Acyclic Acid Or Salt Thereof Patents (Class 514/578)
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Publication number: 20130121985Abstract: Methods for treating male sub-fertility by administering a pharmaceutical composition to a subject in need thereof are provided. The pharmaceutical compositions include an agent that causes a reduction in an effect of extracellular DNA on sperm cells. The agent may be, for example, an enzyme that degrades DNA such as DNase, a substance that blocks the interaction between cell free DNA and sperm cell surface receptors, a substance that binds to DNA, a substance that inhibits endogenous sperm cell DNase, a substance that inhibits a member of a signal transduction pathway mediated by DNA binding to sperm cell surface receptors, or an agent that stimulates production of an endogenous substance that causes a reduction in an antifertility effect of cell free DNA on sperm cells.Type: ApplicationFiled: December 20, 2012Publication date: May 16, 2013Inventors: Benjamin BARTOOV, Ronen YEHUDA, Melamed DOBROSLAV
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Patent number: 8426468Abstract: Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of triglycerides or fatty acids with chain lengths between 5 and 12, to said patient at a level to produce an improvement in cognitive ability.Type: GrantFiled: April 12, 2012Date of Patent: April 23, 2013Assignee: Accera, Inc.Inventor: Samuel T. Henderson
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Publication number: 20130085182Abstract: The present invention refers to 2-mercaptoethane sulfonate or pharmaceutically acceptable salts thereof and to pharmaceutical compositions comprising it for epidural use in the treatment of lumbar pain.Type: ApplicationFiled: October 13, 2011Publication date: April 4, 2013Applicant: UNIVERSITA' CAMPUS BIO-MEDICO DI ROMAInventors: Massimiliano Carassiti, Felice Eugenio Agrò, Vincenzo Denaro, Alberto Corrado Di Martino
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Patent number: 8409630Abstract: The process involves (a) continuously forming bromine chloride from separate feed streams of bromine and chlorine by maintaining said streams under automatic feed rate control whereby the streams are continuously proportioned to come together in equimolar amounts to form bromine chloride; (b) continuously forming an aqueous product having an active bromine content of at least 100,000 ppm (wt/wt), a pH of at least 7, and an atom ratio of nitrogen to active bromine greater than 0.93:1 by continuously feeding into mixing apparatus separate feed streams of (1) bromine chloride formed in (a), and (2) an aqueous solution of alkali metal salt of sulfamic acid, under automatic feed rate control whereby the feed streams are continuously proportioned to come together in amounts that produce an aqueous product having an active bromine content of at least 100,000 ppm (wt/wt), a pH of at least 7, and an atom ratio of nitrogen to active bromine from (1) and (2) greater than 0.Type: GrantFiled: February 16, 2001Date of Patent: April 2, 2013Assignee: Albermarle CorporationInventors: Robert M. Moore, Jr., Christopher J. Nalepa
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Patent number: 8383679Abstract: The present invention relates to a novel crystal form of calcium 3-acetylaminopropane-1-sulfonate, to a process for the preparation thereof, and to the use thereof in medicaments.Type: GrantFiled: August 25, 2009Date of Patent: February 26, 2013Assignee: Merck Patent Gesellschaft mit beschränkter HaftungInventors: Antje Ernst, Clemens Kuehn, Matthias Bartels, Christoph Saal, Nathalie Bosc
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Patent number: 8372886Abstract: Disclosed herein are methods, compounds and compositions for preventing or treating a renal disorder or chronic kidney diseases, including nephropathies such as diabetic nephropathy. The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for the prevention and/or treatment of for preventing or treating a renal disorder complication. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in diabetic patients.Type: GrantFiled: December 22, 2006Date of Patent: February 12, 2013Assignee: Kiacta SarlInventors: Wendy Hauck, Pavel Hamet
