Abstract: A class of anti-fibrotic agents and methods for their use as effective inhibitor substrate analogues of lysyl oxidase in-situ are provided. The inhibitory substrate analogues comprise adjacently positioned diamine compositions which may be employed in-vivo to therapeutically treat a wide variety of different pathological fibrotic diseases, disorders, and abnormalities.

Abstract: A pharmaceutical composition for the treatment of hyperammonemia which comprises a valiolamine compound of the formula ##STR1## wherein A means an acyclic hydrocarbon group of 1 to 10 carbon atoms which may optionally be substituted by hydroxy, phenoxy, thienyl, furyl, pyridyl, chclohexyl or optionally substituted phenyl; a 5- or 6-membered cyclic hydrocarbon group which may optionally be substituted by hydroxy, hydroxymethyl, methyl or amino; or a saccharide residue or a pharmaceutically acceptable salt thereof, the use of said valiolamine compound of the formula [I]0 or a pharmaceutically acceptable salt thereof in the preparation of a medicine for the treatment of hyperammonemia, and a method for the treatment of hyperammonemia which comprises administrating a valiolamine compound of the formula [I] or a pharmaceutically acceptable salt thereof.

Abstract: Cyclohexylamines of the formula ##STR1## where X is a single bond or an alkylene chain, Y is hydrogen or an aryl, cyclohexyl, 4-cyclohexylcyclohexyl, perhydro-1- or 2-naphthyl or piperidyl radical, R.sup.1 and R.sup.2 are hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, cycloalkyl, cycloalkenyl or arylalkyl, or R.sup.1 and R.sup.2 together form an alkylene group and, togehter with the N atom, form a ring, and acid addition salts thereof, with the exception of compounds in which X is a single bond, Y is cyclohexyl, R.sup.1 and R.sup.2 are hydrogen or methyl, and the compounds in which X is C.sub.6 -, C.sub.7 - and C.sub.8 -alkyl, Y is hydrogen and R.sup.1 and R.sup.2 together with the N atom whose substituents they are form a 2,6-dimethylmorpholine radical, and fungicides containing such cyclohexylamines.

Abstract: A mixture of an extract from a plant belonging to the Zygophyllaceae family containing phenolic compositions and a nonalkali metal salt is useful as a pharmaceutical agent, for example, in the treatment of cancer, nonmalignant tumors, osteomyelitis, psoriasis and warts.