Oxygen Single Bonded To Carbon Patents (Class 514/687)
  • Patent number: 9877486
    Abstract: Methods for improving the ability of a population of biological agents to compete and survive in a field setting are provided. By improving the population of biological agents, the modified population of agents is able to grow, compete with other microbial strains and fungi, and provide protection for plants from pathogens. In particular, modified biological agents and modified populations of such agents that are herbicide tolerant or resistant are selected or engineered. In this manner, the protection from disease-causing agents is enhanced. Such modified populations of biological agents can be added to soils to prevent fungal pathogens and the diseases they cause promoting plant growth. Therefore, the present invention is useful for enhancing the competitiveness of modified biological agents particularly over other microbial agents which are not herbicide resistant.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: January 30, 2018
    Assignee: AgBiome, Inc.
    Inventors: Philip E. Hammer, Janice C. Jones, Michael G. Koziel, Kelly S. Smith, Scott Joseph Uknes
  • Patent number: 9127034
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: September 8, 2015
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Christopher Hugh Senanayake, Zhengxu Han
  • Patent number: 9012362
    Abstract: The present invention relates to compositions, in particular within a fungicide composition, which comprises (A) a dithiino-tetracarboximide of formula (I) and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and to the treated seed.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: April 21, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Thomas Seitz, Ulrike Wachendorff-Neumann, Peter Dahmen
  • Publication number: 20150010469
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer, stereoisomer or deuterated analogue thereof, wherein X, R, R1, R2, R3, R4, M1, M2, L1, L2, J1, J2, a1, a2, b1 and b2 are as defined herein, are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Application
    Filed: July 3, 2014
    Publication date: January 8, 2015
    Applicants: British Columbia Cancer Agency Branch, University of British Columbia
    Inventors: Raymond John Andersen, Javier Garcia Fernandez, Marianne Dorothy Sadar
  • Publication number: 20140336258
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 13, 2014
    Inventor: Menachem Shoham
  • Patent number: 8816129
    Abstract: The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: August 26, 2014
    Assignee: Institute of Oceanology, Chinese Academy of Sciences
    Inventors: Dayong Shi, Shuju Guo, Xiao Fan, Weishen Lu, Yongchao Cui
  • Publication number: 20130338120
    Abstract: The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.
    Type: Application
    Filed: June 14, 2013
    Publication date: December 19, 2013
    Inventor: Shengmin Sang
  • Publication number: 20130131182
    Abstract: The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
    Type: Application
    Filed: July 7, 2011
    Publication date: May 23, 2013
    Applicant: INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Dayong Shi, Shuju Guo, Xiao Fan, Weishen Lu, Yongchao Cui
  • Publication number: 20130109758
    Abstract: This invention provides compounds having a structure of Formula (I). Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Application
    Filed: January 6, 2011
    Publication date: May 2, 2013
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Marianne D. Sadar, Nasrin R. Mawji, Carmen Adriana Banuelos, Raymond J. Andersen, Javier Garcia Fernandez
  • Publication number: 20110245082
    Abstract: The present invention relates to a use of a graft copolymer obtainable by free-radical polymerization of a monomer mixture comprising N-vinyllactam, vinyl ester, and a polyether for increasing the activity of a pesticide. The invention also relates to a composition comprising a pesticide and a graft copolymer obtainable by free-radical polymerization of a monomer mixture comprising i) 30 to 80% by weight of N-vinylpyrrolidone, N-vinylcaprolactam or mixtures thereof, ii) 10 to 50% by weight of vinyl acetate, and iii) 10 to 50% by weight of a polyether. It further relates to a method for preparing said composition by mixing the pesticide and the graft copolymer and to a method for controlling phytopathogenic fungi and/or undesired plant growth and/or undesired attack by insects or mites and/or for regulating the growth of plants.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 6, 2011
    Applicant: BASF SE
    Inventors: Murat MERTOGLU, Stefan BECHTEL, Kristin KLAPPACH, Marc NOLTE
  • Patent number: 8026275
    Abstract: The present invention provides novel 2,6-diisopropyl phenol2,6-diisopropyl phenol analogs and sterile, stable pharmaceutical compositions of 2,6-diisopropyl phenol 2,6-diisopropyl phenol and analogs thereof useful as an antioxidant in the treatment of ischemic injury including stroke and other cerebral injury. 2,6-diisopropyl phenol or its analogs are administered in a dosage effective to produce blood levels and brain levels of the drug that can prevent free radical damage associated with ischemic injury.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: September 27, 2011
    Assignee: Abraxis BioScience, LLC
    Inventors: Neil P. Desai, Chunlin Tao, Cheng Zhi Yu, Vuong Trieu, Patrick Soon-Shiong
  • Publication number: 20110218226
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Application
    Filed: March 8, 2011
    Publication date: September 8, 2011
    Inventor: MENACHEM SHOHAM
  • Publication number: 20110112099
    Abstract: The present invention provides therapeutic agents for a cancer resistant to a protease inhibitor which comprises, as an active ingredient, a benzoyl compound represented by formula (I): [wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkyl, CONR7R8 (wherein R7 and R8, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), or the like; R2 represents substituted or unsubstituted aryl or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R4 represents a hydrogen atom or the like; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like] or a pharmaceutically acceptable salt thereof as a heat shock protein 90 (Hsp90) family protein inhibitor, and the like.
