Benzene Ring Containing Patents (Class 514/730)
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Patent number: 11730685Abstract: Booster oils with stable oil soluble actives are described. The oils are suitable to be combined with end use compositions in order to enhance the compositions efficacy and ensure superior topical benefits to consumers after application.Type: GrantFiled: June 21, 2018Date of Patent: August 22, 2023Inventors: Maria Buchalova, Teanoosh Moaddel
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Patent number: 10336675Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.Type: GrantFiled: December 14, 2016Date of Patent: July 2, 2019Assignee: DSM IP ASSETS B.V.Inventors: Igor Bendik, Piero Geotti-Bianchini, Marc Heidl, Eileen Jackson, Alexander Schlifke-Poschalko
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Patent number: 9999227Abstract: Compositions useful for controlling pests are disclosed. In some embodiments, the composition includes a pesticidal natural oil and a polar aromatic solvent. Methods of making and using the compositions are disclosed.Type: GrantFiled: October 4, 2012Date of Patent: June 19, 2018Assignee: 0903608 B.C. LTD.Inventors: Karan Manhas, Annett Rozek
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Patent number: 9999218Abstract: Compositions useful for controlling pests are disclosed. In some embodiments, the composition includes a pesticidal natural oil and a polar aromatic solvent or an alkyl alcohol solvent. Methods of making and using the compositions are disclosed.Type: GrantFiled: April 8, 2014Date of Patent: June 19, 2018Assignee: 0903608 B.C. LTD.Inventors: Karan Manhas, Annett Rozek
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Patent number: 9457003Abstract: The present invention relates to a composition for preventing or treating a nerve gas-induced disease comprising a phenyl carbamate compound and a method for preventing or treating a nerve gas-induced disease therewith. The present invention ensures the enhancement of neuroprotection, such that it is promising for preventing or treating various diseases caused by exposure to nerve gas.Type: GrantFiled: March 12, 2014Date of Patent: October 4, 2016Assignee: Bio-Pharm Solutions Co., Ltd.Inventor: Yong Moon Choi
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Patent number: 9314428Abstract: The present invention relates to a formulation comprising an endothermic cooling agent selected from the group consisting of xylitol, sorbitol, mannitol and erythritol having a heat of enthalpy between ?10 cal/g and ?100 cal/g, and one or more active agents wherein the endothermic agent is present in the formulation at an amount less than 10% w/w.Type: GrantFiled: October 17, 2008Date of Patent: April 19, 2016Assignee: RECKITT BENCKISER HEALTHCARE (UK) LIMITEDInventors: Kingsley Iyoha, Neil Campbell Muir, Robert Rhoades, Alden Rodwell, David Michael Thurgood
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Patent number: 9060966Abstract: The present invention relates to the use of a compound of Formula (I??) or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of arthritis and pain.Type: GrantFiled: August 15, 2007Date of Patent: June 23, 2015Inventors: Pedro Cuevas Sánchez, Guillermo Gimenez Gallego, Javier Angulo Frutos, Rosa Maria Lozano Puerto, Antonio Romero Garrido, Serafin Valverde Lopez, Maria Luisa Krauel
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Publication number: 20150125407Abstract: The present invention relates to vesicular formulations for use in the topical administration of a biologically active agent, methods of administering a biologically active agent, a combined preparation comprising a vesicular formulation and a kit comprising a vesicular formulation.Type: ApplicationFiled: May 10, 2013Publication date: May 7, 2015Applicant: Sequessome Technology Holdings LtdInventors: William Henry, Richard Wolf Garraway, John Mayo
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Patent number: 9023395Abstract: The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoshell, wherein an active agent is loaded with the nanoshell.Type: GrantFiled: April 11, 2008Date of Patent: May 5, 2015Assignee: University of North Texas Health Science Center at Fort WorthInventors: Arthur R. C. Braden, Jamboor K. Vishwanatha
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Patent number: 9006294Abstract: Disclosed is an oral pharmaceutical formulation of pelubiprofen which is improved in dissolution rate and stability. As a result of an improvement in the dissolution rate of pelubiprofen, the oral pharmaceutical formulation can show high bioavailability and thus exert pharmacological effects thereof rapidly. It also can be stored with high stability as a result of the minimal generation of related compounds.Type: GrantFiled: November 11, 2009Date of Patent: April 14, 2015Assignee: Daewon Pharm., Co., Ltd.Inventors: Joungmin Han, Chankyu Jeoung, Sehhyon Song, Se-il Sohn
