Sulfur In R Patents (Class 514/618)
  • Ortho-substituted pentafluorosulfanyl benzenes, method for the production thereof and their use as synthesis intermediates
    Patent number: 7763661
    Abstract: This invention relates to novel substituted pentafluorosulfanylbenzenes of the formula I: and/or salts thereof as claimed, for use as a synthetic intermediates for preparing medicaments, diagnostic aids, liquid crystals, pesticides, herbicides, fungicides, nematicides, parasiticides, insecticides, acaricides, arthropodicides and polymers.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: July 27, 2010
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Heinz-Werner Kleemann, Remo Weck
  • EFLUCIMIBE MEDICAMENTS FOR PREVENTING/TREATING A DISEASE DUE TO SEBACEOUS GLAND DYSFUNCTION IN HUMANS OR ANIMALS
    Publication number: 20100172957
    Abstract: Administration of at least one compound selected from (S)-2-dodecylsulfanyl-N-(4-hydroxy-2,3,5-trimethylphenyl)-2-phenylacetanilide (eflucimibe) of formula (I): or (R)-2-dodecylsulfanyl-N-(4-hydroxy-2,3,5-trimethylphenyl)-2-phenylacetanilide ((R) enantiomer), or pharmaceutically acceptable salt or pharmaceutically acceptable solvate thereof, is useful for preventing or treating disorders due to a sebaceous gland dysfunction in humans or animals, for example, acne and/or or any state or pathological condition related to an overproduction of sebum, e.g., seborrhoeic dermatitis, greasy skin or a greasy scalp.
    Type: Application
    Filed: January 15, 2010
    Publication date: July 8, 2010
    Applicant: GALDERMA RESEARCH & DEVELOPMENT
    Inventor: Thibaud BIADATTI-PORTAL
  • Compositions comprising modafinil compounds
    Patent number: 7749540
    Abstract: Particle-forming compositions of modafinil compounds, and aqueous compositions of particles, wherein the particles comprise a modafinil compound, are disclosed, along with methods of their preparation, and their use in the treatment of diseases.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: July 6, 2010
    Assignee: Cephalon, Inc.
    Inventors: Martin J. Jacobs, Bradley T. McIntyre, Piyush R. Patel, David A. Dickason
  • Substituted phenylacetamides and their use as glucokinase activators
    Patent number: 7745491
    Abstract: Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
    Type: Grant
    Filed: August 9, 2005
    Date of Patent: June 29, 2010
    Assignee: Prosidion Limited
    Inventors: Matthew Colin Thor Fyfe, Vilasben Kanji Shah
  • PHARMACEUTICAL COMPOSITIONS OF POORLY SOLUBLE DRUGS
    Publication number: 20100151035
    Abstract: The present invention relates to a stable pharmaceutical composition of a poorly water-soluble drug with a view to increasing its solubility and bioavailability. The present invention relates to a solid dispersion of a poorly water-soluble drug.
    Type: Application
    Filed: March 10, 2008
    Publication date: June 17, 2010
    Applicant: Sandoz AG
    Inventors: Bharatrajan Ramaswami, Manisha Rajesh Patil, Aditi Das
  • 2-METHYLPROP ANAMIDES AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20100137401
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Application
    Filed: February 2, 2010
    Publication date: June 3, 2010
    Applicant: Incyte Corporation
    Inventors: Wenqing Yao, Colin Zhang, Jincong Zhuo, Meizhong Xu, Konstantinos Agrios, Brian Metcalf
  • Novel Pharmaceutical Formulations of Modafinil
    Publication number: 20100129444
    Abstract: The present invention is related to compositions of modafinil, including compositions of modafinil and one or more diluents, disintegrants, binders and lubricants, and the processes for their preparation thereof.
    Type: Application
    Filed: January 29, 2010
    Publication date: May 27, 2010
    Applicant: Cephalon, Inc.
