Ether Doai Patents (Class 514/715)
  • Patent number: 10071035
    Abstract: Use of benzyl alcohol as a defoaming agent and an antimicrobial agent in an oral care composition including a surfactant. Also described is a method of manufacturing an oral care composition including forming an oral care base composition, subsequently combining the oral care base composition with a defoaming agent and at least one surfactant to form the oral care composition; and defoaming the oral care composition. The surfactant is combined with the oral care base composition no later than the defoaming agent. The defoaming agent is benzyl alcohol.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: September 11, 2018
    Assignee: Colgate-Palmolive Company
    Inventors: Shashank Potnis, Shridhara Kamath, Amit Sirdesai, Jigna Lapsia, Rolando Plata, Maya Bhansali
  • Patent number: 9456995
    Abstract: Provided herein are methods for prevention and treatment of ischemia-reperfusion (IR) injury in the cardiac myocytes of a subject, by administration to the subject, a compound of formula I, or a salt, solvate, or stereoisomer thereof, in a sufficient amount either prior to, or during and/or after an ischemic event to mitigate or prevent IR injury to the cardiac tissue. Pharmaceutical compositions including the compound of formula I, or a salt, solvate, or stereoisomer thereof, and/or at least one additional therapeutic agent, are also provided.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: October 4, 2016
    Assignee: The Johns Hopkins University
    Inventors: Ru Chih Huang, Kotohiko Kimura
  • Patent number: 9034916
    Abstract: The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the composition comprises an active ingredient in the form of genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; or a functional food additive for preventing or alleviating a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the additive comprises genkwanin N or yuanhuacine, a Daphne genkwa extract comprising one or more of the above compounds, or a fraction thereof; and a method for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the method comprises the step of administering the pharmaceutical composition.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: May 19, 2015
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Won Gon Kim, Baek Soo Han, Kyoung Shim Kim, Kwang Soo Kim, Young Mi Kang, Yu Jin Kim, Chun Hyung Kim, Mi Jin Sohn, Hoe Yune Jung
  • Patent number: 9029414
    Abstract: The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.
    Type: Grant
    Filed: September 19, 2009
    Date of Patent: May 12, 2015
    Assignee: Biotechnology Research Corporation
    Inventors: Nancy Yuk-Yu Ip, Fanny Chui-Fun Ip, Yueqing Hu
  • Publication number: 20150118172
    Abstract: The present invention relates to the use of at least one dicyclohexylmethanol derivative of the formula (I) as antimicrobial active compound or as anti-acne, antidandruff, deodorant or antiperspirant active compound, to preparations comprising these compounds, and to specific dicyclohexylmethanol derivatives and to a process for the preparation thereof.
    Type: Application
    Filed: April 5, 2013
    Publication date: April 30, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Thomas Rudolph, Tatjana Best
  • Publication number: 20150118165
    Abstract: The present invention relates to the use of at least one cyclohexanol ether derivative of the formula I as antimicrobial active compound or as anti-acne, antidandruff, deodorant or antiperspirant active compound, to preparations comprising these compounds, and to specific cyclohexanol ether derivatives.
    Type: Application
    Filed: April 5, 2013
    Publication date: April 30, 2015
    Applicant: Merck Patent GmbH
    Inventors: Thomas Rudolph, Sylvia Eisenberg
  • Publication number: 20150110901
    Abstract: The present invention relates to a novel use of sesquiterpenoid compounds, the pharmaceutically acceptable salts thereof, or the extracts of Cyperus rotundus comprising same or the fractions thereof in the prevention or treatment of menopausal diseases. The sesquiterpenoid compound according to the present invention, the extracts of Cyperus rotundus comprising the same or fractions thereof exhibit excellent estrogenic activity or anti-allergic activity, and therefore they can be used for the prevention or treatment of menopausal diseases caused by a decline in estrogen level or by allergic diseases.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
    Inventors: Kyu Hyuck CHUNG, Jong Hwan KWAK
  • Patent number: 9006293
    Abstract: The invention provides compositions comprising xanthohumol/cyclodextrin complexes that are water soluble and that have increased stability relative to xanthohumol alone.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: April 14, 2015
    Assignee: Flaxan GmbH & Co. KG
    Inventors: Naoto Yamaguchi, Mitsunori Ono
  • Publication number: 20150098903
    Abstract: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: David R. Elmaleh, Timothy M. Shoup, Hongning Fu
  • Patent number: 8962693
    Abstract: This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: February 24, 2015
    Assignee: Hormos Medical Ltd.
