C Of C-o- Group Is Nuclear C Of A Benzene Ring (e.g., Phenol, Phenolate, Etc.) Patents (Class 514/731)
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Patent number: 12144798Abstract: The invention includes an amount of (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate for administering to a subject and also a method of preventing or treating neurotoxicity or neurodegenerative processes in a subject in need thereof using the amount thereof.Type: GrantFiled: June 7, 2022Date of Patent: November 19, 2024Assignee: ANNOVIS BIO, INC.Inventor: Maria Maccecchini
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Patent number: 12034485Abstract: A method, system, and apparatus for a coherent optical breakout; wherein the optical breakout has a laser; wherein the coherent optical breakout has a set of optical connections; wherein the set has at least two optical connections; wherein the coherent optical breakout enables coherent optical communication of X Gbs across each of the set of optical connections.Type: GrantFiled: July 13, 2022Date of Patent: July 9, 2024Assignee: Cisco Technology, Inc.Inventors: Hongbin Zhang, Christian Rasmussen
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Patent number: 11980593Abstract: Disclosed herein are compositions and methods for delivering cannabidiol to subject in need of hypertension treatment. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering the cannabidiol-containing compositions.Type: GrantFiled: July 5, 2022Date of Patent: May 14, 2024Assignee: POVIVA CORP.Inventors: John Docherty, Christopher Andrew Bunka
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Patent number: 11963936Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.Type: GrantFiled: November 30, 2021Date of Patent: April 23, 2024Assignee: University of Florida Research Foundation, Inc.Inventors: Anuj Chauhan, Robert A. Damitz
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Patent number: 11872305Abstract: The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or ?-? unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.Type: GrantFiled: August 26, 2022Date of Patent: January 16, 2024Inventors: Ashish Anilrao Dubewar, Amit Anil Charkha, Sumitra Ashokkumar Pillai, Pradeep Kumar Kare, Kumar Swamy Ummiti, Shanker Mamidi, Mayur Anshiram Adhav
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Patent number: 11839590Abstract: A flurbiprofen axetil emulsion for injection can be prepared by specific stepwise addition of an oil phase to a water phase with shear mixing under the protection of nitrogen gas to obtain an emulsion. The oil phase includes flurbiprofen axetil, an oil phase solvent, an emulsifier, and a stabilizer, and the water phase includes water for injection and/or an osmotic pressure regulator. In the presence of a stabilizer in the oil phase, the emulsion can improve the emulsification effect by using the stepwise emulsifying technique for the oil phase, so that the obtained flurbiprofen axetil emulsion for injection has more uniform particle size, higher drug entrapment efficiency, and better targeting of the drug to the wounded tissue.Type: GrantFiled: January 21, 2019Date of Patent: December 12, 2023Assignee: Grand life science (wuhan) co., LTDInventors: Ling Huang, Xiaohua Zhang, Jinchun Song, Lei Yin
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Patent number: 11826466Abstract: A ready to use or ready to dilute for use, stable liquid Bendamustine solution formed of 90 to about 200 mg/mL Bendamustine Hydrochloride or a hydrate form thereof, and a co-solvent consisting of 1% v/v to 12% v/v water and 88% v/v to 99% v/v N,N-Dimethylacetamide (DMA). The liquid Bendamustine solution is room-temperature stable for at least 90 days. Optionally, 0.01 to about 0.5 mg/mL antioxidant, preferably, butylated hydroxytoluene is included in the solution.Type: GrantFiled: December 3, 2020Date of Patent: November 28, 2023Assignee: Navinta, LLCInventor: Mahendra R. Patel
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Patent number: 11830598Abstract: A computer-implemented method for testing ocular drug delivery is provided. The ocular drug delivery is characterized by a set of delivery parameters comprising at least one of drug type, drug concentration, drug amount, injection position, penetration depth. The method comprises: providing a model for the human eye, wherein the model comprises: a geometry equation defining a three-dimensional generalized limacon for the geometry of the vitreous body, geometry equations describing all components of the eye; and a set of equations defining a drug convection in the vitreous body; setting a target drug state in the vitreous body; using the model to perform at least one simulation of the ocular drug delivery with a given set of values for the set of delivery parameters, wherein the at least one simulation provides a simulated drug state in the vitreous body; comparing the target drug state and the simulated drug state.Type: GrantFiled: April 2, 2019Date of Patent: November 28, 2023Assignee: UNIVERSITÄT HEIDELBERGInventors: Elfriede Friedmann, Simon Dörsam, Vladislav Olkhovskiy