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Patent number: 9006293Abstract: The invention provides compositions comprising xanthohumol/cyclodextrin complexes that are water soluble and that have increased stability relative to xanthohumol alone.Type: GrantFiled: February 26, 2009Date of Patent: April 14, 2015Assignee: Flaxan GmbH & Co. KGInventors: Naoto Yamaguchi, Mitsunori Ono
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Patent number: 8993618Abstract: New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting F. assa-foetida with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.Type: GrantFiled: July 21, 2014Date of Patent: March 31, 2015Assignee: Kaohsiung Medical UniversityInventors: Yang-Chang Wu, Fang-Rong Chang, Lien-Chai Chiang
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Publication number: 20150051295Abstract: The invention relates to the use of propanol and propenol derivatives as antioxidants, to compositions comprising propanol and propenol derivatives and the preparation thereof, and to certain propanol and propenol derivatives and the preparation thereof.Type: ApplicationFiled: September 27, 2012Publication date: February 19, 2015Applicant: MERCK PATENT GMBHInventors: Thomas Rudolph, Rene Peter Scheurich
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Patent number: 8946262Abstract: Methods of preventing and treating gastrointestinal dysfunction, particularly postoperative ileus and post-partum ileus, in a patient undergoing surgery or other biological stress by administering 4-aryl-piperidine derivatives are disclosed.Type: GrantFiled: November 29, 2004Date of Patent: February 3, 2015Assignee: Adolor CorporationInventors: David D Christ, Bruce A Wallin, Deanne D Garver, William K Schmidt, David Jackson
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Publication number: 20140364418Abstract: A topical composition providing reduced irritation that contains aromatic alcohols such as phenoxyethanol and a TRPV-1 antagonist is described. The composition is substantially free of parabens. The composition may be used for example for cleansing the skin.Type: ApplicationFiled: May 15, 2014Publication date: December 11, 2014Applicant: Johnson & Johnson Consumer Companies, Inc.Inventors: Slawomir Cebulski, Michelle Garay, Karien J. Rodriguez, Michael D. Southall, Simarna Kaur
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Patent number: 8895628Abstract: A composition including a retinoid, an NF?B-inhibitor, and a cosmetically-acceptable topical carrier is provided. Methods of treating the skin are also provided.Type: GrantFiled: October 25, 2010Date of Patent: November 25, 2014Assignee: Johnson & Johnson Consumer Companies, Inc.Inventor: Thierry Oddos
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Patent number: 8877820Abstract: A composition including a retinoid, an NF?B-inhibitor, and a cosmetically-acceptable topical carrier is provided. Methods of treating the skin are also provided.Type: GrantFiled: February 22, 2013Date of Patent: November 4, 2014Assignee: Johnson & Johnson Consumer Companies, Inc.Inventor: Thierry Oddos
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Patent number: 8877234Abstract: The invention relates to clear, liquid preservatives, which contain a) one or several 1-hydroxy-4-methyl-6-alkyl-2(1H)-pyridones and/or one or several salts thereof, wherein alkyl represents a linear, branched or cyclic alkyl group having 1-12 carbon atoms, and b) one or several alcohols containing one or several aromatic groups.Type: GrantFiled: January 25, 2006Date of Patent: November 4, 2014Assignee: Clariant Finance (BVI) LimitedInventors: Waltraud Simsch, {dot over (P)}eter Klug, Sonja Klein
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Publication number: 20140323457Abstract: The present invention relates to beta-O/S/N fatty acids and derivatives thereof, in particular the compounds of formula (I) as described and defined herein, and their pharmaceutical use, including their use in the treatment or prevention of bacterial as well as protozoan infections, in particular the treatment or prevention of infections with Gram-positive and/or Gram-negative bacteria and infectious diseases caused by and/or related to Gram-positive and/or Gram-negative bacteria. The invention further relates to the use of these compounds for preventing or eliminating biofilms.Type: ApplicationFiled: December 6, 2012Publication date: October 30, 2014Inventors: Thomas Böttcher, Vadim Korotkov, Katrin Lorenz-Baath, Oliver Baron, Stephan Sieber
