The Aryl Ring Or Aryl Ring System And Amino Nitrogen Are Bonded Directly To The Same Acylic Carbon, Which Carbon Additionally Has Only Hydrogen Or Acyclic Hydrocarbyl Substituents Bonded Directly Thereto Patents (Class 514/655)
  • Propenylamines, pharmaceutical compositions containing them and their use as pharmaceuticals
    Patent number: 4755534
    Abstract: A compound of the formula: ##STR1## wherein the double bond is in the trans configuration and R.sub.1 is a radical of formula IIa, ##STR2## R.sub.2, R.sub.3, R.sub.5, R.sub.7 and R.sub.8 are each hydrogen, R.sub.4 is methyl, andR.sub.6 is a radical of formula IIIa--C.tbd.C--R.sub.11 IIIawhere R.sub.11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof;processes for their production, their use as pharmaceuticals and pharmaceutical compositions containing them.
    Type: Grant
    Filed: September 4, 1984
    Date of Patent: July 5, 1988
    Assignee: Sandoz Ltd.
    Inventor: Anton Stuetz
  • Prolonged action drug formulation
    Patent number: 4731359
    Abstract: The time during which a drug is pharmacologically active is prolonged by coating the drug with at least one chemical derivative of the drug having minor relative pharmacological activity.
    Type: Grant
    Filed: February 6, 1984
    Date of Patent: March 15, 1988
    Assignee: University of Southern California
    Inventor: James Swarbrick
  • Acceleration of lipid metabolism using vanillylamine derivatives
    Patent number: 4680313
    Abstract: A food product comprising a food substance in combination with vanillylamine or a vanillylamide.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: July 14, 1987
    Assignee: Ajinomoto Co., Inc.
    Inventor: Kazuo Iwai
  • Compounds
    Patent number: 4657929
    Abstract: There are provided pharmaceutical compounds useful in treating hypertension, heart diseases and renal failure. These compounds are 4-hydroxy phenethylamines wherein the 3 position on the phenyl nucleus is occupied by either an amino, amide, carbamyl, urea sulfonamide, substituted alkyl or fluorine atom, and the amine group is further linked to another phenyl radical through an alkylene radical which may contain nitrogen, oxygen, sulfur or cyclic hydrocarbon radicals as intervening groups.
    Type: Grant
    Filed: October 18, 1984
    Date of Patent: April 14, 1987
    Assignee: Fisons plc
    Inventors: Francis Ince, Alan C. Tinker
  • Hypotensive 2-nitro-1,1-ethenediamines
    Patent number: 4567188
    Abstract: Compounds of the formula ##STR1## in which R.sup.1 is an optionally substituted aryl or heteroaryl radical,R.sup.2 is an alkyl or alkenyl radical which is optionally substituted by alkoxy or cycloalkyl, or an optionally substituted aryl or heteroaryl radical, and X is an optionally aklyl-substituted methylene radical or a direct bond, but if X is a direct bond R.sup.2 is not aryl,or physiologically acceptable acid addition salts thereof, exhibit activity on the circulation system particularly as hypotensive agents.
    Type: Grant
    Filed: August 10, 1983
    Date of Patent: January 28, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ekkehard Niemers, Andreas Knorr, Bernward Garthoff
  • Pharmacologically active cyclopropane derivatives
    Patent number: 4500541
    Abstract: Cyclopropane derivatives of the formula ##STR1## wherein Ar is phenyl or phenyl monosubstituted or polysubstituted by F, Cl, Br, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-4 alkenyloxy, C.sub.1-4 alkylthio, OH, SH, CN, methylenedioxy or CF.sub.3 ; and R is H, C.sub.1-4 alkyl or benzyl, or a physiologically acceptable acid addition salt thereof, have valuable pharmacological properties, e.g., as antidepressants.
    Type: Grant
    Filed: June 17, 1983
    Date of Patent: February 19, 1985
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Hans-Heinrich Hausberg, Jurgen Uhl, Christoph Seyfried, Klaus-Otto Minck