Persulfide (e.g., R-s-s-r, Etc.) Patents (Class 514/707)
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Patent number: 5863954Abstract: The progression of infection and other pathologies produced by a viral infection may be inhibited by administering an effective dosage of Ajoene. Additionally, Ajoene has anti-tumor, anti-shock, and anti-inflammation effects. In general, Ajoene may be used to treat any integrin-mediated disease or condition.Type: GrantFiled: January 11, 1996Date of Patent: January 26, 1999Assignee: John B. DavidsonInventors: Alexander V. Tatarintsev, Ali S. Turgiev, John B. Davidson
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Patent number: 5856363Abstract: The progression of infection and other pathologies produced by a viral infection may be inhibited by administering an effective dosage of Ajoene. Additionally, Ajoene has anti-tumor, anti-shock, and anti-inflammation effects. In general, Ajoene may be used to treat any integrin-mediated disease or condition.Type: GrantFiled: January 11, 1996Date of Patent: January 5, 1999Assignee: John B. DavidsonInventors: Alexander V. Tatarintsev, Ali S. Turgiev, John B. Davidson
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Patent number: 5645825Abstract: The subject invention involves topical depilatory compositions, at a pH of 7 or below, comprising sulfhydryl compounds. The subject invention further relates to methods for removing vellus hair from mammalian skin comprising topical application of a composition, at a pH of 7 or below, comprising a sulfhydryl compound or a cosmetically- and/or pharmaceutically-acceptable salt thereof.Type: GrantFiled: June 7, 1995Date of Patent: July 8, 1997Assignee: The Procter & Gamble CompanyInventors: Greg George Hillebrand, Vladimir Gartstein
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Patent number: 5472483Abstract: An antifouling agent containing, as an active ingredient, one or more compounds represented by formula (I): ##STR1## wherein R represents an alkyl group; R.sub.1 represents an alkylene group; n represents an integer of 2 to 5; m and p each represent 0 or 1; X represents a nitro group, an alkyl group, an alkoxy group, a halogen atom or a hydrogen atom; and Y represents a nitro group or a halogen atom; provided that the sum of m and p is 1 or 2.Type: GrantFiled: November 18, 1994Date of Patent: December 5, 1995Assignee: Asahi Denka Kogyo Kabushiki KaishaInventors: Ryoji Kimura, Mitsuhiro Hamajima
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Patent number: 5373021Abstract: This invention discloses a rapid-diffusion injectable formulation, comprising disulfiram or a suitable salt or analog of disulfiram. Unlike slow-release injectable formulations designed to ensure that chronic alcoholics have significant quantities of disulfiram in their blood at all time, the rapid-diffusion injectable formulation disclosed herein is designed to reduce the hypoxic or ischemic damage caused by crisis events such as stroke, heart attack, cardiac arrest, or asphyxiation. A rapid-diffusion injectable formulation can contain disulfiram mixed with water, an organic compound having a plurality of hydroxyl groups (such as pharmaceutically acceptable glycols or polysaccharides; propylene glycol, dextrans, and cyclodextrins are often used for such purposes), and a buffer.Type: GrantFiled: April 26, 1993Date of Patent: December 13, 1994Assignee: Cypros Pharmaceutical CorporationInventor: Paul J. Marangos
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Patent number: 5334612Abstract: Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.Type: GrantFiled: November 8, 1990Date of Patent: August 2, 1994Assignee: ASTA Pharma AktiengesellschaftInventors: Joachim Kalden, Bernhard Fleckenstein, Andreas Baur, Thomas Harrer
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Patent number: 5270058Abstract: An alkali-metal dithionite is readily transformed into an aldehyde sulfoxylate microbicide which is absorbed through plant leaves and is more stable against oxidation.Type: GrantFiled: September 25, 1992Date of Patent: December 14, 1993Assignee: Mauricio KlingInventors: Jorge Miller, Alberto Kling
