Abstract: A low odor, aqueous, quick acting room temperature disinfectant solution primarily useful for medical instruments to disinfect within a half hour or less. The composition comprises a reacting or synergistic combination of hydrogen peroxide and from about 1% to 30% by weight of a water soluble organic acid or salt form thereof with the acid preferably being selected from the group consisting of malonic and succinic acids.

Abstract: A method of remediating methyl amine and/or methyl amine derivative odors in aqueous systems by contacting the methyl amine or methyl amine derivative with a compound having amide or imide functionality, such as a hydantoin composition, in the presence of hydrogen peroxide. The amide/imide composition is preferably a non-halogenated, singe-ring hydantoin that binds methyl amines to the amide or imide functional group of the hydantoin.

Abstract: Topical application to regions of tissue scarring of a composition comprising several ingredients commonly used in cosmetic products, such as benzoyl peroxide, leads to a reduction and a softening of scar tissue.

Abstract: The present invention provides a composition and method of administering same for inhibiting the growth of microorganisms. The composition of the present invention includes sufficient amounts of a peracetic acid or peracetic acid/peracid blend and a non-oxidizing biocide. The method of the present invention includes the step of adding sufficient amounts of the peracetic acid or peracetic acid/peracid blend and the non-oxidizing biocide to industrial process waters.

Abstract: Compositions for treating acne that contain a peroxide and an antibiotic selected from the lincomycin family are disclosed. In particular, compositions containing benzoyl peroxide and clindamycin are disclosed along with methods of treating acne using these compositions.

Abstract: Method of preserving mineral slurries from microbiological attack comprising introducing a nitrite or TBIP followed by sufficient 3-isothiazolone biocide to protect the slurry from attack. Mineral slurries which are so protected are also disclosed.

Abstract: The acne treatment method of the present invention includes applying to skin a composition including an effective amount of acne treatment medication selected from the group consisting of benzoyl peroxide and salicylic acid, an effective amount of a vasoconstrictor and an inert carrier. The acne treatment medication is therapeutic to acne conditions by acting as an antibacterial agent. The vasoconstrictor removes the redness normally associated with acne conditions as well as additional redness which may be caused by the benzoyl peroxide itself. The carrier is simply an inert flowing carrier to permit the application of the active ingredients to the skin. In preferred embodiments about 1 to 15% of the acne treatment medication based on the total weight of the composition is included. The preferred acne treatment medication is benzoyl peroxide and the preferred vasoconstrictor is tetrahydrozoline hydrochloride or a combination of tetrahydrozoline hydrochloride and zinc sulfate.

Abstract: Gelled vaginal pharmaceutical composition containing:a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.

Abstract: Compositions suitable for the treatment of acne by topical application comprise clindamycin and benzoyl peroxide. Kits for preparing the compositions include a solution of clindamycin in a first container and a gel suspension of benzoyl peroxide in a second container. Each component is stored at a pH which promotes stability, and the combination of the two components provides a final composition having a pH which promotes stability and enhances viscosity.

Abstract: A peroxyacid antimicrobial concentrate and use composition is provided comprising a C.sub.1 to C.sub.4 peroxycarboxylic acid, and a C.sub.6 to C.sub.18 peroxyacid. The combination of these acids produces a synergistic effect, providing a much more potent biocide than can be obtained by using these components separately. Other components can be added to the composition such as hydrotrope coupling agents, stabilizers, etc. An effective antimicrobial use solution is formed at low concentrations when the concentrate composition is diluted with water to a pH in the range of about 2 to 8. Sanitizing of substantially fixed, "in-place" processing lines in dairies, breweries, and other food processing operations is one utility of the composition.

Abstract: The present invention relates to novel biologically-active organic peroxides and to novel uses of both known and new organic peroxides. More specifically, this invention details organic endoperoxides having antiparasitic activity, methods for their preparation and methods for treating malaria and cerebral toxoplasmic encephalitis with the organic endoperoxides.

Abstract: A method for whitening teeth which utilizes laser light to activate bleaching agents applied to the teeth. The mouth is first prepared so that the soft tissues of the gums are protected and only the teeth are exposed. The teeth are cleaned to remove any materials which will reduce or nullify the effects of the bleaching agents. A mixture of peroxide and a first catalyst are prepared and applied to the teeth. The teeth are exposed to laser light from an argon laser which light activates the peroxide and catalyst to accelerate the bleaching process without heat. Next, a mixture of peroxide and a second catalyst are prepared and applied to the teeth. The teeth are briefly exposed to laser light from a carbon dioxide laser which heat activates the peroxide and catalyst to accelerate the bleaching process.

