Nitroxides, Oxyamines Or Hydroxylamines (i.e., N-o Or N-oh) Patents (Class 514/645)
  • Patent number: 5276029
    Abstract: Wood preservatives contain a copper salt, a polyamine and a fatty amine and are used for preserving wood from fungi and termites.
    Type: Grant
    Filed: November 1, 1990
    Date of Patent: January 4, 1994
    Assignee: Dr. Wolman GmbH
    Inventors: Reimer Goettsche, Hans-Volker Borck
  • Patent number: 5187194
    Abstract: Wood preservatives which contain a mixture of an N-organyldiazeniumdioxy-metal salt and a complex-forming polymeric nitrogen compound are used for preserving wood.
    Type: Grant
    Filed: October 16, 1990
    Date of Patent: February 16, 1993
    Assignee: Dr. Wolman GmbH
    Inventors: Reimer Goettsche, Wolfgang Reuther
  • Patent number: 5186947
    Abstract: Water-soluble wood preservatives which contain mixtures of a metal compound, a metal-fixing acid and a complexing polymeric nitrogen compound, and methods for protecting wood with such mixtures.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: February 16, 1993
    Assignee: Dr. Wolman GmbH
    Inventors: Reimer Goettsche, Wolfgang Reuther
  • Patent number: 5169867
    Abstract: Compounds of formula ##STR1## wherein R.sub.1 is amino or is a radical ##STR2## wherein R.sub.3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, carboxy, lower alkoxycarbonyl, phenyl, phenyl substituted by lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, halogen, hydroxy, lower alkoxy, lower alkanoyloxy and/or by nitro, pyridyl, pyridyl substituted by lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, phosphonooxy-lower alkyl, lower alkanoyl, carboxy, lower alkoxycarbonyl, hydroxy, lower alkoxy, lower alkanoyloxy, nitro and/or by oxido, or quinolyl, R.sub.4 is hydrogen, lower alkyl, hydroxy-lower alkyl or halo-lower alkyl, or R.sub.3 and R.sub.4 together are C.sub.4 -C.sub.6 alkylene or benzo-C.sub.4 -C.sub.6 alkylene, and R.sub.2 is straight-chain C.sub.1 -C.sub.4 alkyl, and salts thereof, have a strong specific inhibitory action on the enzyme ornithine decarboxylase. The compounds of Formula I are prepared according to processes known per se.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: December 8, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Jaroslav Stanek, Jorg Frei
  • Patent number: 5110831
    Abstract: The present invention relates to vinylogous hydroxamic acids, processes for their manufacture, pharmaceutical preparations containing them, and their use in the treatment of various disorders.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: May 5, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Ronald L. Magolda, Stephen W. Wright
  • Patent number: 5039705
    Abstract: This invention concerns anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently chosen from straight chain and branched chain C.sub.1 -C.sub.12 alkyl groups and benzyl, with the proviso that no branch occur on the alpha carbon atom of the alkyl groups; or R.sub.1 and R.sub.2 together with the nitrogen atom they are bonded to form a pyrrolidino, piperidino, piperazino or morpholino group, M.sup.+ is a pharmaceutically acceptable cation, wherein X is the valence of the cation.
    Type: Grant
    Filed: September 15, 1989
    Date of Patent: August 13, 1991
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Larry K. Keefer, David A. Wink, Tambra M. Dunams, Joseph A. Hrabie
  • Patent number: 4981865
    Abstract: The present invention includes N-hydroxyamide, N-hydroxyurea, N-hydroxythioamide, and N-hydroxythiourea derivatives of fenamates, indomethacin, cicloprofen, oxepinac, and indoprofen as dual inhibitors or selective inhibitors of cyclooxygenase and 5-lipoxygenase.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: January 1, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Thomas R. Belliotti, Wiaczeslaw A. Cetenko, David T. Connor, Daniel L. Flynn, Catherine R. Kostlan, James B. Kramer, Jagadish C. Sircar
  • Patent number: 4880840
    Type: Grant
    Filed: June 30, 1987
    Date of Patent: November 14, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans Lindel, Axel Ingendoh, Friedrich Berschauer, Anno de Jong, Martin Scheer
  • Patent number: 4863926
    Abstract: New nitro aliphatic compounds useful as antithrombotic and antihypertensing agents are disclosed.
