Acyclic Patents (Class 514/722)
  • Patent number: 10392332
    Abstract: The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to compositions comprising these compounds.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: August 27, 2019
    Assignee: MERCK PATENT GmbH
    Inventors: Reiner Friedrich, Gerhard Jonschker
  • Patent number: 10010572
    Abstract: Described herein are compositions and methods of treatment for musculoskeletal pain.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: July 3, 2018
    Inventor: Winston C. V. Parris
  • Patent number: 9980923
    Abstract: A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general anesthesia in a patent. A method of preparation of stable liquid formulations of volatile gas anesthetics is presented, as well as a method for directly testing the concentration of a volatile gas anesthetic in a stable liquid formulation. A kit comprising an amount of a stable liquid formulation of a volatile gas anesthetic, and the non-specialized equipment for administration of the same to a patient, either in an operating room environment or in the field, is also described herein.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: May 29, 2018
    Assignee: University of Miami
    Inventors: Ernesto Pretto, Jr., Camillo Ricordi, Kyota Fukazawa, Antonello Pileggi, Christopher Fraker
  • Patent number: 9655867
    Abstract: The present invention provides compositions useful in reducing or preventing pain in a subject in need thereof. In certain embodiments, the compositions comprise a halogenated volatile compound. The present invention further includes a method of reducing or preventing pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one composition of the invention. Dosing regimens contemplated within the invention include one-time administration, continuous administration or periodic administration.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 23, 2017
    Assignee: Vapogenix, Inc.
    Inventors: Danguole Spakevicius, Heather Giles, Terry Farmer
  • Patent number: 9309451
    Abstract: An azeotropic mixture-like composition containing 1,1,1,3,3,3-hexafluoroisopropylmethylether (HFE-356mmz) and hexafluoroisopropanol (HFIP) is provided. 1,1,1,3,3,3-hexafluoroisopropylmethylether may be contained at a ratio higher than or equal to 0.1% by mass and lower than or equal to 99.9% by mass.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: April 12, 2016
    Assignee: CENTRAL GLASS COMPANY, LIMITED
    Inventors: Yoshio Nishiguchi, Satoru Okamoto, Masatomi Kanai, Takuya Tonomura
  • Patent number: 9308269
    Abstract: A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general anesthesia in a patent. A method of preparation of stable liquid formulations of volatile gas anesthetics is presented, as well as a method for directly testing the concentration of a volatile gas anesthetic in a stable liquid formulation. A kit comprising an amount of a stable liquid formulation of a volatile gas anesthetic, and the non-specialized equipment for administration of the same to a patient, either in an operating room environment or in the field, is also described herein.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 12, 2016
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Ernesto Pretto, Jr., Camillo Ricordi, Kyota Fukazawa, Antonello Pileggi, Christopher Fraker
  • Patent number: 9000048
    Abstract: The present invention provides therapeutic formulations, including therapeutic emulsions and nanoemulsions, and related methods for the delivery of fluorinated therapeutic compounds, including an important class of low boiling point perfluorinated and/or perhalogenated volatile anesthetics. Emulsion-based fluorinated volatile anesthetic formulations compatible with intravenous administration are provided that are capable of delivering and releasing amounts of fluorinated volatile anesthetic compounds effective for inducing and maintaining anesthesia in patients. Intravenous delivery of the present emulsion-based fluorinated volatile anesthetic formulations permits anesthetic levels in a patient to be selectively adjusted very rapidly and accurately without the need to hyperventilate patients and without the use of irritating agents.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: April 7, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Sandro Mecozzi, Robert A. Pearce, Jonathan P. Fast
  • Patent number: 8940943
    Abstract: The invention relates to compounds of the general formula (I), where R1 is a branched alkyl(ene) radical having from 10 to 22 carbon atoms and having at least one branch in position 1, 2, 3 or 4 relative to the oxygen atom, R2 is a linear or branched alkyl(ene) radical having from 1 to 13 carbon atoms and R1 and R2 are selected so that the total number of carbon atoms in formula (I) is from 11 to 23. The compounds of the invention are suitable for preparation of or in cosmetic and/or pharmaceutical preparations, in particular as oily substances.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: January 27, 2015
    Assignee: Cognis IP Management GmbH
    Inventors: Burkhard Beckedahl, Markus Dierker, Rolf Kawa, Stefan Brüning
  • Patent number: 8932615
    Abstract: Implantable devices formed of or coated with a material that includes a polymer having a non-fouling acrylate or methacrylate polymer are provided. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: January 13, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Stephen D. Pacetti
  • Publication number: 20140256828
    Abstract: A stable liquid nanoemulsion of a volatile gas anesthetic, such as, isoflurane or sevoflurane, is disclosed which is effective in inducing and maintaining a state of anesthesia and/or general anesthesia in a patent. A method of preparation of stable liquid formulations of volatile gas anesthetics is presented, as well as a method for directly testing the concentration of a volatile gas anesthetic in a stable liquid formulation. A kit comprising an amount of a stable liquid formulation of a volatile gas anesthetic, and the non-specialized equipment for administration of the same to a patient, either in an operating room environment or in the field, is also described herein.
