Abstract: Pharmaceutical compositions for the treatment of hypertension comprising an effective anti-hypertensive amount of at least one compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound having one of the formulae (I), or (II), and methods for the treatment of hypertension or effecting anti-hypertensive action which comprises administering to a patient requiring anti-hypertensive therapy or effect at least one of the above-described compounds.

Abstract: Several new powerful chelating agents, suitable for the removal of a variety of certain heavy metal ions from the body of a mammal by oral application, have been synthesized and tested. Structurally, these compounds are partially lipophilic polyaminocarboxylic acids (PACA). They were synthesized in non-aqueous media from triethylenetetramine (TT) by monoalkylation of a primary amino group, followed by exhaustive carboxymethylation of the remaining amino groups using ethylbromoacetate and subsequent alkaline hydrolysis of the ester. In contrast to their non-lipophilic counterparts EDTA and DTPA, compositions of the present inventions exhibit appreciable absorption from the intestine and, therefore, can be administered orally. By varying the length of the alkyl chain, the chelons can be directed primarily to selected target organs. In addition, the compounds can be modified to target particular absorbed heavy metals.

Abstract: A mosquito insecticidal composition and method for controlling the growth of mosquitos employing a mosquito insecticidally effective amount of a compound having one of the formulae: ##STR1## wherein: R.sub.1 and R.sub.6 may be the same or different and are alkyl having from 1 to 12 carbon atoms or hydrocarbyl aralkyl having up to 12 carbon atoms;R.sub.2 -R.sub.5 may be the same or different and are H, R.sub.1 or R.sub.6 ;R.sub.7 is H, alkyl having from 1 to 12 carbon atoms, hydrocarbyl aryl or hydrocarbyl aralkyl each having up to 12 carbon atoms;m is an integer from 3 to 6, inclusive;n is an integer from 3 to 6, inclusive; or(IV) a salt thereof with an acid and a carrier therefor.

Abstract: Wood preservatives contain a copper salt, a polyamine and a fatty amine and are used for preserving wood from fungi and termites.

Abstract: A sprayable composition for deterring criminals, e.g., muggers, robbers, rapists, etc., consists essentially of a sprayable lachrymatory agent, such as MACE (chloroacetophenone) or orthochlorobenzyl-malononitrile dissolved in N,N-dimethyl formamide or N,N-dimethyl acetamide, or the like, admixed with a minor but effective amount of a dye which is substantive for human skin and difficult to remove and a minor but effective amount of a persistent odorant such as oil of skunk (a complex mercaptan), aliphatic diamines, such as putrescine (tetramethylene diamine) or cadaverine (pentamethylene diamine), or the like. The composition is supplied in a pressurized canister of the type conventionally used for containing and spraying MACE and when sprayed on an at-tacker repels the attacker and identifies him both by the stain and the smell.

Abstract: Several new powerful chelating agents, suitable for the removal of a variety of certain heavy metal ions from the body by oral application, have been synthesized and tested. Structurally, these compounds are partially lipophilic polyaminocarboxylic acids (PACA). They were synthesized in non-aqueous media from triethylenetetramine (TT) by monoalkylation of a primary amino group, followed by exhaustive carboxymethylation of the remaining amino groups using ethylbromoacetate and subsequent alkaline hydrolysis of the ester. Gel permeation chromatography of a mixture of the PACA and actinide elements have shown these substances to be strong chelating agents similar to EDTA or DTPA. In contrast to their non-lipophilic counterparts EDTA and DTPA, compositions of the present inventions exhibit appreciable absorption from the intestine and, therefore, can be administered orally. By varying the length of the alkyl chain, the chelons can be directed primarily to selected target organs.

Abstract: This invention relates to a composition of food having animal and/or vegetable origin which contains lysozyme and a chelating agent in amounts that are effective at preventing contamination of the food by Clostridium botulinum.

Abstract: A method is disclosed for controlling macroinvertebrates in aqueous systems, such as lakes, comprising adding to the aqueous system in recognized need of such control an effective controlling amount of an anionic toxicant containing the anion I.sup.- or F.sup.-, such as ethylenediamine (EDDI) or sodium fluoride (NaF).

Abstract: The present invention relates to fluorochemical blood substitutes used for preserving mammalian tissue having lysophosphatidyl compounds in non-toxic concentrations. More specifically, the invention relates to aqueous fluorochemical emulsions of a fluorochemical and an emulsifier useful as oxygen delivery agents and methods of preserving tissue in investigational and clinical settings, particularly those settings involving in in vivo transfusion, cardiac and other organ preservation, and in vitro organ perfusion.

