Persulfide (e.g., R-s-s-r, Etc.) Patents (Class 514/707)
  • Publication number: 20150147288
    Abstract: The invention generally relates to environmental friendly pesticide compounds, formulations, methods of preparation and application and utilities thereof. More particularly, the invention relates to pesticide compounds and formulations that include terpenes or terpenoids having chemical formula of (C5H8)n, and its derivatives and analogs thereof, as active insecticidal ingredients; certain botanical essential oils as synergists, and other select ingredients as additives.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 28, 2015
    Inventor: Tao Zhong
  • Publication number: 20150094381
    Abstract: A method for reducing parasites in aquatic animals is provided. The method includes reducing a plurality of parasites infecting an aquatic animal by administrating to the aquatic animal a compound comprising propyl propane thiosulfonate (PTSO) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 2. In yet a different embodiment, a method for reducing a plurality of parasites infecting an aquatic animal includes administrating to the aquatic animal a compound comprising and propyl propane thiosulfinate (PTS) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 1. In even yet another embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTS. In a different embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTSO.
    Type: Application
    Filed: October 1, 2013
    Publication date: April 2, 2015
    Applicant: INVESTFOOD, LLC
    Inventors: Cristina Núñez Lechado, Alberto Baños Arjona, Enrique Guillamón Ayala, Adela Valero López, Mª Concepción Navarro Moll, Ana Sanz Rus
  • Patent number: 8992991
    Abstract: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: March 31, 2015
    Assignee: The Johns Hopkins University
    Inventors: Jordan J. Green, Joel C. Sunshine, Nupura S. Bhise, Ron B. Shmueli, Stephany Y. Tzeng
  • Patent number: 8962692
    Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: February 24, 2015
    Assignees: Marquette University, UWM Research Foundation, Inc.
    Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
  • Publication number: 20140377007
    Abstract: The present invention relates to a photocatalytic film including at least one polymer layer (1) including at least one photocatalyst, said layer being pervious to both the vapours of at least one fumigating compound and ultraviolet radiation capable of activating the photocatalyst. The present invention also relates to a method for treatment by fumigation using said photocatalytic film and at least one fumigant.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 25, 2014
    Applicant: ARKEMA FRANCE
    Inventors: Patrick Charles, Thierry Fouillet
  • Publication number: 20140323562
    Abstract: The present application provides compound of Formula X wherein A is an optionally substituted aliphatic or an optionally substituted aryl, and B is a moiety that stabilizes the partial positive charge at the carbon adjacent the divalent sulfur. The compound of Formula X is useful as a reversible antioxidant in a variety of applications. Also provided are methods of synthesizing the compound of Formula X.
    Type: Application
    Filed: November 23, 2012
    Publication date: October 30, 2014
    Inventors: Philip Jessop, Paul David Thornton, Shannon Marie Decker, Derek Pratt, Feng Zheng, Donna Lynn Leger
  • Publication number: 20140303070
    Abstract: The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C?C— bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
    Type: Application
    Filed: December 7, 2011
    Publication date: October 9, 2014
    Applicant: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Thomas Bjarnsholt, Niels Høiby, Peter Østrup Jensen, Richard Phipps, Meenakshi Sundaram Shanmugham, Maria Alhede, Louise Dahl Hultqvist, Tim Holm Jakobsen, David Tanner, Thomas Ostenfeld Larsen, Michael Givskov
  • Publication number: 20140235565
    Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 21, 2014
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: EDWARD TUROS, KEVIN D. REVELL
  • Patent number: 8791093
    Abstract: Disclosed are injectable pharmaceutical compositions that contain a therapeutically effective amount of an anti-addictive agent, an anti-inflammatory agent, and a pharmaceutically acceptable liquid carrier, methods of making the compositions, and uses thereof for treating addictions including substance abuse (or addiction to an abused substance) and addictive or compulsive behavior, by administering the composition to a subject in need thereof.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: July 29, 2014
    Inventor: Lance L. Gooberman
  • Publication number: 20140120159
    Abstract: Cyanide antidote compositions and methods of use are described herein. A cyanide antidote composition may include a sulfur analog, sulfur analog derivative, or a pharmaceutically acceptable derivative of a sulfur analog.