    Type: Application
    Filed: August 21, 2008
    Publication date: May 12, 2011
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Takayuki Nakashima, Yukimasa Shiotsu
  • Patent number: 7915247
    Abstract: Fenofibric acid formulations comprising 105 mg of fenofibric acid are described as well as methods of use thereof. Dosage forms include, for example, immediate-release dosage forms.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: March 29, 2011
    Assignee: Mutual Pharmaceutical Company, Inc.
    Inventors: Kristin Anne Arnold, Hengsheng Feng
  • Publication number: 20100322875
    Abstract: Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 23, 2010
    Applicant: Advanced Bio-Technologies, Inc.
    Inventor: Paul Guilbaud
  • Patent number: 7846958
    Abstract: The use of benzophenones of the formula I in which R is hydrogen or C1-C4-alkyl and Hal is fluorine, chlorine or bromine for controlling Pseudocercosporella herpotrichoides in crop plants is described.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: December 7, 2010
    Assignee: BASF SE
    Inventors: Markus Gewehr, Ingo Rose, Bernd Müller, Eberhard Ammermann, Ann Orth, Henry Van Tuyl Cotter
  • Publication number: 20100303744
    Abstract: In one embodiment, a personal-care composition in the form of a water-in-oil emulsion comprises at least about 10% of a non-polar silicone oil; from about 0.1% to about 10% of a first oil-soluble solid sunscreen; and from about 0.1% to about 10% of a second oil-soluble solid sunscreen. The weight ratio of the first sunscreen to the second sunscreen may be from about 0.8 to about 2.0, or from about 1.0 to about 1.5. The first sunscreen may be oxybenzone. The second sunscreen may be avobenzone. The composition may further comprise a skin-care active selected from the group consisting of a vitamin B3 compound, a sugar amine, a peptide, a hexamidine compound, and combinations thereof. In another embodiment, the invention relates to a method for improving the solubility of a second oil-soluble solid sunscreen in the oil phase of a water-in oil emulsion.
    Type: Application
    Filed: March 19, 2010
    Publication date: December 2, 2010
    Inventors: Laurie Ellen Breyfogle, Rebecca Ann Finley
  • Publication number: 20100291231
    Abstract: The present invention relates to compositions which, in sprayable or form, are suitable as wound sealants for woody plants. The invention also relates to a method of protecting woody plants from infection with phytopathogenic fungi, in particular ESCA infection, using such wound sealants. These compositions comprise: a) a water-insoluble sealing agent in dissolved or dispersed form, which is selected among film-forming water-insoluble polymers, waxes and their mixtures; b) at least one plant protectant, c) at least one volatile diluent, in particular an aqueous diluent, and, if appropriate, d) at least one nonionic surface-active substance in an amount of from 10 to 100% by weight, in particular 10 to 80% by weight, based on the sealing agent.
    Type: Application
    Filed: September 23, 2008
    Publication date: November 18, 2010
    Applicant: BASF SE
    Inventors: Reinhold Stadler, Michael Vonend, Erich Birner, Heike Pfistner, Steffen Henkes, Michael Merk, Sven Harmsen, Egon Haden
  • Patent number: 7741374
    Abstract: Fenofibric acid formulations comprising 105 mg of fenofibric acid are described as well as methods of use thereof. Dosage forms include, for example, immediate-release dosage forms.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: June 22, 2010
    Assignee: Mutual Pharmaceutical Company, Inc.
