Peroxide Doai Patents (Class 514/714)
-
Publication number: 20130338235Abstract: Intermediate compositions, and in particular gels and suspensions for preparing foam compositions, are described. The compositions can include benzoyl peroxide. Also described, is the dermatological use of such compositions.Type: ApplicationFiled: December 22, 2011Publication date: December 19, 2013Applicant: GALDERMA RESEARCH & DEVELOPMENTInventor: Emmanuelle At
-
Publication number: 20130324502Abstract: A dermal, transdermal and/or mucosal formulation for topical application on skin, comprising an active pharmaceutical ingredient and a pharmaceutically acceptable solvent, and an anti-solvent; wherein the active pharmaceutical ingredient is soluble in the solvent in the absence of the anti-solvent, and wherein the active pharmaceutical ingredient is substantially in the solid state in the presence of the anti-solvent. A method for increasing the stability of an active pharmaceutical ingredient.Type: ApplicationFiled: February 10, 2012Publication date: December 5, 2013Applicant: MOBERG PHARMA ABInventors: Åke Lindahl, Peter Kaufmann
-
Patent number: 8586008Abstract: The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.Type: GrantFiled: November 30, 2011Date of Patent: November 19, 2013Assignee: Stiefel West Coast, LLCInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Publication number: 20130287713Abstract: A shaving aid composition is provided that includes an organic polyhalogenic agent that both promotes post application foaming and increases lubricity. The shaving aid is optionally used to deliver one or more therapeutics to the skin of a subject and is therefore operable to prevent or treat a skin condition.Type: ApplicationFiled: October 29, 2010Publication date: October 31, 2013Inventor: John E. Kulesza
-
Patent number: 8563535Abstract: An aqueous gel composition of the present invention comprising about 0.1 to 0.3 wt % adapalene and about 2.5 to 5.0 wt % benzoyl peroxide, as active ingredients, wherein both the active ingredients are stabilized in hydrophilic gelling matrix of pH dependent gelling agent comprising crosslinked, acrylic acid-based polymer(s).Type: GrantFiled: March 23, 2012Date of Patent: October 22, 2013Inventors: Kamal Mehta, Lalatendu Panigrahi, Uday Kumar Nayak, Balakrishna Patro
-
Patent number: 8557871Abstract: Dermatological compositions containing, in a physiologically acceptable medium, at least one retinoid, dispersed benzoyl peroxide and at least one gelling agent of the family of the carrageenans, are useful for treating dermatological conditions and afflictions linked to disorders of cell differentiation and/or proliferation and/or keratinization, notably for treating acne vulgaris.Type: GrantFiled: July 9, 2010Date of Patent: October 15, 2013Assignee: Galderma Research & DevelopmentInventors: Fabienne Louis, Sandrine Segura, Nathalie Willcox
-
Publication number: 20130243837Abstract: Methods, compounds, and topical formulations for reduction of skin sagging, creasing and/or wrinkling are disclosed. The methods comprise topically applying a composition comprising an ?2 adrenergic receptor agonist. Amelioration of skin sagging, creasing and/or wrinkling begins within minutes after topical application of a disclosed composition. A single application can significantly reduce skin sagging, creasing and/or wrinkling for at least about 8 hours.Type: ApplicationFiled: April 15, 2013Publication date: September 19, 2013Applicant: Galderma Laboratories Inc.Inventors: Jack DeJovin, Isabelle Jean DeJovin
-
Publication number: 20130224123Abstract: The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.Type: ApplicationFiled: December 4, 2012Publication date: August 29, 2013Applicant: Alkermes Pharma Ireland LimitedInventor: Alkermes Pharma Ireland Limited
-
Publication number: 20130202712Abstract: The present invention relates to compositions and methods for the treatment of immuno-inflammatory conditions comprising the administration of a polyphenolic phytoalexin compartmentalized in a biocompatible and/or biodegradable polymeric carrier, and to the use of biocompatible and/or biodegradable polymeric carriers comprising resveratrol and block copolymers and these compositions with an additional compartmentalized pharmaceutically active agent.Type: ApplicationFiled: March 2, 2011Publication date: August 8, 2013Applicant: VINDICO NANOBIO TECHNOLOGY, INC.Inventors: Eric M. Ostertag, Paul C. Tumeh, P. Peter Ghoroghchian
-