Abstract: A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

Abstract: Method of controlling fresh water mussels of the Dreissenidae family (zebra and quagga mussels) by direct contact with peracetic acid or indirectly by application to an environment where control is desired. The biofouling of environments, such as fresh water intakes, conduits and storage systems of power and water treatment systems, and of processing streams of industrial plants, is thereby reduced or eliminated.

Abstract: The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention.

Abstract: The present invention relates to anti-acne compositions having good efficacy, low skin irritation, and good physical and chemical stability. These compositions comprise a benzoyl peroxide, a wetting agent, water, a non-volatile emollient component which is a liquid at 25.degree. C. and which has a weighted arithmetic mean solubility parameter of less than or equal to about 7, and a water soluble or dispersible gelling agent.

Abstract: Dermatological conditions are treated by topically applying to the affected area an effective amount of a combination benzoyl peroxide and clindamycin composition.

Abstract: Composition and method for the treatment of acne including a peroxide and an antibiotic selected from the lincomycin family of antibiotics.

Abstract: A topical agent and method for the treatment and prevention of pseudofolliculitis barbae, related secondary bacterial infections and other skin conditions associated with shaving result from a combination of three ingredients, namely benzoyl peroxide, camphor oil and aloe vera present in 15:4:1 parts by volume of the composition, respectively.

Abstract: A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of a cephalosporin antibiotic effective to treat the acne and acneiform dermal disorders. The antibiotic is blended with a carrier suitable for topical application to dermal tissues. The carrier is selected from the group consisting of an aqueous liquid, an alcohol base, a water soluble gel, a lotion, an ointment, a nonaqueous liquid base, a mineral oil base, a blend of mineral oil and petrolatum, liposomes, a time-release patch, and a liquid-absorbed wipe. The cephalosporin can also be combined with benzoyl peroxide in a gel carrier.

Abstract: The present invention provides a method of medical treatment for a medical condition in a mammal. In this method, a pharmacologically effective amount for treatment of the condition of a trioxolane or a diperoxide of a non-terpene unsaturated hydrocarbon is applied to the mammal. The invention also provides methods of modulating the immune system in a mammal, of treating inflammation of a tissue in a mammal, and of treating bacterial, fungal, protozoal and viral infections in a mammal.

Abstract: Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy,(CR.sub.1 R.sub.2).sub.p -(CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -C.ident.C-Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

Abstract: A peroxyacid antimicrobial concentrate and use composition is provided comprising a C.sub.1 to C.sub.4 peroxycarboxylic acid, and a C.sub.6 to C.sub.18 peroxyacid. The combination of these acids produces a synergistic effect, providing a much more potent biocide than can be obtained by using these components separately. Other components can be added to the composition such as hydrotrope coupling agents, stabilizers, etc. An effective antimicrobial use solution is formed at low concentrations when the concentrate composition is diluted with water to a pH in the range of about 2 to 8. Sanitizing of substantially fixed, "in-place" processing lines in dairies, breweries, and other food processing operations is one utility of the composition.

Abstract: Open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.

Abstract: A non-gritty brushless, or gel-foam shaving cream composition is provided containing a therapeutically effective amount of benzoyl peroxide. The shaving cream composition can be used in the topical treatment of acne vulgaris, pseudofolliculitis barbae and other skin conditions.

Abstract: A composition for control of cold symptoms comprising 80-90% of 8% strength hydrogen peroxide, 3-7% hammermelis water 3-7% orange flower water, 0.1-0.5% magnesium carbonate, 0.05-0.15% almond essence and 3-6% ethyl alcohol. The composition is applied topically to the nasal mucous whereafter reduction in mucous production is realized.

Abstract: This invention relates to a method for treating or preventing anaerobe infections in humans and lower animals. This invention further relates to compositions and kits containing peroxy acids useful for treating or preventing anaerobe infections according to the method of the present invention.

Abstract: A stable composition and method for cutaneous therapy, particularly for treatment of acne, dermatophyte infection, poison ivy reactions and body odor development. The composition includes benzoyl peroxide particles, water and a solvent for benzoyl peroxide which has a boiling point substantially greater than 100.degree. C. Evaporation of the water leaves a solvent-benzoyl peroxide solution particularly non-irritative and effective in activity against cutaneously abiding microorganisms and contactants characteristic of certain plants.

Abstract: A composition for use an an insulin mimic comprising substances containing:a) vanadate; andb) peroxide.