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Publication number: 20130004589Abstract: Compositions and methods for treating and/or preventing conditions such as diaper rash and atopic dermatitis are disclosed. The compositions and methods are particularly useful in the treatment and prevention of diaper rash and diaper dermatitis caused by the prolonged contact of human skin with body waste. The methods employ the topical application of a trypsin-inhibiting agent to the area in need of such treatment, or the area where prevention is desired. The trypsin-inhibiting agent is preferably a divalent cation/anion pair.Type: ApplicationFiled: June 28, 2011Publication date: January 3, 2013Inventors: Connie B. Lin, Euen Thomas Graham Ekman Gunn, Ya-Ping Hu, Neema Kulkarni, Mary Catherine Mack
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Patent number: 8343947Abstract: The invention describes the use of betaine for treating and preventing arterites. The invention also describes an orally administered composition for treating arterites and, in particular, intermittent claudication, said composition containing, as an active ingredient, an active therapeutic quantity of betaine glycine by single dose. The invention particularly describes a medicament provided for treating a patient suffering from an intermittent claudication caused by peripheral circulatory disorders such as arteriosclerosis obliterans or by thromboangiitis obliterans.Type: GrantFiled: March 17, 2010Date of Patent: January 1, 2013Inventor: Jallal Messadek
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Publication number: 20120328519Abstract: The present invention relates to the novel compound classes of dendritic polyglycerol sulfates and sultanates as well as to their production and use for the treatment of diseases, particularly inflammatory diseases, and to their use as selectin inhibitors and selectin indicators. The dendritic polyglycerol sulfates and sulfonates are also suitable for imaging diagnostics, particularly with respect to inflammatory diseases.Type: ApplicationFiled: August 3, 2007Publication date: December 27, 2012Inventors: Rainer Haag, Jens Dernedde, Rudolf Tauber, Gesche Bernhard, Sven Enders, Heidemarie Weinhart, Arne Von Bonin, Ulrich Zügel, Holger Türk
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Publication number: 20120316206Abstract: The present invention provides a composition having an excellent controlling activity on plant disease. The composition comprising the compound represented by the formula (1) and one or more carbamate fungicidal compound selected from the group (A) shows an excellent controlling activity on a plant disease.Type: ApplicationFiled: March 2, 2011Publication date: December 13, 2012Applicant: Sumitomo Chemical Company, LimitedInventors: So Kiguchi, Soichi Tanaka, Mayuko Ozawa, Atsushi Iwata
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Publication number: 20120315298Abstract: A method for treating a neurofibroma, e.g. dermal neurofibroma, a subdermal neurofibroma, or a superficial plexiform neurofibroma, in a subject in need of such treatment is disclosed. The method comprises locally applying a composition to a neurofibroma either topically or intralesionally. This method does not encompass systemic administration of the composition to the subject to have an effect on the neurofibromas. Compositions useful for such treatments and methods of preparing the compositions are disclosed.Type: ApplicationFiled: June 15, 2012Publication date: December 13, 2012Applicant: NEXGENIX PHARMACEUTICALS, INCInventors: Ruihong CHEN, Allan E. Rubenstein, Xiaodong Shen, Scott Stewart, Jin-Chen Yu
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Publication number: 20120282351Abstract: Disclosed is a system that prevents the development of infection and biofilm establishment in medical devices in general, and in particular Urinary Tract Infections (UTI), including Catheter-Associated Urinary Tract Infections (CAUTI). The system comprises a medical device (such as a catheter) and an antimicrobial composition containing an antimicrobial compound. A medical device delivers the composition both to the inside and/or outside portions of the device, as well as to the inside of the bladder itself and to the urethra. Reduction or elimination of the infection may be accomplished by irrigating the medical device, bathing the bladder, or irrigating the bladder with the composition.Type: ApplicationFiled: June 14, 2012Publication date: November 8, 2012Inventors: Ramin Najafi, Mansour Bassiri, Lu Wang, Behzad Khosrovi
