Monoether Patents (Class 514/670)
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Patent number: 8835485Abstract: The present invention provides a means for prevention and treatment of sarcopenia by administration of a substance that both reduces the sensibility of beta-adrenergic receptors and of 5-HT1a receptors. (S)-pindolol, (S)-propanol, tertalol, or bopindolol are preferred for this purpose.Type: GrantFiled: April 29, 2010Date of Patent: September 16, 2014Assignee: PsiOxus Therapeutics LimitedInventors: Jochen Springer, Stefan Anker, Andrew Coats, John Beadle
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Publication number: 20140056951Abstract: Methods of treating or reducing biofilms, treating a biofilm-related disorder, and preventing biofilm formation using polyamines is described.Type: ApplicationFiled: November 4, 2013Publication date: February 27, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Richard LOSICK, Illana KOLODKIN-GAL, Jon CLARDY, Shugeng CAO, Matt CABEEN, Roberto KOLTER, Liraz CHAI, Thomas BÖTTCHER
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Publication number: 20140056952Abstract: Methods of treating or reducing biofilms, treating a biofilm-related disorder, and preventing biofilm formation using polyamines is described.Type: ApplicationFiled: November 4, 2013Publication date: February 27, 2014Applicant: President and Fellows of Harvard CollegeInventors: Richard LOSICK, Illana KOLODKIN-GAL, Jon CLARDY, Shugeng CAO, Matt CABEEN, Roberto KOLTER, Liraz CHAI, Thomas BÖTTCHER
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Publication number: 20130165368Abstract: A composition for use in the prevention and/or treatment of microbial infection comprising essentially of one or more pure alkanol alkoxylates, diol alkoxylates and/or triol alkoxylates.Type: ApplicationFiled: February 1, 2011Publication date: June 27, 2013Inventors: Ian Steel, Paul Armstrong
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Publication number: 20120252733Abstract: Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.Type: ApplicationFiled: June 4, 2010Publication date: October 4, 2012Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Michael W. Epperly, Abhay Sudhir Gokhale, Joel S. Greenberger, Peter Wipf, Julianne Glowacki
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Publication number: 20110177108Abstract: The present invention provides compounds, or pharmaceutically acceptable salts or analogs thereof, which exhibit anti-tumor activity. The present invention also includes methods for inhibiting the growth of cancer cells by contacting an effective amount of a compound of the present invention with the cancer cells in vitro or in vivo.Type: ApplicationFiled: August 10, 2009Publication date: July 21, 2011Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.Inventors: Stanislav I. Svetlov, Anatoliy Vakulenko
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Publication number: 20110130456Abstract: A hair growth regulating agent containing, as an active ingredient, a compound represented by the following formula (I): [wherein R1 represents a substituted or unsubstituted, linear or branched C2 to C25 alkyl group; a group represented by the following formula (II): (wherein R1? represents a substituted or unsubstituted, linear or branched C2 to C20 alkylene group, or —(CH2)n-{O—(CH2)m}o-O—(CH2)p- in which each of n, m, o, and p is an integer from 1 to 6; X? represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y? represents a substituted or unsubstituted C1 to C4 alkylene group; R2? represents a hydrogen atom or a C1 to C4 alkyl group; R3? represents a C1 to C4 alkyl group; and when R2? and R3? each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other); or a group represented by the following formula (III): (wherein R1?, X?, and Y? have the same meanings as defined above; R4?, R5?, and R6?, which may be identical to or different from one another,Type: ApplicationFiled: August 4, 2009Publication date: June 2, 2011Applicant: Kao CorporationInventors: Yasuto Suzuki, Naoko Morisaki, Michiyo Sasajima
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Publication number: 20100273875Abstract: A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO— or —O—; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R3 is an alkyl group having 1 to 4 carbon atoms; R2 and R3 are the same as or different from each other; R4, R5 and R6, which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A? is a counter ion.Type: ApplicationFiled: November 5, 2008Publication date: October 28, 2010Applicant: KAO CORPORATIONInventors: Yasuto Suzuki, Kazue Tsukahara