Abstract: A topical composition comprising LYCD together with known topically active useful medicinal agents such as anti-wrinkling, antibiotic, anticancer, antifungal, antiinflammatory such as anti-acne, antiviral, wound healing, and hair-growing agents. The LYCD works together with the other active agents to achieve a synergistic result more effective than can be obtained from the topical agents individually, and more effective than could be predicted from the mere addition of the known efficacies of the individual ingredients.

Abstract: A novel antimicrobial, aromatic and deodorizing agent composition and a method of reducing microbial concentration or inhibiting microbial growth using the composition are provided, which composition comprises a zeolote or porous glass carrier and a saturated monoterpene hydroperoxide as an active ingredient, the monoterpene hydroperoxide preferably selected from pinane hydroperoxide, thujane hydroperoxide, carane hydroperoxide, bornane hydroperoxide, paramenthane hydroperoxide, metamenthane hydroperoxide, and mixtures of the foregoing, etc.

Abstract: A pharmaceutical and cosmetic composition for topical application comprises in a physiologically acceptable medium a combination of benzoyl peroxide and a quaternary ammonium salt selected from a quaternary ammonium alkyl sulfate of sulfonate, an aryl sulfonate and an alkyl aryl sulfonate.

Abstract: A process and nourishing agent for treating and nourishing the scalp and hair to promote conditions for the natural growth of hair on a human head for the reversal of male pattern baldness in individual cases. The process includes the steps of cleansing the scalp and hair, opening the pores and follicles in the scalp and softening and removing clogging deposits from the pores and hair follicles, and then applying to the scalp a nourishing agent comprising a mixture of chalaza extracted from chicken eggs, unflavored powdered gelatin, and aqueous saline solution. In the preferred form of the invention, the pores of the scalp and hair follicles are opened and sanitized by repeated applications of a benzoic acid mixture and heat, and the clogging deposits and foreign matter are softened and separated by the application of a carbamide peroxide solution and heat.

Abstract: A stable composition and method for cutaneous therapy, particularly for treatment of acne, dermatophyte infection, poison ivy reactions and body odor development. The composition includes benzoyl peroxide particles, water and a solvent for benzoyl peroxide which has a boiling point substantially greater than 100.degree. C. Evaporation of the water leaves a solvent-benzoyl peroxide solution particularly non-irritative and effective in activity against cutaneously abiding microorganisms and contactants characteristic of certain plants.

Abstract: Aqueous solutions of aromatic percarboxylic acids, such as perbenzoic acids, stabilized with at least an equal amount in parts by weight as the amount of aromatic percarboxylic acid of the corresponding aromatic carboxylic acid and an aqueous solution of perglutaric acid stabilized with hydrogen peroxide and/or a 10% to 60% aqueous solution of hydrogen peroxide.

Abstract: A composition absent animal, vegetable and mineral oils, which composition has an oil and water emulsion which includes a volatile oil-like material which evaporates while on a wearer after a period of time. The emulsion also includes basically deionized water and emulsifiers. Further, the composition includes additives such as stabilizers, oil absorbers, modifiers, dispersants, humectants and preservatives. The composition can be changed to be a make-up, therapeutic or enhanced moisture lotion composition.

Abstract: A pharmaceutical or cosmetic composition contains as an active principle a peroxide having an aromatic radical and a saturated group and having the formula ##STR1## wherein R.sub.1 represents linear or branched alkyl having 3 to 17 carbon atoms, substituted or not by one or more halogens, interrupted or not by a carbonyl group and carrying a terminal carboxylic acid group esterified or not or R.sub.1 represents cycloalkyl having 5 to 10 carbon atoms, and R.sub.2 represents hydrogen, halogen, --CF.sub.3, methoxy, ethoxy or acyl having 2 to 16 carbon atoms.The composition is usefully employed in the treatment of various dermatoses including acne.

Abstract: This invention relates to an aqueous gel comprising a specified capped polyether polymer and a surfactant. Preferred capped polyether polymers can be obtained by modifying a conventional polyether polyol with an alpha-olefin epoxide having an average of about 20 to 45 carbon atoms or mixtures thereof.

Abstract: Liquid, aqueous disinfectants based on alcohol and hydrogen peroxide which contain one or more C.sub.2 -C.sub.8 alcohols, hydrogen peroxide or a compound which forms peroxide in aqueous phase, one or more carboxylic acids, one or more microbicidally active nitrogen-containing organic compounds, one or more microbicidally active phenolic compounds, and optionally other active substances and/or auxiliaries typically present in disinfectants, and to the use of such disinfectants for disinfection of the skin and mucous membrane.