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Publication number: 20140323586Abstract: Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein R1 and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 represents an alkyl group having 1 to 6 carbon atoms, R4 represents a hydrogen atom, a methyl group or an ethyl group, and a double line composed of a dotted line and a solid line represents a single bond or a double bond.Type: ApplicationFiled: January 4, 2013Publication date: October 30, 2014Applicant: Kao CorporationInventors: Kazuki Kinoshita, Tomohiro Shirai, Kentaro Kumihashi, Hirohisa Fujihara, Nanae Mugita
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Patent number: 8871815Abstract: A (?)-stereoisomer of formula (I): wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.Type: GrantFiled: September 23, 2013Date of Patent: October 28, 2014Assignee: Signature Therapeutics, Inc.Inventor: Thomas E. Jenkins
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Publication number: 20140315792Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.Type: ApplicationFiled: February 14, 2014Publication date: October 23, 2014Inventors: Rolf Wagner, John K. Pratt, Dachun Liu, Michael D. Tufano, David A. DeGoey, Warren M. Kati, Charles W. Hutchins, Pamela L. Dooner, John T. Randolph, Christopher E. Motter, Lissa T. Nelson, Sachin V. Patel, Mark A. Matulenko, Ryan G. Keddy, Tammie K. Jinkerson, Todd W. Rockway, Clarence J. Maring, Douglas K. Hutchinson, Charles A. Flentge, David A. Betebenner, Kathy Sarris, Kevin R. Woller, Seble H. Wagaw, Jean C. Califano, Wenke Li, Daniel D. Caspi, Mary E. Bellizzi, Yi Gao, Allan C. Krueger
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Patent number: 8865721Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.Type: GrantFiled: October 1, 2013Date of Patent: October 21, 2014Assignee: Versi Group, LLCInventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, William Pendergast, Shyi-Tan Jan
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Publication number: 20140296343Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.Type: ApplicationFiled: March 31, 2014Publication date: October 2, 2014Inventors: Frank M. LONGO, Stephen M. MASSA, Sandeep GUPTA
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Patent number: 8846072Abstract: The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.Type: GrantFiled: March 7, 2013Date of Patent: September 30, 2014Assignee: Durect CorporationInventor: A. Neil Verity
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Publication number: 20140242138Abstract: Method for the preparation of microencapsulated essential oils or a formulation thereof for various non-agricultural applications.Type: ApplicationFiled: May 7, 2014Publication date: August 28, 2014Applicant: BOTANOCAP LTD.Inventors: Amnon Kritzman, Arie Markus, Pnina Strongin, Charles Linder
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Patent number: 8815949Abstract: New pharmaceutical compositions extracted from Ferula assa-foetida are confirmed to effectively treat influenza A (H1N1) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting F. assa-foetida with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.Type: GrantFiled: May 7, 2013Date of Patent: August 26, 2014Assignee: Kaohsiung Medical UniversityInventors: Yang-Chang Wu, Fang-Rong Chang, Lien-Chai Chiang
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Patent number: 8808755Abstract: A skin disinfectant in ready-to-use concentrated liquid or dry powdered form. Ready-to-use liquid forms have a pH of from about 2 to about 6 and include: (a) hydrogen peroxide in a concentration of from about 0.01 to about 4% w/w of the solution; (b) at least one surfactant chosen from imidazoline derivatives, alkyl betaines, alkyl amidopropyl betaine amides, alkyl amidopropyl betaines, alkylsulfo betaines, amine oxides and derivatives thereof in a concentration of from about 0.01 to about 15% w/w of the solution; (c) at least one hydrogen peroxide stabilizer in a concentration of from about 0.01 to about 4% w/w of the solution; (d) at least one member chosen from cyclic carboxylic acids and salts thereof in a concentration of from about 0.01 to about 4% w/w of the solution; and (e) at least one skin conditioning agent in a concentration of from about 0.01 to about 10% w/w of the solution.Type: GrantFiled: February 8, 2011Date of Patent: August 19, 2014Assignee: Virox Technologies Inc.Inventor: Navid Omidbakhsh
