The Aryl Ring Or Aryl Ring System And Amino Nitrogen Are Bonded Directly To The Same Acylic Carbon, Which Carbon Additionally Has Only Hydrogen Or Acyclic Hydrocarbyl Substituents Bonded Directly Thereto Patents (Class 514/655)
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Patent number: 11771685Abstract: Compounds and methods are provided for the treatment of neurological or mitochondrial diseases, including epilepsy. In some embodiments, the compounds are substituted 1,4-naphthoquinones.Type: GrantFiled: July 29, 2019Date of Patent: October 3, 2023Assignee: MUSC Foundation for Research DevelopmentInventors: James C. Chou, Sherine S. L. Chan, Richard A. Himes
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Patent number: 11400061Abstract: Compositions and methods are presented that provide substantially improved physical and pharmacological parameters for subungually administrable formulations. Most beneficially, the compositions presented herein have a viscosity and film-forming capacity that retain the liquid formulation in sufficient quantities and that help penetrate the polysaccharide matrix commonly associated with onychomycosis. In especially preferred aspects, the carrier is formulated to have a high concentration of the active pharmaceutically active agent (API), to allow migration of the formulation within the subungual space, and to reduce systemic absorption while promoting diffusion of the API into the nail plate at or above minimum inhibitory concentration into a larger treatment space.Type: GrantFiled: September 14, 2021Date of Patent: August 2, 2022Assignee: HALLUX INC.Inventors: Christopher Ronald Agee, Robert L. Orr, Thomas Mark Tremblay
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Patent number: 10926071Abstract: Provided herein are methods for treating nail infections, in particular fungal nail infections, comprising applying a drug delivery system comprising a desiccant such as silica gel to an external surface of the infected nail.Type: GrantFiled: May 23, 2017Date of Patent: February 23, 2021Inventor: Jane Brucker
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Patent number: 10869866Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.Type: GrantFiled: June 18, 2019Date of Patent: December 22, 2020Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The United States Government as represented by the Department of Veterans AffairsInventors: Beibei Chen, Rama K. Mallampalli
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Patent number: 10272054Abstract: Aqueous, topical antifungal compositions contain an allylamine or an azole as the antifungal agent together with a lactate ester, an organic acid (pKa 3.8-5), a C2 to C6 saturated aliphatic alcohol, and a cationic galactomannan gum.Type: GrantFiled: October 7, 2016Date of Patent: April 30, 2019Assignee: Exodos Life Sciences LPInventors: Servet Buyuktimkin, Nadir Buyuktimkin, James L. Yeager
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Patent number: 10039727Abstract: The present invention relates to a method for treating a Chlamydiales infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof: W-L1-NH-L2-Ar?? (I) Wherein W, L1, L2 and Ar are as defined in claim 1.Type: GrantFiled: April 20, 2016Date of Patent: August 7, 2018Assignee: Commissariat a l'Energie Atomique et aux Energies AlternativesInventors: Daniel Gillet, Julien Barbier, Jean-Christophe Cintrat, Valérie Pons, Thomas Rudel, Jo-Ana Herweg, Annette Fischer
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Patent number: 9857686Abstract: The present invention provides a composition for forming a resist underlayer film, containing an organic solvent and either or both of a compound shown by the following general formula (1) and a condensate of the compound. There can be provided a composition for forming a resist underlayer film that is capable of forming an underlayer film, especially for use in a three-layer resist process, that can reduce reflectance, has high pattern-bend resistance, and prevents line fall and wiggling after etching of a high aspect line especially thinner than 60 nm, and a patterning process using the same.Type: GrantFiled: June 10, 2016Date of Patent: January 2, 2018Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Tsutomu Ogihara, Daisuke Kori, Jun Hatakeyama, Naoki Kobayashi
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Patent number: 9522167Abstract: The invention provides extracts of the microalga Aphanizomenon Flos Aquae Aquae Ralfs ex Born. & Flah. Var. flos aquae (AFA Klamath) and purified components thereof useful for the prevention or treatment of neurological, neurodegenerative and mood conditions or diseases.Type: GrantFiled: June 26, 2007Date of Patent: December 20, 2016Assignee: Nutratec, s.r.l.Inventors: Stefano Scoglio, Franco Canestrari, Serena Benedetti, Yanina Benedetti, Maria Delgado-Esteban
