N-s-s Containing Patents (Class 514/606)
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Patent number: 8173820Abstract: Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.Type: GrantFiled: December 17, 2008Date of Patent: May 8, 2012Assignee: Glaxo Group LimitedInventors: Nicolas Bertheleme, Wai Ngor Chan, Jaqueline Sandra Scott, Simon E. Ward
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Publication number: 20080146445Abstract: The present invention concerns nematicidal compounds, their formulation as nematicidal composition and their use for controlling nematodes, preferably plant parasitic nematodes.Type: ApplicationFiled: December 16, 2005Publication date: June 19, 2008Applicant: Devgen NVInventors: Jan Octaaf De Kerpel, Dirk Leysen
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Patent number: 5304724Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the bicarbonate and glutathione are freeze-dried, packaged and separately stored in lyophilized powder form until just preceding the operation, at which time the lyophilized powder containing the bicarbonate and glutathione is dissolved directly into a conventional I.V. solution.Type: GrantFiled: February 19, 1992Date of Patent: April 19, 1994Assignee: Entravision, Inc.Inventor: Walter A. Newton
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Patent number: 5124348Abstract: A compound of Formula (I):R.sup.1 (CA.dbd.CA.sup.1).sub.x --C(.dbd.X)NR.sup.2 R.sup.3 (I)where R.sup.1 is alkyl optionally substituted by a group selected from alkoxy, alkenyl, alkynyl, alkenyloxy, alkynyloxy, aryl, aryloxy, arylalkoxy and cycloalkyl fused to an aryl ring; x=1 or 2; X=O or S; each A and A.sup.1 is independently hydrogen, alkyl or haloalkyl; R.sup.2 is alkyl, alkenyl or cycloalkyl any of which may be substituted by halo, alkenyl, alkyl, cycloalkyl, alkynyl, dioxalanylalkyl or alkoxy; and R.sup.3 is selected from groups (A) to (D):(A) --Y.dbd.X.sup.1 --(R.sup.4).sub.a where X.sup.1 is O or S, Y is phosphorus or carbon, R.sup.4 is hydrogen, alkyl, alkoxy, acyl or CO.sub.2 R.sup.5 where R.sup.5 is alkyl or aryl, and a is 1 or 2(B) --S(R.sup.6)(O).sub.b where R.sup.6 is alkyl, aryl, aryloxy, alkoxy, thioalkoxy, thioaryl, alkythio, alkoxythio or arylthio and b is 0, 1 or 2(C) --S(O).sub.c NR.sup.7 R.sup.8 where c is 0, 1 or 2, R.sup.7 is --COR.sup.9 or --CO.sub.2 R.sup.9 where R.sup.Type: GrantFiled: May 17, 1991Date of Patent: June 23, 1992Assignee: Burroughs Wellcome Co.Inventors: Malcolm H. Black, Robert J. Blade, Robert J. Peek
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Patent number: 5104663Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the chloride salts (Ringer solution) are packaged and stored in solution and the bicarbonate and glutathione are freeze-dried and packaged and separately stored in powder form until immediately preceeding the operation, at which time the bicarbonate and glutathione are dissolved directly into the solution of chloride salts. The resulting solution is mixed within 24 hours of use.Type: GrantFiled: September 4, 1990Date of Patent: April 14, 1992Assignee: Entravision, Inc.Inventors: Walter A. Newton, Douglas V. Carter
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Patent number: 4990505Abstract: The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof.The compounds of formula (I) have a selective stimulant action at .beta..sub.2 -adrenoreceptors and are useful, in particular in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.Type: GrantFiled: April 18, 1989Date of Patent: February 5, 1991Assignee: Glaxo Group LimitedInventors: Ian F. Skidmore, Lawrence H. C. Lunts, Harry Finch, Alan Naylor, Ian B. Campbell
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Patent number: 4975419Abstract: In a tissue irrigating solution of the type containing the combination of glutathione, bicarbonate, and Ringer solution (GBR), the chloride salts (Ringer solution) and packaged and stored in solution and the bicarbonate and glutathione are freeze-dried and packaged and separately stored in powder form until immediately preceeding the operation, at which time the bicarbonate and glutathione are dissolved directly into the solution of chloride salts. The resulting solution is mixed within 24 hours of use.Type: GrantFiled: September 9, 1988Date of Patent: December 4, 1990Assignee: Entravision, Inc.Inventors: Walter A. Newton, Douglas V. Carter