    Type: Application
    Filed: October 30, 2013
    Publication date: May 1, 2014
    Applicant: Sam Houston University
    Inventors: Ilona Petrikovics, Csaba Jaszberenyi
  • Publication number: 20140107222
    Abstract: The use of Pak1 inhibitors to treat social or learning disabilities is disclosed. In one embodiment patients exhibiting social or learning disabilities as well as abnormally low NF1 activity are administered PAK inhibitors to treat the social or learning disabilities. Reductions in PAK activity have been found to ameliorate the effects of aberrant neurofibromatosis type 1 activity.
    Type: Application
    Filed: October 15, 2013
    Publication date: April 17, 2014
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Anantha SHEKHAR, D. Wade CLAPP
  • Patent number: 8663669
    Abstract: In order to replace methyl bromide in all the uses thereof in soil or substrate treatment, the invention relates to the use of at least one sulphur compound having general formula: wherein R represents an alkenyl or alkyl radical, n is equal to 0, 1 or 2, x is a number between 0 and 4 and R? represents an alkenyl or alkyl radical or, only if n=x=0, a hydrogen or alkali-metal atom. The sulphur compounds (in particular dimethyldisulphide) can be applied according to standard soil treatment methods (by injection, spraying, dripping, sprinkling) and said compounds have no phototoxic effects.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: March 4, 2014
    Assignee: Arkema France
    Inventors: Thierry Aubert, Jacques Auger
  • Patent number: 8623923
    Abstract: A process for the preparation of ajoene, and of ajoene having a relatively high purity which may be obtained by the process. This invention also relates to processes for the preparation of allicin, and to a process for freeze concentrating allicin.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: January 7, 2014
    Assignee: Neem Biotech Limited
    Inventors: David Michael Williams, Robert Alun Saunders, Gareth James Street Evans
  • Patent number: 8586636
    Abstract: Compositions and methods for the treatment of cancer are provided.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: November 19, 2013
    Assignee: Lankenau Institute for Medical Research
    Inventors: Iraimoudi S. Ayene, George C. Prendergast
  • Patent number: 8524781
    Abstract: Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumor cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: September 3, 2013
    Assignee: University of Cape Town
    Inventors: Catherine Hart Kaschula, Roger Hunter, Mohamed Iqbal Parker
  • Publication number: 20130171104
    Abstract: What is disclosed is pharmaceutical compositions which contain a pharmaceutically active amount of at least one active substance which increases the available NO concentration in the cell, together with at least one active substance which stimulates the NADPH oxidase.
    Type: Application
    Filed: August 10, 2011
    Publication date: July 4, 2013
    Applicant: Universitaetsklinikum Freiburg
    Inventor: Georg Bauer
  • Patent number: 8455552
    Abstract: The present invention relates to S-allylmercapto-N-acetylcysteine (ASSNAC) and its pharmaceutically acceptable salts and solvates, which are useful for up-regulation of cellular glutathione levels and expression of phase II detoxifying enzymes. The invention further provides methods of use thereof in the prevention, alleviation or treatment of oxidative stress induced by reactive oxygen species (ROS).
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: June 4, 2013
    Assignees: RAMOT et Tel Aviv University Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Naphtali Savion, David Mirelman, Aharon Rabinkov, Alex Khenkin
  • Publication number: 20130129809
    Abstract: The invention relates to compositions and methods for treating cancer comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, methods of inhibiting the growth of cancer stem cells or tumor initiating cell comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, and methods of enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells comprising administering to a subject in need a pharmaceutically effective dose of a chemotherapeutic drug and a pharmaceutically effective dose of a cancer stem cell inhibitor.
