Benzene Ring Nonionically Bonded Patents (Class 514/568)
Polycyclo ring system (Class 514/569)
Carboxy or salt thereof only attached indirectly to the benzene ring (Class 514/570)
  • BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR
    Publication number: 20080255198
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 16, 2008
    Inventors: Chang An Chu, Paul Gillespie, Jefferson Wright Tilley
  • PPAR active compounds
    Publication number: 20080249137
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Application
    Filed: September 6, 2006
    Publication date: October 9, 2008
    Inventors: Jack Lin, Patrick Womack, Byunghun Lee, Shenghua Shi, Chao Zhang, Dean R. Artis, Prabha N. Ibrahim, Weiru Wang, Rebecca Zuckerman
  • Cosmetic Composition and Methods of Use
    Publication number: 20080241291
    Abstract: A cosmetic composition is provided including about 25 wt % to about 55 wt % Aloe vera gel, about 9 wt % to about 33 wt % exfoliant, about 5 wt % to about 20 wt % vitamin C, and about 0.25 wt % to about 1.0 wt % retinyl propionate (vitamin A), wherein said composition has a pH of about 2.0 to about 3.7. Methods of using said composition are also included.
    Type: Application
    Filed: April 2, 2007
    Publication date: October 2, 2008
    Inventor: Sheikh Ahmed Abdullah
  • Preventive and/or Remedy for Hyperkalemia Containing Ep4 Agonist
    Publication number: 20080234337
    Abstract: The present invention relates to a preventive and/or therapeutic agent for hyperkalemia, and a potassium excretion promoter containing EP4 agonist. Since EP4 agonist promotes potassium excretion, it is useful as a preventive and/or therapeutic agent for hyperkalemia. In addition, if selective EP4 agonist uses, it is a preventive and/or therapeutic agent for hyperkalemia without side effects. Further, if EP4 agonist is used, it is useful as improving agent for various symptoms (e.g. paresthesia, error of perception, weakness, myoparalysis, nausea, vomit, abdominal pain, diarrhea, arrhythmia, atrioventricular block, ventricular fibrillation, atrial fibrillation, cardiac arrest, asphyxia and/or dyspnoea etc.).
    Type: Application
    Filed: August 9, 2005
    Publication date: September 25, 2008
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Atsukazu Kuwahara, Yuichi Suzuki, Takayuki Maruyama
  • COMPOSITIONS AND METHODS FOR ANTI-INFLAMMATORY TREATMENTS
    Publication number: 20080233206
    Abstract: The present invention relates to an improved method for treating a wide range of inflammatory disorders by administering a tetracycline compound together with an effective inhibitor of tetracycline absorption, such as polyvalent metals. Pharmaceutical compositions used in that method are also taught.
    Type: Application
    Filed: March 21, 2008
    Publication date: September 25, 2008
    Applicant: Molecular Research Center, Inc.
    Inventor: Piotr Chomczynski
  • PPAR ACTIVE COMPOUNDS
    Publication number: 20080221127
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Inventors: Jack Lin, Patrick Womack, Shenghua Shi, Chao Zhang, Dean R. Artis, Prabha N. Ibrahim, Weiru Wang
  • Compounds and Methods for the Inhibition of the Expression of VCAM-1
    Publication number: 20080214660
    Abstract: This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
    Type: Application
    Filed: May 15, 2008
    Publication date: September 4, 2008
    Inventors: Russell M. Medford, Patricia K. Somers, Lee K. Hoong, Charles O. Meng
  • Substituted aryloximes
    Patent number: 7420083
    Abstract: The present invention relates to substituted aryl oximes and methods of using them.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: September 2, 2008
    Assignee: Wyeth
    Inventors: Lisa Marie Havran, John Anthony Butera, Hassan Mahmoud Elokdah, Douglas John Jenkins, Eric Gould Gundersen
  • Glepp-1 Inhibitors in the Treatment of Autoimmune and/or Inflammatory Disorders
    Publication number: 20080207722
    Abstract: The present invention is related to the use of a Glepp-1 inhibitor for the manufacture of a medicament for the treatment of an autoimmune and/or an inflammatory disorder.