    Inventors: Risto Santti, Tomi Streng
  • Patent number: 8927579
    Abstract: A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: January 6, 2015
    Inventors: Nnae-Meka Ikechukwu Amobi, Christopher Smith
  • Publication number: 20140357725
    Abstract: The present application provides terpene analogues of Formula 1 and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain specifically. wherein: Y is a C1 to C20 alkylene, C?O, SO, SO2, or absent; X is H, OR1, N—(R2)2, a C1 to C20 alkyl, or a heterocyclyl (for example, heteroaryl), wherein when Y is absent X is not H; R1 is H, a C1 to C20 alkyl, or a CH2-aryl; R2 is independently H, a C1 to C20 alkyl, aryl, OR1, CN or C(?O)—R3; R3 is a substituted or unsubstituted C1 to C20 alkyl, or a aryl; W is H, C1 to C20 alkyl, or aryl; and Z is C1 to C20 alkylene; or a pharmaceutically acceptable isomer, salt or ester thereof. These terpene analogues are useful in treating pain and can also be used to treat other electrical disorders in the central and peripheral nervous system.
    Type: Application
    Filed: July 13, 2012
    Publication date: December 4, 2014
    Applicant: NEUROQUEST INC.
    Inventors: Donald F. Weaver, Mark Andrew Reed, Alexander McLellan, Shengguo Sun
  • Patent number: 8895627
    Abstract: The present invention provides an essential oil containing cineole for eliciting tomato resistance to disease by fungal infection. The present invention also provides a method to elicit tomato resistance to disease by fungal infection.
    Type: Grant
    Filed: March 6, 2011
    Date of Patent: November 25, 2014
    Assignee: Ecoflora Agro SAS
    Inventors: Luis F. Echeverri L., James A. Jimenez M., Luis F. Torres
  • Patent number: 8859824
    Abstract: Compounds are provided herein which are coordination complexes of the formula, AxByCit2Fz.mH2O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table; B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions; A and B are different; “Cit” is tribasic citric acid anion; the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0; m is 0-12; and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: October 14, 2014
    Assignee: Mission Pharmacal Company
    Inventors: Mary Ann Walter, Jian Gao, Neill Bailey Walsdorf
  • Patent number: 8841349
    Abstract: A stabilizer composition having (a) one or more 1- or 2-(C1- to C24-alkyl) glycerol ethers (glycerol monoalkyl ethers) and (b) a mixture of at least two different aromatic alcohols (b1, b2) chosen from the groups of i) aryloxyalkanols, ii) arylalkanols and iii) oligoalkanol aryl ethers, where the two different aromatic alcohols belong to different groups i), ii) and iii).