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Publication number: 20120277245Abstract: A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO3, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.Type: ApplicationFiled: May 24, 2012Publication date: November 1, 2012Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventors: Robert J. Gillies, David L. Morse, Ariosto Siqueira Silva, Arig A. Ibrahim Hashim, Robert A. Gatenby, Gary Martinez
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Publication number: 20120270939Abstract: Methods, formulations, and compositions for the treatment of amyloidosis are described.Type: ApplicationFiled: May 15, 2012Publication date: October 25, 2012Inventors: Denis Garceau, Wendy Hauck, Richard Briand
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Patent number: 8293793Abstract: The present invention relates to propionic acid-comprising compositions in solid and essentially pure form comprising at least one compound according to formula (I) (Mn+)(H+)x(CH3CH2C(O)O?)(n+x)??(I), where Mn+ is an n-valent alkali metal cation or alkaline earth metal cation, n being equal to 1 or 2; and x is a number in the range from 0.25 to 5; with the proviso that x is not in the range from 0.75 to 1.75 when Mn+ is potassium; a method for producing such propionic acid-comprising compositions; and also the use of such compositions as silage additive, preservative, acidifier, food supplement, feedstuff or feedstuff additive for animal feed.Type: GrantFiled: December 29, 2006Date of Patent: October 23, 2012Assignee: BASF SEInventors: Alexander Hauk, Stefan Gropp, Gerd Diebold, Florian Weigel, Gerhard Laux
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Publication number: 20120220642Abstract: Methods for increasing the bioabsorption of amino acids and for preventing the development of nitrate tolerances in a human or animal are disclosed. The methods include administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or nitrite of an amino acid selected from the group consisting of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, Phenylalanine, Carnitine, Taurine, and Betaine.Type: ApplicationFiled: May 7, 2012Publication date: August 30, 2012Applicant: THERMOLIFE INTERNATIONAL, LLCInventors: Ronald Kramer, Alexander Nikolaidis
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Publication number: 20120220643Abstract: A method for increasing the vasodilative characteristics of amino acids in a human or animal is disclosed. The method includes administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or nitrite of an amino acid selected from the group consisting of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, Phenylalanine, Carnitine, Taurine, and Betaine.Type: ApplicationFiled: May 10, 2012Publication date: August 30, 2012Applicant: THERMOLIFE INTERNATIONAL, LLCInventors: Ronald Kramer, Alexander Nikolaidis
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Publication number: 20120202883Abstract: Point mutations of the NADP+-dependent isocitrate dehydrogenases (IDH1 and IDH2) occur early in the pathogenesis of gliomas. When mutated, IDH1 and IDH2 gain the ability to produce the metabolite (R)-2-hydroxyglutarate (2HG), but the downstream effects of mutant IDH1 and IDH2 proteins or of 2HG on cellular metabolism are unknown. Here, we profiled >200 metabolites in human oligodendroglioma cell line (HOG) cells to determine the effects of expression of IDH1 and IDH2 mutants. Levels of amino acids, glutathione metabolites, choline derivatives, and tricarboxylic acid (TCA) cycle intermediates were altered in both mutant IDH1- and IDH2-expressing cells. These changes were similar to those identified after treatment of the cells with 2HG. Remarkably, N-acetyl-aspartyl-glutamate (NAAG), a common dipeptide in brain, was 50-fold reduced in cells expressing IDH1 mutants and 8.3-fold reduced in cells expressing IDH2 mutants.Type: ApplicationFiled: January 20, 2012Publication date: August 9, 2012Applicant: DUKE UNIVERSITYInventors: Yan Hai, Darell Bigner, Yiping He, Genglin Jin, Zachary Reitman
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Publication number: 20120172450Abstract: A formulation comprising jasmonate for improving skeletal muscle function in a mammal, particularly a human is provided. This may be accomplished by reducing muscle fatigue and/or increasing skeletal muscle performance.Type: ApplicationFiled: December 9, 2011Publication date: July 5, 2012Applicant: BROADY HEALTH SCIENCES, LLCInventor: Brunde Broady