    Type: Application
    Filed: July 26, 2012
    Publication date: September 11, 2014
    Applicant: University of Miami
    Inventors: Ernesto Pretto, JR., Camillo Ricordi, Kyota Fukazawa, Antonello Pileggi, Christopher Fraker
  • Patent number: 8829053
    Abstract: An antimicrobial composition with synergistic biocidal activity is described which comprises at least one antimicrobial polymeric biguanide and at least one antimicrobial vicinal diol, said vicinal diol comprises at least one monoalkyl glycol, monoalkyl glycerol, or monoacyl glycerol, to diminish or eliminate biofilm communities. Such synergistic interaction is effective in wound treatment, particularly for chronic wounds, burns and battlefield-induced wounds, as well as for disinfecting non-biological surfaces. The antimicrobial composition can also be prepared as viscous solutions or as gels. The antimicrobial composition may be added to a substrate and dried, such as to a catheter, or to a foam, or to a fiber wound dressing, or coated as a viscous solution or gel upon such devices, to provide controlled release antimicrobial activity.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: September 9, 2014
    Assignee: Rochal Industries LLP
    Inventors: Joseph Salamone, Ann Beal Salamone
  • Patent number: 8790673
    Abstract: Methods for treating arthropods comprising depositing at least one drop of a liquid formulation containing at least one surfactant on a solid surface of an arthropod at a contact angle sufficient to cause rapid and enhanced knockdown (KD) of the arthropod. The contact angle comprises an angle formed between a resting drop of the liquid formulation and the solid surface on which the drop rests measured, after a period of about 80 milliseconds (ms) or more from the time that a drop of the liquid formulation is deposited on the solid surface, at a contact point between a tangent line drawn on a liquid/vapor interface surface of the resting drop in contact with the solid surface and a tangent to the solid surface on which the drop rests.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: July 29, 2014
    Assignee: OMS Investments, Inc.
    Inventors: Shannon Hollis, Casey McDonald, Jason Rader
  • Publication number: 20140199373
    Abstract: The present invention provide compositions and methods for treating a dermatological disorder or disease.
    Type: Application
    Filed: June 21, 2012
    Publication date: July 17, 2014
    Applicant: Vapogenix, Inc.
    Inventor: Danguole Spakevicius
  • Publication number: 20140140948
    Abstract: The present invention relates to a method of pre-rinsing laundry and treating other surfaces employing a composition that can kill bedbug eggs. The composition includes an anionic compound and is at pH just above neutral, e.g., about 7 to about 9.
    Type: Application
    Filed: November 20, 2012
    Publication date: May 22, 2014
    Applicant: Ecolab USA Inc.
    Inventors: Kim R. Smith, Erik Olson, Yvonne Killeen, Victor Man, Joelle Olson, Erin Loosbrock
  • Publication number: 20140142196
    Abstract: The present invention relates to a method of pre-rinsing laundry and treating other surfaces employing a composition that can kill bedbug eggs. The composition includes a fatty alcohol and an alcohol ethoxylate.