    Type: Application
    Filed: May 21, 2012
    Publication date: May 23, 2013
    Applicant: Glax L.L.C.
    Inventors: Rakesh K. Srivastava, Sharmila Shankar
  • Publication number: 20130109570
    Abstract: Fumigant compositions including hexafluoropropene or 1,1,3,3,3-pentafluoropropene, and methods of preparing such compositions, are provided herein. The fumigant compositions may be suitable for use as soil fumigant compositions and structural fumigant compositions against a variety of undesirable species such as weeds, nematodes, pathogens, animals and insects. The fumigant compositions also have low toxicity and low Global Warming Potential.
    Type: Application
    Filed: October 15, 2012
    Publication date: May 2, 2013
    Applicant: HONEYWELL INTERNATIONAL INC.
    Inventor: HONEYWELL INTERNATIONAL INC.
  • Patent number: 8357723
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 22, 2013
    Assignee: Piramal Enterprises Limited and Apparao Satyam
    Inventor: Apparao Satyam
  • Patent number: 8354455
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 15, 2013
    Assignee: Piramal Enterprises Limited and Apparao Satyam
    Inventor: Apparao Satyam
  • Patent number: 8349901
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 8, 2013
    Assignee: Piramal Enterprises Limited and Apparao Satyam
    Inventor: Apparao Satyam
  • Patent number: 8318816
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: November 27, 2012
    Assignee: University of Washington
    Inventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
  • Publication number: 20120282334
    Abstract: Disclosed is a method for preparing ajoene including: (a) obtaining garlic pulp or garlic extract from garlic; (b) mixing the garlic pulp or garlic extract with animal lipid to form a reaction mixture; and (c) heating the reaction mixture to obtain ajoene. The ajoene prepared according to the present disclosure may be encapsulated with gelatin. According to the present disclosure, ajoene can be prepared with a yield 2 times or more than that of the existing methods. Thus, ajoene can be provided as active ingredient for foods and medicines more cost-effectively. Also, the production protocol according to the present disclosure is suitable for large-scale production of ajoene.
    Type: Application
    Filed: November 7, 2011
    Publication date: November 8, 2012
    Applicant: KOREA FOOD RESEARCH INSTITUTE
    Inventors: Dong Bin Shin, Mi Young Yoo, Ho Moon Seog, Jae Ho Ha, Sang Hee Lee, Yong Sun Cho
  • Publication number: 20120219621
    Abstract: A composition with enhanced thermogenic activity and the use thereof in the prevention and treatment of obesity Pharmaceutical compositions of a dietary supplement or medical device, useful for the treatment and prevention of overweight and obesity and metabolic syndrome comprising: a) menthol or a peppermint essential oil comprising menthol, in association with one or more components having a thermogenetic activity, selected from: b1) capsaicin or a capsacinoid derived from Capsicum genus or a Capsicum extract containing capsaicin and/or capsacinoids; b2) a sulphur containing active principle derived from the Allium genus or an Allium extract containing it; b3) a catechin active substance derived from the genus Camellia or a Camellia extract containing it. The menthol and mint essential oil have a potentiating action on the biological activities of the other aforementioned components.
    Type: Application
    Filed: October 11, 2010
    Publication date: August 30, 2012
    Applicant: MEDESTEA BIOTECH S.P.A.
