Oxygen Single Bonded To Carbon Patents (Class 514/687)
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Patent number: 6468553Abstract: The invention discloses an extract containing puccoon and Chinese angelica, and a formula and preparation method of an ointment containing the extract. The extract is used for treating burns and scalds and is characterized by superior shelf-life. The puccoon and Chinese angelica are extracted with an organic solvent having a polarity of between 0.35 and 0.95, which are then filtrated, concentrated and mixed with a physiologically acceptable carrier or excipient.Type: GrantFiled: August 3, 2000Date of Patent: October 22, 2002Assignee: Pharmaceutical Industry Technology and Development CenterInventors: Ce-Shing Sheu, Yi-Ching Wu, Jun-Hung Kuo
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Patent number: 6465525Abstract: A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.Type: GrantFiled: October 22, 1998Date of Patent: October 15, 2002Assignee: Surmodics, Inc.Inventors: Patrick E. Guire, Aron B. Anderson, Richard A. Amos, Terrence P. Everson
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Patent number: 6444618Abstract: The novel emulsifiable concentrate (EC) formulation comprising at least one pesticidal crop protection active compound, at least one non-polar organic solvent, optionally, at least one polar aprotic cosolvent, an emulsifying surfactant system enabling an oil-in-water emulsion to be formed when the formulation is added to water, and at least one defoaming or foam breaking agent selected from the group consisting of perfluoroalkylphosphonic acids, perfluoroalkylphosphinic acids and perfluoroaliphatic polymeric esters is useful for combating pests or diseases caused by pests at a locus by treating the locus with a composition obtained from emulsifying the EC in water.Type: GrantFiled: January 26, 2000Date of Patent: September 3, 2002Assignee: BASF AktiengesellschaftInventors: Michael Aven, Friedrich Schmidt
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Publication number: 20020107246Abstract: The invention relates to a method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination ofType: ApplicationFiled: November 29, 2001Publication date: August 8, 2002Inventor: Ian Paul Dalton
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Publication number: 20020081338Abstract: A calcium-based ophthalmic composition for treating dry eye including a hydrophobic carrier, such as petrolatum, and a calcium salt. Also a method for treating dry eye comprising the step of administering the composition according to the present invention.Type: ApplicationFiled: June 26, 2001Publication date: June 27, 2002Inventor: Donald L. MacKeen
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Publication number: 20020065313Abstract: A fungicidal composition comprises an acceptable carrier and/or surface active agent and a synergistically effective amount ofType: ApplicationFiled: February 13, 2001Publication date: May 30, 2002Applicant: BASF AktiengesellschaftInventors: Ewald Sieverding, Gunter Reichert
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Patent number: 6346535Abstract: The invention relates to a novel fungicidal composition comprising synergistically effective amounts of at least one benzophenone of formula I wherein R1 represents a halogen atom, an optionally substituted alkyl, alkanoyloxy or alkoxy group; or a hydroxy group, R2 represents a halogen atom or an optionally substituted alkyl group, R3 independently represents a halogen atom, an optionally substituted alkyl or alkoxy group or a nitro group; m is 0 or an integer of 1 to 3; R4 represents a halogen atom, a cyano, carboxy, hydroxy or nitro group or an optionally substituted alkyl, alkoxy, alkenyl, alkylthio, alkylsulphinyl, alkylsulphonyl or amino group; R5 represents an optionally substituted alkyl group; R6 represents a halogen atom or a nitro group, an optionally substituted alkyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, cycloalkyl, cycloalkyloxy, aryloxy group; R7 independently represents a halogen atom, an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynylType: GrantFiled: January 29, 1999Date of Patent: February 12, 2002Assignee: American Cyanamid CompanyInventors: Henry Van Tuyl Cotter, Gunther Reichert, Ewald Sieverding, Petrus Martinus Franciscus Emanuel Jegerings
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Patent number: 6242498Abstract: Substituted benzophenone compounds and a process for manufacturing them, are disclosed. The compounds have the formula: The compounds are useful as fungicides having high systemicities.Type: GrantFiled: August 5, 1998Date of Patent: June 5, 2001Inventors: Juergen Curtze, Werner Simon, Andreas Waldeck, Henry Van Tuyl Cotter, Annerose Rehnig