    Type: Application
    Filed: July 14, 2006
    Publication date: August 28, 2008
    Applicant: LABORATORIES SERONO SA
    Inventors: Agnes Bombrun, Rob Hooft Van Huijsduijnen, Catherine Jorand-Lebrun, Pierre-Alain Vitte, Patrick Gerber
  • Day and Night Composition and method for treating Pseudofolliculitis Barbae
    Publication number: 20080206359
    Abstract: An effective formulation for the treatment and prevention of pseudofolliculitis barbae, commonly called razor bumps, and the skin irritation associated with the condition. The treat formulation can be used as the last step in a multi-step shaving system consisting of a shaving gel, aftershave balm and the aforementioned treat. The treat can also be used as a standalone product and is formulated to treat and prevent shaving symptoms day and night.
    Type: Application
    Filed: February 23, 2007
    Publication date: August 28, 2008
    Inventor: Nikita Wilson
  • Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
    Publication number: 20080207742
    Abstract: The invention provides for the use of protein kinase activators or boosters of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or other neurotrophic factors to treat head trauma. Specifically, the present invention provides methods of treating head trauma comprising the steps of identifying a subject having suffered a head trauma and administering to said subject an amount of a pharmaceutical composition comprising a protein kinase C(PKC) activator or 4-methylcatechol acetic acid (MCBA) and a pharmaceutically acceptable carrier effective to treat at least one symptom of head trauma.
    Type: Application
    Filed: February 11, 2008
    Publication date: August 28, 2008
    Inventors: Ofer Zohar, Daniel L. Alkon
  • Composition and Method for Modulating and Maintaining Vaginal Bacterial Flora and Vaginal Acidity
    Publication number: 20080193428
    Abstract: The present invention relates to the use of benzoic acid and/or its sodium salt in combination with saccharide(s) as active components in the manufacture of a vaginal composition for modulating vaginal flora and vaginal acidity, thereby maintaining the pH value of vaginal secretion within a range from 3.5 to 4.5; and the present invention further relates to a vaginal composition and a method for modulating and maintaining normal vaginal flora and vaginal acidity.
    Type: Application
    Filed: April 27, 2006
    Publication date: August 14, 2008
    Applicants: Shenzhen Phlora Biotechnology Limited, HK Phlora Health Science & Technology Ltd.
    Inventors: Ruyun Zhou, Zhongming Zeng
  • 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof
    Publication number: 20080194608
    Abstract: Compounds of the formula (I): in which R1, R2, R3, R?3 and R4 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, the pharmaceutical compositions comprising them, and the processes for the preparation of these compounds.
    Type: Application
    Filed: December 22, 2005
    Publication date: August 14, 2008
    Inventors: Michel Brunet, Herve Dumas, Catherine Vidal, Nathalie Adje, Benoit Van Hille, Francis Contard
  • BLOOD FLUIDITY IMPROVING AGENT
    Publication number: 20080188563
    Abstract: A blood fluidity-improving agent, a blood circulation promoter or a cerebrovascular disease-improving agent, containing as an active ingredient thereof one or more ingredients selected from the group consisting of chlorogenic acids, caffeic acids, ferulic acids and pharmaceutically acceptable salts of these acids. The present blood fluidity-improving agent, blood circulation promoter or cerebrovascular disease-improving agent is highly safe and can be orally taken over longer periods of time.
