Patent number: 6797707
Abstract: Disclosed are compounds having the formula:
where
R1=H, C1-C6 alkyl, cycloalkyl,
R2=H, C1-C6 alkyl, cycloalkyl
W=CnH2n-m—NH (n=1-6, m=0, 2, or 4),
Z=CONR8(CH2)n, CONR8(CH2)nCO, P(CH3)OCHR8OCOR9, SO2, SO2(CH2)n, SO2(CH2)nCO, SO2NR8(CH2)n, SO2NR8(CH2)nCO, n=1-4
R4=H, (CH2)nOH, (CH2)nOCOR10, (CH2)nNR10R11, (CH2)nCONR10R11, n=0-4
R5=H, (CH2)nNR12R13, n=0-4
R6=H, (CH2)nNR14R15, n=0-4
R7=H, C1-C6 alkyl, cycloalkyl; R8=H, C1-C6 alkyl, cycloalkyl; R9=H, C1-C6 alkyl, cycloalkyl;
R10=H, C1-C6 alkyl, cycloalkyl; R11=H, C1-C6 alkyl, cycloalkyl; R12=H, C1-C6 alkyl, cycloalkyl;
R13=H, C1-C6 alkyl, cycloalkyl; R14=H, C1-C6 alkyl, cycloalkyl; R15=H, C1-C6 alkyl, cycloalkyl
Dashed lines: optional; conformational constraint by (CH2)n, n=1-3, R′=H or O(═)
as well as pharmaceuticals c
Type:
Grant
Filed:
March 29, 2002
Date of Patent:
September 28, 2004
Assignee:
University of Florida
Inventor:
Laszlo Prokai
Patent number: 6562782
Abstract: The present invention related to an oligocycloalkanoid compound comprising formula (I)
wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O—, carbonyl, oxygen, or sulfur; X and Y are independently hydrogen, hydroxy, alkyl, or in combination an electrophilic group; and R1 through R10 are independently hydrogen, hydroxy, alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, N-, S-, or O-heterocycles, fused or multi-ring aryl with or without hetero ring members, arylalkyl, arylalkenyl, arylalkynyl, alkylphenyl, alkenylphenyl, alkynylphenyl, alkoxy, alkenyloxy, alkynyloxy, substituted or unsubstituted aryloxy, substituted or unsubstituted arylalkoxy, alkylacyl, alkenylacyl, alkynylacyl, arylacyl, aroyl, alkylaroyl, aminoaroyl, aminoalkylacyl, aminoalkyl, aminoalkenyl, aminoalkynyl, amino, alkylamino, alkenylamino, alkynylamino, arylamino, dialkylamino, dialkenylamino, dialkynylamino, arylalkylamino, arylalk
Type:
Grant
Filed:
May 10, 2000
Date of Patent:
May 13, 2003
Assignee:
University of Rochester
Inventors:
Benjamin L. Miller, Robert D. Hubbard