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Patent number: 7632869Abstract: The use of compositions containing one or more ether amine antimicrobial agents and/or ether amine derivative antimicrobial agents in an amount effective to disinfect and/or preserve medical devices is described. Solutions containing one or more ether amine antimicrobial agent- and/or ether amine derivative antimicrobial agent-containing compositions and methods of making and using the same are also described.Type: GrantFiled: May 24, 2004Date of Patent: December 15, 2009Assignee: Bausch & Lomb IncorporatedInventors: Erning Xia, Alyce K. Dobie, John Denick
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Patent number: 7601872Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: October 13, 2009Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Publication number: 20080227865Abstract: The present invention relates to novel colipase-lipase inhibitors of the general formulae to be used in the treatment of prophylaxis of obesity, as well as pharmaceutical compositions containing the same, and method for treating obesity using said compounds.Type: ApplicationFiled: June 27, 2007Publication date: September 18, 2008Applicant: FORSKARPATENT I SYD ABInventor: Charlotte Erlanson-Albertsson
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Publication number: 20080090913Abstract: The present invention relates to specific sphingolipids/sphingolipid derivatives as pharmaceutical compositions as well as their use in the preparation of medicaments for the treatment, prevention and/or amelioration of disorders relating to pathological processes in lipid rafts.Type: ApplicationFiled: June 29, 2005Publication date: April 17, 2008Inventors: Tobias Braxmeier, Tim Friedrichson, Wolfgang Frohner, Gary Jennings, Georg Schlechtingen, Cornelia Schroeder, Hans-Joachim Knolker, Kai Simons, Marino Zerial, Teymuras Kurzchalia
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Patent number: 7307071Abstract: Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bcr-Abl tyrosine kinase, imatinib.Type: GrantFiled: December 3, 2002Date of Patent: December 11, 2007Assignee: Onyx Pharmaceuticals, IncInventors: John F. Lyons, Gideon Bollag
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Patent number: 7250157Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: October 14, 2005Date of Patent: July 31, 2007Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 7145039Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: January 21, 2005Date of Patent: December 5, 2006Assignee: Invitrogen Corp.Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
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Patent number: 7060731Abstract: This application relates to the use of certain amines of formula (I) for combatting and preventing systemic and local complement activation, and in particular to the use of meglumine and derivatives and optionally salts thereof in combatting and preventing said activation. The amines are also of use in combatting activation of the kinin/kallikrein system or blood coagulation system.Type: GrantFiled: September 12, 2002Date of Patent: June 13, 2006Assignee: Amersham Health ASInventors: Anne Juelsrud, Gunn Ragnhild Hoigaard Bjerke
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Patent number: 6964782Abstract: Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable towelette forms of H2O2. Optional ingredients of topical pain relievers and skin protectants are also disclosed, as are their methods of use.Type: GrantFiled: July 7, 2003Date of Patent: November 15, 2005Assignee: Tec Labs, Inc.Inventors: Robert Lee Smith, Steven Dale Smith, Wendy S. Langley, John Mark Christensen, Vernon W. Smith
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Patent number: 6964984Abstract: Desensitization of receptors that control disease is prevented by inhibiting G-protein receptor kinases. This has applicability, e.g., for patients with heart failure or on a left ventricular heart device or a heart pump after surgery or about to undergo surgery and at high risk for a cardiac event or on an opiate or addicted to opiate or with cystic fibrosis or rheumatoid arthritis.Type: GrantFiled: June 30, 2003Date of Patent: November 15, 2005Assignee: Duke UniversityInventors: Jonathan S. Stamler, Robert J. Lefkowitz, Erin J. Whalen, Walter J. Koch, Claude A. Piantadosi