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Publication number: 20150148301Abstract: The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumour-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.Type: ApplicationFiled: May 23, 2013Publication date: May 28, 2015Inventors: Virginie Clement-Schatlo, Thomas Fessard, Damien Barbaras, Joana Matos, Erick Carreira
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Publication number: 20150133510Abstract: The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure.Type: ApplicationFiled: May 17, 2013Publication date: May 14, 2015Applicant: Universitetet I OsloInventors: Kjetil Tasken, Birgitte Lygren, Ellen Ostensen, Jo Klaveness
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Publication number: 20150126467Abstract: The disclosure relates to use of alginate oligomers to enhance the effects of antifungal agents. The invention provides a method to improve the efficacy of an antifungal agent against a fungus, said method comprising using said antifungal agent together with an alginate oligomer. The fungus may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antifungal agent in treating a subject infected, suspected to be infected, or at risk of infection, with a fungus. In another aspect the method can be used to combat fungal contamination of a site e.g., for disinfection and cleaning purposes.Type: ApplicationFiled: September 14, 2012Publication date: May 7, 2015Applicant: AlgiIPharma ASInventors: Edvar Onsøyen, Arne Dessen, David William Thomas, Katja Etel Hill, Hàvard Sletta, Anne Tøndervik, Geir Klinkenberg, Rolf Myrvold
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Publication number: 20150119461Abstract: The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR?, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPAR? modulation such as diabetes.Type: ApplicationFiled: January 9, 2015Publication date: April 30, 2015Inventors: Veera KONDA, Jan URBAN, Anuradha DESAI, Clinton J. DAHLBERG, Brian J. CARROLL
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Publication number: 20150111971Abstract: The present invention relates to a topical pharmaceutical composition comprising, based on the total weight of the composition: a) from 1.5 wt. % to 5 wt. % of terbinafine or any pharmaceutically acceptable salt thereof; b) from 15 wt. % to 35 wt. % of urea; and c) more than 25 wt. % of water.Type: ApplicationFiled: May 13, 2013Publication date: April 23, 2015Inventors: Dirk-Heinrich Evers, Sabine Fielhauer, Sascha Gorissen, Michael Herbig, Henning Mallwitz, Christoph Willers
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Patent number: 9012511Abstract: Described are compositions of stable nanoparticulate cinacalcet or a salt thereof, and methods of making and using them. The compositions exhibit an improved dissolution rate, improved bioavailability, and reduced difference in absorption when administered orally under fed as compared to fasting conditions.Type: GrantFiled: May 18, 2011Date of Patent: April 21, 2015Assignee: Alkermes Pharma Ireland LimitedInventors: Deborah Neville, Scott Jenkins, David Manser
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Publication number: 20150094294Abstract: The present disclosure provides compounds, specifically pyrimidin-4,6-dicarboxylic acid amide derivatives, or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing said compounds. Also provided are methods for treating a mammal having malaria, or killing or inhibiting the growth of a Plasmodium species, comprising administering to said mammal or contacting said Plasmodium species with, an effective amount of a pyrimidin-4,6-dicarboxylic acid amide derivative.Type: ApplicationFiled: February 28, 2013Publication date: April 2, 2015Inventors: Richard W. Scott, Robert W. Kavash, Wenxi Pan, Katie Freeman, Michael J. Costanzo, Doron Greenbaum, Yongjiang Xu, Trevor Young