    Inventors: Vincent Corvari, George Grandolfi, Alpa Parikh
  • SURFACE-TREATED MODAFINIL PARTICLES
    Publication number: 20100112045
    Abstract: The present invention is directed to solid oral dosage forms comprising surface-treated particles comprising modafinil particles and a hydrophilic treating agent, methods of making the same, and uses thereof.
    Type: Application
    Filed: January 6, 2010
    Publication date: May 6, 2010
    Applicant: CEPHALON, INC.
    Inventors: Salah U. AHMED, Muhammed A. HOSSAIN, Pruthvi R. KATIKANENI, Zhijun JIANG
  • Modafinil compound and cyclodextrin mixtures
    Patent number: 7704975
    Abstract: Mixtures of a modafinil compound with a cyclodextrin, methods for their use, and compositions thereof are disclosed, along with complexes comprising a modafinil compound and a cyclodextrin which are taste-masked and suitable for oral consumption in an aqueous solution.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: April 27, 2010
    Assignee: Cephalon, Inc.
    Inventors: Martin J. Jacobs, Piyush R. Patel
  • LYOPHILIZED PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING AND USING SAME
    Publication number: 20100080829
    Abstract: The present invention relates to a new lyophilized pharmaceutical composition capable of adhering to oral mucosal tissue for an extended period of time for delivering active pharmaceutical ingredient through the oral mucosal tissue using transmucosal absorption.
    Type: Application
    Filed: October 1, 2009
    Publication date: April 1, 2010
    Applicants: CEPHALON FRANCE, CEPHALON, INC.
    Inventors: Claire Dulieu, Steve Durfee, Richard J. Holl, Tam Nguyen
  • 2-methylprop anamides and their use as pharmaceuticals
    Patent number: 7687665
    Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: March 30, 2010
    Assignee: Incyte Corporation
    Inventors: Wenqing Yao, Colin Zhang, Jincong Zhuo, Meizhong Xu, Konstantinos Agrios, Brian Metcalf
  • Mixed co-crystals and pharmaceutical compositions comprising the same
    Patent number: 7671093
    Abstract: A mixed co-crystal comprising an API, a first co-crystal former, and a second co-crystal former which is isomorphically substitutable with said first co-crystal former is described. A pharmaceutical composition comprising a mixed co-crystal, methods of making mixed co-crystals, and methods of using mixed co-crystals are also described.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: March 2, 2010
    Assignee: Transform Pharmaceuticals, Inc.
    Inventors: Matthew Peterson, Magali Bourghol Hickey, Mark Oliveira, Örn Almarsson, Julius Remenar
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048718
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 5.23, 5.03, 4.22 and 4.10 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • CATHEPSIN B INHIBITORS
    Publication number: 20100048717
    Abstract: Compounds of formula (I): are found to be selective inhibitors of cathepsin B, and hence useful in treating a variety of pathological conditions.
    Type: Application
    Filed: September 24, 2007
    Publication date: February 25, 2010
    Applicant: MERCK FROSST CANADA LTD, Merk & Co., Inc.
    Inventors: Jacques Yves Gauthier, Vouy-Linh Truong
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048719
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.31, 8.54, 7.27 and 3.62 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048720
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stéphanie Graf, Gilles Serrure, Gérard Fransois Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES
    Publication number: 20100041657
    Abstract: The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
    Type: Application
    Filed: May 11, 2006
    Publication date: February 18, 2010
    Applicant: NOVO NORDICK A/S
    Inventors: Preben Houlberg Olesen, Holger Claus Hansen, Lise Brown Christiansen, Flemming Elmelund Nielsen, Anders Klarskov Petersen
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100022653
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 8.54, 4.56, and 3.78 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: January 28, 2010
    Applicant: Cephalon France
    Inventors: Olivier NECKEBROCK, Laurent COURVOISIER, Stéphanie GRAF, Gilles SERRURE, Gérard Francois COQUEREL, Sébastien ROSE, Christine BESSELIEVRE, Franck Patrick MALLET, Adriaan Jan VAN LANGEVELDE
  • Modafinil polymorphic forms
    Patent number: 7649020
    Abstract: Polymorphic forms of modafinil racemate, methods of preparation thereof, pharmaceutical compositions and methods of therapeutic treatment involving modafinil polymorphic forms.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: January 19, 2010
    Assignee: Cephalon France
    Inventors: Michel Broquaire, Véronique Broquaire, legal representative, Laurent Courvoisier, Armand Frydman, Gerard Coquerel, Franck Mallet
  • 5 HT RECEPTOR MEDIATED NEUROGENESIS
    Publication number: 20100009983
    Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a 5HTR agent, in combination with one or more other neurogenic agents, or anti-astrogenic agent, to stimulate or activate the formation of new nerve cells.
