C-o- Group In R Patents (Class 514/622)
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Publication number: 20040132786Abstract: The invention is directed to novel biaryl derivatives, to the uses of these compounds in various medicinal applications, including the treatment, prevention and control of proliferative diseases such as tumors, and to pharmaceutical compositions comprising these compounds. Compounds of the invention can be used to treat or prevent diseases or disorders that involve the activity of MIF-1 and/or adenosine kinase.Type: ApplicationFiled: December 18, 2003Publication date: July 8, 2004Applicant: IRM LLC, a Delaware Limited Liability CompanyInventors: Jason Chyba, Quinn Deveraux, Garret Hampton, Fred King
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Publication number: 20040106583Abstract: Polysubstituted indan-1-ol compounds of formula I, its physiologically acceptable salts and physiologically functional derivatives are disclosed 1Type: ApplicationFiled: October 27, 2003Publication date: June 3, 2004Applicant: Aventis Pharma Deutschland GmBHInventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
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Publication number: 20040097500Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: ApplicationFiled: August 27, 2003Publication date: May 20, 2004Inventors: Jun Liao, David Gschneider, John J. Weidner, Nai Fang Wang
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Patent number: 6734204Abstract: Analogs related to oleamide are employed for potentiating the 5-HT2A and 5-HT1A responses to serotonin (5-HT). With respect to the potentiation of the 5-HT2A receptor response, it is disclosed that, of the naturally occurring fatty acids, the primary amide of oleic acid (oleamide) is the most effective potentiating agent of serotonin and that the potentiating activity of oleamide analogs is highly dependent upon their structural features. In particular, the presence, position, and stereochemistry of the 9-cis double bond is required and even subtle structural variations reduce or eliminate activity. Secondary or tertiary amides may replace the primary amide but follow a well-defined relationship requiring small amide substituents suggesting that the carboxamide serves as a hydrogen bond acceptor but not donor. Alternative modifications at the carboxamide as well as modifications of the methyl terminus or the hydrocarbon region spanning the carboxamide and double bond typically eliminate activity.Type: GrantFiled: September 28, 2000Date of Patent: May 11, 2004Assignee: The Scripps Research InstituteInventor: Dale L. Boger
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Patent number: 6730701Abstract: The present invention provides compositions useful for the treatment of inflammation in humans, and related methods of treatment for the same. In one embodiment the composition is: In another embodiment, the composition is: In yet another embodiment, the composition is: Additional alternative embodiments are R or R″ are therapeutic moieties.Type: GrantFiled: October 29, 2002Date of Patent: May 4, 2004Assignee: Nobex CorporationInventors: Nnochiri Nkem Ekwuribe, Jennifer A. Riggs-Sauthier
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Patent number: 6716421Abstract: This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.Type: GrantFiled: March 5, 2001Date of Patent: April 6, 2004Assignee: University of Florida Research Foundation, Inc.Inventors: Philip Frederick Brode, III, Garry Steven Garrett, Leo Timothy Laughlin, Randall Stryker Matthews, Dale Edwin Barker, Daniel James Kinne, Gary Eugene McKibben, Christopher Miles Miller, Timothy Robert Probst
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Patent number: 6716881Abstract: The present invention provides carbanilides of formula (I), wherein A, Q, R, X, Z and m are as defined herein. A plurality of processes for preparing these compounds is provided, along with methods of using the compounds to control microorganisms in crops and in the protection of materials. The compounds of the present invention also find use in controlling animal pests.Type: GrantFiled: May 30, 2002Date of Patent: April 6, 2004Assignee: Bayer AktiengesellschaftInventors: Hans-Ludwig Elbe, Bernd-Wieland Krüger, Robert Markert, Ralf Tiemann, Dietmar Kuhnt, Stefan Dutzmann, Klaus Stenzel, Christoph Erdelen, Martin Kugler, Hans-Ulrich Buschhaus
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Patent number: 6713510Abstract: The present invention provides compositions useful for the treatment of inflammation in humans, and related methods of treatment for the same. In one embodiment the composition is In another embodiment, the composition is Additional alternative embodiments are R or R″ that are therapeutic moieties.Type: GrantFiled: August 19, 2002Date of Patent: March 30, 2004Assignee: Nobex CorporationInventors: Nnochiri Nkem Ekwuribe, Jennifer A. Riggs