    Type: Application
    Filed: March 31, 2008
    Publication date: August 7, 2008
    Applicant: KAO CORPORATION
    Inventors: Youichi Arai, Takuya Watanabe, Atsushi Suzuki, Hiroko Joukura
  • MEDICAMENT FOR PREVENTIVE AND THERAPEUTIC TREATMENT OF PHYSICAL DYSFUNCTION CAUSED BY NERVE DAMAGE
    Publication number: 20080182905
    Abstract: A medicament for preventive and/or therapeutic treatment of a physical dysfunction such as motor dysfunction caused by nerve damage resulting from an accident, cerebral crisis and the like, which comprises as an active ingredient a compound or a salt thereof represented by the following general formula (I): wherein R1 to R5 represents hydrogen atom, an alkyl group, or an alkyl-substituted silyl group, X represents —CONH— or —NHCO—, and A represents a carboxylic acid-substituted aromatic group which may be substituted or a tropolonyl group which may be substituted.
    Type: Application
    Filed: February 1, 2007
    Publication date: July 31, 2008
    Applicants: ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE, R&R INC.
    Inventors: Mitsuko Takenaga, Koichi Shudo, Tetsuro Matsuishi, Miwako Ishido
  • SOIL AMENDMENT COMPOSITIONS AND METHODS FOR USING THE SAME
    Publication number: 20080176808
    Abstract: Soil amendment compositions and methods for using the same are provided. The subject compositions are aqueous compositions consisting essentially of a carbon-skeleton energy component, a predisposing agent and a vitamin-cofactor component. The subject compositions find use in a variety of soil amendment applications, including: the control of soil born pests and pathogens; the improvement in soil fertility and/or characteristics, e.g. mineral release, water filtration; the neutralization and/or degradation of toxins, etc.
    Type: Application
    Filed: July 20, 2007
    Publication date: July 24, 2008
    Inventor: THOMAS T. YAMASHITA
  • Bone targeting compounds for delivering agents to bone for interaction therewith
    Patent number: 7399789
    Abstract: The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the bone for interaction therewith.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: July 15, 2008
    Assignee: University of Louisville Research Foundation
    Inventors: William M. Pierce, Leonard C. Waite, K. Grant Taylor
  • Receptor Function Regulation Agent
    Publication number: 20080167378
    Abstract: An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
    Type: Application
    Filed: November 26, 2004
    Publication date: July 10, 2008
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Kohji Fukatsu, Ryo Fujii, Makoto Kobayashi, Jinichi Yonemori, Toshio Tanaka
  • Antiallergic Latex or Pvc Products and the Method of Making Thereof
    Publication number: 20080166383
    Abstract: The present invention provides an antiallergic latex or PVC product, which includes one or more natural antiallergic medicines selected from baicalin, matrine, liquorice saponin, tea polyphenol, arctigenin, oleanolic acid, tetrandrine, sodium ferulate, total alkaloid of asiatic moonseed rhizome, extraction of cortex dictamni radics, ginkgo bilobal A, total glycoside of Rhizoma Anemones flaccidae, extraction of engelhardtia chryolepis, magnolin, osthole, catechin. The latex or PVC products of the present invention are generally in the forms of glove or condom. The present invention solves the problem of hypersensitivity to condom or glove in prior arts by adding the natural antiallergic medicine into the matrix of latex or PVC.
    Type: Application
    Filed: December 9, 2005
    Publication date: July 10, 2008
    Inventors: Zhengming Zhou, Yan Jiang
  • Diagnosis and treatment of cancer related to human dormancy
    Publication number: 20080160007
    Abstract: New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
    Type: Application
    Filed: January 2, 2008
    Publication date: July 3, 2008
    Inventor: Michael Powell
  • Pharmaceutical Preparation For the Oral Cavity
    Publication number: 20080153915
    Abstract: A throat, mouth and/or gum sprayable pharmaceutical preparation in the form of an aqueous solution. One embodiment of such a solution may comprise: a non-steroidal anti-inflammatory drug (NSAID) also having analgesic activity; a biologically compatible buffer consisting essentially of an organic amine selected from at least one D-glucamine, meglumine, trometamol (tris buffer) and a mixture thereof, in a quantity suitable for buffering the pH of the preparation within the range of between about 6.5 and about 8.0; and pharmaceutical grade water; wherein the NSAID is flurbiprofen.
    Type: Application
    Filed: December 20, 2004
    Publication date: June 26, 2008
    Applicant: THERAPICON S.R.L.