    Type: Application
    Filed: June 25, 2009
    Publication date: January 14, 2010
    Applicant: BrainCells, Inc.
    Inventors: Carrolee Barlow, Todd A. Carter, Andrew Morse, Kai Treuner, Kym I. Lorrain
  • USE OF MODAFINIL TO TREAT RESTLESS LEG SYNDROME
    Publication number: 20100010092
    Abstract: A method for relieving, treating, improving or attenuating one or more symptoms of RLS and related movement disorders such as PLMS, and snoring ICSD 780.53-1 is disclosed. The method includes the administration to a host afflicted with RLS or related disorder a pharmaceutically effective amount of a modafinil compound or a related compound. The method of the present invention is to treat a host to reduce or diminish snoring, the unpleasant leg sensations associated with unwanted leg movements and to diminish or eliminate the unwanted, involuntary leg movements at rest, awake or asleep, typically occurring in the evenings and at night.
    Type: Application
    Filed: December 19, 2007
    Publication date: January 14, 2010
    Inventors: Thomas N. Lavin, Catherine H. Koo
  • ANTIPARASITIC AGENTS
    Publication number: 20100010093
    Abstract: The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R1, R2, R3, R4 and R5 are each independently selected from H, halo, CN, CF3 and CONH2; compositions containing such compounds and the uses of such compounds as antiparasitic agents.
    Type: Application
    Filed: September 15, 2009
    Publication date: January 14, 2010
    Applicant: PFIZER LIMITED
    Inventors: Stuart Nicholas Comlay, Joanne Clare Hannam, William Howson, Christelle Lauret, Yogesh Anil Sabnis
  • PERSONALIZED PHARMACEUTICAL KITS, PACKAGING AND COMPOSITIONS FOR THE TREATMENT OF ALLERGIC CONDITIONS
    Publication number: 20090325999
    Abstract: This invention relates to personalized pharmaceutical kits, packaging, compositions, and methods for treatment of a mammal, comprising at least one antihistamine for treating an allergic disease or condition in a mammal, in combination with at least one wakefulness promoting agent for preventing sedative effects during day time use, while promoting the antihistamine and sedating effect during evening use.
    Type: Application
    Filed: June 27, 2008
    Publication date: December 31, 2009
    Inventor: Jie Du
  • 5 HT RECEPTOR MEDIATED NEUROGENESIS
    Publication number: 20090325949
    Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a 5HTR agent, optionally in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.
    Type: Application
    Filed: June 25, 2009
    Publication date: December 31, 2009
    Applicant: BrainCells, Inc.
    Inventors: Carrolee Barlow, Todd Carter, Andrew Morse, Kai Treuner, Kym I. Lorrain
  • MODAFINIL-BASED TREATMENT FOR PREMATURE EJACULATION
    Publication number: 20090318559
    Abstract: Methods and compositions comprising modafinil are described for treating premature ejaculation in a male individual.
    Type: Application
    Filed: August 13, 2007
    Publication date: December 24, 2009
    Inventor: Daniel E. Katzman
  • FORMULATIONS FOR CATHEPSIN K INHIBITORS
    Publication number: 20090318560
    Abstract: The instant invention relates to pharmaceutical compositions comprising cathepsin K inhibitors as the active ingredient with excipients which include binders, diluents, lubricants, and disintegrants. Also disclosed are processes for making said pharmaceutical compositions for oral and intravenous delivery.
