Abstract: Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the epoxide hydrolases, and in agricultural applications. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 ##STR1## wherein X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R.sub.1 -R.sub.4 is hydrogen, R.sub.2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R.sub.4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R.sub.1 and R.sub.3 are each independently a substituted or unsubstituted alkyl, haloalkyl, cycloalkyl, aryl, acyl, or heterocyclic, or being a metabolite or degradation product thereof.
Type:
Grant
Filed:
February 18, 1999
Date of Patent:
November 21, 2000
Assignee:
The Regents of the University of California
Inventors:
Bruce D. Hammock, Christophe H. Morisseau, Jiang Zheng, Marvin H. Goodrow, Tonya Severson, James Sanborn
Abstract: A process is provided for both removing and controlling biofilms present in industrial cooling and process waters. The process provides a composition which includes the reaction products of an amino base, a formaldehyde, an alkylenepolyamine, and the ammonium salt of an inorganic or organic acid. The composition may be used to remove existing biofilms from process water equipment. Further, lower maintenance dosages may be used to maintain the equipment in a substantially biofilm-free condition.
Abstract: The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
Type:
Grant
Filed:
January 26, 1998
Date of Patent:
November 14, 2000
Assignee:
Centre International de Recherches Dermatologiques Galderma
Abstract: The invention provides a means of inhibiting bacterial growth particularly on a coated substrate. It comprises a method of forming a substantially dry powder coating containing a biocide, applying the powder coating composition to form a coating on the substrate, the biocide being capable of retaining effective biocidal activity in the coating.
Abstract: A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a combination of compounds selected from the group consisting of hydroxyurea, a nucleoside analog, and a protease inhibitor.
Type:
Grant
Filed:
March 7, 1997
Date of Patent:
September 5, 2000
Assignee:
Research Institute for Genetic and Human Therapy (R.I.G.H.T.)
Abstract: The invention concerns a series of novel bis-urea derivatives, nonpeptides, which show good binding affinity for the CCK-B receptor. The compounds, compositions containing them, methods of preparation, and utilities including anxiety, gastric acid secretion inhibition, and psychoses are included.
Type:
Grant
Filed:
October 19, 1994
Date of Patent:
August 15, 2000
Assignee:
Warner-Lambert Company
Inventors:
Bradley Dean Tait, Michael William Wilson
Abstract: A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus is inhibited by treatment of the cells with a synergistic combination mixture of a dideoxy-ribonucleoside excluding AZT and hydroxycarbamide.
Type:
Grant
Filed:
March 8, 1995
Date of Patent:
July 25, 2000
Assignee:
The United States of America as represented by the Department of Health and Human Services
Abstract: The present invention is directed to a method of inhibiting the growth of disease organisms on and in plants by directly applying an aqueous solution comprising urea and at least one water-soluble salt of a divalent cation and a monovalent anion to the seeds, stems, bark, leaves, seed heads or sub-surface root zones of said plants. The weight percent ratio of urea to divalent cation in these solutions should be from about 0.25-10.0 to 1.0. Preferred divalent cations include those of the alkaline earth metals and the transition metals. Most preferred are calcium, magnesium, zinc, manganese, copper, iron, cobalt, nickel and mixtures thereof. Preferred anions include nitrate, chloride, bromide and mixtures thereof. In more preferred solutions, the ratio of urea to divalent cation is from about 2.0-7.0 to 1.0. Particularly preferred solutions include calcium chloride as the water-soluble salt. Optionally, a second water-soluble salt of a divalent cation and a monovalent anion may be included.
Abstract: A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse-transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.
Type:
Grant
Filed:
May 17, 1994
Date of Patent:
April 4, 2000
Assignee:
The United States of America as represented by the Department of Health and Human Services
Inventors:
Franco Lori, Andrea Cara, Wen-Yi Gao, Robert C. Gallo
Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR2## wherein: A.sup.1 is a single bond, alkylene or alkenylene; A.sup.2 is or alkenylene; A.sup.3 is a single bond, alkyleneor alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or various other groups; R.sup.6 is alkyl or phenyl; R.sup.7 is hydrogen or alkyl; R.sup.8 is alkyl or various other groups; and n is 0 and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.