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: September 23, 2014
    Assignee: Air Liquide Sante (International)
    Inventors: Wolfgang Beilfuss, Ralf Gradtke, Petra Kolditz, Klaus Weber
  • Publication number: 20140243404
    Abstract: This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
    Type: Application
    Filed: September 13, 2011
    Publication date: August 28, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Scott Alan Snyder, Daniel S. Treitler, Alexandria P. Brucks, Andreas Gollner, Maria I. Chiriac, Nathan E. Wright, Jason J. Pflueger, Steven P. Breazzano
  • Patent number: 8796326
    Abstract: A fire ant killer chemical composition (the “FAK Composition”) for effective killing of fire ants where the FAK Composition utilizes a minimal amount of active ingredients thereby significantly reducing safety concerns with respect to the use of said active ingredients, the FAK composition having a dish detergent composition and an insecticide composition.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: August 5, 2014
    Inventor: Harold V. Hutchins
  • Patent number: 8784862
    Abstract: The invention concerns oligosaccharides and polysaccharides as well as the use of these oligosaccharides and/or polysaccharides, which contain the sugar unit N-acylglucosamine or N-acylgalactosamine for the production of hemocompatible surfaces as well as methods for the hemocompatible coating of surfaces with said oligosaccharides and/or polysaccharides, which imitate the common biosynthetic precursor substance of heparin, heparan sulphates and chitosan. The invention further describes methods for producing said oligosaccharides and/or polysaccharides and discloses various possibilities of using hemocompatibly coated surfaces. The invention relates particularly to the use of said oligosaccharides and/or polysaccharides on stents with at least one according to invention deposited hemocompatible coating, which contains an antiproliferative, antiinflammatory and/or antithrombotic active agent, methods for the preparation of said stents as well as the use of said stents for the prevention of restenosis.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: July 22, 2014
    Assignee: Hemoteq AG
    Inventors: Roland Horres, Marita Katharina Linssen, Michael Hoffmann, Erika Hoffmann, Donate DiBiase, Volker Faust
  • Patent number: 8778968
    Abstract: A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: July 15, 2014
    Inventors: Nnaemeka Ikechukwu Amobi, Ian Christopher Smith
  • Publication number: 20140193371
    Abstract: A method for preventing and treating one or more disease states including the steps of altering the diet of an individual and then administering a drug to the individual. Plasma vitamin C level is reduced from a first level to a second level that is lower than the first level, such that a pharmacological response of the body of the individual to a drug at the first level is different from the pharmacological response of the body of said individual to the drug at the second level.
    Type: Application
    Filed: January 7, 2014
    Publication date: July 10, 2014
    Inventor: Harold Edward Siess
  • Patent number: 8697103
    Abstract: An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ?99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: April 15, 2014
    Assignee: Deb IP Limited
    Inventors: Marcel Veeger, Markus Himming
  • Patent number: 8658630
    Abstract: The invention provides a means capable of effectively inactivating and removing allergen or a precursor thereof. The invention relates to an allergen-reducing agent containing water and a water-soluble polymer compound having units having hydroxy or carboxy groups wherein at least a part of hydrogen atoms of the hydroxy or carboxy groups are substituted by specific groups containing a polyether group.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: February 25, 2014
    Assignee: Kao Corporation
    Inventors: Satoshi Nagai, Katsuyuki Takano, Masahiro Suzuki, Takeshi Ban, Michio Yokosuka, Takeshi Ihara, Tohru Nishioka
  • Patent number: 8641816
    Abstract: Provided are new functionalized surfactants and methods of their preparation and use. The surfactants are compounds of formula I: wherein R1, R2, and R3 are as defined herein.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: February 4, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Matthias S. Ober, Edward D. Daugs, Wanglin Yu, Cynthia L. Rand
  • Patent number: 8609636
    Abstract: The present invention relates to novel oxime derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: December 17, 2013
    Assignee: Allergan, Inc.
    Inventors: Wenkui K. Fang, Liming Wang, Evelyn G. Corpuz, Ken Chow, Wha-Bin Im
  • Patent number: 8569383
    Abstract: A preparation for creating a clearing feeling in a pharyngeal cavity and nasal cavity comprising a rhinologically active substance of formula (I): In formula (I), variable x and substituents R1, R2 and R3 have the following meanings: x is 0 or 1, R1 denotes an alkyl group having 1 to 4 carbon atoms, R2 denotes a methyl or ethyl group, and R3 denotes a monocyclic saturated carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms. The compound of formula (I) can be mixed with one or more other flavor substances or aroma substances. The preparation can be an oral care composition, such as a toothpaste or a mouth wash.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: October 29, 2013
    Assignee: Symrise AG
    Inventors: Horst Surburg, Arnold Machinek, Hubert Loges
  • Publication number: 20130210775
    Abstract: Provided is an agent for reducing odors of pyrazine derivatives based on an olfactory receptor antagonism. The agent for reducing odors of pyrazine derivatives includes at least one antagonist of olfactory receptor OR5K1 as an active ingredient.