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Publication number: 20150087712Abstract: The present invention relates to methods for reducing testosterone levels in a male subject and methods of treating, suppressing, reducing the incidence, reducing the severity, or inhibiting prostate cancer, advanced prostate cancer, castration resistant prostate cancer (CRPC), metastatic castration resistant prostate cancer (mCRPC), and methods of reducing high or increasing PSA levels and/or increasing SHBG levels in a subject suffering from prostate cancer, advanced prostate cancer, castration resistant prostate cancer (CRPC) and metastatic castration resistant prostate cancer (mCRPC). The compounds of this invention suppress free or total testosterone levels despite castrate levels secondary to ADT and reduce high or increasing PSA levels. This reduction in testosterone levels may be used to treat prostate cancer, advanced prostate cancer, CRPC and mCRPC without causing bone loss, decreased bone mineral density, increased risk of bone fractures, increased body fat, hot flashes and/or gynecomastia.Type: ApplicationFiled: October 24, 2014Publication date: March 26, 2015Inventors: James T. Dalton, Mitchell S. Steiner, Christopher C. Coss, Robert H. Getzenberg
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Patent number: 8986664Abstract: The invention provides a method for improving hair biology, e.g., hair growth. The method comprises administering to a subject a monoamine oxidase inhibitor and a vasodilator, a zinc salt of a carboxylic acid, a xanthine compound, pyrithione or a salt thereof, saponin, tritapene, crataegolic acid, celastrol, asiatic acid, an inhibitor of 5-alpha-reductase, 1,4-methyl-4-azasteroid, an androgen receptor antagonist, azelaic acid or a derivate thereof, cyclosporin, triiodothyronine, diazoxide, retinoic acid, a prostaglandin analog, aminexil, carnitine tartrate, apigenin, procapil, or adenosine, in an amount effective to achieve a desired effect. The invention further provides a method of reducing or delaying the appearance of an age-related skin imperfection. The method comprises administering to the subject a composition comprising an MAO inhibitor. A kit for improving hair growth also is provided.Type: GrantFiled: October 13, 2011Date of Patent: March 24, 2015Assignee: The Procter & Gamble CompanyInventors: Teresa DiColandrea, Robert Scott Youngquist, Sancai Xie, Robert Lloyd Binder, Gary Richard Fuentes, Deborah Lade
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Publication number: 20150071864Abstract: A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth.Type: ApplicationFiled: September 22, 2014Publication date: March 12, 2015Applicant: Broda Technologies Co., Ltd.Inventors: Shao Xiang LU, Jeffrey LU, Letian LIU
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Patent number: 8952070Abstract: There is provided a pharmaceutical composition for the treatment of fungal infection of the nail comprising a anti-fungal allylamine compound present in an amount of about 10%, an organic acid or an ester thereof, a diol and a sequestering agent where the pharmacological composition is essentially water-free.Type: GrantFiled: February 10, 2012Date of Patent: February 10, 2015Assignee: Moberg Pharma ABInventor: Ake Lindahl
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Publication number: 20150038512Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.Type: ApplicationFiled: October 6, 2014Publication date: February 5, 2015Inventors: Ryan Looper, Dustin Williams, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hariprasada R. Kanna Reddy
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Publication number: 20150017234Abstract: The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle.Type: ApplicationFiled: October 2, 2014Publication date: January 15, 2015Inventors: Nardo ZAIAS, Pichit SUVANPRAKORN, Panida VAYUMHASUWAN
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Publication number: 20150017231Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.Type: ApplicationFiled: March 14, 2013Publication date: January 15, 2015Applicant: University of Central Florida Research Foundation, Inc.Inventors: Otto Phanstiel, IV, Aaron Muth
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Publication number: 20150005337Abstract: The invention relates to a transdermal or transmucosal non-occlusive, semi-solid pharmaceutical formulation that includes at least one systemically active agent that acts on the Central Nervous System (CNS) of a mammal; and a permeation enhancing solvent system present in an amount sufficient to solubilize the at least one active ingredient.Type: ApplicationFiled: September 17, 2014Publication date: January 1, 2015Inventors: Dario Norberto R. Carrara, Arbaud Grenier, Igno Alberti, Laetitia Henry, Celine Decaudin
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Patent number: 8921428Abstract: There is provided a pharmaceutical composition for the treatment of fungal infection of the nail comprising a anti-fungal allylamine compound present in an amount of about 10%, an organic acid or an ester thereof, a diol and a sequestering agent where the pharmacological composition is essentially water-free.Type: GrantFiled: February 10, 2012Date of Patent: December 30, 2014Assignee: Moberg Pharma ABInventor: Ake Lindahl