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Patent number: 11785944Abstract: Disinfecting compositions for aerosols and vapors comprising thymol, monoterpenoids, essential oils and/or phenols wherein said compositions are fortified with antimicrobial agents of natural and/or synthetic origin. A method of disinfection of mucous membranes, skin, surfaces and air by using aerosols and vapors comprising thymol, monoterpenoids and/or phenols.Type: GrantFiled: August 29, 2020Date of Patent: October 17, 2023Assignee: INNOTECTInventor: Vijay Duggal
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Patent number: 11591547Abstract: The present invention is directed to biodegradable cleaning compositions, in particular hard surface cleaning compositions, and their use. The compositions according to the invention comprise one or more biosurfactants(s), one or more sorbitan ester(s) and one or more further surfactant(s), which is/are neither a biosurfactant nor a sorbitan ester.Type: GrantFiled: April 26, 2018Date of Patent: February 28, 2023Assignee: Evonik Operations GmbHInventors: Zheng Xue, Andras Nagy, Dennis Parrish, Sam Christy, Jennifer Goodyear, Jeff Davidson
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Patent number: 11534412Abstract: The invention relates to application of totarol for production of a preparation for treatment of vaginal mucous membrane inflammations of bacterial origin, for alleviation of symptoms in such a treatment, and for prophylaxis and prevention of relapses of such inflammations. The invention includes also a pharmaceutical composition for treatment of vaginal mucous membrane inflammations of bacterial origin, for alleviation of symptoms in such a treatment and for prophylaxis and prevention of relapses of such inflammations, the composition containing from 75 to 95 parts by wt. of a cellulose derivative, from 0.5 to 5 parts by wt. of lactic acid, from 0.5 to 5 parts by wt. of a basic polymer, wherein the stoichiometric ratio of lactic acid to the basic polymer is comprised in the range of 1:1 to 8:1, and comprising totarol in an amount of 0.001 to 5 parts by wt. as the active substance.Type: GrantFiled: July 4, 2018Date of Patent: December 27, 2022Assignee: EMERGOPHARM SP. Z O.O. SP.K.Inventors: Mariusz Ciȩciara, Artur Wrzosek
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Patent number: 11364254Abstract: A composition comprising one or more polyphenols, such as oleuropein, rutin, curcumin or quercetin, can treat or prevent sarcopenia, reduce a loss of muscle functionality (e.g. muscle strength, gait speed, etc.), increase muscle functionality, and/or improve recovery of muscle functionality after muscle atrophy. The composition can be administered to an individual who is elderly and/or frail.Type: GrantFiled: September 5, 2019Date of Patent: June 21, 2022Assignee: Societe des Produits Nestle S.A.Inventors: Marie Noelle Horcajada, Fanny Membrez, Denis Breuille, Claire Boutry
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Patent number: 11266621Abstract: Stable methocarbamol ready to use compositions for parenteral administration including parenteral infusion are provided. In certain embodiments, the compositions are sterile, isotonic, and particulate-matter-free. Further, the compositions reduce or avoid allergic reactions to latex, reduce or avoid extravasation, and permit administration of methocarbamol to subjects having renal pathology. Methods of manufacture and methods of administration are also provided.Type: GrantFiled: November 19, 2020Date of Patent: March 8, 2022Assignee: Exela Sterile Medicines LLCInventors: Phanesh B. Koneru, John Maloney
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Patent number: 11219606Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.Type: GrantFiled: October 9, 2014Date of Patent: January 11, 2022Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Anuj Chauhan, Robert A. Damitz
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Patent number: 11207251Abstract: The invention relates to an antimicrobial mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one and chlorphenesin, and also to a cosmetic composition containing such a mixture. Use in caring for, making up and cleansing keratin materials.Type: GrantFiled: June 27, 2018Date of Patent: December 28, 2021Assignee: L'OREALInventors: Gael Malet, Sylvie Cupferman
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Patent number: 11051516Abstract: The present invention relates to antimicrobial sanitizing compositions for use as skin sanitizers, especially sanitizers for the hands and feet, and air sanitizers and deodorisers. The sanitizing compositions comprise a combination of three ammonium compounds (ie. an alkoxy silyl ammonium compound, a benzalknonium chloride or benzethonium chloride and a polymeric biguanide) in a non-ionic surfactant carrier. The non-ionic surfactant system comprises an alcohol ethoxylate and an alkylglucoside or alkylpolyglycoside. Methods of use of the compositions are also described.Type: GrantFiled: March 17, 2015Date of Patent: July 6, 2021Assignee: Global Bioprotect IP Pty LtdInventors: Paul Geoffrey Smyth, Michael Paul Bralkowski