Abstract: The present invention includes a method for increasing meat production while reducing fat in ruminant and non-ruminant animals and for increasing egg production in poultry and milk production in ruminant animals. The method includes mixing ingredients that include 190 proof ethanol in a concentration of about 9% by weight of a food supplement with clay and a nitrogen source such as urea to form the food supplement. The food supplement for ruminant animals additionally includes a condensed distiller's soluble fraction. The mixed ingredients are added to an animal feed such as corn. The animal feed and supplement are fed to an animal at least one per day.
Abstract: Modified tall oil supplemented pig diet is provided which increases the average daily gain and improves the carcass characteristics of pigs. The diets of the invention include from about 12-50% by weight of total protein (e.g., from corn and soy) and from about 0.25% to about 0.75% by weight modified tall oil. In one embodiment, the diet includes a mixture of conjugated linoleic acids having a specific fatty acid profile.
Type:
Grant
Filed:
March 13, 1998
Date of Patent:
February 1, 2000
Assignee:
Kansas State University Research Foundation
Inventors:
Patrick R. O'Quinn, Kevin Q. Owen, Jim L. Nelssen, Mike Tokach, Robert D. Goodband
Abstract: A composition of matter and the method of making that provides a low pH acidic composition that is useful for destroying microorganisms that are undesirable and useful for destroying or reducing melanoma on human skin. The composition and method include sulfuric acid combined with distilled water and ammonium sulfate under at least 15 psi pressure in a pressurized container, all of which is heated to around 1200.degree. F. for at least 3 hours. The final cooled mixture is stabilized with 10 percent of the original mixture. The resultant composition is useful for preserving food, such as fresh fish, and for skin treatment of melanoma.
Abstract: Methods and compositions for treating CF by mobilizing mutant forms of CFTR, which retain at least some functional activity, to the plasma membrane where they can mediate chloride ion transport are disclosed.
Abstract: A cold chemical sterilant capable of killing a challenge of vegetative target organisms including bacterial spores comprising a composition of interactive constituents including a monohydric alcohol, an urea salt, a polyhydric alcohol, a surface active agent and water in proportion by weight to destroy the protective integrity of the walls of the bacterial spores, to penetrate the walls of the bacterial spores and to kill the bacterial spores and other vegetative target organisms.
Abstract: The invention provides a means of inhibiting bacterial growth particularly on a coated substrate. It comprises a method of forming a substantially dry powder coating containing a biocide, applying the powder coating composition to form a coating on the substrate, the biocide being capable of retaining effective biocidal activity in the coating.
Abstract: A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a combination of compounds selected from the group consisting of hydroxyurea, a nucleoside analog, and a protease inhibitor.
Abstract: The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.10 alkyl or the like; L is C(.dbd.O)NH or the like; R.sub.2, R.sub.3 and R.sub.4 are independently halogen or the like; R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen or the like; m is an integer of 0 to 4; n is an integer of 0 to 2; X is chlorine or the like; Y is oxygen or the like; and Z is oxygen or the like, which have excellent insecticidal activity so that they are satisfactorily effective for the control of noxious insects.
Abstract: The present invention relates to the use of butyrate esters of threitol, alone or in combination with other agents, in pharmaceutical compositions and methods for increasing fetal hemoglobin and gamma globin in a patient. These methods are particularly useful in treating .beta.-hemoglobinopathies, such as sickle cell syndromes and .beta.-thalassemia syndromes. Compositions comprising butyrate esters of threitol, alone or in combination antiproliferative and differentiating agents are also useful in methods for inducing cell differentiation in malignant cells. These methods are useful in treating cancer, particularly the tetrabutyrate ester.
Abstract: Compounds characterized generally as ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of cardiovascular disorders. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 wherein X is selected from oxygen atom and methylene; wherein each of R.sub.1 and R.sub.9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, .beta.,.beta.,.beta.-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R.sub.1 and R.sub.9 are attached may be combined with oxygen to form an N-oxide; wherein R.sub.2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R.sub.3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R.sub.5 is propargyl or a propargyl-containing moiety; wherein R.sub.7 is cyclohexylmethyl; wherein each of R.sub.4 and R.sub.