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Patent number: 8916596Abstract: An embodiment of the invention provides preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the protein LSD1 and/or a monoamine oxidase inhibitor. Another embodiment of the invention provides preventing or treating reactivation of a virus after latency in a host, comprising administering to the host an effective amount of an inhibitor of the protein LSD1 and/or a monoamine oxidase inhibitor. Another embodiment of the invention provides preventing or treating a viral infection in a mammal that has undergone, is undergoing, or will undergo an organ or tissue transplant, comprising administering to the mammal an effective amount of an inhibitor of the protein LSD1 and/or a monoamine oxidase inhibitor before, during, and/or after the organ or tissue transplant. The viral infection may be due to a herpesvirus, such as herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2), varicella zoster virus (VZV), or cytomegalovirus (CMV).Type: GrantFiled: July 23, 2009Date of Patent: December 23, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Thomas Kristie, Yu Liang
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Publication number: 20140350482Abstract: The present invention relates to methods for reconstituting and relates to reconstitution devices suitable for reconstituting many different materials. Furthermore, the present invention includes methods of treatment and methods of use related to a reconstitution device or apparatus. Some embodiments are suitable for reconstituting small amounts of a pharmaceutical compositions and using the pharmaceutical composition for the treatment of sexual dysfunction.Type: ApplicationFiled: July 6, 2012Publication date: November 27, 2014Inventors: Bassam B. Damaj, Richard Martin, Michael Mueller, Daniel W. Frank
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Publication number: 20140350017Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.Type: ApplicationFiled: November 8, 2013Publication date: November 27, 2014Applicants: The University of Utah, Curza Global, LLCInventors: Dustin Williams, Ryan Looper, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hari Kanna Reddy
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Patent number: 8889163Abstract: Facially amphiphilic polyphenylene and heteroarylene polymers and articles made therform having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a methods to attach facially amphiphilic polmers to a solid support. Utility as a contact disinfectant is disclosed.Type: GrantFiled: March 7, 2002Date of Patent: November 18, 2014Assignee: The Trustees of the University of PennsylvaniaInventors: William F. DeGrado, Gregory N. Tew, Michael L. Klein
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Publication number: 20140322293Abstract: The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be formulated as solutions, solids, semisolids, microparticles, or crystals.Type: ApplicationFiled: April 29, 2014Publication date: October 30, 2014Applicant: Hallux, Inc.Inventors: Frank Kochinke, Corinne Bright
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Publication number: 20140322304Abstract: Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.Type: ApplicationFiled: July 10, 2014Publication date: October 30, 2014Inventors: Gavin P. Robertson, Raghavendra Gowda Chandagalu D., Subbarao V. Madhunapantula, Gajanan S. Inamdar, Omer F. Kuzu
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Patent number: 8865143Abstract: A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth.Type: GrantFiled: March 21, 2012Date of Patent: October 21, 2014Assignee: Broda Technologies Co., Ltd.Inventors: Shao Xiang Lu, Jeffrey Lu, Letian Liu
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Patent number: 8853278Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.Type: GrantFiled: November 8, 2013Date of Patent: October 7, 2014Assignees: Curza Global, LLC, University of Utah Research FoundationInventors: Ryan Looper, Dustin Williams, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hari Kanna Reddy
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Patent number: 8853452Abstract: Compounds and their syntheses are disclosed herein. Compositions and pharmaceutical compositions comprising a compound are also described, and include compositions also comprising liposomes. Methods for the treatment of cancer in animals comprising administering a compound or a composition comprising a compound are also described.Type: GrantFiled: February 9, 2010Date of Patent: October 7, 2014Assignee: The Administrators of the Tulane Educational FundInventors: Barbara S. Beckman, Maryam Foroozesh, Jiawang Liu