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Patent number: 6221637Abstract: Xanthene compounds represented by the formula: wherein R1 is a carboxyl group which may be esterified or amidated; R2 is a hydrogen atom, a hydroxyl group, or a hydrocarbon group which may be substituted; R3 and R4 are the same or different and are a hydroxyl group which may be substituted; R5 and R6 are a hydrogen atom or a halogen atom; R7 is a hydrogen atom, a nitro group, a halogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, or an acyl group which may be substituted; n is an integer of 0 to 2; and Y is an oxygen atom or two hydrogen atoms; and when n is 0, R2 may be a group represented by the formula: wherein the symbols have the same meanings as defined above, or a salt thereof inhibit a binding of B7-1 to CD28, prevent the B7-1-dependent activation of T cells and inhibit IL-2 production from T cells, thus being used as an immunomodulator such as a graft rejection inhibitor or a pharmaceutical composition for theraType: GrantFiled: March 4, 1997Date of Patent: April 24, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Tsuneaki Hida, Masahiko Hattori, Tsutomu Kurokawa, Atsushi Nakanishi
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Patent number: 6063815Abstract: This invention provides compounds of Formula I having the structure ##STR1## wherein Y is ##STR2## R.sup.1 and R.sup.2 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, perfluoroalkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, phenyl or phenyl mono-, di- or tri-substituted with trifluoromethyl, chloro, methoxy, or trifluoromethoxy;R.sup.3 and R.sup.4 are each, independently, hydrogen, carboxyl, hydroxyl, hydoxyalkyl of 1-6 carbon atoms, hydroxyalkanoyl of 1-6 carbon atoms, aryloxycarbonyl of 7-13 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, perfluoroalkoxycarbonyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, aminoalkyl of 1-6 carbon atoms, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, tetrazolyl, mercapto, alkylsulfanyl of 1-6 carbon atoms, nitrile, nitro, amino, --NHSO.sub.2 CF.sub.Type: GrantFiled: May 10, 1999Date of Patent: May 16, 2000Assignee: American Home Products CorporationInventor: Paul J. Dollings
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Patent number: 6001883Abstract: Substituted benzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.Type: GrantFiled: June 24, 1998Date of Patent: December 14, 1999Assignee: American Cyanamid CompanyInventors: Juergen Curtze, Gerd Morschhaeuser, Henry Van Tuyl Cotter
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Patent number: 5945567Abstract: Substituted benzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.Type: GrantFiled: August 20, 1997Date of Patent: August 31, 1999Assignee: American Cyanamid CompanyInventors: Juergen Curtze, Werner Simon, Gerd Morschhaeuser, Andreas Waldeck, Karl-Otto Stumm, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Gunther Reichert
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Patent number: 5880162Abstract: A pesticidal compound of formula I: ##STR1## in which formula: either R.sup.1 is hydrogen and R.sup.2 represents a cyclopropyl group or R.sup.1 and R.sup.2 each represent an alkyl group, which alkyl groups may be the same or different;Ar.sub.A represents an optionally substituted phenyl or naphthyl group;Ar.sub.B represents a phenoxy, phenyl, benzyl or benzoyl-substituted phenyl group which is optionally further substituted;the configuration of the groups Ar.sub.A --CR.sup.1 R.sup.2 and --CH.sub.2 Ar.sub.B about the double bond being mutually trans.Preferably Ar.sub.A is a substituted phenyl group; more preferably being substituted at the 4-(para) position by halogen, alkoxy or haloalkyl.Further provided is a process for the preparation of a pesticidal compound of formula I in which a compound comprising a moiety ##STR2## and a compound comprising a moiety Ar.sub.B -- are reacted together forming a link --CH.dbd.C(F)CH.sub.2 -- between ##STR3## and Ar.sub.B in the compound of formula I.Type: GrantFiled: October 21, 1996Date of Patent: March 9, 1999Assignee: British Technology Group, Ltd.Inventors: Bhupinder Pall Singh Khambay, Mu-Guang Liu
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Patent number: 5776439Abstract: Cosmetic compositions containing sunscreens against sun radiation ranging from 280 to 380 nm, and their use for the protection of the skin from UV radiation. The sunscreens comprise, with respect to the weight of the composition:a) from 1 to 10% of one or more compounds of formula (I) ##STR1## wherein Q is hydrogen or C.sub.1 -C.sub.4 alkoxy and G is C.sub.1 -C.sub.8 alkyl; andb) from 0.5 to 10% of one or more compounds of formula (II): ##STR2## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl and R.sub.2 is hydrogen or an SO.sub.3 M group wherein M is hydrogen, an alkali metal, or a mono- or polyalkyl-substituted ammonium group;with the condition that the weight ratio between the compounds of formula (II) and the compounds of formula (I) is at least 0.5.Type: GrantFiled: November 29, 1996Date of Patent: July 7, 1998Assignee: 3V Inc.Inventors: Giuseppe Raspanti, Alverio Malpede