    Type: Application
    Filed: February 22, 2008
    Publication date: December 24, 2009
    Inventors: Wayne Parent, Mahtab Afaghi, David Breslin, Mireille Granger, Lei Wang, Jeff Zimmerman
  • METHODS AND COMPOSITIONS FOR PRODUCING ANTI-ANDROGENIC EFFECTS
    Publication number: 20090317464
    Abstract: The invention provides a method and a composition for producing an anti-androgenic effect in a mammal. The method comprises administering a modified release pharmaceutical composition of bicalutamide to a mammal, with a reduced dosing frequency, for improved patient convenience and compliance. The composition of the invention also provides for a higher bioavailability and improved pharmacokinetic profile as compared to a conventional bicalutamide composition.
    Type: Application
    Filed: July 5, 2007
    Publication date: December 24, 2009
    Applicant: PANACEA BIOTEC LTD.
    Inventors: Amarjit Singh, Sarabjit Singh, Shivanand Puthli
  • MODAFINIL FORMULATIONS
    Publication number: 20090317481
    Abstract: The invention provides an oral pharmaceutical composition comprising modafinil particles, wherein at least about 5% of said modafinil particles have a diameter greater than 200 microns.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 24, 2009
    Applicant: CEPHALON, INC.
    Inventors: Moshe Bentolila, Aldo Shusterman, Moshe Arkin, Joseph Kaspi
  • COMBINATION OF MODAFINIL AND AN ANTAGONIST OR INVERSE AGONIST OF THE H3 RECEPTOR
    Publication number: 20090312367
    Abstract: The invention relates to a combination of modafinil and at least one histamine H3 receptor antagonist or inverse agonist, which can be used in particular for the treatment of narcolepsy-cataplexy and more generally for disorders of sleep, wakefulness and vigilance.
    Type: Application
    Filed: July 20, 2007
    Publication date: December 17, 2009
    Applicant: Bioprojet
    Inventors: Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • USE OF GSK-3 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER
    Publication number: 20090304663
    Abstract: A method of combating prostate cancer in a mammalian individual, the method comprising administering an inhibitor of glycogen synthase kinase-3 (GSK-3), or a polynucleotide which encodes an inhibitor of GSK-3, to the individual. A further anti-cancer agent can also be administered. Use of an inhibitor of GSK-3, or a polynucleotide which encodes an inhibitor of GSK-3, in the preparation of a medicament for combating prostate cancer. The medicament may contain a further anti-cancer agent.
    Type: Application
    Filed: August 17, 2005
    Publication date: December 10, 2009
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventor: Robert Martin Kypta
  • Novel crystalline forms of armodafinil and preparation thereof
    Publication number: 20090292025
    Abstract: The invention encompasses crystalline forms of armodafinil, processes for preparing the crystalline forms, and pharmaceutical formulation.
    Type: Application
    Filed: June 8, 2009
    Publication date: November 26, 2009
    Applicant: Teva Pharmaceutical Industries Ltd.