    Type: Application
    Filed: December 4, 2012
    Publication date: August 15, 2013
    Applicant: Kao Corporation
    Inventor: Kao Corporation
  • Publication number: 20130203718
    Abstract: The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.
    Type: Application
    Filed: May 9, 2011
    Publication date: August 8, 2013
    Inventors: Marie-Edith Rafestin-Oblin, Mouad Alami, Hugues Loosfelt, Abdallah Hamze, Ali Junaid Khan, Abdellatif Tikad, Marc Lombes, Jean-Daniel Brion
  • Patent number: 8501821
    Abstract: The present invention provides an essential oil containing cineole for eliciting tomato resistance to disease by fungal infection. The present invention also provides a method to elicit tomato resistance to disease by fungal infection.
    Type: Grant
    Filed: March 6, 2011
    Date of Patent: August 6, 2013
    Assignee: Ecoflora Agro SAS
    Inventors: Luis F. Echeverri L., James A. Jimenez M., Luis F. Torres
  • Patent number: 8487009
    Abstract: The invention provides novel 1,2-diphenylethene derivatives and pharmaceutically acceptable salts thereof, the process for production of these compounds and their pharmaceutical composition and the use of these compounds as modulators of T-cells, neutrophils, macrophages and their associated cytokines as agents for treating immune, inflammatory and auto-immune diseases.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 16, 2013
    Assignee: Glaxo Group Limited
    Inventors: Genhui Chen, John M. Webster, Jianxiong Li, Wei Liu
  • Patent number: 8481600
    Abstract: Disclosed herein are ways to solubilize aspirin for parenteral administration containing aspirin and a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of acute coronary syndromes as well as other disease states. The solution so constituted is stable at room temperature for prolonged periods without decomposition and avoids significant hydrolysis of the aspirin and thus the loss of the anti-platelet action when stored.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 9, 2013
    Assignee: Academic Pharmaceuticals, Inc.
    Inventors: John Charin Somberg, Vasant V Ranade
  • Publication number: 20130123370
    Abstract: Methods of inhibiting the onset and progression of Alzheimer's disease (AD), mild cognitive impairment (MCI), and related neurodegenerative disorders involving amyloidosis are provided. The methods involve administering a composition comprising a therapeutically effective amount of D-pinitol to individuals who are at risk of developing the disease or have one or more symptoms of the disease. Also provided are methods of treating or preventing Alzheimer's disease or MCI that involve the use of such compositions. Also provided are methods of using D-pinitol to promote a healthy nervous system and as a food supplement.
    Type: Application
    Filed: June 1, 2012
    Publication date: May 16, 2013
    Applicant: MOUNT SINAI SCHOOL OF MEDICINE
    Inventor: Giulio M. Pasinetti
  • Patent number: 8435497
    Abstract: The invention relates to pharmaceutical compositions containing combinations of formoterol and ciclesonide and the use of such pharmaceutical compositions in medicine, in particular, the prophylaxis and treatment of respiratory disease.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: May 7, 2013
    Assignee: Takeda GmbH
    Inventors: Klaus Dietzel, Helgert Mueller
  • Patent number: 8431558
    Abstract: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: April 30, 2013
    Assignee: The Regents of the University of California
    Inventors: Carolyn Ruth Bertozzi, Nicholas J. Agard, Jennifer A. Prescher, Jeremy Michael Baskin, Ellen May Sletten
  • Publication number: 20130084257
    Abstract: The present invention provides a substance which promotes the transdermal absorption of a pharmacologically active component while little irritating the skin. The present invention relates to a transdermal absorption promoter which comprises, as the active component, at least one member selected from among isopulegol, 2-(menthoxy)ethanol and 2-methyl-3-(menthoxy)propane-1,2-diol; and an external skin formulation which comprises a pharmacologically active component such as a psychotropic component, an anti-inflammatory component, an analgesic component, an antipyretic component, a whitening component or a hair growth-promoting component, together with the aforesaid transdermal absorption promoter.