Abstract: An emulsion comprising an oily phase dispersed in an aqueous phase with the aid of a silicone emulsifying agent, the oily phase comprising at least 50% by weight of silicone oil and the aqueous phase containing at least one polyol in a quantity which imparts a water activity value to the emulsion of .ltoreq.0.85.
Abstract: The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.
Type:
Grant
Filed:
December 18, 1996
Date of Patent:
August 3, 1999
Assignees:
Syntex (U.S.A.) Inc., Agouron Pharmaceuticals, Inc.
Inventors:
Steven Lee Bender, Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Lawrence Emerson Fisher, Robert Than Hendricks, Keshab Sarma
Abstract: Topically applicable pharmaceutical/dermatological/cosmetic compositions, well suited for the therapeutic treatment of neurogenic red skin blotches and rosacea afflicting the skin, scalp and/or mucosae of a human subject, comprise a therapeutically/cosmetically effective amount of at least one TNF-alpha antagonist.
Abstract: In a method for treating or preventing allergy or allergic disorders an effective amount of a compound that inhibits intracellular generation of phosphatidic acid and diacylglycerol is administered. The intracellular generation of phosphatidic acid and diacylglycerol results from allergen presentation or mast cell/basophil activation.
Type:
Grant
Filed:
April 1, 1994
Date of Patent:
January 12, 1999
Assignee:
Cell Therapeutics, Inc.
Inventors:
Elisa Eiseman, Emer Clarke, Jack W. Singer, Stuart L. Bursten
Abstract: A skin blemish treatment combines a base with therapeutically effective amounts of carbamide peroxide and alpha-hydroxy acid ("AHA"). The resulting formulation effectively treats human acne vulgaris while exhibiting none of the severe adverse side effects associated with benzoyl peroxide. The AHA can be any synthetic or naturally occurring alpha-hydroxy acid. Salicylic acid can augment the composition, as can an anti-inflammatory such as allantoin. Fragrance, coloring agents, and preservatives can also be added.
Abstract: Methods and compositions for treating CF by mobilizing mutant forms of CFTR, which retain at least some functional activity, to the plasma membrane where they can mediate chloride ion transport are disclosed.
Abstract: A preparation containing salicylic acid, lactic acid and urea in a moisturizing base, which can be used for the topical treatment of psoriasis.
Abstract: A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus is inhibited by treatment of the cells with a synergistic combination mixture of a dideoxy-ribonucleoside excluding AZT and hydroxycarbamide.
Type:
Grant
Filed:
March 18, 1996
Date of Patent:
April 7, 1998
Assignee:
Compagnie de Developpment Aguettant S.A.
Abstract: A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus is inhibited by treatment of the cells with a synergistic combination mixture of a dideoxy-ribonucleoside excluding AZT and hydroxycarbamide.
Abstract: The present invention relates to a class of THF-containing sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention.
Abstract: The present invention provides a medicinal feed for fish, which comprises a triphenylmethane derivative or a combination of triphenylmethane derivatives alone or in combination with at least one compound selected from the group consisting of thionine, nitrothiazole, nitrofuran, quinoline and acridine derivatives, compounds splitting off aldehydes, transition metal derivatives, metal colloids, hexamethylenetetramine and/or quaternary ammonium salts as active materials.
Type:
Grant
Filed:
August 9, 1994
Date of Patent:
February 17, 1998
Assignee:
Tetra Werke Dr. rer. nat. U. Baensch GmbH
Abstract: The present invention provides a cathepsin L inhibitor containing a compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which may be substituted; R.sup.2 and R.sup.3 independently are a hydrogen atom or a hydrocarbon residue which may be substituted; R.sup.4 is an alkanoyl, sulfonyl, carbonyloxy, carbamoyl or thiocarbamoyl group which may be substituted; X is formula: --CHO or --CH.sub.2 OB (wherein B is a hydrogen atom or a protecting group of hydroxyl group); m and n independently are an integer of 0 or 1; provided that R.sup.4 is an alkanoyl group substituted by aryl, a sulfonyl group substituted by aryl having more than 9 carbon atoms or by lower alkyl, or a carbamoyl or thiocarbamoyl group which may be substituted when R.sup.1 is an unsubstituted lower alkyl, arylalkyl on methylthioethyl group, R.sup.2 and R.sup.3 independently are a lower alkyl or arylalkyl, X is --CHO, m is 1 and n is 0 or 1, or a salt thereof.