    Type: Grant
    Filed: November 10, 1987
    Date of Patent: September 5, 1989
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masanori Okamoto, Morita Iwami, Shigehiro Takase, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Konsaka, Hiroshi Imanaka
  • Patent number: 4863717
    Abstract: Nitroxide contrast agents for MRI have a long useful life and can be administered in low concentration doses. Such agents include nitroxide-doped liposomes that encapsulate an oxidant and large molecules having surfaces covered with persistent nitroxide free radicals.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: September 5, 1989
    Assignee: The State of Oregon Acting by and Through the State Board of Higher Education on Behalf of the University of Oregon
    Inventor: John F. W. Keana
  • Patent number: 4847291
    Abstract: Aryl ethanol-hydroxylamines of the formula ##STR1## in which Ar represents aryl or heteroaryl, each of which can optionally be substituted, andR represents alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or cycloalkyl, each of which can optionally be substituted,or physiologically tolerated salts thereof, exhibit animal growth-promoting properties. Intermediates therefor of the formula ##STR2## with the exception of phenyl and p-bromophenyl, are also new.
    Type: Grant
    Filed: July 11, 1986
    Date of Patent: July 11, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Axel Ingendoh, Hans Lindel, Friedrich Berschauer, Anno de Jong, Martin Scheer
  • Patent number: 4778804
    Abstract: New nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.
    Type: Grant
    Filed: October 11, 1985
    Date of Patent: October 18, 1988
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masanori Okamoto, Morita Iwami, Shigehiro Takase, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
  • Patent number: 4767768
    Abstract: New Nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.
    Type: Grant
    Filed: December 8, 1983
    Date of Patent: August 30, 1988
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masanori Okamoto, Morita Iwami, Shigehiro Takase, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
  • Patent number: 4751245
    Abstract: N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine derivatives are provided having the general formula ##STR1## wherein R.sub.1 is methoxy, iminomethyl or 1-iminoethyl and R.sub.2 and R.sub.3 are each hydrogen; or R.sub.1 is methyl and one of R.sub.2 and R.sub.3 is hydrogen and the other is halogen.The above compounds as well as acid-addition salts thereof are useful as antifungal agents.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: June 14, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gregory S. Bisacchi, Robert Zahler
  • Patent number: 4656034
    Abstract: The absorption of a scavenger of oxygen free radicals generated at the time of reperfusion or the absorption of an agent preventing the cytotoxic effects on healthy cells in a mammal. e.g. superoxide dismutase or S-aminotrimethyleneaminoethyl thiophosphate is enhanced by substantially simultaneously administering an absorption enhancing agent therefore, e.g. hydroxylamine or a non-toxic salt thereof. It is also part of the invention to inject WR-2721 intravenously or intramuscularly as a scavenger of oxygen free radicals even in the absence of an absorption enhancing agent.
    Type: Grant
    Filed: May 20, 1985
    Date of Patent: April 7, 1987
    Assignee: Survival Technology, Inc.
    Inventor: Stanley J. Sarnoff
  • Patent number: 4613616
    Abstract: The present invention relates to polymeric iron chelators based upon hydroxamic acids having the general formula: ##STR1## wherein R is hydrogen or lower alkyl. The present compound is useful for the treatment of iron overload disorders particularly arising from iron poisoning and the disease .beta.-thalassemia otherwise known as Cooley's Anemia. The polymeric hydroxamic acids of the present invention exhibit high selectivity for iron, good water solubility for both the chelator and its iron complex, low toxicity and, most significantly, increased bioactivity, i.e., the ability to remove iron in vivo.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: September 23, 1986
    Assignee: Research Corporation
    Inventors: Anthony Winston, D. V. P. R. Varaprasad