    Type: Application
    Filed: June 16, 2011
    Publication date: April 4, 2013
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kenya Ishida, Yasuko Obata, Kozo Takayama
  • Publication number: 20130005807
    Abstract: The objective of the present invention is to provide an antimicrobial composition that can be safely used with a broad range of foods and beverages, cosmetics, drugs, and other similar products while showing growth inhibition activity against a wide variety of microorganisms. The present invention relates to the antimicrobial composition comprising at least one cooling agent selected from the group consisting of menthyl 3-hydroxybutanoate, 2-methyl-3-(menthoxy)propane-1,2-diol, 2-(menthoxy)ethanol, 3-menthoxypropan-1-ol, 2-(2-menthoxyethoxy)ethanol, and menthyl glyoxylate.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kenya ISHIDA, Tomoko YAMAMOTO, Miho SUZUKI
  • Patent number: 8344006
    Abstract: Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: January 1, 2013
    Assignee: Cephalon, Inc.
    Inventors: Anthony S. Drager, Rachel Y. Labell, Piyush R. Patel
  • Publication number: 20120251492
    Abstract: Provided are a triterpene derivative represented by a general formula (I), a pharmaceutically acceptable salt thereof, and an agent for preventing or treating chronic hepatitis C comprising the triterpene derivative or the salt as an active ingredient: [in the formula (I), R1 represents a carboxyl group, a hydroxymethyl group, —CH2OSO3H, or and R2 represents —OR3 or —O— (CH2) m-OR4, where R3 represents a benzyl group which may be substituted with a hydroxymethyl group, a dimethylaminomethyl group, a phenylaminomethyl group, a morpholinomethyl group, a carboxyl group, or a formyl group, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or a hydroxy C1-6 alkyl group, R4 represents a phenyl group which may be substituted with a carboxyl group, and m represents an integer of 1 to 3, with the proviso that a case where R1 is —CH2OH, and R3 is a C1-6 alkyl group, a C2-6 alkenyl group, or a benzyl group is excluded].
    Type: Application
    Filed: December 15, 2010
    Publication date: October 4, 2012
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Makoto Ishikawa, Shigeki Suzuki, Makoto Aoki, Nobuto Minowa, Kokichi Suzuki
  • Patent number: 8193249
    Abstract: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: June 5, 2012
    Assignee: Emory University
    Inventors: Susheng Wang, Dennis C. Liotta, James P. Snyder, Hariharan Venkatesan
  • Patent number: 8192743
    Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: June 5, 2012
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Richard B. Greenwald, Susan L. Adler, legal representative
  • Publication number: 20120129924
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating hyperlipidemia, fatty liver, diabetes and obesity comprising a sesquiterpene derivative as an active ingredient. The sesquiterpene derivatives of the present invention leads to decrease in body fat weight, visceral fat weight and total cholesterol levels, triglyceride of plasma and liver tissue, blood glucose and blood insulin levels in a fast state, finally exhibiting efficacies on prevention or treatment of hyperlipidemia, fatty liver, diabetes and obesity.
    Type: Application
    Filed: October 20, 2008
    Publication date: May 24, 2012
    Applicant: KWANG DONG PHARM. CO., LTD.
    Inventors: Tae-Sun Park, Ha-Won Kim
  • Publication number: 20120087981
    Abstract: A skin engaging member suitable for use in a hair removal device, said skin engaging member comprising an encapsulated active contained in a matrix material, an encapsulated active comprising at least one nano-particle encapsulated in a micro-particle, wherein said nano-particle comprises a shell comprising a hydrophobic material, and wherein said micro-particle comprises a shell comprising a water sensitive material; and wherein at least one of said nano-particle and said micro-particle comprises a skin care active.
    Type: Application
    Filed: October 7, 2011
    Publication date: April 12, 2012
    Inventors: Xiandong Wang, Michael Joseph Kwiecien
  • Publication number: 20120071528
    Abstract: The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.