    Type: Application
    Filed: November 20, 2012
    Publication date: May 22, 2014
    Applicant: Ecolab USA Inc.
    Inventors: Kim R. Smith, Erik C. Olson, Yvonne M. Killeen, Victor F. Man, Joelle F. Olson, Erin F. Loosbrock
  • Publication number: 20140066521
    Abstract: The present invention relates to an antibacterial and/or preserving composition which contains 3-butoxy-1,2-propanediol as a preserving agent. The antibacterial or preserving composition according to the present invention has an excellent resistance to microorganisms and has an excellent moisturizing effect, and hardly causes skin troubles.
    Type: Application
    Filed: November 4, 2011
    Publication date: March 6, 2014
    Applicant: LG HOUSEHOLD & HEALTH CARE LTD.
    Inventors: Min-Ji Gu, Jung-Jin Choi, Gug-In Jeong, Sug-Youn Chang
  • Patent number: 8642663
    Abstract: This invention relates to a new type of insect repellent which contains an acetal as the active component.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: February 4, 2014
    Inventor: Franz Bencsits
  • Patent number: 8641816
    Abstract: Provided are new functionalized surfactants and methods of their preparation and use. The surfactants are compounds of formula I: wherein R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: February 4, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Matthias S. Ober, Edward D. Daugs, Wanglin Yu, Cynthia L. Rand
  • Publication number: 20130287713
    Abstract: A shaving aid composition is provided that includes an organic polyhalogenic agent that both promotes post application foaming and increases lubricity. The shaving aid is optionally used to deliver one or more therapeutics to the skin of a subject and is therefore operable to prevent or treat a skin condition.
    Type: Application
    Filed: October 29, 2010
    Publication date: October 31, 2013
    Inventor: John E. Kulesza
  • Publication number: 20130273141
    Abstract: The present invention provides methods for reducing pain in a subject in need thereof by delivering a volatile anesthetic in a solution or an emulsion that can additionally include an extractive solvent in an amount effective to reduce pain without substantially interfering with motor function. Chronic or acute pain may be treated, or the volatile anesthetic may be delivered as a regional anesthetic to a subject to anesthetize a portion of the subject prior to surgery. Dosing regimes including a one-time administration, continuous and/or periodic administration are contemplated.
    Type: Application
    Filed: December 20, 2012
    Publication date: October 17, 2013
    Inventors: Allen BURTON, Phillip C. PHAN, Hatice OZSOY, Christopher C. CAPELLI
  • Publication number: 20130267571
    Abstract: The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.
    Type: Application
    Filed: September 14, 2011
    Publication date: October 10, 2013
    Applicant: NeuroQuest Inc.
    Inventors: Mark A. Reed, Donald Weaver, Shengguo Sun, Alexander McLellan, Erhu Lu
  • Patent number: 8470861
    Abstract: The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: June 25, 2013
    Assignee: University of Rochester
    Inventors: Marion W. Anders, James L. Robotham, Shey-Shing Sheu, Paul Spencer Brookes, Jalil Shojaie, Leif Olson, Richard L. Parton
  • Patent number: 8436050
    Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: May 7, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Shanta Modak, Trupti A. Gaonkar, Lauser Caraos, Lester Sampath
  • Patent number: 8337824
    Abstract: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
    Type: Grant
    Filed: August 22, 2009
    Date of Patent: December 25, 2012
    Assignee: Relypsa, Inc.
    Inventors: Detlef Albrecht, Michael Burdick, Han-Ting Chang, Dominique Charmot, Ramakrishnan Chidambaram, Eric Connor, Sherin Halfon, I-Zu Huang, Mingjun Liu, Jonathan Mills, Werner Strüver
  • Patent number: 8338481
    Abstract: Disclosed are alkoxyalkyl S-prenylthiosalicylates and pharmaceutical compositions containing the same and a pharmaceutically acceptable carrier. Methods for treating a human afflicted with cancer, including solid tumors, or a hematological malignancy by administering to the human in need thereof an effective amount of an alkoxyalkyl S-prenylthiosalicylate are also disclosed.