Patent number: 8475770Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: GrantFiled: September 2, 2011Date of Patent: July 2, 2013Assignee: Stiefel Research Australia Pty LtdInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Publication number: 20130149194Abstract: Multifunctional organic peroxides are used as microbiological inactivators and/or for degrading nucleic acids. These include at least one carbon atom and at least two organic peroxide groups. The inactivator is ideally a hydroperoxide. The invention is particularly useful during preparation of viral vaccines.Type: ApplicationFiled: May 6, 2011Publication date: June 13, 2013Inventors: Jens Peter Gregersen, Thomas Grundemann
-
Patent number: 8449918Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.Type: GrantFiled: September 23, 2011Date of Patent: May 28, 2013Assignee: Sol-Gel Technologies Ltd.Inventors: Noa Lapidot, Shlomo Magdassi, David Avnir, Claudi Rottman, Orit Gans, Alon Seri-Levy
-
Patent number: 8445543Abstract: Adapalene or a pharmaceutically acceptable salt thereof formulated into a pharmaceutical composition is useful for reducing the number of acne lesions, via daily topical application, in combination or in association with benzoyl peroxide (BPO); such treatment may be via administration of a pharmaceutical composition combining adapalene and BPO or by a concomitant application of two pharmaceutical compositions, one containing adapalene and the other containing BPO.Type: GrantFiled: November 30, 2011Date of Patent: May 21, 2013Assignee: Galderma Research & DevelopmentInventors: Marie-line Abou-Chacra Vernet, Denis Gross, Christian Loesche, Michel Poncet
-
Publication number: 20130096203Abstract: An active agent delivery composition is provided that allows topical delivery of active agents including vitamin A and its derivatives. A polyhalogenic vehicle such as methoxyonafluorobutane or ethoxyonafluorobutane serves as a coupler for an active agent and a silicone carrier so as to allow solubilization of active agents not normally miscible in silicones and providing a moisture maintaining composition.Type: ApplicationFiled: November 26, 2012Publication date: April 18, 2013Applicant: YOUNG PHARMACEUTICALS, INC.Inventor: YOUNG PHARMACEUTICALS, INC.
-
Publication number: 20130053353Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.Type: ApplicationFiled: May 4, 2011Publication date: February 28, 2013Applicant: FOAMIX LTD.Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz
-
Publication number: 20130028962Abstract: Control of the fusion activity of liposomes by adsorbing biocompatible nanoparticles to the outer surface of phospholipid liposomes is disclosed. The biocompatible nanoparticles effectively prevent liposomes from fusing with one another. Release of cargo from the liposome is accomplished via trigger mechanisms that include pH triggers, pore forming toxing triggers and photosensitive triggers. Dermal drug delivery to treat a variety of skin diseases such as acne vulgaris and staph infections is contemplated.Type: ApplicationFiled: September 7, 2012Publication date: January 31, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Liangfang Zhang, Dissaya Pornpattananangkul, Chun-Ming E. Huang
-
Publication number: 20130012460Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following, application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: ApplicationFiled: September 13, 2012Publication date: January 10, 2013Applicant: Dow Pharmaceutical Sciences, Inc.Inventors: Yunik Chang, Gordon J. Dow
-
Publication number: 20130011342Abstract: A substantially surface active agent-free and foam adjuvant-free composition which includes a hydrophobic solvent, a wax and a propellant. A substantially surface active agent-free and foam adjuvant-free composition, further comprising, a tetracycline antibiotic, or one or More other active agents. A method of treatment, using a substantially surface active agent-free and substantially foam adjuvant-free composition.Type: ApplicationFiled: October 1, 2010Publication date: January 10, 2013Applicant: FOAMIX LTD.Inventors: Dov Tamarkin, Elana Gazal, Irakliy Papiashvili, Yohan Hazot, David Schuz, Rita Keynan, Nukzi Papiashvile
-
Patent number: 8337819Abstract: The invention is a pharmaceutical composition for the oral hygiene for the treatment of the periodontal illnesses and the Halitosis. It consists of a mixture 0.01 to 5 g of Hydrogen Peroxide; 0.001 to 0.5 g of Eugenol: 0.001 to 0.5 g of Permonochlorophenol; 0.001 to 0.3 g of Camphor; 10 to 40 g of Maltitol; 0.01 to 0.1 g of coloring matter; 0.1 to 1 g of appetizing substance and enough quantity of demineralized water to complete 100 g of oral pharmaceutical preparation.Type: GrantFiled: September 15, 2006Date of Patent: December 25, 2012Inventor: Tomas Bernardo Galvan
-
Publication number: 20120269874Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.Type: ApplicationFiled: June 13, 2012Publication date: October 25, 2012Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer TOLEDANO, Hanan SERTCHOOK, Natalia LOBODA, Haim BAR-SIMANTOV, Leora SHAPIRO, Raed ABU-REZIQ