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Patent number: 6706766Abstract: The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.Type: GrantFiled: July 16, 2002Date of Patent: March 16, 2004Assignee: President and Fellows of Harvard CollegeInventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
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Patent number: 6703421Abstract: A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-&kgr;B inhibitor in a therapeutically effective amount, wherein said NF-&kgr;B inhibitor is a benzoquinone derivative represented by the following formula (I): wherein R1, R2 and R3 are each independently a hydrogen atom, an alkyl group having 1 to 5 carbons or an alkoxy group having 1 to 5 carbons; R4 is a hydrogen atom, a hydroxymethyl group, an alkyl group, or a carboxyl group which is optionally esterified or amidated; Z is and n is an integer from 0 to 6, or its hydroquinone form, or a pharmaceutically acceptable salt thereof, is provided.Type: GrantFiled: May 17, 2001Date of Patent: March 9, 2004Assignee: Daiichi Suntory Pharma Co., Ltd.Inventors: Yoichi Nunokawa, Akira Matsumori
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Patent number: 6696484Abstract: Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5&agr;-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catechins, particularly epigallocatechin derivatives, fatty acids, and the salts, esters, analogues, pro-drugs, isomers, racemic mixtures, or derivatives of any of the foregoing. The use of testosterone (or DHT) combinations with the aforementioned 5&agr;-reductase inhibitor compounds is also contemplated.Type: GrantFiled: April 24, 2002Date of Patent: February 24, 2004Assignee: University of Chicago Office of Technology and Intellectual PropertyInventors: Shutsung Liao, Richard Hiipakka
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Publication number: 20040034102Abstract: Oral pediatric trimethobenzamide compositions and methods for treating and controlling nausea and/or vomiting are disclosed in warm blooded animals, especially humans including children. The oral pediatric trimethobenzamide compositions and methods of the present invention are believed to be at least as effective as a 200 mg intramuscular (I.M.) trimethobenzamide HCl injectable formulation when administered at a dose of about 100 mg. In addition, an oral pediatric composition containing about 120 mg of trimethobenzamide HCl is believed to be uniquely approximately bioequivalent to a 200 mg intramuscular (I.M.) trimethobenzamide HCl injectable formulation when administered at a dose of about 100 mg.Type: ApplicationFiled: February 6, 2003Publication date: February 19, 2004Applicant: King Pharmaceuticals, Inc.Inventors: Jefferson J. Gregory, Robert G. Bruns, Dean R. Cirotta, Thomas K. Rogers, Charles L. Pamplin
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Publication number: 20040034096Abstract: The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula 1Type: ApplicationFiled: July 3, 2003Publication date: February 19, 2004Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
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Patent number: 6683211Abstract: The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is halogen, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkenylthio; optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenylsulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonType: GrantFiled: November 15, 2002Date of Patent: January 27, 2004Assignee: Syngenta Crop Protection, Inc.Inventors: Clemens Lamberth, Martin Zeller, Walter Kunz, Fredrik Cederbaum
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Patent number: 6677376Abstract: The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.Type: GrantFiled: September 7, 2000Date of Patent: January 13, 2004Assignee: Guilford Pharmaceuticals, Inc.Inventors: Gregory S. Hamilton, Joseph P. Steiner, Mark J. Vaal, Chi Choi, Ling Wei
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Publication number: 20030220398Abstract: Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): 1Type: ApplicationFiled: June 5, 2002Publication date: November 27, 2003Applicant: KAO CORPORATIONInventors: Atsushi Suzuki, Ryuji Ochiai, Ichiro Tokimitsu
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Publication number: 20030212074Abstract: Dihydroxybenzamides, useful for treatment of chronic renal failure and uremic bone disease, are disclosed.Type: ApplicationFiled: October 29, 2002Publication date: November 13, 2003Inventors: Dimitri Gaitanopoulos, Gerald R. Girard, Joseph Weinstock
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Patent number: 6635650Abstract: The invention relates to compounds of formula (I): A-G1-Cy-G2-Cy-G3-B (I) wherein: A represents NR1C(Q)R2, C(Q)NR2R3 or NR1C(Q)NR2R3, B represents NR1C(Q)R2, C(Q)NR2R3, NR1C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2 or NR2R3, G1 and G3 represent an optionally substituted alkylene chain, Cy represents a ring structure G2 represents a chain and medicinal products containing the same which are useful in treating or in preventing melatoninergic disorders.Type: GrantFiled: August 8, 2001Date of Patent: October 21, 2003Assignee: Les Laboratoires ServierInventors: Daniel Lesieur, Said Yous, Carole Descamps-Francois, François Lefoulon, Gérald Guillaumet, Marie-Claude Viaud, Caroline Bennejean, Philippe Delagrange, Pierre Renard