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Patent number: 5231114Abstract: A lipid peroxidation inhibitor contains a polysulfide compound represented by formula (I) as an active ingredient:R.sup.1 --(S).sub.m --R.sup.2 (I)wherein R.sup.1 and R.sup.2 are same or different hydrocarbon chains having 1 to 16 carbon atoms and m is an integer of 3 to 10. Among compounds (I) are found novel which are:R.sup.3 --(S).sub.n --R.sup.4 (II)wherein R.sup.3 and R.sup.4 are same or different lower alkenyl groups and n is an integer of 6 to 10. Pharmaceutical compositions which contain a polysulfide compound represented by formula (I) as an active ingredient, for preventing and curing diseases of thrombosis, arteiosclerosis, liver troubles, pulmonary edema, skin troubles, eye troubles and aging are also disclosed.Type: GrantFiled: April 13, 1992Date of Patent: July 27, 1993Assignee: Wakunaga Seiyaku Kabushiki KaishaInventors: Shoji Awazu, Toshiharu Horie, Yukihiro Kodera, Shinji Nagae, Hiromichi Matsuura, Yoichi Itakura
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Patent number: 5206264Abstract: A method is disclosed for reducing cardiovascular damage caused by hypoxic or ischemic events such as heart attack and cardiac arrest. This method involves the administration of disulfiram, or a suitable salt or analog of disulfiram, to a mammal in need of such treatment. Disulfiram can inhibit enzymes such as xanthine oxidase which would otherwise generate oxygenated free radicals, which are highly reactive chemical compounds that non-specifically attack and damage essential molecules and cells. It can also chelate copper and iron, thereby suppressing lipid peroxidation and protecting cell membranes from destruction. It also generates metabolites such as tryptophol which reduce the rate of metabolic activity in neurons and affected tissue, which can be useful during cytotoxic events. This invention also discloses injectable formulations that rapidly release disulfiram into the circulating blood.Type: GrantFiled: November 4, 1991Date of Patent: April 27, 1993Assignee: Cypros Pharmaceutical CorporationInventor: Paul J. Marangos
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Patent number: 5041240Abstract: Aqueous thiocarbonate solutions are stabilized by the addition of base, sulfide and/or polysulfide, and the stability and safety of the more concentrated solutions containing 1 weight percent or more equivalent CS.sub.2 as a thiocarbonate are achieved as reflected by significant reduction of CS.sub.2 partial pressure in such solutions.Type: GrantFiled: October 28, 1988Date of Patent: August 20, 1991Assignee: Union Oil Company of CaliforniaInventors: James A. Green, II, Donald C. Young
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Patent number: 5039664Abstract: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.Type: GrantFiled: March 8, 1989Date of Patent: August 13, 1991Assignee: Merck & Co., Inc.Inventors: Arthur A. Patchett, William H. Parsons, William J. Greenlee, Prasun K. Chakravarty
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Patent number: 5037807Abstract: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.Type: GrantFiled: March 8, 1989Date of Patent: August 6, 1991Assignee: Merck & Co., Inc.Inventors: Arthur A. Patchett, William J. Greenlee, William H. Parsons, Prasun K. Chakravarty
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Patent number: 4876281Abstract: An antifungal agent comprising as an effective component a polysulfide compound represented by formulaR.sub.1 --S(O).sub.p --R.sub.2 (A)whereinR.sub.1 is CH.sub.3 --, CH.sub.2 .dbd.CHCH.sub.2 -- or C.sub.2 H.sub.5 OCO(CH.sub.2).sub.3 --,p is an integer 1 or 2, andR.sub.2 is --S--CH.sub.2 CH.dbd.CH.sub.2 or --CH.sub.2 CH(H) CH(H)--S.sub.q --S(O).sub.r --R.sub.3in which--CH.sub.2 CH(H) CH(H)-- is --CH.sub.2 CH.sub.2 CH.sub.2 -- or--CH.sub.2 CH.dbd.CH--,q is an integer 0 or 1, r is integer from 0 to 2, and R.sub.3 is selected from the group consisting of alkyl having 1 to 6 