-
Patent number: 8293790Abstract: The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the treatment of disease and/or disorders such as acne or atopic dermatitis.Type: GrantFiled: May 23, 2012Date of Patent: October 23, 2012Assignee: Dignity Sciences LimitedInventors: Mehar Manku, John Climax, David Coughlan
-
Patent number: 8288434Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: GrantFiled: June 3, 2009Date of Patent: October 16, 2012Assignee: Dow Pharmaceutical Sciences, Inc.Inventors: Yunik Chang, Gordon J. Dow
-
Publication number: 20120258177Abstract: The present invention provides microcapsules comprising benzoyl peroxide and topical compositions comprising them, optionally along with other active ingredients, particularly for the treatment of acne.Type: ApplicationFiled: October 7, 2010Publication date: October 11, 2012Inventors: Danny Goldstein, Tal Sade, Yuri Yasman, Olga Privalova, Lior Benaltabet
-
Patent number: 8263097Abstract: A method for treating acne on the skin. The method has the steps of (a) providing an drapeable or flexible porous article impregnated with an aqueous cleansing composition having a carrier, benzoyl peroxide, and one or more cleansing agents; (b) contacting an area of the skin affected by acne with the porous article such that the skin is contacted by the composition; and (c) removing the composition from the skin wherein residual benzoyl peroxide remains on the skin in an anti-acne effective amount. There are also anti-acne compositions.Type: GrantFiled: December 22, 2011Date of Patent: September 11, 2012Assignee: Medicis Pharmaceutical CorporationInventors: Waranush Jitpraphai, Eugene Gans
-
Publication number: 20120225102Abstract: A perfluorocarbon gel composition is disclosed with numerous uses including topical medical and cosmetic uses.Type: ApplicationFiled: April 16, 2012Publication date: September 6, 2012Inventors: Gerald Klein, Richard Kiral, Chris J. Stern
-
Publication number: 20120202695Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.Type: ApplicationFiled: December 30, 2010Publication date: August 9, 2012Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco-Dagan
-
Publication number: 20120115954Abstract: Embodiments of this invention relate to a composition containing both benzoyl peroxide and a retinoid. Additionally, it relates to the treatment of acne vulgaris by applying an aqueous gel comprising BPO and a retinoid.Type: ApplicationFiled: January 18, 2012Publication date: May 10, 2012Applicant: MEDICIS PHARMACEUTICAL CORPORATIONInventors: Mitchell S. Wortzman, Waranush Jitpraphai, Manzer Durrani
-
Publication number: 20120115801Abstract: Powder containing benzoyl peroxide is readily wetted by contacting the powder with a liquid containing one or more of a polyol, a polyol, ether, and a low-carbon organic alcohol.Type: ApplicationFiled: January 18, 2012Publication date: May 10, 2012Applicant: Dow Pharmaceutical Sciences, Inc.Inventor: Gordon Jay Dow
-
Patent number: 8158109Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: GrantFiled: March 29, 2007Date of Patent: April 17, 2012Assignee: Stiefel Research Australia Pty LtdInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Publication number: 20120082710Abstract: A method for treating acne on the skin. The method has the steps of (a) providing an drapeable or flexible porous article impregnated with an aqueous cleansing composition having a carrier, benzoyl peroxide, and one or more cleansing agents; (b) contacting an area of the skin affected by acne with the porous article such that the skin is contacted by the composition; and (c) removing the composition from the skin wherein residual benzoyl peroxide remains on the skin in an anti-acne effective amount. There are also anti-acne compositions.Type: ApplicationFiled: December 22, 2011Publication date: April 5, 2012Applicant: MEDICIS PHARMACEUTICAL CORPORATIONInventors: Waranush Jitpraphai, Eugene Gans
-
Publication number: 20120064135Abstract: The present invention relates to the preparation of compositions comprising benzoyl peroxide, with or without other additional active ingredients. The process involves introducing benzoyl peroxide, along with any other active ingredients present, into a fatty substance that contains and protects the ingredients that would otherwise be unstable when in contact with one another. The composition is designed to allow all ingredients to become available for skin contact or skin absorption when the fatty substance softens and/or melts as the composition is applied to the skin. The benzoyl peroxide may be pre-micronized to a particle distribution size of about d90 of 0.1 to 150 microns, preferably d90 of 10 to 15 microns.Type: ApplicationFiled: August 16, 2011Publication date: March 15, 2012Applicant: Norac PharmaInventors: Daniel Levin, Arthur Harms