    Inventor: Mariana Gabriela Alvarez Favela
  • Patent number: 8217084
    Abstract: Nutraceutical and dietary supplement formulations for delivering bioavailable thiols to a host, comprising certain organosulfur radicals, such as the allyl mercapto radical, bound to larger molecules such as proteins, resulting in the formation in the host's body of various allium-related compounds such as allicin. The formulations are produced by treating an ingestible material comprising a cysteine-containing protein with a thiol, disulfide, mixed disulfide, thiosufinate or mixed thiosulfinate so as to cause thiol residues to become disulfide bonded to cysteines contained in the protein.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: July 10, 2012
    Assignee: Allium Vitalis Incorporated
    Inventor: David M. Ott
  • Publication number: 20120148690
    Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
  • Publication number: 20120022105
    Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Application
    Filed: October 6, 2011
    Publication date: January 26, 2012
    Applicants: Tomlin Scientific, Inc., PiGNX, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20120021032
    Abstract: In order to replace methyl bromide in all the uses thereof in soil or substrate treatment, the invention relates to the use of at least one sulphur compound having general formula: wherein R represents an alkenyl or alkyl radical, n is equal to 0, 1 or 2, x is a number between 0 and 4 and R? represents an alkenyl or alkyl radical or, only if n=x=0, a hydrogen or alkali-metal atom. The sulphur compounds (in particular dimethyldisulphide) can be applied according to standard soil treatment methods (by injection, spraying, dripping, sprinkling) and said compounds have no phototoxic effects.
    Type: Application
    Filed: June 20, 2011
    Publication date: January 26, 2012
    Inventors: Thierry Aubert, Jacques Auger
  • Patent number: 8101667
    Abstract: The present invention is directed to the pesticidal treatment of stored foodstuffs, chambers, structures and works of art, using a volatile sulphur compound of general formula: in which R represents an alkyl or alkenyl radical containing from 1 to 4 carbon atoms, n is equal to 0, 1 or 2, x is a number ranging from 0 to 4, and R? represents an alkyl or alkenyl radical containing from 1 to 4 carbon atoms or, only if n=x=0, a hydrogen atom. These sulphur compounds (in particular dimethyl disulphide) are applied by nebulization directly to the material to be treated.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: January 24, 2012
    Assignee: Arkema France
    Inventors: Thierry Aubert, Jacques Auger
  • Publication number: 20110319496
    Abstract: A process for the preparation of ajoene, and of ajoene having a relatively high purity which may be obtained by the process. This invention also relates to processes for the preparation of allicin, and to a process for freeze concentrating allicin.
    Type: Application
    Filed: March 2, 2010
    Publication date: December 29, 2011
    Applicant: NEEM BIOTECH LIMITED
    Inventors: David Michael Williams, Robert Alun Saunders, Gareth James Street Evans
  • Publication number: 20110190368
    Abstract: Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumour cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.
    Type: Application
    Filed: August 5, 2009
    Publication date: August 4, 2011
    Applicant: University of Cape Town
    Inventors: Catherine Hart Kaschula, Roger Hunter, Mohamed Iqbal Parker
  • Patent number: 7932294
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: April 26, 2011
    Assignees: Apparao Satyam, Piramal Life Sciences Limited
    Inventor: Apparao Satyam
  • Publication number: 20110061649
    Abstract: A method and device to prevent and cure body diseases caused by infection factors such as: bacteria, virus, fungi, parasites as well as preventing fat accumulation in body blood vessels, lowering blood pressure, lowering cholesterol level in the blood and destroying body organs cancer cells is done by inhaling vapors of fresh crushed or sliced garlic or vapors of synthetic allicin.
    Type: Application
    Filed: August 17, 2008
    Publication date: March 17, 2011
    Inventor: Israel Hirshberg
  • Publication number: 20100298412
    Abstract: Compositions and methods for the treatment of cancer are provided.
    Type: Application
    Filed: November 19, 2008
    Publication date: November 25, 2010
    Inventor: Iraimoudi S. Ayene
  • Publication number: 20100260733
    Abstract: The present invention discloses novel mechanisms in the aging process and describes novel methods for high-throughput screening to identify, detect, and purify agents to be used for improving mitochondrial function, maintaining the cell cycle-arrested state in senescent and post mitotic cells, and thus preventing or treating age-related diseases or disorders associated with accelerated mitochondrial function loss, telomere dysfunction, and/or deterioration of the growth-arrested state. The present invention also discloses a number of compounds or compositions identified from this method. The present invention further provides the use of low doses of rapamycin or its analogs as a mimic of caloric restriction in preventing age-related diseases or disorders.