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Patent number: 8188004Abstract: An organic herbicide is disclosed and comprises oxidized natural oils such as clove oil, and cinnamon oil. A natural surfactant is disclosed comprising 30-50% by weight casein, 50-70% by weight whole egg powder and 0-5% by weight Konjac glucomannan.Type: GrantFiled: May 10, 2008Date of Patent: May 29, 2012Assignee: JH Biotech, Inc.Inventors: Hsinhung John Hsu, Sergejs Trusovs, Franz R. Fernandez
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Publication number: 20120129793Abstract: The present application describes compounds of Formula I and Formula IA and as disclosed herein, that are useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.Type: ApplicationFiled: October 18, 2011Publication date: May 24, 2012Inventors: Rakesh K. Jain, Timothy Shiau, Charles Francavilla, Eddy Low, Eric Douglas Turtle, Donogh John Roger O'Mahony
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Publication number: 20120107300Abstract: Cannabinoid compositions and methods of administering said cannabinoid compositions are disclosed. The cannabinoid compositions disclosed herein include compounds which have been strategically selected to eliminate, or least mitigate, one of the negative side effects associated with consuming cannabinoids. A daytime formula includes compounds aimed at nullifying the negative side effects that cannabinoid consumption has on a patient's daily operations and activities. A nighttime formula includes compounds aimed at nullifying the negative side effects that cannabinoid consumption has a patient's sleep.Type: ApplicationFiled: November 1, 2010Publication date: May 3, 2012Inventor: Jeffrey Nathan Schirripa
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Patent number: 8153165Abstract: The invention describes novel preparations and their use for reducing the acute damaging effect of ammonia in organisms living in the keeping water of aquariums, garden ponds, or aquaculture systems. The preparations consist of adducts of sodium hydrogen sulfite at an aliphatic aldehyde of the general formula X—(CH2)n—CO—H, wherein n means the numbers 0 to 3, and X means an —OH, —COOH, or —CO—H group, wherein X cannot be —OH, if n=0. The preparations are used in the keeping water with a concentration of 10 to 140 mg/l.Type: GrantFiled: September 20, 2007Date of Patent: April 10, 2012Assignee: Tetra GmbHInventor: Günter Ritter
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Publication number: 20120077878Abstract: Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described.Type: ApplicationFiled: September 28, 2011Publication date: March 29, 2012Applicant: DEPOMED, INC.Inventors: Bret Berner, Cuiping Chen
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Publication number: 20120074014Abstract: Products based on salt of peroxymonosulfuric acid are suitable for treating or/and preventing diseases and other debilitating medical conditions caused by bacterial, eukaryotic, prion, and viral pathogens and by non-pathogenic inflammation. The products may alternatively be based on inorganic halide and an oxidizing agent reactable in water with the inorganic halide to generate hypohalite ions. In addition, the products can be employed in other applications such as commercial and industrial applications.Type: ApplicationFiled: March 14, 2011Publication date: March 29, 2012Inventors: David Van Tran, David Nguyen Tran
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Publication number: 20120053243Abstract: To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives.Type: ApplicationFiled: November 7, 2011Publication date: March 1, 2012Applicant: SHISEIDO COMPANY, LTD.Inventors: Mikiko Kaminuma, Masaru Suetsugu, Toshii Iida, Shinji Inomata, Keiko Takada, Yuji Katsuta
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Publication number: 20120020881Abstract: This invention relates to novel compounds suitable for labeling by positron emitting isotopes, such as 18F, 11C, 13N and 15O, through appropriate labeling reagents, such as 18F reagents and methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).Type: ApplicationFiled: December 4, 2009Publication date: January 26, 2012Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFTInventors: Lutz Lehmann, Timo Stellfeld, Keith Graham, Jessica Becaud, Linjing Mu