    Inventor: Paolo Alberto Veronesi
  • ALPHA-2-DELTA LIGAND/NSAID THERAPEUTIC TREATMENT OF LOWER URINARY TRACT DISORDERS
    Publication number: 20080153888
    Abstract: The invention relates to a method of treating at least one symptom of lower urinary tract disease in a subject in need of treatment comprising administering to said subject a combination of an ?2? calcium channel subunit (A2d) ligand and a non-steroidal anti-inflammatory drug (NSAID), wherein the administered amounts of A2d ligand and NSAID together comprise a therapeutically effective amount of an active combination of agents. The combination of A2d ligand and NSAID can result in a synergistic therapeutic effect, wherein the combined effect is greater than the additive effect resulting from separate, single administration of A2d ligand or NSAID. Combination of A2d ligand and NSAID is particularly useful in treatment of lower urinary tract disease which manifests symptoms of urinary incontinence.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 26, 2008
    Applicant: Recordati Ireland Limited
    Inventors: Amedeo Leonardi, Luciano Guarneri, Patrizia Angelico
  • USE OF ANISIC ACID FOR PROMOTING DESQUAMATION
    Publication number: 20080153839
    Abstract: Use of anisic acid or a derivative thereof for promoting desquamation of the skin and/or for stimulating epidermal renewal. Associated compositions. Especially useful for improving the radiance of the complexion and/or the grain of the skin and/or for smoothing out the skin's microrelief, and/or for attenuating age spots.
    Type: Application
    Filed: December 12, 2007
    Publication date: June 26, 2008
    Applicant: L'OREAL
    Inventors: Thierry Cotton, David Amar
  • Pharmaceutical Formulations
    Publication number: 20080152714
    Abstract: The present invention provides a modified release formulation comprising an active agent in a hydrophilic polymer matrix wherein the active agent is a salt of fenofibric acid wherein the release rate of the formulation in an in vitro dissolution is substantially independent of the ionic strength of the dissolution media.
    Type: Application
    Filed: October 12, 2007
    Publication date: June 26, 2008
    Inventors: Yi Gao, Tzuchi R. Ju, Dennis Y. Lee, Nicole Nguyen, Huailiang Wu
  • HDL-boosting combination therapy complexes
    Patent number: 7390504
    Abstract: A pharmaceutical composition including therapeutically effective amounts of at least one HMG-CoA reductase inhibitor present as a dyhydroxyacid salt and at least one additional therapeutic agent.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: June 24, 2008
    Assignee: JJ Pharma, Inc.
    Inventor: Josefino B. Tunac
  • Methods and articles having a high antiviral and antibacterial efficacy
    Publication number: 20080145390
    Abstract: Method and article for providing a rapid, broad spectrum bacterial control, and a rapid and persistent antiviral control on an inanimate surface is disclosed. In the method, a compound or composition capable of lowering surface pH to less than about 4 is applied to the surface, and preferably is allowed to remain on the surface, and the nonvolatile components of the composition can form a barrier film or layer on a treated surface.
    Type: Application
    Filed: June 4, 2007
    Publication date: June 19, 2008
    Applicant: THE DIAL CORPORATION
    Inventors: Timothy J. Taylor, Harry E. Towner, Janice L. Fuls, Bruce R. Cox, George E. Fischler, Priscilla S. Fox, Nancy D. Rodgers, James Dalton, Daniel E. Pedersen, John J. Rolando, Richard K. Staub
  • Fc Receptor Modulating Compounds and Compositions
    Publication number: 20080146632
    Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc?RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.
    Type: Application
    Filed: February 1, 2008
    Publication date: June 19, 2008
    Applicant: TRILLIUM THERAPEUTICS, INC.
    Inventors: Mark Phillip Hogarth, Geoffrey Allan Pietersz, Gerard Peter Moloney
  • SPECIFIC INHIBITORS FOR VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
    Publication number: 20080139585
    Abstract: The present application describes isoindoles and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful inhibitors of VEGFR.