    Type: Application
    Filed: April 12, 2010
    Publication date: October 14, 2010
    Inventor: HAIYAN QI
  • Publication number: 20100204337
    Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 12, 2010
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Edward Turos, Praveen Ramaraju
  • Publication number: 20100130555
    Abstract: A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I): R1—(S)n—R2 ??(I) or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Application
    Filed: October 16, 2009
    Publication date: May 27, 2010
    Applicant: Ikaria, Inc.
    Inventors: Edward A. Wintner, Fuqiang Ruan
  • Patent number: 7678833
    Abstract: A method for increasing the bioavailability of cysteine within an animal by reducing extracellular cysteine disulfide molecules to produce extracellular cysteine molecules. A membrane permeable thiol molecule that forms a membrane permeable disulfide molecule after becoming oxidized participates in thiol-disulfide exchange reactions on both sides of the cellular membrane, crossing the membrane randomly via simple diffusion. The membrane permeable disulfide, within or upon entering the highly reductive environment of a cell, becomes reduced to form a membrane permeable thiol molecule. the membrane permeable thiol can then diffuse to the exterior of the cell, where it is available to reduce another cystine molecule. This process can continue cycling, producing net cumulative increase in the concentration of extracellular cysteine. This is beneficial for providing cysteine as a nutrient to cells that require cysteine for nourishment.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: March 16, 2010
    Assignee: Allium Vitalis Incorporated
    Inventor: David M. Ott
  • Patent number: 7622507
    Abstract: The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: November 24, 2009
    Assignee: Acea Biosciences Inc.
    Inventors: Xiao Xu, Haoyun An, Xiaobo Wang
  • Publication number: 20090275667
    Abstract: The present invention provides the use of allicin in (i) the treatment of leishmanimis; (b) as a disinfectant or biocidal treatment of aquatic species; (iii) as an antimicrobial agent for animal feed; (iv) as a preservative agent in foodstuffs; (v) as a water disinfectant or biocide; (vi) as an antiparasitic treatment or antibacterial treatment for bees (apis); or (vii) in the preparation of a medicament for the treatment of Glycopeptide Intermediate Resistant Stapohylococcus aureus.
    Type: Application
    Filed: May 14, 2009
    Publication date: November 5, 2009
    Applicant: Stone Island Holdings Ltd
    Inventors: Norman J. Bennett, Peter D. Josling
  • Publication number: 20090232827
    Abstract: The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in time of survival in cancer patients, wherein the cancer either: (i) overexpresses thioredoxin or glutaredoxin and/or (ii) exhibits evidence of thioredoxin- or glutaredoxin-mediated resistance to one or more chemotherapeutic interventions. The present invention also discloses and claims methods and kits for the administration of said compositions to properly treat cancer patients. Additionally, the present invention discloses and claims methods and kits for quantitatively determining the level of expression of thioredoxin or glutaredoxin in the cancer cells of a cancer patient, methods of using those determined levels in the initial diagnosis and/or planning of subsequent treatment methodologies for said cancer patient, as well as ascertaining the potential growth “aggressiveness” of the particular cancer and treatment responsiveness of the particular type of cancer.
    Type: Application
    Filed: July 15, 2008
    Publication date: September 17, 2009
    Inventor: Frederick H. Hausheer
  • Publication number: 20080249186
    Abstract: A fungicidal preparation comprising: (i) a fungicidal composition consisting essentially of (a) at least one allyl sulfide; and (b) at least one alkyl or alkenyl benzene substituted with at least one group selected from the group consisting of hydroxy, alleoxy, and oxo groups; in a weight ratio of (a) to (b) is from 1:0.5 to 1:19; and optionally (ii) one or more further constituents is disclosed. The fungicidal preparation preferably includes essential oils such as garlic, clove and thyme oils. Also provided are methods for producing said fungicidal preparations, as well as methods of use for the fungicidal preparations.