carbon atoms, benzyl, --CH.sub.2 CH.dbd.CH.sub.2, --CH.sub.2 CH.dbd.CHCH.sub.3, --(CH.sub.2).sub.3 COOC.sub.2 H.sub.5, and --CH.dbd.CHCH.sub.2 --S--(CH.sub.2).sub.3 COOC.sub.2 H.sub.5,with the proviso that p is 2 when R.sub.1 is CH.sub.2 .dbd.CHCH.sub.2 --, R.sub.2 is --CH.sub.2 CH(H) CH(H)--S.sub.q --S(O).sub.r --R.sub.3, --CH.sub.2 CH(H) CH(H)-- is --CH.sub.2 CH.dbd.CH--, q is 1, r is 0 and R.sub.3 is --CH.sub.2 CH.dbd.CH.sub.2.Type: GrantFiled: September 4, 1987Date of Patent: October 24, 1989Assignee: Wakunaga Seiyaku Kabushiki KaishaInventors: Susumu Yoshida, Shizutoshi Nakagawa, Tsuyoshi Ushiroguchi, Hiromichi Matsuura, Akira Yazaki
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Patent number: 4665088Abstract: This invention relates to compounds of the structures: ##STR1## which structure includes its isomers, conventionally designated (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide and commonly termed (E,Z)-ajoene. This invention also relates to a process for preparing the compounds which comprises extracting and isolating allyl disulfide oxide (allyl 2-propenethiosulfinate) from the bulbs of garlic plants and thereafter treating it with a lower alkyl alcohol to produce such compound and the compounds as antibiotic and particularly as antithrombotic agents.Type: GrantFiled: November 14, 1984Date of Patent: May 12, 1987Assignee: The Research Foundation of State University of New YorkInventors: Rafael J. Apitz-Castro, Mahendra K. Jain
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Patent number: 4643994Abstract: This invention relates to novel organic trithio oxides of the formula:R.sup.1 --X --R--X.sup.1 --R.sup.1wherein R is selected from --CH.sub.2 CH.dbd.CH--, ##STR1## and (CH.sub.2).sub.3 ; X is selected from ##STR2## X.sup.1 is selected from --S--S, ##STR3## and, each R.sup.1 is independently selected from carboxyalkyl, alkoxy, alkylthio, amino, alkylamino and acyl substituted and unsubstituted lower alkyl, lower alkenyl, lower alkynyl, phenyl and lower alkylphenyl; provided when R is --CH.sub.2 CH.dbd.CH--, X is ##STR4## and X.sup.1 is --S--S--, then R.sup.1 is not in both instances --CH.sub.2 CH.dbd.CH.sub.2.This invention also relates to a method of preparing the above-identified compounds by heating and further oxidizing various oxides of organic disulfides and to antithrombotic uses of the compounds.Type: GrantFiled: December 17, 1984Date of Patent: February 17, 1987Assignee: The Research Foundation of State University of New YorkInventors: Eric Block, Saleem Ahmad
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Patent number: 4596706Abstract: A method for treating or aiding in the treatment of a tobacco habit or addiction in a human by controlling the craving for tobacco or controlling tobacco withdrawal symptoms which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving or said withdrawal symptoms so as to reduce the desire for tobacco.Type: GrantFiled: April 12, 1985Date of Patent: June 24, 1986Assignee: Elena AvramInventor: Emanuel Revici
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Patent number: 4565689Abstract: A method for treating or aiding in the treatment of the manifestations of alcoholism or alcohol intoxication by aiding in the control of the craving for alcohol or by aiding in the control of alcohol withdrawal symptoms, or by aiding in the control of alcohol intoxication in a human which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving, symptoms, or intoxication so as to counteract the effects of alcohol.Type: GrantFiled: April 12, 1985Date of Patent: January 21, 1986Assignee: Wirth Maschinen-und Bohrgerate-Fabrik GmbHInventor: Emanuel Revici
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Patent number: 4565690Abstract: A method for treating drug addiction from compounds which cause a catabolic effect on the human body, which comprises administering to said body, a sufficient amount of an anabolic agent containing bivalent negative selenium or sulfur.Type: GrantFiled: April 12, 1985Date of Patent: January 21, 1986Assignee: Elena AvramInventor: Emanuel Revici