    Type: Grant
    Filed: January 20, 2010
    Date of Patent: December 25, 2012
    Assignees: Ramot at Tel-Aviv University Ltd., Kadmon Corporation, LLC
    Inventors: Yoel Kloog, Liat Goldberg, Victor J. Bauer
  • Publication number: 20120316247
    Abstract: Disclosed herein is a method for administering compositions. Also disclosed are kits comprising a compound of formula (I) to (V), or an enantiomer, an analog, a derivative, an isomer, prodrug, or a pharmaceutically acceptable salt thereof, for use in temporal proximity to anesthesia. The methods, compositions and kits provided herein can be used for reducing anesthesia-induced neurotoxicity and post-operative cognitive dysfunction (POCD) in a subject.
    Type: Application
    Filed: October 20, 2010
    Publication date: December 13, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Zhongcong Xie, Rudolph Tanzi
  • Patent number: 8329738
    Abstract: The invention relates to the use of imidazole derivatives of the formula (1): in which A, R?1, R?2 and R?3 are as defined in the description, as AMPK activators. The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them. Certain compounds of the formula (1) are novel and, in this respect, also form part of the invention.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: December 11, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Gerard Moinet, Dominique Marais, Sophie Hallakou-Bozec, Christine Charon
  • Patent number: 8293802
    Abstract: Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: October 23, 2012
    Assignee: The Trustees of Columbia University
    Inventors: Shanta Modak, Trupti A. Gaonkar, Lauserpina Algenio Caraos, Lester Sampath
  • Patent number: 8247450
    Abstract: The present invention is directed to a methods and compositions for enhancing the probability that a subject will become pregnant. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a linoleic acid active agent, e.g., linoleic acid, a polyunsaturated fatty acid analog thereof, etc. Also provided are kits that find use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications, including but not limited to the treatment of infertility conditions.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: August 21, 2012
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee, Albert Cha
  • Publication number: 20120171281
    Abstract: The present invention provides methods for treating inflammation or a wound in a subject in need of such wound treatment or inflammation treatment by delivering a volatile anesthetic to the wound or the inflammation site.
    Type: Application
    Filed: May 5, 2010
    Publication date: July 5, 2012
    Inventors: Danguole Spakevicius, Hatice Ozsoy
  • Patent number: 8115033
    Abstract: Antimicrobially active 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone of the following formula 1 is described, as is a method for producing this compound and the use thereof as an antimicrobial active ingredient.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: February 14, 2012
    Assignee: Symrise AG
    Inventors: Oskar Koch, Gerhard Schmaus
  • Publication number: 20110306676
    Abstract: The present invention relates to a method and an apparatus for treating pain in a patient, such as a veterinary patient. The method comprises the step of administering an inhalation anaesthetic at sub-anaesthetic levels to the patient during an anaesthesia of the patient. A suitable agent may be methoxyflurane.
    Type: Application
    Filed: October 24, 2008
    Publication date: December 15, 2011
    Inventor: Colin Dunlop
  • Publication number: 20110301617
    Abstract: Provided is a system and method for immobilizing and killing a tick on a host, allowing for removal of the tick without triggering of the tick's regurgitation reflex. Further provided are compositions and kits related thereto.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 8, 2011
    Inventor: Gregory P. Bach
  • Publication number: 20110269843
    Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.
    Type: Application
    Filed: July 14, 2011
    Publication date: November 3, 2011
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Phillip C. Phan, Allen W. Burion
  • Patent number: 7981915
    Abstract: This invention features methods for treating diseases associated with mutations in the CFTR gene by administering PPAR agonists, specifically PPAR?, PPAR?, and PPAR? agonists, PPAR inducers, and/or antioxidants. Also disclosed are screening methods for identifying therapeutically useful candidate compounds.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: July 19, 2011
    Assignee: Beth Israel Deaconess Medical Center
    Inventor: Steven D. Freedman
  • Publication number: 20110159078
    Abstract: The present invention provides methods for reducing pain in a subject in need thereof by delivering a volatile anesthetic in a solution or an emulsion that can additionally include an extractive solvent in an amount effective to reduce pain without substantially interfering with motor function. Chronic or acute pain may be treated, or the volatile anesthetic may be delivered as a regional anesthetic to a subject to anesthetize a portion of the subject prior to surgery. Dosing regimes including a one-time administration, continuous and/or periodic administration are contemplated.