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Patent number: 10835608Abstract: The invention comprises compounds, methods of making, and methods of using. The compounds may have a linear or cylic backbone and three or four appended functional groups: one or two lipohilic compounds including sterols or “fat soluble” vitamins, one or two hydrophilic polymer, and one or two carbohydrate. A group of polymer-carbohydrate conjugates having a central backbone and three appended functional groups are disclosed wherein one lipophilic compound is void of both steroid acids. The conjugate may have fatty acids as the primary lipophilic carrier, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes.Type: GrantFiled: December 5, 2014Date of Patent: November 17, 2020Inventor: Nian Wu
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Patent number: 10568834Abstract: Provided is a novel dilutable delivery systems and propofol microemulsions suitable for intravenous delivery of propofol.Type: GrantFiled: June 29, 2016Date of Patent: February 25, 2020Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Nissim Garti, Sharon Garti Levi, Abraham Aserin, My Perlstein
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Patent number: 10537534Abstract: The present invention provides compositions, methods and kits for treating acne and other skin conditions influenced by C. acnes, which combine administration of low levels of at least one substituted resorcinol and blue light to skin in need of treatment for such conditions.Type: GrantFiled: June 25, 2019Date of Patent: January 21, 2020Assignee: Johnson & Johnson Consumer Inc.Inventors: Ali Fassih, Kelly A. Lewis, Davide Miksa, Christina Roberts, Michael D. Southall
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Patent number: 10450295Abstract: This invention relates to methods of reversing and inhibiting liver fibrosis and hepatitis using a small indolinone molecule Hesperadin and related compounds. Methods of identifying such agents and using them to inhibit the expression of collagens and ECM proteins including MMPs and TIMPs in purified hepatic stellate cells are provided. In vivo data of Hesperadin in inhibiting induced collagen production are presented. This method of specifically targeting drugs to hepatic stellate cells in vivo, provides a novel therapy for liver diseases.Type: GrantFiled: August 9, 2013Date of Patent: October 22, 2019Assignee: Acclaim BioMed USA LLCInventors: Kenneth Ka-Ho Lee, Stanton Hon-Lung Kok, Tsz-Wai Kok, Sing-Wan Wong, John Yeuk-Hon Chan
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Patent number: 10226498Abstract: The present invention relates to a phytocomplex or natural concentrate rich in polyphenolic compounds, such as hydroxytyrosol and 3,4-DHPA-EDA, derived from the vegetation waters of oil-bearing olives or from olive pomace resulting from the olive milling process for use in the treatment and prevention of angiogenesis and inflammation. In particular, the angiogenesis and inflammation to which reference is made is pathologic angiogenesis and inflammation, for example that which sustains the development and spread of a tumor or angiogenesis and inflammation tied to non-tumor pathologies. The present invention further relates to a beverage comprising the polyphenol concentrate and the use thereof in the treatment and prevention of angiogenesis and inflammation.Type: GrantFiled: October 31, 2014Date of Patent: March 12, 2019Assignee: FATTORIA LA VIALLA DI GIANNI, ANTONIO E BANDIDO LO FRANCO —SOCIETA' AGRICOLA SEMPLICEInventors: Gianni Lo Franco, Adriana Albini, Massimo Pizzichini, Teresa Rossi, Antonino Bruno, Arianna Pagani
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Patent number: 10143663Abstract: The invention relates to a food additive which includes at least one clay interspersed with volatile antimicrobial agents. Such an additive can be added to the feed of certain animals, in particular poultry and ruminants, in order to act as a growth promoter and to reduce the risks of infection, as well as the risks of intoxication by mycotoxins.Type: GrantFiled: January 25, 2018Date of Patent: December 4, 2018Assignee: ADNANE REMMALInventor: Ahmed Reda Chami
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Patent number: 9901550Abstract: The invention relates to a food additive which includes at least one clay interspersed with volatile antimicrobial agents. Such an additive can be added to the feed of certain animals, in particular poultry and ruminants, in order to act as a growth promoter and to reduce the risks of infection, as well as the risks of intoxication by mycotoxins.Type: GrantFiled: December 31, 2013Date of Patent: February 27, 2018Inventor: Adnane Remmal
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Patent number: 9872499Abstract: The invention provides a virus-inactivating composition with pH of 3.8 to 5.5, containing (A) 0.02 to 0.3 M arginine and (B) a component such as 0.01 to 10 mM flavonoid, polyphenol, or ascorbic acid derivative, 0.005 to 5 mass % of an arginine derivative, and 0.1 to 2.5 mass % of an extract solution of natural product.Type: GrantFiled: August 22, 2012Date of Patent: January 23, 2018Assignee: AJINOMOTO CO., INC.Inventors: Daisuke Ejima, Haruna Sato, Hajime Koyama, Tsutomu Arakawa
