignee: Novartis Consumer Health S.A.Inventor: Michel Steiger
-
Publication number: 20140120162Abstract: Compositions containing one or more active agents, one or more bioadhesives elements, and one or more charge masking agents are described herein. In some embodiments, the one or more active agents are biomolecules or macromolecules, such as polysaccharides, proteins, peptides, or nucleic acids, which are charged at physiological pH. The one or more charge masking agents are selected based on the nature of the charge on the active agent. The compositions may also contain one or more controlled release materials, such as extended or sustained release materials or delayed release materials, in order to modify release of the active agent.Type: ApplicationFiled: June 6, 2012Publication date: May 1, 2014Applicant: PEROSPHERE INC.Inventors: Edith Mathiowitz, Solomon S. Steiner, Bryan E. Laulicht, Sasha Bakhru
-
Patent number: 8709500Abstract: A drug delivery system for the controlled release of a pharmaceutically-active compound by oral route comprises an intercalate of a layered double hydroxide having, before intercalation, layers of metal hydroxides, and having intercalated therein a pharmaceutically-active compound having at least one anionic group. A preferred layered double hydroxide is one that has layers which comprise [LiAl2(OH)6]+. The drug delivery system has use in the delivery of drugs such as 4-biphenylacetic acid, Diclofenac, Gemfibrozil, Ibuprofen, Naproxen, 2-Propylpentanoic acid and Tolfenamic acid.Type: GrantFiled: June 23, 2010Date of Patent: April 29, 2014Assignee: Isis Innovation LimitedInventor: Dermot Michael O'Hare
-
Patent number: 8710099Abstract: The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy.Type: GrantFiled: September 10, 2010Date of Patent: April 29, 2014Assignees: New York University, Maine Medical CenterInventors: Peter C. Brooks, James Canary, Leonard Liebes
-
Publication number: 20140113971Abstract: Topical pharmaceutical compositions comprising a topically administrable NSAID, a sensate agent and optionally a self-warming system, when administered to a patient in need thereof, provide significant improvements in the rate and extent of skin absorption, as well as impart a sensation of rapid and complete relief from pain.Type: ApplicationFiled: December 23, 2013Publication date: April 24, 2014Inventors: Joanna ZHANG, Emily LESICA
-
Publication number: 20140113970Abstract: The invention provides systems and methods for controlled dispensing of topical analgesics contained in a metered dispensing system. The systems and method are useful for treating signs and symptoms of osteoarthritis. The method includes depressing a hand pump to dispense a dose of a topical pain reliever in a viscous solution from the hand pump, wherein the hand pump is configured to dispense the dose within a tolerance specified by a corresponding label approved by a government regulatory agency; and spreading the topical solution on skin.Type: ApplicationFiled: October 22, 2012Publication date: April 24, 2014Applicants: Mallinckrodt LLC Covidien, Nuvo Research Inc.Inventors: Nuvo Research Inc., Mallinckrodt LLC
-
Patent number: 8703816Abstract: Provided is a levodopa prodrug that overcomes the problems attributed to the blood kinetics of levodopa such as large number of doses and the incidence of side effects due to frequent dosing. (2S)-2-Amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid, a salt thereof, or a solvate thereof is a levodopa prodrug, and provides a flat blood concentration-time profile of levodopa through oral administration, and therefore is useful as a preventive and/or therapeutic agent for Parkinson's disease and/or Parkinson's syndrome that overcomes the problems associated with pharmaceutical preparations of levodopa.Type: GrantFiled: December 1, 2011Date of Patent: April 22, 2014Assignee: Ono Pharmaceuticals Co., Ltd.Inventors: Masaya Kokubo, Koji Yano
-
Publication number: 20140105898Abstract: This invention relates generally to methods and agents for modulating adiposity-related conditions. More particularly, the present invention relates to the use of TRAIL death receptor agonists, including nucleic acids such as TRAIL polynucleotides, peptides and polypeptides including TRAIL polypeptides, TRAIL DR agonist antigen-binding molecules, TRAIL DR peptide agonists as well as small molecule TRAIL DR agonists in compositions and methods for treating or preventing adiposity-related conditions such as obesity, diabetes mellitus and metabolic syndrome.Type: ApplicationFiled: February 27, 2012Publication date: April 17, 2014Applicant: Istituto Di Ricovero E Cura A Carattere Scientific Materno-Infantile Burlo GaroInventors: Merlin C. Thomas, Giorgio Zauli, Paola Secchiero, Bruno Fabris, Stella Bernardi
-
Publication number: 20140107210Abstract: A method is provided for treating pain in patients recovering from post-surgical trauma by administering between about 13 to about 30 mg of diclofenac potassium in a liquid dispersible formulation over a period of at least 24 hours, wherein the daily total amount of diclofenac potassium administered is less than or equal to about 100 mg. The method is particularly useful in treating acute pain in bunionectomy patients.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Applicant: Depomed, Inc.Inventors: Mark M. Kowalski, James L. Young, Keith A. Moore
-
Publication number: 20140105983Abstract: In one aspect, the invention is related to a method of treating a patient with Parkinson's disease, the method including administering to the respiratory tract of the patient particles that include more than about 90 weight percent (wt %) of levodopa. The particles are delivered to the patient's pulmonary system, preferably to the alveoli or the deep lung.Type: ApplicationFiled: October 17, 2013Publication date: April 17, 2014Applicant: Civitas Therapeutics, Inc.Inventors: Blair C. Jackson, David J. Bennett, Raymond T. Bartus, Dwaine F. Emerich
-
Publication number: 20140105973Abstract: The present invention discloses a method of treating a disease condition susceptible to baclofen therapy, said method comprising orally administering once-a-day in the evening a controlled release drug delivery system comprising baclofen or its pharmaceutically acceptable salt or its derivatives and pharmaceutically acceptable excipients.Type: ApplicationFiled: December 16, 2013Publication date: April 17, 2014Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Nitin Bhalachandra DHARMADHIKARI, Yashoraj Rupsinh ZALA
-
Publication number: 20140107209Abstract: The present invention is directed to a pharmaceutical composition containing a unit dose of a diclofenac compound effective to induce analgesia; and a beta-cyclodextrin compound; wherein the dose of the diclofenac compound is less than 10 mg. The present invention is also directed to methods of treating a subject in need of analgesia with the pharmaceutical compositions of the invention.Type: ApplicationFiled: October 10, 2013Publication date: April 17, 2014Inventors: Curtis Wright, Daniel B. Carr, Fred H. Mermelstein
-
Publication number: 20140107085Abstract: The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor modulators. The invention further includes methods of treatment using the compositions of the invention.Type: ApplicationFiled: October 10, 2013Publication date: April 17, 2014Applicant: The Trustees of The University of PennsylvaniaInventors: Trevor M. Penning, Adegoke O. Adeniji, Michael C. Burns, Jeffrey Winkler, Barry Twenter
-
Patent number: RE44874Abstract: The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseasesType: GrantFiled: December 19, 2012Date of Patent: April 29, 2014Assignee: Glaxo Group LimitedInventors: Philip Charles Box, Diane Mary Coe, Brian Edgar Looker, Panayiotis Alexandrou Procopiou