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Patent number: 6955804Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: September 22, 2003Date of Patent: October 18, 2005Assignee: Applied Genetics Incorporated DematicsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6932985Abstract: Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and amine. The azide can be selected from the group consisting of sodium azide and potassium azide or a combination of the two. The composition provides an effective pesticide, without causing significant harm to the environment. The composition may be applied to soil to control a population of a deleterious organism.Type: GrantFiled: October 8, 2002Date of Patent: August 23, 2005Assignee: Auburn UniversityInventor: Rodrigo Rodriguez-Kabana
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Patent number: 6900244Abstract: The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically effective dose of a compound of Formula I.Type: GrantFiled: May 23, 2003Date of Patent: May 31, 2005Assignee: Pharmacia CorporationInventors: Jennifer Ann Van Camp, James W. Malecha, Julie M. Miyashiro, Gary A. DeCrescenzo, Joe T. Collins, Monica J. Kalman
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Patent number: 6623724Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.Type: GrantFiled: May 28, 1998Date of Patent: September 23, 2003Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6566397Abstract: A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an isoprenoid ether-linked compound, wherein the isoprenoid ether-linked compound comprises a first acyclic isoprenoid molecule linked via an ether linkage to a second molecule, wherein the second molecule can suppress tumor formation.Type: GrantFiled: July 16, 2001Date of Patent: May 20, 2003Assignee: Wisconsin Alumni Research FoundationInventors: Charles E. Elson, Manfred Jung, Huanbiao Mo
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Patent number: 6541038Abstract: A method for treating wood, characterized by impregnating wood with a metal-containing treating agent containing lignin and/or lignin derivatives and a metal, a metal compound, and/or a metal ion and oxidizing and/or macromolecularizing of the lignin and/or lignin derivatives in the wood to fix the metal component in the wood, and wood and woody materials obtained by the treating method. According to the method of the present invention, while effectively utilizing lignins, lignosulfonic acids, or lignosulfonic acid salts, leaching of the metal component can be suppressed to a low level to thereby retain the effects due to the incorporation of the metal components for a prolonged period.Type: GrantFiled: May 25, 2000Date of Patent: April 1, 2003Assignee: SDS Biotech K.K.Inventors: Keijitsu Tanaka, Hirobumi Aoki, Takashi Echigo
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Publication number: 20020082244Abstract: The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of an isoprenoid compound.Type: ApplicationFiled: December 21, 2001Publication date: June 27, 2002Applicant: MERCK & Co., Inc.Inventors: Alfred A. Reszka, Edward S. Scolnick
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Patent number: 6376547Abstract: The invention relates to the use of an N,N′-substituted glycine or of an N,N′-substituted derivative of glycine (a) of the general formula I in which R1 is hydrogen or a straight-chain or branched, saturated or unsaturated alkyl, alkaryl or aralkyl radical having 1 to 30 C atoms, which can optionally contain heteroatoms such as O, S and N, R2 is a straight-chain or branched, saturated or unsaturated alkyl, alkaryl or aralkyl radical having 1 to 30 C atoms containing at least one primary, secondary or tertiary amino group and X is OH, OR3, NH2, NHR4, NR4R5 or O−M+, where R3, R4 and R5 are straight-chain or branched, saturated or unsaturated alkyl, alkaryl or aralkyl radicals which can be identical to or different from one another, and M is a metal cation, as active compound in a tuberculocidal disinfectant.Type: GrantFiled: January 15, 1999Date of Patent: April 23, 2002Assignee: L'Air Liquide SANTE (International)Inventors: Sabine Behrends, Andreas Dettmann, Michael Mohr
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Patent number: 6290937Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: May 28, 1998Date of Patent: September 18, 2001Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
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Patent number: 6274630Abstract: A method and pharmaceutical composition for inhibiting or preventing the intracellular biosynthesis of EIf5A by the administration to a human or non-human mammal in need thereof an amount of a polyamine analogue or salt thereof sufficient to deplete the supply of intracellular spermidine required for EIf5A biosynthesis.Type: GrantFiled: September 12, 1997Date of Patent: August 14, 2001Assignee: University of Florida Research Foundation, Inc.Inventor: Raymond J. Bergeron, Jr.