    Type: Application
    Filed: January 22, 2009
    Publication date: June 30, 2011
    Applicant: VAPOGENIX, INC
    Inventors: Allen Burton, Phillip C. Phan, Hatice Ozsoy
  • Publication number: 20110137285
    Abstract: A kit of tamponing liquids comprising a first liquid having a density lower than 1.00 g/cm3 and a second liquid having a density higher than 1.00 g/cm3 which are immiscible with water and, at body temperature, one miscible with the other, for sequential use in the surgical treatment of tears and/or detachments of the retina, and a method for the treatment of tears and/or detachments of the retina using such liquids comprising the steps of injecting first the first liquid, or, respectively, the second liquid, into the vitreous cavity and maintaining it within the vitreous cavity for a determined period of time, thereafter injecting the second liquid, or respectively, the first liquid, into the vitreous cavity to mix with the other liquid and create with the latter a homogeneous solution having a density that is higher or lower than 1.00 g/cm3 respectively, if the first injected liquid had a density that was lower or higher than 1.00 g/cm3.
    Type: Application
    Filed: December 3, 2010
    Publication date: June 9, 2011
    Applicant: AL.CHI.MI.A. S.R.L.
    Inventors: Mauro BECCARO, Enrico BETTINI, Paolo SIGNORI
  • Publication number: 20110105507
    Abstract: Provided are new functionalized surfactants and methods of their preparation and use. The surfactants are compounds of formula I: wherein R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 21, 2010
    Publication date: May 5, 2011
    Inventors: Matthias S. Ober, Edward D. Daugs, Wanglin Yu, Cynthia L. Rand
  • Publication number: 20110039944
    Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery, hi certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.
    Type: Application
    Filed: January 22, 2009
    Publication date: February 17, 2011
    Inventors: Christopher C. Capelli, Phillip C. Phan, Allen W. Burton
  • Publication number: 20110020228
    Abstract: A method for the treatment of cancer involves delivering a surface active agent to an organism, where the surface active agent selectively partitions to and kills cancer cells as opposed to healthy cells. The surface active agent can be an ionic or a non-ionic surfactant with a HLB of less than 29 or a mixture of surface active agents with a HLB of less than 40, where the hydrophobic portion is a lesser fraction of the surface active agent than the hydrophilic portion. A fluorescence method of detecting and locating cancer cells in an organism involves delivering a surface active agent, where the surface active agent includes a fluorescence moiety that upon selective partitioning of the surface active agent to the cancer cells and irradiation by a radiation source to excite the fluorescence moiety, a fluorescence emission is observed permitting the detection and location of the cancerous tissue by local volumes of relatively high intensity emission.
    Type: Application
    Filed: February 2, 2009
    Publication date: January 27, 2011
    Applicant: University of Florida Resarch Foundation, Inc.
    Inventors: Brij M. Moudgil, Manoj Varshney, Stephen R. Grobmyer
  • Publication number: 20100330011
    Abstract: Silicone organic gels and gel paste compositions are disclosed containing a silicone organic elastomer in a carrier fluid. The silicone organic elastomer is a reaction product of a linear or branched organohydrogensiloxane, an ?, ?-unsaturated polyoxyalkylene, and a hydrosilylation catalyst. The silicone organic elastomer is particularly useful to ge! organic earner fluids, The gels and gels pastes also provide enhanced compatibility with many personal and health care actives.