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Publication number: 20110319790Abstract: Provided is a pharmaceutical composition for permeabilizing fetal membranes including an active ingredient having a log K in the range of 2 to 4, where K is the octanol/water partition coefficient. The active ingredient may be, for example, bupivacaine, sodium lauryl sulfate or oleic acid. Further provided is a system for transfetal membrane transport. The system includes a probe unit adapted for insertion into a female reproductive tract and releasing a substance onto fetal membranes that permeabilizes the membranes. The system is also configured to apply ultrasound radiation to the fetal membranes to further increase the membrane permeability.Type: ApplicationFiled: November 25, 2009Publication date: December 29, 2011Applicant: B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.Inventors: Joseph Kost, Mordechai Halak, Drora Shmilovitch, Tamar Triatel, Rivka Goldbart, Aharon Azaguri, Lior Wollach
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Publication number: 20110305756Abstract: A coated solid preparation includes an active ingredient including valproic acid or a pharmacologically acceptable salt thereof, and a coating layer containing polyvinyl alcohol and swelling clay coating the active ingredient wherein mass ratio of the polyvinyl alcohol to the swelling clay is 8:2 to 3:7 and the swelling clay is dispersed as a laminated structure.Type: ApplicationFiled: March 3, 2010Publication date: December 15, 2011Applicant: TORAY INDUSTRIES, INC.Inventors: Yuki Hayashi, Ryoji Yoshii, Yasuhide Horiuchi
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Patent number: 8071646Abstract: The present invention provides highly purified omega-3 fatty acid formulations. Certain formulations provided herein contain greater than 85% omega-3 fatty acids by weight. Certain other formulations provided herein contain EPA and DHA in a ratio of from about 4.01:1 to about 5:1. The invention also provides methods of using the dosage forms to treat a variety of cardiovascular, autoimmune, inflammatory, and central nervous system disorders by administering a formulation of the invention to a patient in need thereof.Type: GrantFiled: October 28, 2009Date of Patent: December 6, 2011Assignee: Cenestra LLCInventors: Seth D. Feuerstein, Ann Coric, Louis C. Sanfilippo
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Publication number: 20110293582Abstract: Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.Type: ApplicationFiled: February 3, 2010Publication date: December 1, 2011Applicant: CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Leonard I. Zon, Pulin Li
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Publication number: 20110281951Abstract: Therapeutic compounds and methods for modulating amyloid aggregation in a subject, whatever its clinical setting, are described. Amyloid aggregation is modulated by the administration to a subject of an effective amount of a therapeutic compound of the formula or a pharmaceutically acceptable salt or ester, such that modulation of amyloid aggregation occurs. R1 and R2 are each independently a hydrogen atom or a substituted or unsubstituted aliphatic or aryl group. Z and Q are each independently a carbonyl (C?O), thiocarbonyl (C?S), sulfonyl (SO2), or sulfoxide (S?O) group. “k” and “m” are 0 or 1, provided when k is 1, R1 is not a hydrogen atom, and when m is 1, R2 is not a hydrogen atom. In an embodiment, at least one of k or m must equal 1. “p” and “s” are each independently positive integers selected such that the biodistribution of the therapeutic compound for an intended target site is not prevented while maintaining activity of the therapeutic compound.Type: ApplicationFiled: April 14, 2011Publication date: November 17, 2011Inventors: Walter Szarek, Donald Weaver, Xianqi Kong, Heather Gordon
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Patent number: 8048435Abstract: A process of producing a concentrated liquid biocide formulation is described. Mixed together are (a) bromine and (b) an aqueous solution of alkali metal salt of sulfamic acid having a pH of at least about 12, in amounts such that (i) the active bromine content of the solution is at least about 100,000 ppm (wt/wt), and (ii) the atom ratio of nitrogen to active bromine from (a) and (b) is greater than 1. A continuous process for producing the concentrated liquid biocide composition is provided. This process comprises continuously feeding into mixing apparatus (i) bromine and (ii) an aqueous solution of alkali metal salt of sulfamic acid; the desired product is withdrawn from the mixing apparatus at a rate sufficient to enable the continuous feeding to be maintained. Also described are methods for disinfecting surfaces and for sanitizing bodies of water using a single-feed, bromine-based biocide. These methods use concentrated liquid biocide compositions comprising biocidally active bromine as the biocide.Type: GrantFiled: June 8, 2009Date of Patent: November 1, 2011Assignee: Albemarle CorporationInventors: Robert M. Moore, Jr., Christopher J. Nalepa