    Inventors: Kristin Anne Arnold, Hengsheng Feng
  • Patent number: 7741373
    Abstract: Fenofibric acid formulations comprising 105 mg of fenofibric acid are described as well as methods of use thereof. Dosage forms include, for example, immediate-release dosage forms.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: June 22, 2010
    Assignee: Mutual Pharmacuetical Company, Inc.
    Inventors: Kristin Anne Arnold, Hengsheng Feng
  • Publication number: 20100098690
    Abstract: The present invention provides a pharmaceutical composition comprising a combination of an Hsp 90 family protein inhibitor and at least one compound, the said pharmaceutical composition wherein the Hsp 90 family protein inhibitor is a benozoyl compound represented by formula (I): [wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkyl, CONR7R8 (wherein R7 and R8, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), or the like; R2 represents substituted or unsubstituted aryl, or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like], or a prodrug thereof; or a pharmaceutically acceptable salt thereof, and the like.
    Type: Application
    Filed: March 5, 2008
    Publication date: April 22, 2010
    Applicant: KYOWA HAKKO KIRIN CO., LTD.
    Inventors: Shiro Soga, Toshihiko Ishii, Takayuki Nakashima, Yukimasa Shiotsu, Shiro Akinaga
  • Publication number: 20090275575
    Abstract: Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.
    Type: Application
    Filed: September 21, 2007
    Publication date: November 5, 2009
    Applicant: CHONG KUN DANG PHARMACEUTICAL CORP.
    Inventors: Nam-Song Choi, Young-Mi Kim, Young-Hoon Kim, Jae-Kwang Lee, In-Taek Lim, Ho-Jin Choi, Hyun-Mo Yang, Seung-Kee Moon, Soo-Jin Kim, Hyun-Jung Yu, Jae-Su Shin, Young-Min Kwon, Sung-Sook Lee, Soon-Kil Ahn
  • Patent number: 7586008
    Abstract: The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: September 8, 2009
    Assignee: Abraxis Bioscience, Inc.
    Inventors: Chunlin Tao, Cheng Zhi Yu, Neil P. Desai, Vuong Trieu
  • Patent number: 7569612
    Abstract: Fenofibric acid formulations comprising 105 mg of fenofibric acid are described as well as methods of use thereof. Dosage forms include, for example, immediate-release dosage forms.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: August 4, 2009
    Assignee: Mutual Pharmaceutical Company, Inc.
    Inventors: Kristin Anne Arnold, Hengsheng Feng
  • Publication number: 20080275100
    Abstract: The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.
    Type: Application
    Filed: July 9, 2008
    Publication date: November 6, 2008
    Applicant: ABRAXIS BIOSCIENCE, INC.
    Inventors: Chunlin TAO, Cheng Zhi YU, Neil P. DESAI, Vuong TRIEU
  • Patent number: 7109380
    Abstract: Compounds and methods useful in the control, treatment, and prevention of fungal activity, of the following formula: where R1-3 are independently H, alkyl, methyl, acyl, halogen, phenyl, R4 is H, alkyl, methyl, acyl, alkoxy, halogen, phenyl provided that when R3 is methyl and R4 is H, R1 and R2 are not both H; and stereoisomers, analogs, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: September 19, 2006
    Assignees: The University of Mississippi, The United States of America as represented by the Secretary of Agriculture
    Inventors: Xing-Cong Li, Melissa R. Jacob, David Wedge
  • Patent number: 7071235
    Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: July 4, 2006
    Assignee: SurModics, Inc.
