Abstract: Alkylthioalkylamine carbamic acid derivatives are prepared which correspond to the formula: ##STR1## wherein R and R.sub.1 are both independently alkyl groups containing from 6 to 16 carbon atoms, and m and n are both independently integers of from 2 or 3. Compositions containing these compounds inhibit the growth of organisms such as bacteria, yeast, fungi, mold, algae, mollusks, hydroids, or tunicates on surfaces.
Type:
Grant
Filed:
February 7, 1991
Date of Patent:
June 2, 1992
Assignee:
The Dow Chemical Company
Inventors:
Attila G. Relenyi, Richard W. Walter, Charles D. Gartner
Abstract: A bacterial composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of glutaraldehyde and 2-(decylthio) ethanamine (DTEA). The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Abstract: A method for preparing antimicrobial formulations of 2-(alkylthio)ethanamines hydrohalides is disclosed. The formulations are prepared directly from the hydrolysis product of 2-(alkylthio)ethyl propionamides, thereby eliminating both waste streams and isolation procedures.
Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
Type:
Grant
Filed:
May 4, 1990
Date of Patent:
June 4, 1991
Assignee:
Merrell Dow Pharmaceuticals Inc.
Inventors:
Michael G. Palfreyman, Philippe Bey, Ian A. McDonald
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of glutaraldehyde and 2-(decylthio) ethanamine (DTEA). The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Abstract: A method of controlling the fouling potential of macroinvertebrates, such as mollusks in aqueous systems which comprises adding to the system an effective controlling amount of an alkylthioalkylamine or acid addition salt thereof.
Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
Type:
Grant
Filed:
September 19, 1989
Date of Patent:
July 24, 1990
Assignee:
Merrell Dow Pharmaceuticals Inc.
Inventors:
Michael G. Palfreyman, Ian A. McDonald, Philippe Bey
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and methylene bis(thiocyanate). The method comprises administering between about 0.1 to about 200 parts of this combined treatement (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 10, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Wilson K. Whitekettle, Deborah K. Donofrio
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and B-bromo-B-nitrostyrene. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 10, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Wilson K. Whitekettle, Deborah K. Donofrio
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and 2,2-dibromo-3-nitrilo propionamide. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 10, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Wilson K. Whitekettle, Deborah K. Donofrio
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and N-tri butyl tetradecyl phosphonium chloride. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 10, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Deborah K. Donofrio, Wilson K. Whitekettle
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)-ethanamine hydrochloride and 2-bromo-2-nitropropane-1,3-diol. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 3, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Deborah K. Donofrio, Wilson K. Whitekettle
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and n-alkyl dimethyl benzyl ammonium chloride. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 3, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Deborah K. Donofrio, Wilson K. Whitekettle
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio) ethanamine hydrochloride and a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one ("Kathon 886F"). The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 3, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Deborah K. Donofrio, Wilson K. Whitekettle
Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and n-dodecylguanidine or water soluble salt thereof. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
April 3, 1990
Assignee:
Betz Laboratories, Inc.
Inventors:
Deborah K. Donofrio, Wilson K. Whitekettle
Abstract: Pharmaceutical preparations for veterinary use, in the form of concentrate solutions, containing Thiamphenicol as active ingredient are described.
Abstract: A method of fighting fungus infections by using compounds having the formula: ##STR1## wherein: R is H, a C.sub.1 -C.sub.4 alkyl, an alkenyl, or an alkynyl radical; n is 1 or 2;A represents a C.sub.1 -C.sub.6 alkylene bridge, an arylene or a heterocyclic bridge;X represents O, S, SO, SO.sub.2 ; andR.sup.1 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl radicals, a phenyl radical, optionally substituted, polyfluoroalkyl radicals containing from 1 to 4 carbon atoms and at least 2 fluorine atoms, polyfluoroalkenyl radicals containing from 2 to 4 carbon atoms and at least 2 fluorine atoms, but excluding compounds having the formula (I) wherein A is an alkylene radical, n is 2, and R.sup.1 is a C.sub.1 -C.sub.6 alkyl radical.
Type:
Grant
Filed:
April 9, 1987
Date of Patent:
October 17, 1989
Assignee:
Montedison S.p.A.