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Patent number: 6632836Abstract: The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.Type: GrantFiled: October 21, 1999Date of Patent: October 14, 2003Assignee: Merck & Co., Inc.Inventors: Robert K. Baker, Jianming Bao, Jennifer Chee, Maria L. Garcia, Gregory J. Kaczorowski, Frank Kayser, Andrew Kotliar, Chou Juitsai Liu, Shouwu Miao, William H. Parsons, Kathleen M. Rupprecht, William A. Schmalhofer, Christopher F. Claiborne, David A. Claremon, Nigel Liverton, Wayne J. Thompson
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Publication number: 20030187007Abstract: The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: May 28, 2002Publication date: October 2, 2003Inventors: Sheldon Xiaodong Cao, Pierre-Yves Bounaud, Xiaohua Chen, Hyun-Ho Chung, Sunil Kumar KC, Changhee Min, Jae Young Yang, Melissa C. Long
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Publication number: 20030171617Abstract: The invention relates to N-alkyl-2-(3,4-dihydroxyphenyl)-2-hydroxyacetamides and to cosmetic and/or pharmaceutical preparations and foods comprising these compounds.Type: ApplicationFiled: December 19, 2002Publication date: September 11, 2003Inventor: Jakob Peter Ley
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Publication number: 20030166693Abstract: The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.Type: ApplicationFiled: March 14, 2003Publication date: September 4, 2003Applicant: AJINOMOTO CO., INCInventors: Yukio Iino, Kohichi Fujita, Takashi Tsuji, Ariko Kodaira, Kenji Takehana, Tsuyoshi Kobayashi, Takashi Yamamoto
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Publication number: 20030166728Abstract: The present invention is directed to a pharmaceutical composition containing a cancer-treating effective amount of a class of prostacyclin derivatives, and a pharmaceutically acceptable carrier, and to kits and methods of employing the same for the treatment of cancer.Type: ApplicationFiled: January 16, 2002Publication date: September 4, 2003Inventors: Robert Shorr, Martine Rothblatt
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Publication number: 20030162789Abstract: The present invention relates to 4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them. More particularly, it relates to 4-hydroxycinnamamide derivatives showing superior antioxidant activity compared to the known antioxidant compounds, their pharmaceutically acceptable salt, and pharmaceutical compositions containing them. It can be usefully used in treating neurodegerative diseases such as aging, cancer, diabetes, ischemic stroke, Parkin's disease, dementia and Huntinton's disease.Type: ApplicationFiled: November 22, 2002Publication date: August 28, 2003Inventors: No-Sang Park, Young-Sik Jung, Churl-Min Seong, Hee-Jong Lim, Joong-Ho Yoon, Jae-Yang Kong, Woo-Kyu Park
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Publication number: 20030160610Abstract: Featured is an MRI/NMR methodology or process to detect amide protons of endogenous mobile proteins and peptides via the water signal. Such methods and processes can be used for the purposes of detection of pH effects and amide proton content or content changes and related mobile protein and peptide content or content changes using MR imaging. Also featured are methods whereby assessment of determined pH effects and amide proton content or content changes and related mobile protein and/or peptide content or content changes can be used in connection with diagnosis, program and treatment of brain related disorders and diseases, cardiac disorders and diseases, and cancer and to use such methods for monitoring, detecting and assessing protein and peptide content in vivo and pathologically for any of a number of diseases or disorders of a human body, including but not limited to cancers, ischemia, Alzheimers and Parkinsons.Type: ApplicationFiled: December 13, 2002Publication date: August 28, 2003Applicant: The Johns Hopkins University School of MedicineInventors: Peter C. M. Van Zijl, Jinyuan Zhou
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Publication number: 20030130295Abstract: The invention is directed to substituted 2-aminoacetamides represented by formula (II): 1Type: ApplicationFiled: December 2, 2002Publication date: July 10, 2003Applicant: Euro-Celtique S.A.Inventors: Nancy C. Lan, Yan Wang, Sui Xiong Cai