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Publication number: 20110262559Abstract: A controlled release remediation composition or compositions, a method making such composition(s), a method of using such composition(s), and a remediation system including such composition(s) are disclosed. The disclosed controlled release remediation composition or compositions include at least one chemical oxidant agent, optionally, at least two chemical oxidant agents; at least one encapsulant polymer; and, optionally, at least one matrix polymer. The disclosed controlled release remediation composition or compositions are capable of substantially constantly releasing an amount of the at least one chemical oxidant agent, optionally, amounts of the at least two chemical oxidant agents, for example, into an aqueous system such as may be found at a contaminated site, over at least about a one month period up to over about a three month period.Type: ApplicationFiled: October 15, 2008Publication date: October 27, 2011Inventor: Stephanie Luster-Teasley
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Patent number: 8044100Abstract: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.Type: GrantFiled: December 21, 2005Date of Patent: October 25, 2011Assignee: Bellus Health Inc.Inventors: Xianqi Kong, Xinfu Wu, Abderrahim Bouzide, Isabelle Valade, David Migneault, Francine Gervais, Daniel Delorme, Benoit Bachand, Mohamed Atfani, Sophie Levesque, Bita Samim
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Patent number: 8034799Abstract: Methods are provided for reducing copper values for, by way of example, treating, preventing or ameliorating tissue damage such as, for example, tissue damage that may be caused by (i) disorders of the heart muscle (for example, cardiomyopathy or myocarditis) such as idiopathic cardiomyopathy, metabolic cardiomyopathy which includes diabetic cardiomyopathy, alcoholic cardiomyopathy, drug-induced cardiomyopathy, ischemic cardiomyopathy, and hypertensive cardiomyopathy, (ii) atheromatous disorders of the major blood vessels (macrovascular disease) such as the aorta, the coronary arteries, the carotid arteries, the cerebrovascular arteries, the renal arteries, the iliac arteries, the femoral arteries, and the popliteal arteries, (iii) toxic, drug-induced, and metabolic (including hypertensive and/or diabetic disorders of small blood vessels (microvascular disease) such as the retinal arterioles, the glomerular arterioles, the vasa nervorum, cardiac arterioles, and associated capillary beds of the eye, the kidneyType: GrantFiled: September 7, 2005Date of Patent: October 11, 2011Assignee: Philera New Zealand LimitedInventors: Garth J. S. Cooper, John R. Baker
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Publication number: 20110237676Abstract: Provided herein are new spermicidal compositions that include one or more fluorous surfactants, e.g., non-ionic fluorous surfactants, anionic fluorous surfactants, cationic fluorous surfactants, and combinations thereof. Also provided are methods of preventing fertilization of an ovum, which include a step of contacting at least one spermatozoon with one or more fluorous surfactants. Additionally described herein are methods of preventing infection, which include a step of contacting at least one infectious pathogenic microorganism with one or more fluorous surfactants. Numerous fluorine-containing surfactants are demonstrated to be efficacious as human spermicides.Type: ApplicationFiled: August 20, 2008Publication date: September 29, 2011Applicant: LEHIGH UNIVERSITYInventors: Barry Bean, Robert A Flowers, Jennifer J Venditti, Rajni Singh
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Patent number: 8021648Abstract: Agricultural crops are protected from the growth of undesirable vegetation as well as nematode and insect infestations, by the application of hydrogen cyanamide in combination with a short-chain, water-soluble monocarboxylic acid, with improved pesticidal effect.Type: GrantFiled: September 25, 2008Date of Patent: September 20, 2011Assignee: Metbro PartnersInventor: Rodrigo Rodriguez-Kabana