    Inventors: Patrick E. Guire, Aron B. Anderson, Richard A. Amos, Terrence P. Everson, Peter H. Duquette
  • Patent number: 7019035
    Abstract: A method for attenuating free radical formation resulting from a bodily insult includes the step of administering bicarbonate to the body of a subject. The bicarbonate is administered at a dosage of at least 1.5 mEq/kg of body weight within a 24-hour period.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: March 28, 2006
    Assignee: MD Scientific LLC
    Inventor: W. Patrick Burgess
  • Patent number: 6790463
    Abstract: The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a penetrating solvent, such as dimithyl sulfoxide; a dye containing a chelated metal, such as hematoporphyrin; and an aromatic redox compound, such as benzoquinone.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: September 14, 2004
    Inventors: Robert F. Hofmann, Robert H. Carpenter
  • Patent number: 6777578
    Abstract: The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective antineoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: August 17, 2004
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Matthew P. Grealish
  • Patent number: 6734202
    Abstract: The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at least one benzophenone of formula I wherein R1, R2, R3, R4, R5, R6, R7, m and n have the meaning given; at least one fungicidal active ingredient selected from the following groups (A), (B), (C), (D) and (E): (A) an ergosterol biosynthesis inhibitor; (B) a strobilurine derivative, (C) a melanin biosynthesis inhibitor; (D) a compound selected from the group consisting of acibenzolar, benomyl, captan, carboxin, chlorothalonil, copper, cyprodinil, dinocap, dithianon, dimethomorph, dodine, ethirimol, famoxadone, fenpiclonil, fluazinam, mancozeb, metalaxyl, pyrifenox, sulfur, vinclozolin and (E) an azolopyrimidine of formula II in which R8, R9, R10, R11, A, L and p have the meaning given; and to a method of controlling the growth of phytopathogenic fungi at a locus which comprises a
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: May 11, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Henry Van Tuyl Cotter, Gunther Reichert, Ewald Sieverding, Petrus Martinus Franciscus Emanuel Jegerings
  • Publication number: 20040054000
    Abstract: Fungicidal mixtures, comprising
    Type: Application
    Filed: July 14, 2003
    Publication date: March 18, 2004
    Inventors: Karl Eicken, Ingo Rose, Eberhard Ammermann, Reinhard Stierl, Gisela Lorenz, Siegfried Strathmann, Maria Scherer, Klaus Schelberger, Egon Haden
  • Patent number: 6696497
    Abstract: A fungicidal composition comprises an acceptable carrier and/or surface active agent and a synergistically effective amount of (a) at least one benzophenone of formula I wherein R1, R2, R3, R4, R5, R6, R7, m and n have the meaning given; and at least one compound of formula II in which Ar and R8 have the meaning given. The composition is useful in a method of controlling the growth of phytopathogenic fungi at a locus. The method comprises applying synergistically effective amounts of (a) and (b) to the locus.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: February 24, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Ewald Sieverding, Gunter Reichert
  • Patent number: 6689776
    Abstract: The invention relates to a method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of a) a benzophenone of formula I  wherein R1 is methoxy or methyl, R2 is C1-C4alkoxy or 2-halogenbenzyloxy, R3 is C1-C4alkoxy, R4 is C1-C4alkyl, halogen or trifluoromethyl, and R5 is hydrogen, halogen, C1-C4alkoxy, trifluoromethyl or nitro; in association with b) a compound selected from the group comprising compounds of formulae II, III, IV, V, VI, VII, VIII, IX, X and XI as described herein.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: February 10, 2004
    Assignee: Syngenta Crop Protection, Inc.
    Inventor: Ian Paul Dalton
  • Publication number: 20030220304
    Abstract: The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective anti neoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells.