-
Publication number: 20120064136Abstract: The present invention relates to methods for treating, preventing, minimizing, and/or diminishing signs of aging in the skin comprising administering to the subject in need thereof a nanoemulsion composition.Type: ApplicationFiled: September 9, 2011Publication date: March 15, 2012Inventors: James R. Baker, JR., Susan M. Ciotti
-
Patent number: 8129362Abstract: Acne lesions, whether of inflammatory and/or non-inflammatory type, are simultaneously or sequentially treated and their number reduced, via daily topical regimen, with the combination or association of adapalene or pharmaceutically acceptable salt thereof and benzoyl peroxide (BPO).Type: GrantFiled: July 13, 2007Date of Patent: March 6, 2012Assignee: Galderma Research & DevelopmentInventors: Marie-Line Abou Chacra Vernet, Denis Gross, Christian Loesche, Michel Poncet
-
Publication number: 20120015014Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.Type: ApplicationFiled: September 23, 2011Publication date: January 19, 2012Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Noa LAPIDOT, Shlomo Magdassi, David Avnir, Claudi Rottman, Orit Gans, Alon Seri-Levy
-
Publication number: 20110313051Abstract: The present invention is a delivery system comprising a pad and a liquid composition, comprising an insoluble dermatologically active ingredient with a viscosity that permits substantially uniform absorption of the composition onto the pad, and the pad is in then packaged in a sealed container.Type: ApplicationFiled: August 30, 2011Publication date: December 22, 2011Inventors: Bhiku G. Patel, Mohan Vishnupad, Eugene H. Gans, Kuljit S. Bhatia
-
Patent number: 8080537Abstract: Adapalene or a pharmaceutically acceptable salt thereof formulated into a pharmaceutical composition is useful for reducing the number of acne lesions, via daily topical application, in combination or in association with benzoyl peroxide (BPO); such treatment may be via administration of a pharmaceutical composition combining adapalene and BPO or by a concomitant application of two pharmaceutical compositions, one containing adapalene and the other containing BPO.Type: GrantFiled: May 28, 2009Date of Patent: December 20, 2011Assignee: Galderma Research & DevelopmentInventors: Marie-line Abou-Chacra Vernet, Denis Gross, Christian Loesche, Michel Poncet
-
Publication number: 20110306566Abstract: This invention relates to benzoyl peroxide products for skin treatment, and more particularly to a kit containing a benzoyl peroxide product and a topical moisturizing product. In one embodiment the kit contains BenzaClin® brand clindamycin-benzoyl peroxide gel and Viscontour® brand hyaluronic acid serum.Type: ApplicationFiled: August 19, 2011Publication date: December 15, 2011Applicant: SANOFIInventors: Manny MONTALVO, Joanne ROBINETT, David N. WIGLEY
-
Publication number: 20110300083Abstract: Personal care formulations containing alkyl ketal esters having the structure wherein a is 0 or an integer of 1 to 12; b is 0 or 1; R2 is a divalent C1-8 group optionally substituted with up to 5 hydroxyl groups; and R1 is C1-6 alkyl.Type: ApplicationFiled: May 10, 2011Publication date: December 8, 2011Applicant: SEGETIS, INC.Inventors: Dorie J. YONTZ, Lee Richard RIETH, Nicholas MORANTE, Irwin PALEFSKY
-
Patent number: 8071644Abstract: Adapalene or a pharmaceutically acceptable salt thereof formulated into a pharmaceutical composition is useful for reducing the number of acne lesions, via daily topical application, in combination or in association with benzoyl peroxide (BPO); such treatment may be via administration of a pharmaceutical composition combining adapalene and BPO or by a concomitant application of two pharmaceutical compositions, one containing adapalene and the other containing BPO.Type: GrantFiled: January 13, 2009Date of Patent: December 6, 2011Assignee: Galderma Research & DevelopmentInventors: Marie-line Abou-Chacra Vernet, Denis Gross, Christian Loesche, Michel Poncet
-
Publication number: 20110281827Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.Type: ApplicationFiled: May 4, 2011Publication date: November 17, 2011Applicant: FOAMIX LTD.Inventors: Dov TAMARKIN, Elana GAZAL, Yohan HAZOT, David SCHUZ, Irakliy PAPIASHVILI
-
Publication number: 20110274724Abstract: Dermatological/cosmetic gel compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise (i) at least one retinoid, (ii) dispersed benzoyl peroxide and (iii) at least one pH-independent gelling agent, formulated into (iv) a physiologically acceptable medium therefor.Type: ApplicationFiled: May 9, 2011Publication date: November 10, 2011Inventors: Sandrine ORSONI, Nathalie Willcox
-