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Publication number: 20110195039Abstract: A method of treating hair comprising applying a hair building solid agent for use on or with one or more of hair, skin and hair building solids for altering and/or maintaining the electrostatic charge of the hair and/or skin such that it has a substantially negative polarity. The method further comprises applying hair building solids to hair before and/or during and/or after applying the hair building solid agent. The hair building solid agent is applied as a spray on to the hair and/or skin and/or hair building solid.Type: ApplicationFiled: February 11, 2011Publication date: August 11, 2011Applicant: PANGAEA LABORATORIES LTD.Inventor: Elliot Isaacs
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Publication number: 20110196041Abstract: The present invention relates to a novel crystal form of calcium 3-acetylaminopropane-1-sulfonate, to a process for the preparation thereof, and to the use thereof in medicaments.Type: ApplicationFiled: August 25, 2009Publication date: August 11, 2011Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Antje Ernst, Clemens Kuehn, Matthias Bartels, Christoph Saal, Nathalie Bosc
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Publication number: 20110196014Abstract: Provided are methionine analogs which may be useful for inhibiting protein synthesis, inhibiting microbial growth and/or treating infectious diseases. In some instances, the analogs exhibit bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and/or antiviral properties. Also provided are methods of treatment and methods of preparation, as well as kits and unit dosages.Type: ApplicationFiled: July 31, 2009Publication date: August 11, 2011Inventors: Mansour Bassiri, Afsaneh Rahimi-Larijani
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Publication number: 20110182953Abstract: The present invention relates to a new polymorphic form of calcium acetyl-homotaurinate, designated as form B, and processes for the preparation of said form B and of the known crystalline form.Type: ApplicationFiled: September 4, 2009Publication date: July 28, 2011Inventors: Annibale Salvi, Antonio Nardi, Bruno De Angelis
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Publication number: 20110172171Abstract: The present invention relates to taurine or taurine-like substances for the prevention of brain oedema, particularly brain intramyelinic oedema and more particularly brain intramyelinic oedema induced by an anti-convulsive drug such as vigabatrin. The invention relates to a substance selected from the group consisting of taurine, a taurine precursor, a taurine metabolite, a taurine derivative, a taurine analog and a substance required for the taurine biosynthesis for the prevention of brain oedema.Type: ApplicationFiled: September 4, 2009Publication date: July 14, 2011Inventors: Serge Picaud, José-Alain Sahel, Firas Jammoul
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Publication number: 20110159304Abstract: Disclosed are a composition for inhibiting a proliferation of sulphate reducing bacteria comprising at least one of 1,2-benzisothiazol-3(2H)-one, irgasan, benzyl-2-bromoacetate, 2,2-dibromo-2-cyanoacetamide, and 2-bromo-2-nitropropan-1,3-diol as effective ingredients; a method for inhibiting the proliferation of sulphate reducing bacteria comprising the step of including a sufficient amount for inhibiting the proliferation of sulphate reducing bacteria of at least one of 1,2-benzisothiazol-3(2H)-one, irgasan, benzyl-2-bromoacetate, 2,2-dibromo-2-cyanoacetamide, and 2-bromo-2-nitropropan-1,3-diol in a corrosion sensitive material or degradation sensitive material; a sheet comprising the composition; and a steel plate to which the composition is applied.Type: ApplicationFiled: June 2, 2010Publication date: June 30, 2011Applicant: KOREA GAS CORPORATIONInventors: Hong Seok Song, Young Geun Kim, Keun Chang Ryu, Young Min Baek, Young Hyo Chang
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Publication number: 20110158980Abstract: Described herein are methods for treating obesity or promoting weight loss using agents that alter pyruvate flux in an adipocyte. Methods are provided for administering an agent or combination of agents to an obese individual to alter the flux of pyruvate in an adipocyte. Also described herein is a method for modifying triglyceride storage in an adipocyte by contacting an adipocyte with an agent or combination of agents that alter pyruvate flux.Type: ApplicationFiled: August 6, 2009Publication date: June 30, 2011Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Yaguang Si, Kyongbum Lee