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Patent number: 8796339Abstract: The present invention relates to a composition comprising or consisting of: (a) one, two or more compounds selected from the group consisting of benzyl alcohol derivatives of the formula (I) wherein each of the substituents R1, R2, and R3 has a position at the aromatic ring, and wherein the substituents R1, R2, and R3 independently of one another are selected from the group consisting of: H; OH; OCH3; COON; linear or branched, saturated aliphatic hydrocarbon radical having 1 to 8 carbon atoms; linear or branched, unsaturated aliphatic hydrocarbon radical having 2 to 8 carbon atoms; COOR4, wherein R4 is a linear or branched alkyl radical having 1 to 8 carbon atoms; wherein the total number of carbon atoms in substituents R1, R2 and R3 is 1 to 12, and (b) one, two or more compounds selected from the group consisting of: (i) branched or unbranched 1,2-alkanediols having 3 to 14 carbon atoms, (ii) benzoic acid (INCI: Benzoic Acid) and its esters and salts, (iii) 4-hydroxybenzoic acid and its esters (Type: GrantFiled: July 10, 2008Date of Patent: August 5, 2014Assignee: Symrise AGInventors: Gerhard Schmaus, Antje Pfeiffer
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Patent number: 8765819Abstract: The present invention relates to the use of low content of benzoic acid and/or sodium salt thereof in combination with one or more organic acid preservatives as active ingredients in the manufacture of a vaginal composition, wherein the composition has weak inhibition effect on normal vaginal lactobacilli while has strong inhibition effect on vaginal fungi and/or pathogenic vaginal lactobacilli, the organic acid preservatives are selected from the group consisting of dehydroacetic acid and/or sodium salt thereof, propionic acid and/or a salt thereof, sorbic acid and/or a salt thereof. The composition of the present invention is particularly useful in inhibiting vaginal fungi, and/or inhibiting pathogenic vaginal lactobacilli, and/or promoting normal vaginal lactobacilli, and/or maintaining normal vaginal acidity, and/or modulating vaginal microecosystem, and/or modulating vaginal microbials, and/or selectively decontaminating vagina.Type: GrantFiled: October 8, 2010Date of Patent: July 1, 2014Inventors: Zhongming Zeng, Ruyun Zhou
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Patent number: 8758822Abstract: The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring.Type: GrantFiled: April 30, 2009Date of Patent: June 24, 2014Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Bong Hyun Chung, Yong Taik Lim, Jung Hyun Han
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Patent number: 8753665Abstract: The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided. Preferably the composition contains bupivacaine and a sugar ester such as saib.Type: GrantFiled: September 15, 2005Date of Patent: June 17, 2014Assignee: Durect CorporationInventor: A. Neil Verity
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Patent number: 8710103Abstract: A method of preserving a cosmetic product by adding to the cosmetic product a concentrate, which may be in anhydrous form, which includes (a) 1-(2-ethylhexyl) glycerol ether, and (b) one or more aromatic alcohols, (a) and (b) having a weight ratio of (a)/(b) is less than or equal to 0.15.Type: GrantFiled: April 11, 2013Date of Patent: April 29, 2014Assignee: Air Liquide Sante (International)Inventors: Wolfgang Beilfuss, Ralf Gradtke, Wolfgang Siegert, Michael Mohr, Klaus Weber
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Publication number: 20140086879Abstract: Disclosed herein is an isolated Muscodor albus strain producing volatile organic compounds such as aristolene, 3-octanone and/or acetic acid ester, as well as cultures of said strain and compositions, metabolites and volatiles derived from said strain or culture as well as methods of obtaining said compositions, metabolites and volatiles and their methods of use for controlling pests. Also disclosed are artificial compositions having the same components and uses as the volatiles derived from the strain. A method for capturing and sampling the volatiles is also disclosed.Type: ApplicationFiled: September 23, 2013Publication date: March 27, 2014Applicant: Marrone Bio Innovations, Inc.Inventors: Gary Strobel, Vu Phong Bui, Hai Su, Phyllis Himmel, Pamela Marrone, Lijuan Xing, Sarah Lewis
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Publication number: 20140080916Abstract: Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods for treatment, inhibition, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.Type: ApplicationFiled: February 1, 2012Publication date: March 20, 2014Applicant: Cognition Therapeutics, Inc.Inventors: Gilbert M. Rishton, Susan Catalano
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Patent number: 8663608Abstract: A hydroxytyrosol polymer formed by either C—C coupling or C—O—C coupling is provided. Preferred polymers are formed by C—C coupling and the dimer has the following structure: Compounds of the invention have been found to have antioxidant properties and their use in antioxidant compositions forms a further aspect of the invention.Type: GrantFiled: September 22, 2010Date of Patent: March 4, 2014Assignee: University of Cape TownInventors: Stephanie Gail Burton, Lester Merlin Davids