    Type: Application
    Filed: April 24, 2003
    Publication date: November 27, 2003
    Inventors: George R. Pettit, Matthew P Grealish
  • Publication number: 20030166669
    Abstract: The invention comprises a method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of
    Type: Application
    Filed: March 11, 2003
    Publication date: September 4, 2003
    Inventor: Neil Leadbitter
  • Patent number: 6613806
    Abstract: The invention relates to method for the enhancement of the activity and/or systemicity of fungicidal compositions containing at least one benzoylbenzene of formula I wherein R1 through R7, m and n are as defined in claim 1, with the aid of one or more adjuvants selected from the group consisting of (a) alkylpolyglycosides, alkenyl succinic acid derivatives, dialkyl sulfosuccinates, polyvinylpyrrolidones, perfluoroalkyl acids derivatives, perfluoro(C3-20)alkyl esters of carboxylic acids, and mixtures thereof; (b) alkoxylated alcohols, amines or acids; (c) water-immiscible polar aprotic solvents; and to the use of such a composition as a fungicide.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: September 2, 2003
    Assignee: BASF Corporation
    Inventors: Michael Aven, Henry Van Tuyl Cotter
  • Patent number: 6596775
    Abstract: The invention relates to method for the enhancement of the activity and/or systemicity of fungicidal compositions containing at least one benzoylbenzene of formula I wherein R1 through R7, m and n are as defined in claim 1, with the aid of one or more adjuvants selected from the group consisting of (a) alkylpolyglycosides, alkenyl succinic acid derivatives, dialkyl sulfosuccinates, polyvinylpyrrolidones, perfluoroalkyl acids derivatives, perfluoro(C3-20)alkyl esters of carboxylic acids, and mixtures thereof; (b) alkoxylated alcohols, amines or acids; (c) water-immiscible polar aprotic solvents; and to the use of such a composition as a fungicide.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: July 22, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Aven, Henry Van Tuyl Cotter
  • Patent number: 6566308
    Abstract: The invention relates to a stable emulsifiable concentrate (EC) for crop protection active compounds which comprises (a) one or more crop protection active compounds, (b) 150 to 500 g/l of one or more adjuvants, (c) optionally one or more organic, non-polar solvents, (d) an emulsifying surfactant system forming an oil in water emulsion when the formulation is added to water, which essentially consists of one or more non-ionic surfactants, and one or more anionic surfactants, (e) a water-miscible polar aprotic solvent or one or more dimethyl dicarboxylates, and (f) optionally an antifoam agent, and to the use of such a suspension as a pesticide.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: May 20, 2003
    Assignee: BASF Aktiengesellschaft
    Inventor: Michael Aven
  • Patent number: 6555587
    Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: April 29, 2003
    Assignee: Surmodics, Inc.
    Inventors: Patrick E. Guire, Aron B. Anderson, Richard A. Amos, Terrence P. Everson
  • Patent number: 6534088
    Abstract: This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80% of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: March 18, 2003
    Assignee: SkyePharma Canada Inc.
    Inventors: Pol-Henri W. Guivarc'h, Indu Parikh, Robert A. Snow
  • Patent number: 6521628
    Abstract: The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at least one benzophenone of formula I wherein R1, R2, R3, R4, R5, R6, R7, m and n have the meaning given; at least one fungicidal active ingredient selected from the following groups (A), (B), (C), (D) and (E): (A) an ergosterol biosynthesis inhibitor; (B) a strobilurine derivative, (C) a melanin biosynthesis inhibitor; (D) a compound selected from the group consisting of acibenzolar, benomyl, captan, carboxin, chlorothalonil, copper, cyprodinil, dinocap, dithianon, dimethomorph, dodine, ethirimol, famoxadone, fenpiclonil, fluazinam, mancozeb, metalaxyl, pyrifenox, sulfur, vinclozolin and (E) an azolopyrimidine of formula II in which R8, R9, R10, R11, A, L and p have the meaning given; and to a method of controlling the growth of phytopathogenic fungi at a locus which comprises a
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: February 18, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Henry Van Tuyl Cotter, Gunter Reichert, Ewald Sieverding, Petrus Martinus Franciscus Emanuel Jegerings
  • Patent number: 6518275
    Abstract: Fungicidal compositions comprising an acceptable carrier and/or surface active agent and synergistically effective amounts of (a) at least one azolopyrimidine of formula I  in which R1, R2, L1, L2 and L3 have the meaning given in claim 1; and (b) at least one fungicidal active ingredient selected from benomyl, carboxin, captan, chlorothalonil, copper oxychloride, cyprodinil, dimethomorph, dithianon, dodine, famoxadone, fenhexamid, fenpiclonil, fenpropimorph, fluazinam, mancozeb, metalaxyl, pyrimethanil, quinoxifen, sulfur, triforine, vinclozolin, a fungicidal triazole derivative, and a synthetic strobilurine derivative. The invention also provides a method of controlling the growth of phytopathogenic fungi at a locus by applying synergistically effective amounts of at least one azolopyrimidine of formula I and at least one fungicidal active ingredient (b) to the locus.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: February 11, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Henry Van Tuyl Cotter, Leslie May, Gunter Reichert, Ewald Sieverding