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Publication number: 20110152375Abstract: The present invention relates to the use of at least one porous metal-organic framework material (MOF) comprising at least one first and, if appropriate, one second organic compound, where at least the first organic compound binds coordinatively to at least one metal ion in an at least partly bidentate manner, where the at least one metal ion is Mg(II) and where the first organic compound is derived from formic acid and the second organic compound from acetic acid, for reducing the methane level in the total gas produced, and to the use for increasing the total gas formation during feed digestion in ruminants as well as a method for reducing the methane level in the total gas produced and a method for increasing the total gas formation during feed digestion in ruminants.Type: ApplicationFiled: January 18, 2010Publication date: June 23, 2011Applicant: BASF SEInventors: Arnulf Tröscher, Michael Koch, Natalia Trukhan, Ulrich Müller
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Publication number: 20110151025Abstract: Disclosed herein are methods and compositions for the treatment or prophylaxis, in a mammal, of bronchopulmonary infections, obstructive pulmonary disease, cystic fibrosis, and ventilator-associated infections. The methods and compositions include a therapeutically effective amount of one or more N-halogenated or N,N-dihalogenated amines, and their analogues, derivatives, or pharmaceutically acceptable salts and esters.Type: ApplicationFiled: April 10, 2009Publication date: June 23, 2011Inventors: Waldemar Gottardi, Markus Nagl, Ramin Najafi, Lu Wang, Rakesh K. Jain, Timothy Shiau, Eddy Low, Charles Francavilla
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Publication number: 20110138888Abstract: The present disclosure relates to the treatment, e.g. reduction, of body fat mass levels for example in overweight and obese subjects. The present disclosure also relates to weight control in a subject where obesity should be avoided. Disclosed herein are methods of reducing body fat mass e.g reducing obesity or preventing weight gain and agents used in such methods whereby the agents inhibit a sulphur containing amino acid. Also included in the present disclosure include, without being limited to, methods for determining regimes for the treatment of obesity as well as other subject matter.Type: ApplicationFiled: July 21, 2009Publication date: June 16, 2011Inventors: Amany Elshorbagy, Helga Margareta Refsum
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Patent number: 7951232Abstract: The invention provides surface coating compositions comprising a preservative comprising 9-decenoic acid, salts of 9-decenoic acid, esters of 9-decenoic acid, or combinations thereof. The surface coating compositions may be water-based coatings (e.g., a latex paint) or solvent-based coatings (e.g., a solvent-based paint). The surface coating compositions may be paints, stains, varnishes, concrete coatings, anti-graffiti coatings, and the like. Methods for protecting a surface coating composition from in-can spoilage and protecting a coating of the surface coating composition from deterioration by the action of microorganisms are also described.Type: GrantFiled: February 9, 2007Date of Patent: May 31, 2011Assignee: Elevance Renewable Sciences, Inc.Inventors: Jill Louise Zullo, James C. Anderson, Hiroki Kaido, Richard L. Pederson, Yann Schrodi, William H. Sperber, Michael J. Tupy, Earl H. Wagener
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Publication number: 20110110913Abstract: A method of inducing NAD+ synthesis in a subject. The method comprises administering to the subject a therapeutically effective amount of resveratrol or a functionally equivalent analogue or derivative thereof. NAD+ synthesis increases the activity of Poly(ADP-ribose) polymerase (PARP) enzymes and sirtuin enzymes. The PARP enzyme is PARP-1 or PARP-2 and the sirtuin enzyme is selected from the group consisting of SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7.Type: ApplicationFiled: March 3, 2009Publication date: May 12, 2011Inventors: Ross Stewart Grant, Nady Braidy, Gilles Guillemin, George Smythe