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Patent number: 5773663Abstract: There is provided a method for the control of phytopathogenic fungi and disease caused thereby which comprises contacting said fungi with a fungicidally effective amount of a benzophenone compound of formula I ##STR1## There are further provided benzophenone compounds of formula Ia which are useful as fungicidal agents and compositions useful for the protection of plants from the damaging effects of phytopathogenic fungi and fungal disease.Type: GrantFiled: May 1, 1996Date of Patent: June 30, 1998Assignee: American Cyanamid CompanyInventors: Jurgen Curtze, Christine Helene Gertrud Rudolph, Ludwig Schroder, Guido Albert, Annerose Edith Elise Rehnig, Ewald Gerhard Sieverding
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Patent number: 5733532Abstract: Cosmetic compositions containing sunscreens against sun radiation ranging from 280 to 380 nm, and their use for the protection of the skin from UV radiation. The sunscreens comprise, with respect to the weight of the composition:a) from 1 to 10% of one or more derivatives of formula (I) ##STR1## wherein Q is hydrogen or C.sub.1 --C.sub.4 alkoxy and G is C.sub.1 --C.sub.8 alkyl;b) from 0.5 to 10% of one or more derivatives of formula (II): ##STR2## wherein R.sub.1 is hydrogen or C.sub.1 --C.sub.8 alkyl and R.sub.2 is hydrogen or an SO.sub.3 M group in which M is hydrogen, an alkali metal, or an alkyl ammonium group; andc) from 1 to 10% of one or more derivatives of formula (III) ##STR3## wherein R.sub.3 is C.sub.1 --C.sub.8 alkyl and R.sub.4 has independently the same meanings as R.sub.3 or is hydrogen or is an alkali metal;with the condition that the weight ratio between the compounds of formula (II) and the compounds of formula (I) is at least 0.5.Type: GrantFiled: November 29, 1996Date of Patent: March 31, 1998Assignee: 3V Inc.Inventors: Giuseppe Raspanti, Alverio Malpede
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Patent number: 5679716Abstract: A therapeutic agent for osteoporosis comprising as an active ingredient xanthohumol. Xanthohumol obtained from hop extracts has a bone resorption inhibiting activity and is useful as a therapeutic agent for osteoporosis.Type: GrantFiled: September 27, 1996Date of Patent: October 21, 1997Assignee: Hoechst Japan LimitedInventors: Hiroyasu Tobe, Kazuyuki Kitamura, Osamu Komiyama
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Patent number: 5679866Abstract: There is provided a method for the control of phytopathogenic fungi and disease caused thereby which comprises contacting said fungi with a fungicidally effective amount of a benzophenone compound of formula I ##STR1## There are further provided benzophenone compounds of formula Ia which are useful as fungicidal agents and compositions useful for the protection of plants from the damaging effects of phytopathogenic fungi and fungal disease.Type: GrantFiled: June 7, 1995Date of Patent: October 21, 1997Assignee: American Cyanamid CompanyInventors: Jurgen Curtze, Christine Helene Gertrud Rudolph, Ludwig Schroder, Guido Albert, Annerose Edith Elise Rehnig, Ewald Gerhard Sieverding
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Patent number: 5411973Abstract: Compounds of formula I ##STR1## wherein X, A, B, R.sup.1 and R.sup.2 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable ester thereof, processes for preparing the compounds and pharmaceutical compositions comprising them. The compounds are useful as potassium channel openers and as therapeutic agents in the treatment of urinary incontinence.Type: GrantFiled: May 18, 1993Date of Patent: May 2, 1995Assignee: Zeneca LimitedInventors: Keith Russell, James R. Empfield, Cyrus J. Ohnmacht, Keith H. Gibson
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Patent number: 5158775Abstract: A suspension type aerosol inhalations containing (a) 0.015 to 5.00% (w/w) of a pyrido[1,2-a]pyrimidine compound of the formula: ##STR1## where R is a n-propyl or allyl group, A is a tetrazolyl or carboxyl group, and n is a whole number of 0 to 2, and (b) 0.015 to 5.00% (w/w) of a fatty acid ester.Type: GrantFiled: June 14, 1990Date of Patent: October 27, 1992Assignee: Tokyo Tanabe Company, LimitedInventors: Takashi Yazaki, Yukio Goto