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Patent number: 6586475Abstract: A compound of the formula: wherein Ar is an aromatic group; X and Y are a bivalent group selected from —O—, —S—, —CO—, —SO2—, —NR8—, —CONR8—, SO2NR8 and —COO— (wherein R8 is H, a hydrocarbon group or acyl), or a bivalent C1-6 aliphatic hydrocarbon group which may contain one or two above bivalent groups; R1 and R2 are H or C1-6 alkyl, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic ring; and ring A is a monocyclic aromatic ring, or a salt thereof or a prodrug thereof exhibits an excellent inhibitory activity of the production and/or the secretion of amyloid-&bgr; protein.Type: GrantFiled: June 5, 2001Date of Patent: July 1, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Kaneyoshi Kato, Jun Terauchi, Hiroaki Fukumoto, Mitsuru Kakihana
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Publication number: 20030119784Abstract: A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours with an aromatic compound of the invention. The products of the invention are a veterinary preparation of the aromatic compound of the invention and an anti-scours agent, and a pharmaceutical preparation of the aromatic compound of the invention and an anti-diarrheal agent.Type: ApplicationFiled: November 8, 2002Publication date: June 26, 2003Inventors: Wayne I. Lencer, Carlo Brugnara, Seth Alper
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Patent number: 6583319Abstract: The invention relates to compounds of for a (I): wherein: R represents ORa, SRa or Ra or a cyclic group A is a cyclic structure G1 and G2 represent an alkylene chain or a single bond B represents —NR1aC(Q)R2a, —NR1aC(Q)NR2aR3a or C(Q)NR1aR2a p and q are such that 1≦p+q≦4, and medicinal products containing the same which are useful in treating or in preventing melatoninergic disorders.Type: GrantFiled: October 12, 1999Date of Patent: June 24, 2003Assignee: Les Laboratoires ServierInventors: Michel Langlois, Monique Mathe-Allainmat, Marie Lefas-Le Gall, Caroline Bennejean, Pierre Renard, Philippe Delagrange
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Patent number: 6576660Abstract: Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.Type: GrantFiled: April 28, 2000Date of Patent: June 10, 2003Assignee: Arch Development CorporationInventors: Shutsung Liao, Richard A. Hiipakka
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Publication number: 20030092771Abstract: The present invention provides pharmaceutical compositions of salicylanilide inhibitors of transcription factor NF-&kgr;B, and methods for treating diseases in which activation of NF-&kgr;B is implicated. More specifically, the present invention provides methods of treatment of a variety of diseases associated with NF-&kgr;B activation including inflammatory disorders; particularly rheumatoid arthritis, inflammatory bowel disease, and asthma; dermatosis, including psoriasis and atopic dermatitis; autoimmune diseases; tissue and organ rejection; Alzheimer's disease; stroke; atherosclerosis; restenosis; cancer, including Hodgkin's disease; certain viral infections, including AIDS; osteoarthritis; osteoporosis; and Ataxia Telangiestasia by administering to a patient in need thereof a compound of the present invention.Type: ApplicationFiled: July 31, 2002Publication date: May 15, 2003Applicant: SmithKline Beecham CorporationInventors: James F. Callahan, Marie C. Chabot-Fletcher
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Publication number: 20030083386Abstract: The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.Type: ApplicationFiled: July 16, 2002Publication date: May 1, 2003Inventors: Junying Yuan, Alexei Degterev, Timothy J. Mitchison
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Patent number: 6548548Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.Type: GrantFiled: December 6, 2001Date of Patent: April 15, 2003Assignee: CV Therapeutics, Inc.Inventors: Michael Campbell, Prabha N. Ibrahim, Jeff A. Zablocki, Richard Lawn
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Patent number: 6548534Abstract: This invention describes the new, nonsteroidal gestagens of general formula I in which A, B, Ar1, R1, R2 and R3 have the meanings that are indicated in more detail in the description. The new compounds show a very great affinity to the gestagen receptor. They can be used alone or in combination with estrogens in contraceptive preparations. In addition, they can be used for treating endometriosis. Together with estrogens, they can also be used in preparations for treating gynecological disorders, for treating premenstrual symptoms and for substitution therapy. Based on the androgenic action, they can also be used for male birth control, male HRT and hormone therapy and for treating andrological disease agents.Type: GrantFiled: July 27, 2001Date of Patent: April 15, 2003Assignee: Schering AktiengesellschaftInventors: Manfred Lehmann, Klaus Schoellkopf, Peter Strehlke, Nikolaus Heinrich, Karl-Heinrich Fritzemeier, Rolf Krattenmacher, Hans-Peter Muhn