    Type: Application
    Filed: October 9, 2006
    Publication date: October 9, 2008
    Applicant: GIVAUDAN SA
    Inventors: Thomas McGee, Rodrigo Rodriguez-Kabana, Andreas Natsch
  • Publication number: 20080234388
    Abstract: 1,5-Dithiaocta-2,7-diene-5-oxide-1-yl (DODOyl) compounds and derivatives thereof, referred to collectively as DODOyl-derived compounds (DDCs), and chiral enantiomers and derivatives thereof, are described, which are integrin modulators that modulate integrin-mediated functions and/or processes. Pharmaceutical compositions containing integrin modulators and chiral enantiomers thereof, and methods for using integrin modulators and chiral enantiomers thereof are further described.
    Type: Application
    Filed: March 10, 2005
    Publication date: September 25, 2008
    Inventors: John B. Davidson, Ali S. Turgiev
  • Publication number: 20080214678
    Abstract: The present invention relates to compounds based on diallyl polysulfides, and to biopesticides comprising said compositions. The invention also relates to the use of biopesticides based on said compositions rich in diallyl polysulfides for the effective insecticidal activity thereof in relation to a large number of insects. The invention further relates to a method of producing said compositions.
    Type: Application
    Filed: December 9, 2004
    Publication date: September 4, 2008
    Inventors: David Gaudout, Claude Inisan, Serge Durechou, Denis Megard
  • Publication number: 20080193498
    Abstract: Compositions and methods for reducing, preventing, mitigating, and/or delaying the onset of, attenuating the severity of, and/or hastening the resolution of, for example, one or more chemotherapy-associated toxicities in a subject receiving one or more chemotherapeutic agents. In addition compositions and methods for mitigating or preventing a novel form of chemotherapy-induced peripheral neuropathy are disclosed and claimed.
    Type: Application
    Filed: March 14, 2008
    Publication date: August 14, 2008
    Inventor: Frederick H. Hausheer
  • Publication number: 20080161416
    Abstract: Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
    Type: Application
    Filed: November 14, 2007
    Publication date: July 3, 2008
    Inventors: Frederick H. Hausheer, Harry Kochat, Qiuli Huang
  • Publication number: 20080161414
    Abstract: Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
    Type: Application
    Filed: November 14, 2007
    Publication date: July 3, 2008
    Inventors: Frederick H. Hausheer, Harry Kochat, Qiuli Huang
  • Publication number: 20080161415
    Abstract: Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-mercaptoethane sulfonate sodium.
    Type: Application
    Filed: November 14, 2007
    Publication date: July 3, 2008
    Inventors: Frederick H. Hausheer, Harry Kochat, Qiuli Huang
  • Publication number: 20080070839
    Abstract: The present invention provides a compound for treating cancer including an isolated form of dibenzyl trisulfide (DTS) provided in an effective amount to act as an agent against human diseases, including various forms of cancer. The present invention also provides a compound for treating cancer including DTS isolated from Petiveria alliacea L. (guinea hen weed) for providing an effective, potent anti-proliferation and/or cytotoxic activity on a wide range of cancer cell lines. The present invention further provides DTS derivatives (e.g. DTS-albumin complexes) in effective dosage for providing a potent anti-proliferation and/or cytotoxic activity on a wide range of cancer cell lines. Additionally, the present invention provides methods of isolating and/or providing the DTS and/or its derivatives in an effective amount for providing a potent anti-proliferation and/or cytotoxic activity on cancer cell lines.
    Type: Application
    Filed: May 18, 2007
    Publication date: March 20, 2008
    Inventors: Lawrence A.D. Williams, H. George Levy