  • Patent number: 6498194
    Abstract: The invention relates to a novel fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent together with, and synergistically effective amounts of (a) at least one benzophenone of formula I  wherein R1, R2, R3, R4, R5, R6, R7, m and n have the meaning given; at least one fungicidal active ingredient selected from the following groups (A), (B), (C), (D) and (E): (A) an ergosterol biosynthesis inhibitor; (B) a strobilurine derivative, (C) a melanin biosynthesis inhibitor; (D) a compound selected from the group consisting of acibenzolar, benomyl, captan, carboxin, chlorothalonil, copper, cyprodinil, dinocap, dithianon, dimethomorph, dodine, ethirimol, famoxadone, fenpiclonil, fluazinam, mancozeb, metalaxyl, pyrifenox, sulfur, vinclozolin and (E) an azolopyrimidine of formula II  in which R8, R9, R10, R11, A, L and p have the meaning given; and to a method of controlling the growth of phytopathogenic fungi at a locus which
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: December 24, 2002
    Assignee: BASF Aktiengsellschaft
    Inventors: Henry Van Tuyl Cotter, Gunther Reichert, Ewald Sieverding, Petrus Martinus Franciscus Emanuel Jegerings
  • Patent number: 6472428
    Abstract: A method of combating phytopathogenic diseases on crop plants includes applying to the crop plants or the locus thereof being infested with a phytopathogenic disease an effective amount of a combination of a) (E,E)-&agr;-(methoxyimino)-2-[[[[1-[3 (trifluoromethyl)phenyl]ethylidene]amino]oxy]methyl]-benzeneacetic acid methyl ester of formula I  in association with b) a benzophenone of formula II  wherein R1 is hydrogen, halogen, C1-5alkyl or CF3; R2 is halogen, C1-5alkyl or CF3; R3 is C1-5alkyl or optionally substituted benzyl; and R4 is C1-5alkyl.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: October 29, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventor: Neil Leadbitter
  • Patent number: 6472429
    Abstract: A method of combating phytopathogenic diseases on crop plants includes applying to the crop plants or the locus thereof being infested with a phytopathogenic disease an effective amount of a combination of a) (E,E)-&agr;-(methoxyimino)-2-[[[[1-[3(trifluoromethyl)phenyl]ethylidene]amino]oxy]methyl]-benzeneacetic acid methyl ester of formula I  in association with b) a benzophenone of formula II  wherein R1 is hydrogen, halogen, C1-4 alkoxy or NO2; and R2 is C1-6 alkyl or optionally substituted benzyl.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: October 29, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventor: Neil Leadbitter
  • Patent number: 6468553
    Abstract: The invention discloses an extract containing puccoon and Chinese angelica, and a formula and preparation method of an ointment containing the extract. The extract is used for treating burns and scalds and is characterized by superior shelf-life. The puccoon and Chinese angelica are extracted with an organic solvent having a polarity of between 0.35 and 0.95, which are then filtrated, concentrated and mixed with a physiologically acceptable carrier or excipient.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 22, 2002
    Assignee: Pharmaceutical Industry Technology and Development Center
    Inventors: Ce-Shing Sheu, Yi-Ching Wu, Jun-Hung Kuo
  • Patent number: 6465525
    Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: October 15, 2002
    Assignee: Surmodics, Inc.
    Inventors: Patrick E. Guire, Aron B. Anderson, Richard A. Amos, Terrence P. Everson
  • Patent number: 6444618
    Abstract: The novel emulsifiable concentrate (EC) formulation comprising at least one pesticidal crop protection active compound, at least one non-polar organic solvent, optionally, at least one polar aprotic cosolvent, an emulsifying surfactant system enabling an oil-in-water emulsion to be formed when the formulation is added to water, and at least one defoaming or foam breaking agent selected from the group consisting of perfluoroalkylphosphonic acids, perfluoroalkylphosphinic acids and perfluoroaliphatic polymeric esters is useful for combating pests or diseases caused by pests at a locus by treating the locus with a composition obtained from emulsifying the EC in water.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: September 3, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Aven, Friedrich Schmidt
  • Publication number: 20020107246
    Abstract: The invention relates to a method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of
    Type: Application
    Filed: November 29, 2001
    Publication date: August 8, 2002
    Inventor: Ian Paul Dalton