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Publication number: 20030068392Abstract: Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an irritant in an effective amount to impart an irritating sensation to an abuser upon administration of the dosage form after tampering.Type: ApplicationFiled: August 6, 2002Publication date: April 10, 2003Inventor: Richard Sackler
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Publication number: 20030065008Abstract: Novel methods for reduction or elimination the incidence of hot flashes and menopausal symptoms, while decreasing the risk of acquiring breast or endometrial cancer and furthermore treating and/or inhibiting the development of osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, diabetes, loss of muscle mass, obesity, irregular menstruation, Alzheimer's disease, or vaginal dryness in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator, particularly compounds having the general structure 1Type: ApplicationFiled: May 9, 2002Publication date: April 3, 2003Applicant: Endorecherche, Inc.Inventor: Fernand Labrie
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Patent number: 6538029Abstract: A method of treating renal cell carcinoma in a mammal with that disease comprising administering to the mammal a physiologically effective amount of an inhibitor of PDE10.Type: GrantFiled: May 29, 2002Date of Patent: March 25, 2003Assignee: Cell PathwaysInventors: W. Joseph Thompson, John R. Fetter, Robert E. Bellet, Han Li
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Publication number: 20030055096Abstract: The present invention provides a fungicidal composition characterized by containing as active ingredientsType: ApplicationFiled: August 9, 2002Publication date: March 20, 2003Inventor: Yukio Oguri
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Publication number: 20020193436Abstract: The present invention provides non-peptide organic compounds that have a structure analogous to or reminiscent of the TMOF structure and have pesticidal activity. Thus the present invention concerns pesticidal compounds that inhibit digestion in pests by terminating or otherwise blocking synthesis of digestive enzymes by activating a TMOF receptor (collectively referred to herein as “pesticidal compounds”). The pesticidal compounds and other compounds of the present invention are usefully employed in the control of pests, particularly insect pests such as mosquitoes, which ingest blood.Type: ApplicationFiled: June 7, 2001Publication date: December 19, 2002Inventors: Russell J. Linderman, R. Michael Roe, Deborah M. Thompson, Matthew Vanderherehen
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Patent number: 6492425Abstract: The present invention provides pharmaceutical compositions of salicylanilide inhibitors of transcription factor NF-&kgr;B, and methods for treating diseases in which activation of NF-&kgr;B is implicated. More specifically, the present invention provides methods of treatment of a variety of diseases associated with NF-&kgr;B activation including inflammatory disorders; particularly rheumatoid arthritis, inflammatory bowel disease, and asthma; dermatosis, including psoriasis and atopic dermatitis; autoimmune diseases; tissue and organ rejection; Alzheimer's disease; stroke; atherosclerosis; restenosis; cancer, including Hodgkin's disease; certain viral infections, including AIDS; osteoarthritis; osteoporosis; and Ataxia Telangiestasia by administering to a patient in need thereof a compound of the present invention.Type: GrantFiled: December 19, 2000Date of Patent: December 10, 2002Assignee: SmithKline Beecham CorporationInventors: James F. Callahan, Marie C. Chabot-Fletcher
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Patent number: 6489348Abstract: Fungicidal mixtures comprise as active components a) an amide compound of the formula I A—CO—NR1R2 I in which A, R1 and R2 are as defined in the description, and b) compounds of the formula II, their N-oxide or one of their salts where the substituents R12 to R18 are as defined in the description, and/or c) compounds of the formula III where the substituents X1 to X5 and R19 to R22 are as defined in the description, in a synergistically effective amount.Type: GrantFiled: September 24, 2001Date of Patent: December 3, 2002Assignee: BASF AktiengesellschaftInventors: Klaus Schelberger, Maria Scherer, Karl Eicken, Manfred Hampel, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann
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Patent number: 6486178Abstract: The present invention provides medicines for treating cardiac insufficiency which contain as an active ingredient indane derivatives of formula (I) wherein R1 represents hydrogen atom, nitro group, cyano group, C1-6 alkylcarbonylamino, R2 and R3 each independently represent C1-6 alkyl group, R4 represents hydroxyl group or C1-6 alkylcarbonyloxy group or represents a bond or oxygen atom together with R5, R5 represents hydrogen atom or represents a bond or oxygen atom together with R4, R6 represents hydrogen atom, hydroxyl group or NR7R8, n means 0 or an integer of 1 to 4, X represents C═O, CH2, SO2 or NR16, Y represents NR17 when X is C═O, CH2 or SO2 and represents C═O when X is NR16, Z is absent when Y represents NR17 or represents NR18 when Y is C═O, W represents aromatic groups or lactam rings, or pharmaceutically acceptable salt thereof.Type: GrantFiled: November 28, 2000Date of Patent: November 26, 2002Assignee: Nissan Chemical Industries, Ltd.Inventors: Keizo Tanikawa, Kazuhiko Ohrai, Masayuki Sato, Kazufumi Yanagihara, Yukihiro Shigeta, Toru Yamashita