Patent number: 8039020Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.Type: GrantFiled: June 18, 2010Date of Patent: October 18, 2011Assignee: Sol-Gel Technologies Ltd.Inventors: Noa Lapidot, Shlomo Magdassi, David Avnir, Claudio Rottman, Orit Gans, Alon Seri-Levy
-
Publication number: 20110250153Abstract: Oligomeric acylated biosurfactants (“OABs”) having low critical micelle concentrations of from about 1.0 ppm to about 200 ppm, preferably less than about 50 ppm, in an aqueous solution of Minimal Essential Media that can lower the surface tension in the aqueous MEM environment to less than about 50 dynes/cm2 and have the ability to increase metabolic soluble proteins and/or increase synthesis of extracellular skin matrix proteins and/or increase rates of cell turnover while at the same time exhibiting comparatively low toxicity—preferably, an LD50 of greater 200 ppm in 37 year-old female fibroblast cells. Another aspect of the present invention is directed to the use of OABs in formulations that are topically-applied, by which is meant the formulation is placed in direct contact with the skin, hair and nails as well as mucosa of the eyes, ears, nose, mouth, anus and vagina.Type: ApplicationFiled: May 29, 2009Publication date: October 13, 2011Inventors: Donald R. Owen, Lili Fan
-
Publication number: 20110212157Abstract: The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infection, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) comprising at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pressure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.Type: ApplicationFiled: June 26, 2009Publication date: September 1, 2011Applicant: ANTERIOS, INC.Inventors: Jonathan Edelson, Timothy Kotyla, Boke Zhang
-
Publication number: 20110177951Abstract: The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.Type: ApplicationFiled: August 2, 2009Publication date: July 21, 2011Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Hanan Sertchook, Natalia Loboda, Raed Abu-Reziq
-
Publication number: 20110171193Abstract: Provided herein are methods and materials for treating pulmonary hypertension (PH) in a subject. Also provided herein is a method of diagnosing whether a has PH by detecting a PH marker. A PKG pulmonary hypertension marker has been identified and may be useful in predicting PH disease progression and assessing a subject's response to PH therapy.Type: ApplicationFiled: June 12, 2009Publication date: July 14, 2011Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: You-Yang Zhao, Asrar B. Malik
-
Publication number: 20110144003Abstract: A novel maintenance therapy regime/regimen for the treatment of acne related diseases includes administering an oral antibiotic with a topical fixed-dose combination of a retinoid, such as adapalene, and an anti-bacterial agent, such as benzoyl peroxide.Type: ApplicationFiled: May 20, 2009Publication date: June 16, 2011Inventors: Jean-Charles Dhuin, Nabil Kerrouche, Stéphanie Arsonnaud, Pascale Soto
-
Publication number: 20110135584Abstract: Stable pharmaceutical/cosmetic compositions for topical application, notably for the treatment of acne vulgaris include, formulated into a physiologically acceptable medium, at least one naphthoic acid compound, benzoyl peroxide and at least one film-forming agent, the at least one naphthoic acid compound and the benzoyl peroxide advantageously being in a dispersed form therein.Type: ApplicationFiled: May 27, 2010Publication date: June 9, 2011Applicant: GALDERMA RESEARCH & DEVELOPMENTInventor: Claire MALLARD
-
Publication number: 20110117048Abstract: Composition for application to skin comprising a biocide or combination of biocides (such as chlorhexidine, halogenated phenols, quaternary ammonium compounds; povidone-iodine; zinc pyridinethione; alcohols etc.) and at least one transcutaneous vehicle (for example alkyl methyl sulfoxides, alkyl pyrrolidones, glycols, glycol ethers and glycol esters) effective to convey the biocide to a sub epidermal “resident” micro-organism. Also a method for preparing a patient for surgery comprising the step of treating an area of the patient's skin at, and in the surrounding the vicinity of, the site of an intended surgical incision with a composition effective to kill more than 93% of both “transient” and “resident” micro-organisms.Type: ApplicationFiled: January 20, 2011Publication date: May 19, 2011Applicant: Novapharm Research (Australia) Pty Ltd.Inventor: Steven Kritzler
-
Publication number: 20110092562Abstract: Powder containing benzoyl peroxide is readily wetted by contacting the powder with a liquid containing water and one or more water-soluble organic solvents in a concentration sufficient to reduce the surface tension of the liquid to 64 dynes/cm or less.Type: ApplicationFiled: October 15, 2010Publication date: April 21, 2011Inventor: Gordon Jay Dow