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Patent number: 8853280Abstract: The present invention provides compositions comprising allylamine drug compounds for topical treatment of fungal infections of the skin and skin appendages. In some embodiments a positive charge and enhancers are used in the compositions to allow for increased penetration of the active ingredient through skin and skin appendages. In some embodiments the positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The present invention also provides methods for making compositions comprising an allylamine drug compound, and methods of using such compositions for the treatment of fungal infections of the skin and skin appendages.Type: GrantFiled: October 4, 2011Date of Patent: October 7, 2014Assignee: Biophile Corporation, Ltd.Inventors: Pichit Suvanprakorn, Panida Vayumhasuwan, Nardo Zaias
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Publication number: 20140296347Abstract: The present invention is directed to a nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents. The invention is also directed to a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.Type: ApplicationFiled: February 18, 2014Publication date: October 2, 2014Applicant: Polichem SAInventors: Federico Mailland, Michela Legora, Daniela Ceriani, Giuliana Iob
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Publication number: 20140288040Abstract: The invention provides compounds of the formula (6): or a salt, N-oxide or tautomer thereof, wherein A is CH, CF or nitrogen; E is CH, CF or nitrogen; and R0 is hydrogen or C1-2 alkyl; R1a is selected from CONH2; CO2H; an optionally substituted acyclic C1-8 hydrocarbon group; and an optionally substituted monocyclic carbocyclic or heterocyclic group of 3 to 7 ring members, of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from O, N and S; R2 is selected from hydrogen and a group R2a; R2a is selected from an optionally substituted acyclic C1-8 hydrocarbon group; an optionally substituted monocyclic carbocyclic or heterocyclic group of 3 to 7 ring members, of which 0, 1 or 2 ring members are heteroatom ring members selected from O, N and S; and an optionally substituted bicyclic heterocyclic group of 9 or 10 ring members, of which 1 or 2 ring members are nitrogen atoms; wherein at least one of R1 and R2 is other than hydrogen; R3 is an optionally substituted 3- to 10-membered monocyclic or bicycType: ApplicationFiled: October 31, 2012Publication date: September 25, 2014Applicant: ASTEX THERAPEUTICS LIMITEDInventors: Andrew James Woodhead, Gianni Chessari, Gilbert Ebai Besong, Maria Grazia Carr, Steven Douglas Hiscock, Michael Alistair O'Brien, David Charles Rees, Susanne Maria Saalau-Bethell, Hendrika Maria Gerarda Willems, Neil Thomas Thompson
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Publication number: 20140286945Abstract: Disclosed herein is a new and improved therapy for the treatment of diseases including cancer, which comprises the step of altering cell membrane lipid composition by treating a cancer cell with an enzyme inhibitor which inhibits enzymes regulating the cholesterol biosynthetic pathway. The method may also be employed in combination with existing chemotherapeutic agents to combat the drug resistance and enhance the therapeutic efficacy of conventional therapy.Type: ApplicationFiled: October 22, 2012Publication date: September 25, 2014Applicant: The Curators of the University of MissouriInventors: Carl Freter, Indira Benakanakere
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Publication number: 20140256774Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.Type: ApplicationFiled: July 12, 2012Publication date: September 11, 2014Applicant: VANDERBILT UNIVERSITYInventors: L. Jackson Roberts, Venkataraman Amarnath, David G. Harrison
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Patent number: 8829033Abstract: A first aspect of the invention is a compound (sometimes also referred to herein as an “active agent” or “active compound”) of Formula Ia, or more particularly Formula Ib, or a pharmaceutically acceptable salt or prodrug thereof. Compositions thereof and methods of using the same (e.g. for the treatment of a neurological disease) are also described.Type: GrantFiled: September 17, 2010Date of Patent: September 9, 2014Assignee: The University of North Carolina at Chapel HillInventors: Harold L. Kohn, Christophe Salomé, Elise Salomé-Grosjean