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Publication number: 20140039016Abstract: A method of protecting wood through enhanced penetration of wood preservatives includes providing a solution including (a) at least one amine oxide, (b) at least one organic wood preservative and (c) a non-borate buffering based agent. The solution has a pH of 5 to 12.4 and preferably about 7 to 10. The solution is applied to the surface of the wood after which, with or without intervening storage, the materials are activated to effect enhanced penetration of the organic wood preservative into the wood. One may effect application at a solution temperature of about 30° C. to 75° C. and preferably about 50° C. to 60° C. to effect activation at a higher temperature and high relative humidity. In a preferred practice, the wood may be heated before and/or after application of the solution. The solution is also disclosed as a product.Type: ApplicationFiled: October 15, 2013Publication date: February 6, 2014Inventors: ALAN S. ROSS, KENNETH ALLEN CUTLER
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Patent number: 8642599Abstract: Compositions and methods for treatment of Parkinson's disease to reduce the negative side effects of the disease by administering a therapeutically effective diarylmethylpiperazine compound which exhibits delta opioid receptor agonist activity, and optionally, mu receptor antagonist activity.Type: GrantFiled: September 5, 2006Date of Patent: February 4, 2014Assignee: Versi Group, LLCInventors: Kwen-Jen Chang, William Pendergast, Jonathon D. S. Holt
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Patent number: 8637085Abstract: An aqueous disinfecting solution having a pH from about 0.5 to about 6 and consisting essentially of hydrogen peroxide in a concentration from about 0.05 to about 8 w/w % of the total solution; at least one anionic surfactant in a concentration from about 0.02 to about 8 w/w % of the total solution, selected from sulfonated C12 to C22 carboxylic acids and alkali metal, ammonium, calcium and magnesium salts thereof; naphthalene sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; C8 to C22 alkyl sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; and alkyl or alkenyl esters or diesters of sulfosuccinic acids in which the alkyl or alkenyl groups independently contain from six to eighteen carbon atoms and alkali metal, ammonium, calcium and magnesium salts thereof; and benzyl alcohol in a concentration from about 0.1 to about 10 w/w % of the solution.Type: GrantFiled: March 21, 2012Date of Patent: January 28, 2014Assignee: Virox Technologies Inc.Inventors: Jose A. Ramirez, Navid Omidbakhsh
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Publication number: 20140024657Abstract: The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-?) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIII) and by Compounds (1)-(7), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-? induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring necrostatins. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.Type: ApplicationFiled: September 20, 2013Publication date: January 23, 2014Applicant: President and Fellows of Harvard CollegeInventors: Junying YUAN, Emily S. Hsu
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Patent number: 8609642Abstract: The present invention relates to compositions, kits and methods for treating skin at sites of concerns such as infectious lesions and/or points of insertion of an insertable medical device to prevent contamination such as infections or protein absorption that may interfere with the function of the device. The composition can be a topical skin treatment composition that includes polyethylene glycol (PEG), triclosan, one or more of a salicylate, bronopol, and an acrylic emulsion, and, optionally, a solvent.Type: GrantFiled: June 3, 2010Date of Patent: December 17, 2013Assignee: Ex-Tek, LLCInventor: Richard James Whitbourne
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Publication number: 20130331422Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.Type: ApplicationFiled: December 16, 2011Publication date: December 12, 2013Applicant: NEONC Technologies Inc.Inventors: Thomas Chen, Daniel Levin, Satish Puppali, Daniel Anthony Dickman