    Inventors: Viviana Braude, Rinat Moshkovits-Kaptsan, Sigalit Levi
  • Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same
    Patent number: 7622611
    Abstract: Pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings stated in the claims, are suitable, for example, as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: November 24, 2009
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Heinz-Werner Kleemann
  • Tricyclic derivatives and their use
    Patent number: 7622612
    Abstract: The present invention relates to tricyclic colchicine derivatives represented by the formulas (I) or (II), pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an anti-inflammatory effect or a method for treating cancer comprising administering to a patient an effective amount of one or more colchicine derivatives:
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: November 24, 2009
    Assignees: Chemtech Research Incorporation, KT & G Corporation
    Inventors: Dong Jo Chang, Eun Young Yoon, Gun Bong Lee, Soon Ok Kim, Wan Joo Kim
  • Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same
    Patent number: 7618651
    Abstract: The present invention relates to pharmaceutical compositions in the form of a gel for controlled- or sustained-release of a pharmaceutically active agent and to methods for treating or preventing or preventing a condition in an animal by administering to an animal in need thereof the pharmaceutical compositions. One particular type of condition for which the pharmaceutical compositions are useful is a microbial infection, e.g., of the skin, ear, or eye, especially for veterinary applications.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: November 17, 2009
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20090281192
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.38, 8.58, 7.34, 5.00 and 4.09 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: November 12, 2009
    Applicant: Cephalon France
    Inventors: Olivier NECKEBROCK, Laurent COURVOISIER, Stéphanie GRAF, Gilles SERRURE, Gérard Francois COQUEREL, Sébastien ROSE, Christine BESSELIEVRE, Franck Patrick MALLET, Adriaan Jan VAN LAGEVELDE
  • Androgen Receptor Related Methods for Treating Bladder Cancer
    Publication number: 20090282496
    Abstract: Disclosed are compositions and methods for treating bladder cancer.
    Type: Application
    Filed: April 3, 2009
    Publication date: November 12, 2009
    Applicant: University of Rochester Medical Center
    Inventor: Chawnshang Chang
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20090281193
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 9.45, 7.15, 5.13, 4.15 and 3.67 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: November 12, 2009
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gérard François Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal
    Publication number: 20090270512
    Abstract: Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor.
    Type: Application
    Filed: May 15, 2009
    Publication date: October 29, 2009
    Inventors: John Tze-tzun Koh, Paula Lynn McGinley, Hongmu Pan
  • PRODRUGS OF INHIBITORS OF CATHEPSIN S
    Publication number: 20090270511
    Abstract: The present invention provides compounds of formula (I) which are prodrugs of inhibitors of cathepsin S and as such are useful in the prevention and treatment of cathepsin S dependent diseases and conditions including, but not limited to, chronic obstructive pulmonary disease (COPD) and pain.
    Type: Application
    Filed: September 7, 2007
    Publication date: October 29, 2009
    Inventor: Jacques Yves Gauthier
  • GLYCINE TRANSPORT INHIBITORS
    Publication number: 20090270510
    Abstract: The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 21, 2005
    Publication date: October 29, 2009
    Applicant: GLAXO GROUP LIMITED
    Inventors: Daniel Marcus Bradley, Clive Leslie Branch, Wai Ngor Chan, Steven Coulton, Martin Leonard Gilpin, Andrew Jonathan Harris, Justine Yeun Quai Lai, Jacqueline Anne Macritchie, Howard Robert Marshall, David John Nash, Roderick Alan Porter, Simone Spada, Kevin Michael Thewlis, Simon Edward Ward
  • Amino-substituted ()-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders
    Patent number: 7598232
    Abstract: Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2,R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: October 6, 2009
    Assignees: Temple University - Of the Commonwealth System of Higher Education, Onconova Therapeutics, Inc.
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stanley C. Bell
  • Sulphones which modulate the action of gamma secretase
    Patent number: 7595344
    Abstract: Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: May 6, 2008
    Date of Patent: September 29, 2009
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Andrew Pate Owens, Duncan Edward Shaw, Martin Richard Teall, Susannah William, Brian John Williams
  • THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE
    Publication number: 20090239829
    Abstract: There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc metalloproteinases.