    Type: Application
    Filed: September 21, 2007
    Publication date: June 12, 2008
    Applicant: NOVA SOUTHEASTERN UNIVERSITY
    Inventors: Appu Rathinavelu, Sivanesan Dakshanamurthy, Nagarajan Pattabiraman
  • Potentiators Of Glutamate Receptors
    Publication number: 20080139505
    Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
    Type: Application
    Filed: November 15, 2005
    Publication date: June 12, 2008
    Inventors: Thomas Daniel Aicher, Guillermo S. Cortez, Todd Michael Groendyke, Albert Khilevich, James Allen Knobelsdorf, Fredrik Pehr Marmsater, Jeffrey Michael Schkeryantz, Tony Pisal Tang, Nicholas Andrew Magnus
  • Compositions Having a High Antiviral and Antibacterial Efficacy
    Publication number: 20080139656
    Abstract: Antimicrobial compositions having a rapid antiviral and antibacterial effectiveness, and a persistent antiviral effectiveness, are disclosed. The antimicrobial compositions contain a phenolic antimicrobial agent, a disinfecting alcohol, a gelling agent, and an organic acid, wherein the phenolic antimicrobial agent is present in a continuous aqueous phase in an amount of at least 50% of saturation concentration and the composition has a pH of about 5 or less.
    Type: Application
    Filed: December 5, 2005
    Publication date: June 12, 2008
    Applicant: The Dial Corporation
    Inventors: Timothy J. Taylor, Earl P. Seitz Jr., Priscilla S. Fox
  • Phenylbenzoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof
    Publication number: 20080139599
    Abstract: Compounds of the formula (1) in which R1, R2,X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 12, 2008
    Inventors: Michel Brunet, Nathalie Adje, Valerie Guyard-Dangremont, Francis Contard
  • Hydrazide Derivatives
    Publication number: 20080132507
    Abstract: A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation. wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc., R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc., Z1, Z2 and Z3 each independently represent hydrogen, etc., Z4 represents hydrogen, etc. and X represents a single bond or —CO—, etc.
    Type: Application
    Filed: October 13, 2005
    Publication date: June 5, 2008
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Richard Clark, Shinsuke Hirota, Hiroshi Azuma, Kazunobu Kira, Nobuhisa Watanabe, Tadashi Nagakura, Tatsuo Horizoe
  • Use of 2,5-Dihydroxybenzene Derivatives for Treating Actinic Keratosis
    Publication number: 20080125485
    Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or phrophylactic treatment of, inter alia, actinic keratosis.
    Type: Application
    Filed: August 15, 2007
    Publication date: May 29, 2008
    Applicant: Action Medicines
    Inventors: Pedro Cuevas Sanchez, Guillermo Gimenez Gallego, Inigo Saenz de Tejada Morgan, Javier Angulo Frutos, Serafin Valverde Lopez, Antonio Romero Garrido, Rosa Maria Lozano Puerto
  • Use of 2,5-Dihydroxybenzene Compounds and Derivatives for the Treatment of Hematological Dyscrasias and Cancer of an Organ
    Publication number: 20080125486
    Abstract: The present invention refers to the use of the compound of Formula (I?) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological dyscrasias, including myelodisplastic syndromes (MDSs) and for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy. In addition, it relates to the use of a compound of formula (I?) for the treatment and/or prophylaxis of cancer of an organ.
    Type: Application
    Filed: August 15, 2007
    Publication date: May 29, 2008
    Applicant: Action Medicines
    Inventors: Pedro Cuevas Sanchez, Guillermo Gimenez Gallego, Inigo Saenz de Tejada Morgan, Javier Angulo Frutos, Rosa Maria Lozano Puerto, Antonio Romero Garrido, Serafin Valverde Lopez
  • Method for preventing and treating avian influenza in human
    Publication number: 20080119545
    Abstract: A method and composition for preventing and treating Avian Influenza in Humans utilizes an effective quantity of polyphenolic(s) and/or its derivatives in combination with a carrier. The anti-avian influenza ingredient having a composition selected from the group consisting of theaflavin, theaflavin-3,3?-digallate, theaflavin-3-monogallate, theaflavin-3 gallate, theaflavin-3?-gallate, thearubigin, gallic acid, tannic acid, (?)-epigallocatechin gallate (EGCG), (?) epigalloatechin (EGC), (+)-epicatechin (EC), (?)-gallocatechin gallate (GCG), and catechin.