Abstract: A composition for use as an insulin mimic comprising substances containing:(a) vanadate; and(b) peroxide.

Abstract: The solubilized benzoyl peroxide is made by mixing a heated combination of crystalline benzoyl peroxide with silicone glycol copolymer wherein the temperature of the mixture is in the range from 45.degree. to 65.degree. C. The benzoyl peroxide is no longer in crystallized form and hence the benzoyl peroxide is solubilized in the silicone glycol copolymer. The cosmetic solution includes a solubilized benzoyl peroxide as described above. Further, an independent mixture of alcohol, acetone and water is made. The solubilized benzoyl peroxide is then mixed with the second mixture (alcohol, acetone and water). The resulting cosmetic solution is very stable and the benzoyl peroxide remains in solution, i.e., an analysis of the cosmetic solution does not show any crystalline benzoyl peroxide. Further, primary irritation tests indicate this solution to be minimally irritating which is important for its use as a vehicle for topical application.

Abstract: A liquid, essentially anhydrous solution of hydrogen peroxide in at least one organic solvent is employed in therapeutic and cosmetic formulations. The solution contains from 1 to 20 weight percent hydrogen peroxide and less than 1 weight percent water. The therapeutic formulation can be used in the treatment of acne, dermatoses, ulcers and in the lightening and disinfection of the skin. The cosmetic formulations can be used in the bleaching or oxidation dyeing of hair or in the neutralization stage of a permanent wave operation or in the straightening of hair.

Abstract: This invention relates to an aqueous gel comprising a specified capped polyether polymer and a surfactant. Preferred capped polyether polymers can be obtained by modifying a conventional polyether polyol with an alpha-olefin epoxide having an average of about 20 to 45 carbon atoms or mixtures thereof.

Abstract: A peroxide having an aromatic radical and an unsaturated group has the formula ##STR1## wherein R represents linear or branched, mono- or polyunsaturated alkenyl having 5 to 21 carbon atoms or cycloalkenyl having 5 to 10 carbon atoms, n is 1 or 2 and R' represents hydrogen, halogen, --CF.sub.3, methoxy, ethoxy or acyl having 2 to 16 carbon atoms.The peroxide is employed in pharmaceutical or cosmetic compositions for the treatment of various dermatoses, and especially for the treatment of acne.

Abstract: A two component disinfecting and cleaning system for contact lenses comprising a first component containing a peroxo compound and an alkyl glucoside and a second component containing an H.sub.2 O.sub.2 -neutralilzing agent and a buffer salt in an amount sufficient to adjust the pH of an aqueous contact lens solution containing the first and second components to about 7.

Abstract: Process and composition for the topical treatment of acne which comprises as ingredients a peroxide of an organic acid and an erythromycin compound selected from the group consisting of erythromycin and its stearate and glucoheptonate derivatives and in which said peroxide is from one-half to thirty times, the weight of said erythromycin compound, and a suitable pharmaceutically acceptable carrier.

Abstract: A composition comprising a unique facial mask containing benzoyl peroxide as its essential active ingredient which provides a surprisingly effective, efficient and acceptable method to control and mitigate acne vulgaris in individuals susceptible thereto.

Abstract: A stabilized clear benzoyl peroxide composition is provided comprising from about 0.1 to about 3.8% by weight anhydrous benzoyl peroxide in C.sub.6 -C.sub.10 triglycerides.

Abstract: A novel compound, and stable compositions thereof for the effective, nonirritating treatment of microbial colonization are disclosed. The compound is used for the topical treatment of affected areas as well as for control of certain diarrheas. The compound is the ozonide of the liquid wax jojoba oil. The ozonide material of the present invention has the ability to release nascent oxygen directly to locales to at least inhibit the microorganisms without the characteristic dryness and skin irritation associated with previous benzoyl peroxide treatments. The compositions are stable, in contrast to the limited shelf-stability of the previously used benzoyl peroxide formulation. This ozonide and products containing same have no tendency to become rancid, which is a problem with other ozonides.

Abstract: A delivery system for delivering topically active ingredients to the skin is provided which delivery system is formed of a water-in-volatile silicone emulsion which includes an interior water phase and an exterior silicone phase which contains the active ingredient to be topically applied. A volatile silicone and a non-ionic lipophilic low HLB emulsifier are employed in forming the emulsion. The above delivery system may be employed together with active ingredients such as sunscreen agents, various topically active drugs, fragrance oils, moisturizers, anti-perspirants, humectants, and other skin care and cosmetic ingredients such as excipients, colorants, preservatives, diluents and the like.