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Patent number: 5093372Abstract: A pharmaceutical composition which is a physical mixture of exifone and certain water soluble cellulose derivatives. The mixture exhibits surprisingly improved solubility and bio availability.Type: GrantFiled: March 2, 1990Date of Patent: March 3, 1992Assignee: Fujisawa Pharmaceutical Co. Inc.Inventors: Yoshio Uedo, Fumio Shimojo, Mitsuru Yasumara, Kenzo Toyoshima, Nobumitsu Nakahasi
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Patent number: 5041244Abstract: Ophthalmic dosages of chromophores in aqueous gel to block transmission of all or various spectrums of U.V. from the eyes, when used as ophthalmic liquid sunglasses.Type: GrantFiled: May 16, 1990Date of Patent: August 20, 1991Assignee: Liquid Sunglasses CorporationInventor: Neville A. Baron
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Patent number: 5037854Abstract: A compound which has the biological action of inducing cell differentiation has general chemical formula (I), in which R.sub.1 is a straight or branched chain or cyclic alkyl or alkenyl group; R.sub.2 is an alkoxy or hydroxy group; R.sub.3 is a hydrogen or halogen atom; and, R.sub.4 is a halogen atom. Preferred values for the groups are R.sub.1 =C.sub.3 to C.sub.8 alkyl; R.sub.2 =methoxy; and, either or both of R.sub.3 and R.sub.4 =chlorine. The compounds: 1) 2,6-dihydroxy-3,5-dichloro-4-methoxy valerophenone; 2) 2,6-dihydroxy-3,5-dichloro-4-methoxy butyrophenone; and, 3) 2,6-dihydroxy-3-chloro-4-methoxy valerophenone are of particular interest.Type: GrantFiled: January 22, 1990Date of Patent: August 6, 1991Assignee: 3i Research Exploitation LimitedInventors: Howard R. Morris, Robert R. Kay, Mark S. Masento, Graham W. Taylor
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Patent number: 5032580Abstract: Compositions for anti-AIDS virus and other antivirus medicines are disclosed. Included are one having the ingredients other than glycyrrhizin contained in licorice, specifically flavonoids contained in licorice and more specifically not less than one kind of substance selected from a group consisting of liquiritigenin, i-liquiritigenin, liquiritin and i-liquiritin and glycyrrhizin produces allowed to contain not less than 3% of flavonoids contained in licorice based on glycyrrhizin as major constituting elements. Method of preparing said compositions having the filtrate obtained through the ultrafiltration of aqueous extract from licorice using ultrafiltration membrane with a fractionatable molecular weight of 10,000 to 100,000 as an effective ingredient and drugs for the pevention from infection and onset and for the therapy against AIDS used said compositions are also claimed.Type: GrantFiled: November 29, 1988Date of Patent: July 16, 1991Assignee: Sanyo-Kokusaku Pulp Co., Ltd.Inventors: Kazuhiro Watanabe, Makoto Yashiro, Makoto Machida
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Patent number: 4898890Abstract: A novel medicine containing isoliquiritigenin as the active ingredient is disclosed, which exhibits excellent effects when used as a medicine for the therapy and prevention of kidney diseases, a medicine for the therapy and prevention of liver diseases, and a medicine for the therapy and prevention of complication resulting from diseases of these organs.Type: GrantFiled: December 23, 1987Date of Patent: February 6, 1990Assignees: Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories IncorporatedInventors: Toshio Sato, Hitoshi Matsumoto, Hisao Kakegawa
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Patent number: 4801616Abstract: This invention provides certain diphenylmethane derivatives, their pharmaceutical formulations, and their use in treating inflammation and arthritis in mammals.Type: GrantFiled: March 25, 1986Date of Patent: January 31, 1989Assignee: Eli Lilly and CompanyInventor: D. Mark Gapinski
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Patent number: 4530844Abstract: Non-steroidal anti-inflammatory compositions comprising a compound of the formula: ##STR1## wherein R.sub.1 is H or OH; and X, Y, X.sup.1 and Y.sup.1 represent hydrogen or halogen, such as chloro, fluoro, bromo, or iodo radicals, lower alkyl radicals such as C.sub.1 -C.sub.8 radicals, such as methyl, ethyl, propyl and butyl, lower haloalkyl radicals, such as trifluoro, trichloro or tribromo methyl radicals, and lower alkoxy radicals, such as C.sub.1 -C.sub.8 radicals such as methoxy, ethoxy, propoxy, and octyloxy radicals or combinations thereof and the salts thereof, in combination with a compound selected from the group consisting of vitamin E acetate, butylated hydroxytoluene, quercetin, nordihydroguaiaretic acid and mixtures thereof, said combination being contained in a pharmaceutically acceptable carrier.A method of treating pain and inflammation is also disclosed.Type: GrantFiled: July 26, 1984Date of Patent: July 23, 1985Assignee: Warner-Lambert CompanyInventors: Richard V. Smerbeck, Eugene P. Pittz