Inventors:
Augusto Menconi, Giovanni Camaggi, Franco Gozzo, Luigi Mirenna, Carlo Garavaglia
Abstract: Disclosed is a method for inhibiting microorganisms and/or controlling biofouling of cooling towers by use of certain alkylthioalkylamines such as n-decylthioethylamine.
Type:
Grant
Filed:
October 22, 1986
Date of Patent:
March 28, 1989
Assignee:
The Dow Chemical Company
Inventors:
Richard W. Walter, Jr., Attila G. Relenyi, Robert L. Johnson
Abstract: Hair and skin treating compositions containing hydrolyzed proteins having an average molecular weight in the range of from 500 to 2,000 are enhanced with an approximately equimolar quantity of amino acid derived zwitterion having a molecular weight less than 200, such as taurine. Preferably the taurine is present in such a composition in the range of from 1 to 5% by weight, and the composition has a pH in the range of from 3 to 10, the most preferably from 3 to 7.
Type:
Grant
Filed:
March 25, 1987
Date of Patent:
December 27, 1988
Assignee:
Redken Laboratories, Inc.
Inventors:
Roger A. Mathews, Edward R. Moore, David W. Cannell
Abstract: Disclosed are 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and their N-acyl and N-alkyl derivatives. Also disclosed are processes for preparing the disclosed compounds; pharmaceutical compositions comprising such compounds; and a method of treatment comprising administering such compounds and compositions when an antihypertensive effect or radioprotective effect is indicated.
Abstract: Cysteamine is used as an active ingredient in animal feed compositions and in methods for increasing the feed efficiency of immature, monogastric, meat-producing animals. A particularly useful active ingredient of this invention is cysteamine hydrochloride in a quantity selected from the range of 15-1200 ppm.
Abstract: Disclosed are 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and their N-acyl and N-alkyl derivatives. Also disclosed are processes for preparing the disclosed compounds; pharmaceutical compositions comprising such compounds; and a method of treatment comprising administering such compounds and compositions when an antihypertensive effect or radioprotective effect is indicated.
Abstract: A method of decreasing the concentration of prolactin in an animal, which comprises administering to the animal a prolactin-decreasing amount of cysteamine.
Type:
Grant
Filed:
August 24, 1984
Date of Patent:
April 14, 1987
Assignee:
Massachusetts General Hospital
Inventors:
Joseph B. Martin, William Millard, Stephen Sagar
Abstract: This invention relates to novel organic trithio oxides of the formula:R.sup.1 --X --R--X.sup.1 --R.sup.1wherein R is selected from --CH.sub.2 CH.dbd.CH--, ##STR1## and (CH.sub.2).sub.3 ; X is selected from ##STR2## X.sup.1 is selected from --S--S, ##STR3## and, each R.sup.1 is independently selected from carboxyalkyl, alkoxy, alkylthio, amino, alkylamino and acyl substituted and unsubstituted lower alkyl, lower alkenyl, lower alkynyl, phenyl and lower alkylphenyl; provided when R is --CH.sub.2 CH.dbd.CH--, X is ##STR4## and X.sup.1 is --S--S--, then R.sup.1 is not in both instances --CH.sub.2 CH.dbd.CH.sub.2.This invention also relates to a method of preparing the above-identified compounds by heating and further oxidizing various oxides of organic disulfides and to antithrombotic uses of the compounds.
Type:
Grant
Filed:
December 17, 1984
Date of Patent:
February 17, 1987
Assignee:
The Research Foundation of State University of New York
Abstract: A method of treating psoriasis and similar or related ailments comprises applying to an affected skin area a therapeutically effective amount of at least one skin-compatible zwitterionic aminosulfonic acid (ZASA) of the formulaRNR'SO.sub.3 Hwherein R is a straight or branched chain aliphatic radical, or RN is a substituted or unsubstituted nitrogen-containing heterocycle which may have one additional hetero atom; and R' is C.sub.2-4 straight or branched chain alkylene radical. A pharmaceutical composition is also provided, and comprises at least one ZASA of the above formula together with a pharmaceutically acceptable topical carrier or base.