Abstract: Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Type:
Grant
Filed:
May 25, 1995
Date of Patent:
December 30, 1997
Assignee:
G. D. Searle & Co.
Inventors:
John J. Talley, Daniel P. Getman, Ko-Chung Lin, Gary A. DeCrescenzo, Donald J. Rogier, Jr., John N. Freskos
Abstract: A composition for topical application is provided which contains at least one water-sensitive active agent with a topical action and at least one polyol, the latter being present in a quantity which is effective for obtaining a water activity value of the composition of less than or equal to 0.85 with the aim of stabilizing the water-sensitive active agent, the composition containing at least one structuring agent chosen from polymers and oils. The water-sensitive active agent can, in particular, be an enzyme. The composition obtained can be used for cleansing and/or caring for and/or protecting the skin and/or keratinous fibers.
Abstract: There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl containing amino acid or a derivative thereof, the pharmaceutically acceptable salts or esters thereof, or stereoisomers thereof, (2) urea, (1) and (2) being administered in an amount sufficient to enhance the permeation of antifungal drugs through nail tissue, either prior to or, preferably, concurrently with the topical administration to the nail of (3) an effective amount of an antifungal drug.
Type:
Grant
Filed:
December 22, 1994
Date of Patent:
December 9, 1997
Assignee:
Johnson & Johnson Consumer Products, Inc.
Inventors:
Ying Sun, Jue-Chen Liu, Elizabeth S. Kimbleton, Jonas C. T. Wang
Abstract: This invention includes a pharmaceutical composition including a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically salt thereof. The invention also includes a method of treating disease of the cutis which includes applying to cutis tissues in need of such treatment a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically acceptable salt thereof, said disease having symptoms selected from the group consisting of inflammation, erythema, edema, papules, vesicles, macules, pustules, scaling, cracking, crusting, and lesions.
Abstract: The present invention provides a medicinal feed for fish, which comprises a triphenylmethane derivative or a combination of triphenylmethane derivatives alone or in combination with at least one compound selected from the group consisting of thionine, nitrothiazole, nitrofuran, quinoline and acridine derivatives, compounds splitting off aldehydes, transition metal derivatives, metal colloids, hexamethylenetetramine and/or quaternary ammonium salts as active materials.
Type:
Grant
Filed:
July 10, 1995
Date of Patent:
September 23, 1997
Assignee:
Tetra Werke Dr. Rer. Nat. U. Baensch GmbH
Abstract: The present invention is concerned with compounds of formula (I) ##STR1## wherein Ar is a mono- or bicyclic aromatic group optionally containing one or two heteroatoms independently selected from nitrogen, oxygen and sulphur, said group being optionally substituted by one or more atoms or groups independently selected from halogen, nitro, amino, --NRR.sup.1 where R and R.sup.1 are independently selected from hydrogen, C.sub.1-8 alkyl and C.sub.1-8 alkanoyl, cyano, carboxyalkoxy, alkoxycarbonylalkoxy, C.sub.1-8 alkyl (including cycloalkyl and cycloalkylalkyl), C.sub.1-8 alkoxy (including cycloalkoxy and cycloalkylalkoxy), C.sub.
Type:
Grant
Filed:
April 14, 1995
Date of Patent:
August 19, 1997
Assignee:
The University of South Carolina
Inventors:
James Mood Chapman, Jr., Roy Lee Hawke, Karl Witold Franzmann, Kevin Julian O'Connor
Abstract: The present invention relates to an improved method for controlling coccidiosis in poultry which comprises administering to poultry on shuttle medication an additional medication prior to switching from the starter compound to the grower compound, and continuing the additional medication for a period after the switching.