    Type: Application
    Filed: September 20, 2011
    Publication date: March 22, 2012
    Applicant: KAREUS THERAPEUTICS, SA
    Inventors: Ish Khanna, Sivaram Pillarisetti
  • Patent number: 8124115
    Abstract: An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ?99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: February 28, 2012
    Assignee: DEP IP Limited
    Inventors: Marcel Veeger, Markus Himming
  • Publication number: 20120022168
    Abstract: Disclosed are a pest control agent, a method for preparing a pest control agent, and a method for controlling a pest. Generally, the pest control agent is formed by providing a porous starch and an active control agent absorbed within the porous starch, and compressing the porous starch in the presence of heat to form discrete plural particles. Preferably, one or more binders are employed, as are one or more secondary absorbents/fillers. In highly preferred embodiments of the invention, the pest control agent is prepared via pelletizing in a commercial pellet mill. The particles so prepared should be sufficiently durable to withstand bulk transport, such as by rail car or bag shipment. The particles should, however, release the control agent quickly upon contact with water, such that, for instance, the control agent may be released when the pest control agent is introduced to standing water. It is contemplated that the control agent is preferably a mosquito control agent.
    Type: Application
    Filed: August 23, 2011
    Publication date: January 26, 2012
    Applicant: Grain Processing Corporation
    Inventors: Kevin H. Schilling, Richard E. Castle, Sarjit Johal, Frank W. Barresi, Laura E. Chavez Flores
  • Publication number: 20110294901
    Abstract: An objective of the present invention is to provide a composition that has improved oral absorption and comprises a slightly soluble drug, and to provide a process for producing the same. According to the present invention, there is provided a finely pulverized composition comprising a slightly soluble drug such as 22?-methoxyolean-12-ene-3?, 24(4?)-diol and a hydrophilic surfactant. According to the present invention, there is also provided a process for producing the finely pulverized composition according to the present invention, characterized in that, after the dispersion of a slightly soluble drug and a hydrophilic surfactant in a solvent, the dispersion is pulverized with a high-pressure homogenizer.
    Type: Application
    Filed: January 29, 2010
    Publication date: December 1, 2011
    Inventors: Shigeru Chikase, Dai Kawada
  • Publication number: 20110294725
    Abstract: A method of controlling microorganisms such as lactobacilli metabolism in mash in an ethanol production facility includes adding to the mash an effective amount to control such microorganisms of one or more of a substantially water insoluble pristinamycin-type antimicrobial agent, a substantially water insoluble polyether ionophore antimicrobial agent, or both, wherein the term “substantially water insoluble” means the antimicrobial agent has a solubility in pure water at 20° C. of 0.
    Type: Application
    Filed: May 27, 2011
    Publication date: December 1, 2011
    Applicant: Phibro Animal Health Corporation
    Inventors: David Alan Fowlie, Wayne Mattsfield, Dennis P. Bayrock
  • Publication number: 20110288169
    Abstract: The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.
    Type: Application
    Filed: September 19, 2009
    Publication date: November 24, 2011
    Inventors: Nancy Yuk-Yu Ip, Fanny Chui-Fun Ip, Yueqing Hu
  • Patent number: 8062629
    Abstract: Provided is a hair cosmetic composition which comprises the following components (A) to (D): (A): an organic acid, (B): an organic solvent selected from aromatic alcohols, polyols and carbonates, (C): a cationic surfactant, and (D): a higher alcohol, and water and has a pH ranging from 2 to 6. The hair cosmetic composition has excellent effects for repairing or preventing hair damage caused by coloring, permanent waving or blow drying and features good feeling upon use and luster improving effect.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: November 22, 2011
    Assignee: Kao Corporation
    Inventors: Hiroyuki Terazaki, Masako Ueno
  • Publication number: 20110281945
    Abstract: To provide a drug, quasi-drug, food or drink that can act as a gastric acid secretion suppressant or a potassium channel inhibitor by including a composition that can be safely used and can be inexpensively produced. Each of these products contains one or more cooling sensation compositions that are compounds providing cooling sensation in an amount sufficient for exhibiting the efficacy thereof in a living body to which the product is administered.
    Type: Application
    Filed: January 26, 2010
    Publication date: November 17, 2011
    Inventors: Yuichi Suzuki, Kenya Ishida, Mitsuhiko Fujiwhara
  • Patent number: RE44704
    Abstract: The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: January 14, 2014
    Assignee: Immunogen Inc.
    Inventors: Ravi V. J. Chari, Walter A. Blättler