    Type: Application
    Filed: September 20, 2007
    Publication date: May 22, 2008
    Inventors: Charles Hensley, Sung Pyo
  • THERAPEUTIC COMPOUNDS
    Publication number: 20080119538
    Abstract: Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: July 6, 2007
    Publication date: May 22, 2008
    Inventors: DAVID W. OLD, Vinh X. Ngo
  • THERAPEUTIC AMIDES
    Publication number: 20080119539
    Abstract: Compounds of the formula are disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: September 6, 2007
    Publication date: May 22, 2008
    Inventors: David W. Old, Robert M. Burk, Todd S. Gac
  • Compositions and methods for the inhibition of dishevelled proteins
    Publication number: 20080119402
    Abstract: The Wnt signaling pathways are involved in embryo development as well as in tumorigenesis. Dishevelled (Dvl) tranduces Wnt signals from the receptor Frizzled (Fz) to downstream components in canonical and non-canonical Wnt signaling pathways, and the Dvl PDZ domain plays an essential role in both pathways, and the Dvl PDZ domain binds directly to Fz receptors. In the present invention using NMR-assisted virtual ligand screening, several compounds were identified and were found to bind to the Dvl PDZ domain. Molecular dynamics simulation was used to analyze the binding between the PDZ domain and these compounds in detail. These compounds provide a basis for rational design of high-affinity inhibitors of the PDZ domain, which can block Wnt signaling by interrupting the Fz-Dvl interaction.
    Type: Application
    Filed: April 1, 2005
    Publication date: May 22, 2008
    Inventors: Jie Zheng, Jufang Shan, Dianqing Wu
  • MATRIX-EMBEDDED COMPOSITIONS HAVING ORGANIC ACIDS AND FATTY ACIDS
    Publication number: 20080119552
    Abstract: The invention generally provides matrix-embedded compositions having organic acids and fatty acids. The compositions may be administered to an animal to deliver intact organic acids and fatty acids to the animal's small intestine. The invention also provides monograstric feed rations comprising the matrix-embedded compositions.
    Type: Application
    Filed: November 13, 2007
    Publication date: May 22, 2008
    Applicant: NOVUS INTERNATIONAL INC.
    Inventor: Felipe Navarro
  • Aryl dicarboxamides
    Patent number: 7365225
    Abstract: The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: April 29, 2008
    Assignee: Laboratoires Serono SA
    Inventors: Russel J. Thomas, Dominique Swinnen, Jean-Francois Pons, Agnes Bombrun
  • Compounds and methods
    Patent number: 7365085
    Abstract: Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: April 29, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: Ajita Bhat, John Jeffrey McAtee, Scott K. Thompson, James S. Frazee, Lara S. Kallander, Chun Ma, Joseph Marino, Michael J. Neeb, Robert A. Stavenger
  • Solid oral formulations for combination therapy
    Publication number: 20080085314
    Abstract: A first, solid oral pharmaceutical composition includes an extended release acetaminophen, a non-steroidal anti-inflammatory drug, such as naproxen or ibuprofen, and a third drug capable of reducing gastric acid secretion, such as ranitidine or omeprazole. A second, solid oral pharmaceutical composition includes a non-steroidal anti-inflammatory drug and an agent for reducing gastric acid secretion.