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Patent number: 6482846Abstract: Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.Type: GrantFiled: August 30, 2001Date of Patent: November 19, 2002Assignee: NitroMed, Inc.Inventors: David S. Garvey, L. Gordon Letts, H. Burt Renfroe, Sang William Tam
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Patent number: 6479484Abstract: The invention is directed to substituted 2-aminoacetamides represented by formula (II): and to pharmaceutically acceptable salts and prodrugs thereof, wherein the substituents are defined herein. The invention is also directed to the use of substituted 2-aminoacetamides in methods for the treatment of neuronal damage following global and focal ischemia, and for the treatment, prevention or amelioration of pain, as anticonvulsants, as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.Type: GrantFiled: August 8, 2000Date of Patent: November 12, 2002Assignee: Euro-Celtique S.A.Inventors: Nancy C. Lan, Yan Wang, Sui Xiong Cai
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Patent number: 6464996Abstract: Disclosed are novel thickened organic fluid/surfactant compositions that are uniform, flowable and dispersible in water. Also disclosed are novel pesticidal compositions comprising a pesticide and the novel thickened organic fluid/surfactant composition.Type: GrantFiled: May 17, 2001Date of Patent: October 15, 2002Assignee: ExxonMobil Chemical Patents Inc.Inventors: Ralph Martin Kowalik, Karen K. Kuo, Kishore K. Chokshi, Paul Douglas Frisch, R. Scott Tann
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Publication number: 20020143011Abstract: Compounds of general formula (1) are described: 1Type: ApplicationFiled: March 14, 2001Publication date: October 3, 2002Applicant: Celltech Therapeutics, LimitedInventors: Graham John Warrellow, Ewan Campbell Boyd, Rikki Peter Alexander
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Patent number: 6458523Abstract: New compounds of the formula I are described, wherein n is >1; X is O or NR4; L is a n-valent linking group defined in claim 1 and R1 is H, halogen, C1-C25-alkyl, C3-C25-alkenyl, unsubstituted or by C1-C4-alkyl substituted C5-C8-cycloalkyl; R2 and R3 independently of each other are C1-C4-alkyl, or together with the carbon atom they are bonded to, form a carbocyclic C5-C7 ring, especially C5-C7 cycloalkylene; and m is 1-20, especially 2-4. Compounds of the formula I are active as Dox-scavengers in color photographic material.Type: GrantFiled: January 7, 2002Date of Patent: October 1, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Suruliappa Gowper Jeganathan, Stéphane Biry
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Patent number: 6436934Abstract: Fungicidal mixtures comprise as active components a) an amide compound of the formula I A—CO—NR1R2 I in which A, R1 and R2 are as defined in the description, and b) dimethomorph or flumetover, and/or c) a valinamide of the formula III in which R13 is C3-C4-alkyl and R14 is naphthyl or phenyl, where the phenyl radical is substituted in the 4-position by a halogen atom, a C1-C4-alkyl or C1-C4-alkoxy group, and/or d) benalaxyl, ofurace, metalaxyl, furalaxyl or oxydixyl, and/or e) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea in a synergistically effective amount.Type: GrantFiled: June 19, 2000Date of Patent: August 20, 2002Assignee: BASF AktiengesellschaftInventors: Klaus Schelberger, Maria Scherer, Karl Eicken, Manfred Hampel, Eberhard Ammermann, Gisela Lorenz, Siegfreid Strathmann
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Patent number: 6436998Abstract: The present invention relates to the use of &ggr;-hydroxybutyric acid amides in the treatment of drug addiction and alcoholism, more particularly in reducing chronic alcoholics' desire for and habit of consuming alcoholic drinks and in the treatment of the syndrome of abstinence from alcohol.Type: GrantFiled: September 2, 1999Date of Patent: August 20, 2002Assignee: Laboratoric Farmaceutico C.T. S.r.l.Inventors: Roberto Cacciaglia, Antonella Loche, Vincenzo Perlini, Lorenza Guano
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Patent number: RE37873Abstract: Phenylacetic acid derivatives of the formula IType: GrantFiled: April 16, 2001Date of Patent: October 8, 2002Assignee: BASF AktiengesellschaftInventors: Herbert Bayer, Hubert Sauter, Ruth Müller, Wassilios Grammenos, Albrecht Harreus, Reinhard Kirstgen, Franz Röhl, Eberhard Ammermann, Gisela Lorenz