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Patent number: 6265412Abstract: There is provided a composition for external use with a reduced skin irritation comprising minoxidil and 0.01 to 2 parts by weight of at least one antihistaminic agent selected from the group consisting of chlorphenylamine maleate, diphenylimidazole, diphenhydramine and a salt thereof per 1 part by weight of minoxidil.Type: GrantFiled: November 20, 2000Date of Patent: July 24, 2001Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Fuminori Kimura, Kenichi Suzuki, Koji Imamura, Takako Okajima
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Patent number: 6245817Abstract: &agr;-alkoxy and &agr;-thioalkoxyamide compositions and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.Type: GrantFiled: April 20, 1999Date of Patent: June 12, 2001Assignee: Bayer CorporationInventors: Richard D. Connell, Timothy G. Lease, Gaetan H. Ladouceur, Martin H. Osterhout
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Patent number: 6190733Abstract: This invention provides water-based compositions, particularly coating, ink, and agricultural compositions, manifesting reduced equilibrium and dynamic surface tension by the incorporation of a surface tension reducing amount of certain alkylated aminoether compounds of the structure R—HN(CH2)p[O(CH2)n]mO(CH2)qNH—R′ where n is 2-6, m is 0-4, and p and q are 2-6, and R and R′ independently are an alkyl group comprising 5 to 18 carbons, preferably which is branched or in which the point of attachment to nitrogen is on a nonterminal carbon.Type: GrantFiled: June 7, 1999Date of Patent: February 20, 2001Assignee: Air Products and Chemicals, Inc.Inventors: Kevin Rodney Lassila, Kristen Elaine Minnich, Richard Van Court Carr
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Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
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Patent number: 6051056Abstract: This invention provides water-based compositions, particularly coating, ink, and agricultural compositions, manifesting reduced equilibrium and dynamic surface tension by the incorporation of a surface tension reducing amount of certain alkylated aminoether compounds of the structureR--HN(CH.sub.2).sub.p [O(CH.sub.2).sub.n ].sub.m O(CH.sub.2).sub.q NH--R'where n is 2-6, m is 0-4, and p and q are 2-6, and R and R' independently are an alkyl group comprising 5 to 18 carbons, preferably which is branched or in which the point of attachment to nitrogen is on a nonterminal carbon.Type: GrantFiled: March 20, 1998Date of Patent: April 18, 2000Assignee: Air Products and Chemicals, Inc.Inventors: Kevin Rodney Lassila, Kristen Elaine Minnich, Richard Van Court Carr
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Patent number: 6048900Abstract: Amide derivatives and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.Type: GrantFiled: February 13, 1998Date of Patent: April 11, 2000Assignee: Bayer CorporationInventors: Richard D. Connell, Timothy G. Lease, Gaetan H. Ladouceur, Martin H. Osterhout
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Patent number: 5973000Abstract: The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, and a and b are 0 or 1, as well as its use. Thus, there is provided a hair revitalizing tonic composition having an excellent hair loss prevention and hair revitalizing effect and, moreover, an excellent dandruff and itchy scalp prevention effect.Type: GrantFiled: June 3, 1997Date of Patent: October 26, 1999Assignees: Shiseido Company, Ltd., Takeda Chemical Industries, Ltd.Inventors: Tsunao Magara, Yoshiharu Tsuji, Chika Hamada, Yosuke Nakazawa, Eriko Takeoka, Masahiro Tajima, Masazumi Watanabe
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Patent number: 5863946Abstract: Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; X is absent or is alkylene; A is absent or is selected from optionally substituted alkylene, optionally substituted cycloalkylene, optionally substituted cycloalkylene wherein one or two of the carbon atoms is replaced with one or two heteroatoms independently selected from O, S, and N, optionally substituted alkenylene, and ##STR2## or R.sup.2 and A together define a saturated 5- to 8-membered optionally substituted carbocyclic or heterocyclic ring to which the group Z is attached; Z is selected from (a) hydrogen, (b) COM wherein M is selected from the group consisting of --OR.sup.5, a pharmaceutically acceptable cation, --NR.sup.7 R.sup.8, and a pharmaceutically acceptable, metabolically cleavable group, (c) --OR.sup.3, (d) tetrazolyl, (e) --CH(OR.sup.3)--CH.sub.2 OR.sup.9, (f) --CH(OR.sup.3)--CH.sub.2 --CH.sub.2 OR.sup.9, (g) --CH(OR.sup.Type: GrantFiled: June 6, 1996Date of Patent: January 26, 1999Assignee: Abbott LaboratoriesInventors: Clint D. W. Brooks, Richard A. Craig, Teodozyj Kolasa, Andrew O. Stewart