    Type: Application
    Filed: July 27, 2006
    Publication date: April 10, 2008
    Inventor: Shalaby W. Shalaby
  • Pharmaceutical combinations for the treatment of head-aches and migraine attacks as well as blisters and packs that contain them
    Publication number: 20080081798
    Abstract: A pharmaceutical combination comprising at least a triptan and the trimebutine compound [hydrogenated maleate of 2-dimethyl-amino-2-phenylbutyl-3,4,5-trimetoxybenzoate] and an anti-inflammatory or simple analgesic for the treatment of attacks of migraine and other headaches is provided. More particularly, the present invention discloses a pharmaceutical combination comprising triptan and trimebutine for the treatment of migraine attacks. The present invention further discloses blisters and packs containing said pharmaceutical combinations.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 3, 2008
    Inventor: Abouch Valenty Krymchantowski
  • Treatment of Inflammatory Bowel Disease
    Publication number: 20080076827
    Abstract: Actarit or a salt thereof is useful for the treatment of inflammatory bowel disease.
    Type: Application
    Filed: October 20, 2005
    Publication date: March 27, 2008
    Inventors: John Brew, Robin Mark Bannister
  • SYNERGISTIC HIV/AIDS AND/OR IMMUNE DISEASE PHYTO-NUTRACEUTICAL COMPOSITION
    Publication number: 20080063658
    Abstract: Phytoceutical composition for the prevention and treatment of HIV/AIDS and/or immune disorders. A specific combination of extracts of plants is taught, as well as the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence and Organization. Such combination has synergistic effects, with minimal side effects.
    Type: Application
    Filed: September 7, 2006
    Publication date: March 13, 2008
    Inventor: JOSE ANGEL OLALDE RANGEL
  • Preservative blends containing quaternary ammonium compounds
    Patent number: 7342044
    Abstract: The present invention provides a biocidal composition comprising a synergistic mixture of certain quaternary ammonium biocides and one or more ketone acids, aromatic carboxylic acids, salts thereof, or mixtures thereof.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: March 11, 2008
    Assignee: Lonza Inc.
    Inventor: Patrick Jay Lutz
  • Methods to Treat Alzheimer's Disease
    Publication number: 20080058336
    Abstract: The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 6, 2008
    Inventors: Roy Hom, Shumeye S. Mamo, Jay Tung, Andrea Gailunas, Varghese John, Lawrence Y. Fang
  • 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same
    Publication number: 20080058412
    Abstract: The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to a method for preparing said derivatives.
    Type: Application
    Filed: January 7, 2005
    Publication date: March 6, 2008
    Applicant: GENFIT
    Inventors: Karine Caumont-Bertrand, Jean-Francois Delhomel
  • PEELING PROCESS BASED ON SURFACTANTS AND ACIDS
    Publication number: 20080051461
    Abstract: Process for the treatment of human skin, by applying topically onto the skin a composition containing in a physiologically acceptable medium (i) at least one hydroxy acid selected from the ?-hydroxy acids, ?-hydroxy acids, ?-keto acids, ?-keto acids and mixtures thereof, and (ii) at least 5% by weight, relative to the total weight of the composition, of one or more surfactants containing an alkyl chain having from 6 to 16 carbon atoms.
    Type: Application
    Filed: August 21, 2007
    Publication date: February 28, 2008
    Applicant: L'OREAL
    Inventors: Odile AUBRUN-SONNEVILLE, Michelle Rathman Josserand
  • Anti-Degradation Agent
    Publication number: 20080044540
    Abstract: There is provided an anti-degradation agent capable of exhibiting an excellent deterioration-inhibiting property for foods, cosmetics, etc., showing a good effect even when added in a small amount, having a high heat resistance, and being free from adverse influence due to light. There are provided (1) an anti-degradation agent comprising a water-insoluble antioxidant, a water-soluble antioxidant and an emulsifying agent; and (2) an anti-degradation agent comprising a water-soluble antioxidant, and carnosol and/or carnosic acid wherein a total content of the carnosol and the carnosic acid is not less than 4% by weight.
    Type: Application
    Filed: March 17, 2005
    Publication date: February 21, 2008
    Inventor: Hirotsugu Kido