Abstract: Wood preservatives contain a copper salt, a polyamine and a fatty amine and are used for preserving wood from fungi and termites.

Abstract: Water-soluble wood preservatives which contain mixtures of a metal compound, a metal-fixing acid and a complexing polymeric nitrogen compound, and methods for protecting wood with such mixtures.

Abstract: This application relates to an anti-inflammatory, immunosuppressive and analgesic composition, a method for its preparation, a pharmaceutical composition including it and a method of treating auto-immune diseases. The anti-inflammatory, immunosuppressive and analgesic compound is derived from ant venom extract which has been purified of contamination by a variety of non-active components present in crude ant venom extracts. A synthetic venom has also been prepared from various components. The related pharmaceutical composition has been shown to be effective in treating and alleviating the symptoms of auto-immune diseases, particularly rheumatoid arthritis.

Abstract: A fungicidal composition comprisingA) at least one of 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-batan-2-ol of the formula ##STR1## and 1-(4-phenyl-phenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl(butan-2-ol of the formula ##STR2## and B) at least one guanidated aliphatic polyamine of the formula ##STR3## in which R.sup.1 represents a branched or unbranched, divalent aliphatic hydrocarbon radical having 3 to 14 carbon atoms,R.sup.2 represents a branched or unbranched, divalent aliphatic hydrocarbon radical having 3 to 14 carbon atoms,X.sup.1, X.sup.2 and X.sup.3 independently of one another represent hydrogen or the radical of the formula ##STR4## and n represents integers from 0 to 16, it being possible for the divalent aliphatic hydrocarbon radicals which represent R.sup.2 to be different from one another if n represents numbers larger than 1, or their acid addition salts.

Abstract: A fungicidal composition comprisingA) 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-yl-methyl)-pentan-3-ol of the formula ##STR1## and B) at least one guanidated aliphatic polyamine of the formula ##STR2## in which R.sup.1 represents a branched or unbranched, divalent aliphatic hydrocarbon radical having 3 to 14 carbon atoms,R.sup.2 represents a branched or unbranched, divalent aliphatic hydrocarbon radical having 3 to 14 carbon atoms,X.sup.1, X.sup.2 and X.sup.3 independently of one another represent hydrogen or the radical of the formula ##STR3## and n represents integers from 0 to 16, it being possible for the divalent aliphatic hydrocarbon radicals which represents R.sup.2 to be different from one another if n represents numbers larger than 1, or their acid addition salts.

Abstract: A method is described for blocking maturation and production of microfilariae in adult filarial nematodes utilizing a transglutaminase inhibitor, such as monodansyl cadaverine (MDC). Experiments applying this method to several Brugia filarial infections, including Brugia malayi, were successful. Higher concentration of transglutaminase inhibitor proved to be filariacidal.

Abstract: Therapeutic product based on an organic derivative of silicon, particularly useful in the treatment of vascular diseases. The organic silicon compound is associated with a polyamine carrying hydrocarbon chains including carboxyl groups.

Abstract: A nonirritating germicidal animal test dip comprising certain dodecylaminolkylamine derivatives, an emollient and a film-forming ingredient. A method for controlling mastitis in dairy cows is also described.

Abstract: An agricultural granule capable of carrying and releasing incorporated biocidal or nutritional agricultural chemicals. The granule is formed by the agitative agglomeration of a plant fiber slurry and resembles a clay granule in all respects except for its chemical inertness.

Abstract: The importance of polyamines in biological systems is discussed as well as the implications of polyamines in the treatment of various diseases. Novel N-substituted-2,3-butadienyl tri- and tetra-aminoalkanes are disclosed as well as their use inthe treatment of diseases and the pharmaceutical compositions.

Abstract: Disclosed herein are compositions containing aliphatic di- and polyamine, or agmatine which are useful to regulate, i.e., stimulate or inhibit, epithelial cell growth. The compositions containing low concentrations of these compounds, by virtue of their epithelial cell growth stimulating activity, are useful in promoting wound healing, treating burns, treating ischemic, debubitus and peptic ulcers, plastic and reconstructive surgery, dermatological disorders, promoting autograft and homograft growth, stimulating organ and tissue regeneration in vitro and in vivo, as a component in defined (serum protein-free) media for cultured cells.Compositions containing these compounds in higher concentrations are useful in the inhibition of cell growth and are useful in the treatment of psoriasis and in retardation of fibrosis after injuries to the spinal cord and nervous system. Also disclosed are various methodologies for utilizing such compositions.