Abstract: The present invention relates, by way of novel industrial products, to compounds which are structurally related to 15-deoxyspergualin and which have the formula ##STR1## in which: A is a single bond, a group --CH.sub.2 --, a group --CH.sub.2 O--, a group --CH.sub.2 NH--, a group --CH(OH)--, a group --CHF-- or a group --CH(OCH.sub.3)--, andn is equal to 6 or 8,and their addition salts.These novel compounds are useful especially as immunosuppressants. The invention further relates to the method of preparing said compounds.
Type:
Grant
Filed:
February 23, 1995
Date of Patent:
June 10, 1997
Assignee:
Fournier Industrie et Sante
Inventors:
Patrice Renaut, Luc Lebreton, Patrick Dutartre, Soth Samreth, Catherine Derrepas, Jean M. Rognon
Abstract: This invention includes a pharmaceutical composition including a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically salt thereof. The invention also includes a method of treating disease of the cutis which includes applying to cutis tissues in need of such treatment a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically acceptable salt thereof, said disease having symptoms selected from the group consisting of inflammation, erythema, edema, papules, vesicles, macules, pustules, scaling, cracking, crusting, and lesions.
Abstract: A topical ophthalmic preparation utilizing a urea and/or urea derivative or mixtures thereof as the principle active ingredient within a range of about 0.01% by weight to about 30% by weight and a method of using the same. When applied to a mammalian eye affected with an abnormal ophthalmological surface problem resulting in epithelial cell loss, keratinization, and/or scarring, the present invention will heal epithelial defects, soften keratin, decrease scarring, enhance hydration, and have anti-mucolytic activity. The present invention provides a method for treating ocular conditions such as dryness, noninfectious keratitis, corneal or conjunctival epithelial irregularities, ocular scarring and subjective irritations.
Type:
Grant
Filed:
May 30, 1995
Date of Patent:
May 13, 1997
Assignee:
West Virginia University Research Corporation
Abstract: This invention includes a pharmaceutical composition including a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically salt thereof. The invention also includes a method of treating disease of the cutis which includes applying to cutis tissues in need of such treatment a therapeutically effective amount of a composition comprising a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically acceptable salt thereof, said disease having symptoms selected from the group consisting of inflammation, erythema, edema, papules, vesicles, macules, pustules, scaling, cracking, crusting, and lesions.
Abstract: The present invention provides a medicinal feed for fish, which comprises a triphenylmethane derivative or a combination of triphenylmethane derivatives alone or in combination with at least one compound selected from the group consisting of thionine, nitrothiazole, nitrofuran, quinoline and acridine derivatives, compounds splitting off aldehydes, transition metal derivatives, metal colloids, hexamethylenetetramine and/or quaternary ammonium salts as active materials.
Type:
Grant
Filed:
September 22, 1992
Date of Patent:
April 8, 1997
Assignee:
Tetra Werke Dr. rer. nat. U. Baensch GmbH
Abstract: Provided is an anti-microbial composition containing an ester of formic acid, an oxidizer, performic acid and water. Also provided is a premix for making the anti-microbial composition having two parts. One part contains the ester of formic acid and a second part contains the oxidizer. Another method is provided for making the anti-microbial composition in which the ester of formic acid is combined with the oxidizer and water.
Abstract: Compounds of formula (I) are provided: ##STR1## wherein: R.sup.1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are hydrogen or various organic groups; and pharmaceutically acceptable salts thereof; as well as methods for the preparation of such compounds and their use in the treatment and prophylaxis of hypercholesteremia and arteriosclerosis.
Abstract: Insecticidal compositions, comprising normally-employed insecticides but comprising also an effective activity-enhancing amount of capsaicin or other capsaicinoid, especially in the form of capsicum, exhibit synergistic effects against numerous insects, including especially bud worms, boll worms, cabbage loopers, army worms, beet army worms, and beetles, and are especially effective on cotton, soybeans, common garden vegetables, and flowers, when sprayed on the insect or its habitat, especially as an aqueous solution, suspension, or emulsion. Larger crop stands may be effectively treated by aerial spraying from the usual crop-dusting airplane.
Type:
Grant
Filed:
September 29, 1995
Date of Patent:
February 4, 1997
Assignee:
Kalamazoo Holdings, Inc.
Inventors:
Gary C. Hainrihar, James G. Dubberly, John T. Greenlee