Abstract: A compound having the structural formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, C.sub.1 -C.sub.6 alkyl, halogen or C.sub.1 -C.sub.4 alkoxy is disclosed. These compounds demonstrate utility as hypolipidemic agents.The present invention is also directed to a process for controlling lipidemia in mammals comprising treating mammals with a lipidemia controlling effective amount of the above-defined compound.Yet another aspect of the present invention is embodied in a pharmaceutical composition comprising the above compound and a pharmaceutically acceptable carrier therefor.
Abstract: The present invention relates to methods for controlling insect populations and for protecting living plants from insect attack by applying to said plants or to the soil in which they are growin an insecticidally-effective amount of a substituted benzoic acid 1 or 2-alkyl or 2-cycloalkylhydrazide.Novel substituted benzoic acid 1 and 2-alkyl and 2-cycloalkylhydrazides effective as insecticides or intermediates for the preparation of insecticidal diacylhydrazides also are presented.
Type:
Grant
Filed:
November 12, 1986
Date of Patent:
March 21, 1989
Assignee:
American Cyanamid Company
Inventors:
Roger W. Addor, David G. Kuhn, Donald P. Wright, Jr.
Abstract: Novel compounds of the following formula have restorative pharmacological activities in immuno-deficient hosts, ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is hydrogen, carboxy or a protected carboxy group,R.sup.3 is hydrogen, carboxy or a protected carboxy group,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carbamoyl(lower)alkyl or protected carbamoyl(lower)alkyl,R.sup.5 is hydrogen or lower alkyl, andR.sup.6 is hydrogen, hydroxyphenyl(lower)alkyl, imidazolyl(lower)alkyl or indolyl(lower)alkyl.
Abstract: Improved methods of anesthesia for mammals, especially humans, are provided wherein the prolonging effect upon local anesthesia which is exhibited by co-administration of vasoconstrictors, especially vasoconstrictors believed to act upon alpha adrenoreceptor sites on blood vessel walls, are provided. In accordance with a preferred embodiment, alpha adrenoreceptor blocking agents are aministered subsequent to the performance of surgery or dentistry under local anesthesia accomplished through co-administration of anesthesia and vasoconstrictor to cause reduction of prolonged anesthetic effect. Seriatim procedures are facilitated under local anesthesia through employment of the present invention. Improved patient aesthetics, diminution of self-inflicted trauma, and increased sensory feedback from patients are among the benefits conferred by the present invention.
Abstract: A method of reducing local adverse reactions which occur at the site of administration of parenterally administrable physiologically active compositions, to patients which comprises, prior to administration thereof, incorporating in said physiologically active compositions, a small but effective amount of a compound of the formulae, ##STR1## wherein n is an integer of from 1 to 6; R.sup.1 is H or lower alkyl; x is 0 or 1; each Y is H; and R is H, lower alkyl or acyl; and the non-toxic pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
September 7, 1982
Date of Patent:
July 15, 1986
Assignee:
Tetra Consultants, Inc.
Inventors:
Erik Stevens, Ernestina M. Van Hoeyveld
Abstract: The method of improving the storage stability of parenterally administerable physiologically active compositions which comprises, incorporating in said compositions a small but effective amount of a compound of the formulae, ##STR1## wherein R is H, lower alkyl or acyl; each R.sup.1 is H or lower alkyl; and n is an integer of from 1 to 6; x is 0 or 1; each Y is H; and the non-toxic pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
September 7, 1982
Date of Patent:
July 15, 1986
Assignee:
Tetra Consultants Inc.
Inventors:
Erik Stevens, Ernestina M. Van Hoeyveld