    Type: Application
    Filed: July 25, 2007
    Publication date: September 24, 2009
    Applicant: BRACCO IMAGING SPA
    Inventors: Armando Rossello, Elisabetta Orlandini, Aldo Balsamo, Laura Panelli, Elisa Nuti
  • Amide derivative and insecticide containing the same
    Publication number: 20090233962
    Abstract: The present invention is to provide a compound represented by the general formula (1) exhibiting a high insecticidal effect and an insecticide comprising the compound as an active ingredient. The compound represented by the general formula (1) and an insecticide comprising the compound as an active ingredient, wherein, in the formula, A1, A2, A3 and A4 each represent a carbon atom or the like; R1 and R2 each represent a hydrogen atom or the like; G1 and G2 represent an oxygen atom or the like; Xs each represent a hydrogen atom, a halogen atom or the like; n represents an integer of 0 to 4; Q1 represents a substituted phenyl group, a substituted heterocyclic group or the like; Q2 represents a substituted phenyl group, a substituted heterocyclic group or the like.
    Type: Application
    Filed: June 20, 2006
    Publication date: September 17, 2009
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Akiyoshi Kai, Takeo Wakita, Hiroyuki Katsuta, Kei Yoshida, Hidetaka Tsukada, Yusuke Takahashi, Nobuyuki Kawahara, Michikazu Nomura, Hidenori Daido
  • Modafinil compositions
    Patent number: 7566805
    Abstract: Co-crystals and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and several important physical properties are modulated. The solubility, dissolution, bioavailability, dose response, and stability of modafinil can be modulated to improve efficacy in pharmaceutical compositions.
    Type: Grant
    Filed: September 4, 2004
    Date of Patent: July 28, 2009
    Assignee: Cephalon, Inc.
    Inventors: Magali Bourghol Hickey, Matthew Peterson, Orn Almarsson, Mark Oliveira
  • PHARMACEUTICAL COMPOSITIONS
    Publication number: 20090175939
    Abstract: Methods and compositions are provided which comprise effective amounts of analgesic to treat a subject, including reducing or eliminating an adverse effect associated with the analgesic.
    Type: Application
    Filed: January 9, 2009
    Publication date: July 9, 2009
    Applicant: Charleston Laboratories, Inc.
    Inventors: Paul Bosse, John Ameling, Bernard Schachtel, Ray Takigiku
  • Adamantane derivatives
    Publication number: 20090176853
    Abstract: The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 or CH2CH2, E represents C(O)NH or NHC(O) and R3 represents a group of formula (I).
    Type: Application
    Filed: December 4, 2008
    Publication date: July 9, 2009
    Inventors: Lilian Alcaraz, Moya Caffrey, Mark Furber, Timothy Luker, Michael Mortimore, Austen Pimm, Philip Thorne, Paul Willis
  • Amidoacetonitrile Derivatives
    Publication number: 20090176868
    Abstract: The invention relates to compounds of the general formula (I) wherein X, Y and W have the significances given in claim 1 and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites in and on warm-blooded animals.
    Type: Application
    Filed: January 8, 2009
    Publication date: July 9, 2009
    Applicant: Novartis AG
    Inventors: Noelle Gauvry, Thomas Goebel, Pierre Ducray, Francois Pautrat, Ronald Kaminsky, Martin Jung
  • Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
    Patent number: 7553646
    Abstract: The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive oxidation-amidation of benzhydrylsulfanyl carboxylic acid to produce racemic and enantiomers of modafinil using at least one microorganism of yeast, bacteria, or fungus. Also disclosed are pharmaceutical compositions of racemic and enantiomers of modafinil along with their use in the treatment of diseases, including attention deficit hyperactivity disorder and drug addiction.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: June 30, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: Horacio F. Olivo, Antonio Victor Osorio-Lozada
  • FAST RELEASE SOLID FORMULATION, PREPARATION AND USE THEREOF
    Publication number: 20090156683
    Abstract: The present invention relates to a chemically stable formulation of florfenicol, (and structurally related compounds) in compositions such as soluble blended powders, granules, fast-dissolving tablets or pellets suitable for rapid release of the drug in water, and to methods and kits for treating animals with aqueous compositions including florfenicol.
    Type: Application
    Filed: November 5, 2008
    Publication date: June 18, 2009
    Inventors: Robert D. Simmons, Serena Tongiani, Keith Alan Freehauf