    Type: Application
    Filed: June 24, 2008
    Publication date: December 30, 2010
    Inventors: John Joseph Kennan, Kathryn Elizabeth Messner
  • Patent number: 7816409
    Abstract: The present invention has as objective the stabilization of a fluoroether compound against degradation by acid substances. The stabilizers proposed are selected among propylene glycol, polyethylene glycol, hexylene glycol, 1,3-butylene glycol and a saturated cyclic alcohol preferably menthol and are used for preparing stable pharmaceutical compositions of a fluoroether compound. Method for stabilizing a fluoroether compound and use of stabilizers agents for precluding the degradation of a fluoroether are also described.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: October 19, 2010
    Assignee: Cristalia Productos Quimicos Farmaceuticos LTDA
    Inventors: Ogari Pacheco, Elisa Russo, Valter Russo, José Antônio Martins, Maria Alice Bockelmann, Simone Rosatto
  • Patent number: 7767713
    Abstract: The present invention is directed to a methods and compositions for enhancing the probability that a subject will become pregnant. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a linoleic acid active agent, e.g., linoleic acid, a polyunsaturated fatty acid analog thereof, etc. Also provided are kits that find use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications, including but not limited to the treatment of infertility conditions.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: August 3, 2010
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee, Albert Cha
  • Patent number: 7749526
    Abstract: Compounds of formula (I) are described for deterring vermin, wherein R is unbranched or branched C1-C15 alkyl, which is unsubstituted or substituted by halogen, cyano or nitro; R1 and R2 are unbranched or branched C1-C12 alkyl, preferably C1-C6 alkyl, which is unsubstituted or substituted by halogen, cyano or nitro; and X and Y, independently of one another, are a straightchain or branched alkylene bridge with 1 to 20 carbon atoms, preferably an alkylene bridge with 1 to 3 carbon atoms, which is unsubstituted or substituted by halogen, cyano or nitro. Furthermore, an essentially non-therapeutical process for deterring vermin is described, which is based on the usage of these compounds, as well as verminrepellent compositions containing these compounds as the active ingredient, and finally the use of these compounds for producing vermin-deterring compositions and their usage in deterring vermin from animals, humans and objects. New compounds within the scope of formula (I) are also described.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: July 6, 2010
    Assignee: Novartis AG
    Inventors: Thomas Goebel, Tania Cavaliero, Jacques Bouvier
  • Publication number: 20100113570
    Abstract: Methods for the use of uncompetitive NMDA receptor antagonist(s) in inhalational anesthesia are provided herein.
    Type: Application
    Filed: April 23, 2009
    Publication date: May 6, 2010
    Applicants: The General Hospital Corporation, D/B/A MASSACHUSETTS GENERAL HISPITAL
    Inventors: Zhongcong Xie, Rudolph E. Tanzi
  • Patent number: 7709671
    Abstract: The deodorized, polyether-modified polysiloxane composition not producing a substance giving off a foul odor, while being produced or stored, which results from hydrolysis, oxidation or the like of a by-product or unreacted material and temporarily stable, a method for producing the same, and a cosmetic containing the same, wherein a polyether-modified polysiloxane composition, synthesized by hydrosilylation in which a polyoxyalkylene having the carbon-carbon double bond at the terminal is reacted with an organohydrogen polysiloxane, is refined by treatment in the presence of a solid acid.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: May 4, 2010
    Assignee: Dow Corning Toray Co., Ltd.
    Inventors: Kazuhiro Nishijima, Seiki Tamura, Hiroaki Shoji
  • Patent number: 7709515
    Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: May 4, 2010
    Assignee: Esperion Therapeutics, Inc.
    Inventor: Jean-Louis Henri Dasseux
  • Patent number: 7704519
    Abstract: A composition for application to exterior surfaces, such as trees, so as to prevent animal damage to the exterior surface, has asphalt and denatonium benzoate mixed together. The denatonium benzoate is 1% to 50% by weight of the total composition. The asphalt is between 50% and 60% of the total composition. Naphtha and dimethyl ether are further components of the total composition. The composition is sprayable onto the exterior surface.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: April 27, 2010
    Inventor: John Baldwin
  • Publication number: 20100047187
    Abstract: The present invention provides methods of using halogenated volatile compounds, e.g., halogenated ether, for treating a neurological disorder, e.g., Parkinson's disease.
    Type: Application
    Filed: March 17, 2008
    Publication date: February 25, 2010
    Inventor: Thomas G. Hampton
  • Patent number: RE44704
    Abstract: The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: January 14, 2014
    Assignee: Immunogen Inc.
    Inventors: Ravi V. J. Chari, Walter A. Blättler