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Patent number: 8580853Abstract: A soluble aspirin composition, comprising: (i) granules including aspirin, heat-treated bicarbonate salt, pharmaceutically-acceptable resin and surfactant, in mixture with: (ii) crystalline particles of pharmaceutically-acceptable acid; and (iii) crystalline particles of heat-treated bicarbonate salt; wherein the soluble aspirin composition when introduced to water undergoes reaction of the crystalline particles of pharmaceutically-acceptable acid with the heat-treated bicarbonate salt and the aspirin to effect effervescing action and disintegration of the granules with conversion of the aspirin to an acetylsalicylate compound of the bicarbonate salt cation so that the composition rapidly dissolves in the water without occurrence of undissolved residue. The composition is solublizable within 30 seconds in cool to cold water to provide an effervescent analgesic solution that can be readily orally administered to an individual in need of analgesia.Type: GrantFiled: June 13, 2011Date of Patent: November 12, 2013Inventor: Howard Phykitt
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Patent number: 8580861Abstract: The present invention provides preservative compositions suitable for replacing, partially or in totality, conventional preservatives in skin care and hygiene cosmetic or pharmaceutical products. The preservative formulations include an organic carboxylic acid present in a concentration from about 0.01 to about 30 wt./wt. % of the formulation, an alcohol present in a concentration from about 0.01 to about 60 wt./wt. % of the formulation. The formulations include an inorganic salt present in a concentration from about 0.01 to about 80 wt./wt. % of the formulation, and a chelating agent present in a concentration from about 0.01 to about 20 wt./wt. % of the formulation.Type: GrantFiled: August 15, 2008Date of Patent: November 12, 2013Assignee: Pibed LimitedInventors: Pierre Bruno Grascha, Mylene Battut
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Patent number: 8575169Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.Type: GrantFiled: January 2, 2003Date of Patent: November 5, 2013Assignee: Versi Group, LLCInventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, Jr., William Pendergast, Shyi-Tai Jan
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Patent number: 8575400Abstract: A (?)-stereoisomer of formula (I): wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful in the treatment or prevention of nausea and vomiting or for promoting an antiemetic effect.Type: GrantFiled: July 13, 2012Date of Patent: November 5, 2013Assignee: Signature Therapeutics, Inc.Inventor: Thomas E. Jenkins
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Patent number: 8551458Abstract: The invention relates to a composition in the form of an oil-in-water emulsion containing an ester of fatty acid and of polyethylene glycol, an additional surfactant chosen from esters of C16-C22 fatty acid and of sorbitan and esters of C16-C22 fatty acid and of glycerol, a polycondensate of ethylene oxide and of propylene oxide consisting of polyethylene glycol and polypropylene glycol blocks, and a hydroxylated diphenylmethane derivative. The composition has good stability, in particular after 24 hours at 55° C. Application in caring for and making up keratinous substances.Type: GrantFiled: August 12, 2010Date of Patent: October 8, 2013Assignee: L'OrealInventors: Aldo Monello, Melanie Achram
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Patent number: 8551998Abstract: Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.Type: GrantFiled: April 5, 2012Date of Patent: October 8, 2013Assignee: Versi Group, LLCInventors: Kwen-Jen Chang, Klim King, Kestutis P. Biciunas, Robert W. McNutt, Jr., William Pendergast, Shy-Tai Jan
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Patent number: 8545906Abstract: A composition-of-matter comprising a substance usable in producing packaging material and at least one compound selected from the group consisting of ar-turmerone, a sesquiterpene alcohol and a turmeric oleoresin solid residue.Type: GrantFiled: May 31, 2010Date of Patent: October 1, 2013Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Biopack Ltd.Inventors: Shlomo Navarro, Simcha Finkelman, Dov Zehavi, Refael Dias, Sam Angel, Fadel Mansur, Miriam Rindner
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Publication number: 20130231376Abstract: Disclosed are methods of treating and/or preventing infections in mammals caused by microorganisms, by administering to a mammal a therapeutically effective amount of at least one defensin-like molecule, e.g., in a composition that includes such molecule. Also disclosed are the use of such defensin-like molecules for treating and/or preventing infections in mammals; and kits that may include such molecules, or compositions that include such molecules, as well as instructions for using such molecules to treat a mammal.Type: ApplicationFiled: November 4, 2011Publication date: September 5, 2013Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Erik De Leeuw, Alexander D. MacKerell, Jr.