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Patent number: 5854178Abstract: Novel bioactive compounds which when applied to plants in bioregulatory amounts, enhance plant development responses, resulting in enhanced plant properties such as increased total biomass, increased yield, and increased plant quality. Some of the compounds increase the content of taxol and related taxanes in yew plants. One compound, 2-?diethylaminoethyl!-2-methylpropylether causes plants treated with the compound to have resistance to chewing insects. The compound 2-?diethylaminoethyl!-2-methyl-2-phenylpropylether causes plants treated with the compound to have resistance to sucking insects.Type: GrantFiled: July 3, 1997Date of Patent: December 29, 1998Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Henry Yokoyama, Harold W. Gausman
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Patent number: 5723497Abstract: The present invention relates to an amine derivative represented by the following general formula (I) or (II): ##STR1## wherein R.sup.1 means a heteroatom-containing C.sub.1 -C.sub.40 hydrocarbon group which may have a ring structure, or the like; R.sup.2 -R.sup.5 each denote a C.sub.1 -C.sub.20 hydrocarbon group, hydrogen or the like; A.sup.1 represents ##STR2## or R.sup.15 --Z--.sup.16 --(CH.sub.2).sub.n --; B.sup.1 stands for hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen or the like; C.sup.1 denotes hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue or the like; a dermatologic preparation containing the same; and a process for producing the amine derivative. This amine derivative has excellent effects of smoothing or removing wrinkles and improving keratinization.Type: GrantFiled: September 18, 1995Date of Patent: March 3, 1998Assignee: Kao CorporationInventors: Yukihiro Ohashi, Yukihiro Yada, Yoshinori Takema, Taketoshi Fujimori, Akira Kawamata, Hiroyuki Ohsu, Kazuhiko Higuchi, Genji Imokawa, Hiroshi Kusuoku, Ayumi Ogawa, Tsutomu Fujimura
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Patent number: 5622995Abstract: A method is provided for controlling the proliferation of molluscs in target habitat by applying to the habitat a compound or mixture of compounds which are amines, ethoxylated amines, quaternary amines, ethoxylated quaternary amines and cyclic amines.Type: GrantFiled: August 15, 1994Date of Patent: April 22, 1997Assignee: Electric Power Research Institute, Inc.Inventors: Billy D. Fellers, Arthur J. Freedman, Thomas M. Laronge
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Patent number: 5182297Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.Type: GrantFiled: March 6, 1991Date of Patent: January 26, 1993Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael G. Palfreyman, Philippe Bey, Ian A. McDonald
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Patent number: 5021456Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.Type: GrantFiled: May 4, 1990Date of Patent: June 4, 1991Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael G. Palfreyman, Philippe Bey, Ian A. McDonald
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Patent number: 4943593Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.Type: GrantFiled: September 19, 1989Date of Patent: July 24, 1990Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael G. Palfreyman, Ian A. McDonald, Philippe Bey
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Patent number: 4923887Abstract: Antimicrobially active liquid composition formulation which comprises 1,2-benzisothiazolin-3-one and at least one amine-oxyethylate of the formula ##STR1## wherein R is alkyl or alkenyl each having 2 to 22 carbon atoms and the sum of m and n is a number from 2 to 30 is used as an improved biocide to preserve and protect aqueous solutions from infestation with micro-organisms.Type: GrantFiled: August 25, 1988Date of Patent: May 8, 1990Assignee: Cassella AktiengesellschaftInventors: Wolfgang Bauer, Hans-Walter Bucking, Karl-Heinz Wallhausser
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Patent number: 4874786Abstract: A method of fighting fungus infections by using compounds having the formula: ##STR1## wherein: R is H, a C.sub.1 -C.sub.4 alkyl, an alkenyl, or an alkynyl radical; n is 1 or 2;A represents a C.sub.1 -C.sub.6 alkylene bridge, an arylene or a heterocyclic bridge;X represents O, S, SO, SO.sub.2 ; andR.sup.1 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl radicals, a phenyl radical, optionally substituted, polyfluoroalkyl radicals containing from 1 to 4 carbon atoms and at least 2 fluorine atoms, polyfluoroalkenyl radicals containing from 2 to 4 carbon atoms and at least 2 fluorine atoms, but excluding compounds having the formula (I) wherein A is an alkylene radical, n is 2, and R.sup.1 is a C.sub.1 -C.sub.6 alkyl radical.Type: GrantFiled: April 9, 1987Date of Patent: October 17, 1989Assignee: Montedison S.p.A.Inventors: Augusto Menconi, Giovanni Camaggi, Franco Gozzo, Luigi Mirenna, Carlo Garavaglia