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Publication number: 20140248236Abstract: The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.Type: ApplicationFiled: November 7, 2012Publication date: September 4, 2014Inventors: Michael G. Natchus, Richard Arrendale
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Publication number: 20140249233Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.Type: ApplicationFiled: April 17, 2014Publication date: September 4, 2014Applicants: The Hospital for Sick Children, McMaster UniversityInventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
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Publication number: 20140235729Abstract: Herbal compositions and techniques for suppressing appetite and managing weight are described. These compositions and techniques are based at least in part on beneficial results showing that benzylamine can suppress appetite. In at least one embodiment, a composition that includes an effective amount of benzylamine and an effective amount of at least one benzylamine enhancer may be utilized for appetite suppression.Type: ApplicationFiled: February 17, 2014Publication date: August 21, 2014Applicant: ZIJA INTERNATIONAL, INC.Inventor: Joshua James Plant
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Publication number: 20140235713Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.Type: ApplicationFiled: April 17, 2014Publication date: August 21, 2014Applicants: The Hospital for Sick Children, McMaster UniversityInventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
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Publication number: 20140206770Abstract: Disclosed is the use of at least one amine oxidase inhibitor for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical compositions for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one amine oxidase inhibitor suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal.Type: ApplicationFiled: February 4, 2014Publication date: July 24, 2014Applicant: UNIVERSITAETSKLINIKUM FREIBURGInventors: Roland SCHUELE, Eric METZGER
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Publication number: 20140206629Abstract: The invention relates to inhibition of SDF-1? expression in subacromial bursa cells by CXCR-4 inhibitors. Bursal cell migration in response to SDF-? stimulation is also decreased in the presence of CXCR4 inhibitors. Accordingly, provided are methods for treating or ameliorating a musculoskeletal disorder.Type: ApplicationFiled: February 17, 2012Publication date: July 24, 2014Applicant: RHODE ISLAND HOSPITALInventor: Theodore A. Blaine
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Patent number: 8785502Abstract: Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.Type: GrantFiled: December 6, 2011Date of Patent: July 22, 2014Assignee: The Penn State Research FoundationInventors: Gavin P. Robertson, Chandagalu D. Raghavendragowda, SubbaRao V. Madhunapantula, Omer F. Kuzu, Gajanan S. Inamdar
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Publication number: 20140200271Abstract: Memantine compositions and methods of use are described herein. In some embodiments, the compositions comprise memantine and an absorption enhancer, or memantine and an elimination enhancer, or memantine and an absorption enhancer and an elimination enhancer.Type: ApplicationFiled: July 2, 2013Publication date: July 17, 2014Applicant: Cerecor, Inc.Inventors: Blake Paterson, Mark Ginski, Brendan Canning
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Publication number: 20140193518Abstract: The invention relates to kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating disorders, especially cancer.Type: ApplicationFiled: December 28, 2012Publication date: July 10, 2014Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventor: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
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Patent number: 8771726Abstract: The present subject matter provides a nail patch comprising a backing layer and a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive base, terbinafine and/or a pharmacologically acceptable salt thereof, and sodium acetate and/or sorbitan monolaurate as a solubilizer.Type: GrantFiled: July 6, 2007Date of Patent: July 8, 2014Assignee: Hisamitsu Pharmaceutical Co., IncInventors: Arata Toshimitsu, Naoko Matsuda, Toshihiro Kogure, Kazuya Ishida
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Patent number: RE49353Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.Type: GrantFiled: August 20, 2020Date of Patent: January 3, 2023Assignee: Aragon Pharmaceuticals, Inc.Inventor: Isan Chen