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Patent number: 9724311Abstract: Curcumin compositions herein are described for improving muscle performance, endurance capacity and resistance to fatigue, when administered in effective amounts to a subject in need of such improvement. The compositions are comprised of curcumin and at least one pharmaceutically and/or nutraceutically acceptable excipient such as a hydrophilic carrier and exhibit enhanced bioavailability. More particularly methods are described and include use of curcumin compositions to increase exercise time, performance and capacity and to prevent muscle soreness, fatigue and injury. The compositions enhance mitochondrial biogenesis by modulating mitochondrial function, increasing mitochondrial mass and oxygen consumption, thus increasing mitochondrial aerobic capacity. The compositions reduce oxidative muscle stress, by decreasing inflammatory cytokines and inflammatory markers.Type: GrantFiled: April 17, 2015Date of Patent: August 8, 2017Assignee: OmniActive Health Technologies LimitedInventors: Jayant Deshpande, Vijaya Juturu
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Patent number: 9532947Abstract: A formulation for oral transmucosal administration of at least one active principle with antispasmodic and/or analgesic effect, including the active principle in base form and/or in salt form, an aqueous alcohol solution titrating at least 35° alcohol by weight, the active principle being present in a state of stable and complete dissolution in the aqueous alcohol solution. Also, a method of preparing this formulation and its use for treating spastic crises.Type: GrantFiled: January 12, 2010Date of Patent: January 3, 2017Inventors: Philippe Perovitch, Marc Maury
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Patent number: 9522194Abstract: Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand-drug conjugates were active in vitro and in vivo in inhibiting cell proliferation and are represented by the general structure of Lv-[(LU)0-1-(D)1-4]p wherein L- is Ligand unit; LU is a Linker unit (LU); v is 1; p is an number ranging from about 1 to about 20; and D is a drug moiety having the formula: wherein the moiety —N(R9)Z1 is a phenylalanine bioisostere, wherein Z1 is —CH(R10)Z2 so that the phenylalanine bioisostere has the structure of Formula A: and wherein the substituents R2-R10, X1 and Z2 are as defined.Type: GrantFiled: September 30, 2014Date of Patent: December 20, 2016Assignee: Seattle Genetics, Inc.Inventors: Svetlana O Doronina, Toni Beth Kline, Scott Jeffrey, Peter D Senter, Damon Meyer
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Patent number: 9474701Abstract: The present invention relates to antimicrobial formulations containing carvacrol and at least one of the following 2-phenoxyethanol, caprylyl glycol and hexylene glycol.Type: GrantFiled: September 9, 2015Date of Patent: October 25, 2016Assignee: HYDROMER, INC.Inventors: Manfred F. Dyck, Silke von Dyck, Eric Becktel, Irina Grigorian
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Patent number: 9422254Abstract: A pharmaceutical composition of fungicide including at least a compound represented by Formula (I). The pharmaceutical composition of fungicide can further include an emulsifier, a cosolvent, a stabilizer, and a solvent. The fungicide can prevent and treat powdery mildew, downy mildew, gray mold, brown spot, scab of vegetables and fruits, southern leaf blight of corn, rice false smut, citrus stem-end rot, and rape sclerotinia rot, with high efficiency, low toxicity, and relative environmental friendliness. A method of preparing the fungicide and a method of using thereof are also provided.Type: GrantFiled: July 27, 2010Date of Patent: August 23, 2016Assignee: Central China Normal UniversityInventors: Guangfu Yang, Peiliang Zhao, Wei Huang, Zuming Liu, Hualong Wu
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Patent number: 9364002Abstract: The present invention provides compounds and compositions for attracting or repelling sap-sucking insects, such as whitefly, as well as methods for using such compositions.Type: GrantFiled: September 25, 2008Date of Patent: June 14, 2016Assignee: Keygene N.V.Inventors: Petronella Martina Bleeker, Kai Ament, Paul Johan Diergaarde, Michiel Theodoor Jan De Both, Robert Cornelis Schuurink
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Patent number: 9358216Abstract: Methods and formulations for infusing bioavailable resveratrol tinctures into food, beverage, cosmetic or drug products with minimal effect on the alcohol by volume of the product is provided. A resveratrol tincture includes an amount of trans-resveratrol mixed with a solvent of pure, or majority by weight, ethanol. The tincture is added to various food and beverages to make a bioavailable amount of trans-resveratrol to be absorbed and metabolized by the body providing demonstrated health benefits.Type: GrantFiled: July 31, 2015Date of Patent: June 7, 2016Assignee: Heart Healthy Spirits, LLCInventors: Jeffrey J Keaffaber, Kim A. Popejoy
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Patent number: 9357771Abstract: Foaming formulations including a quaternary ammonium compound and a foam stabilizer are disclosed. These foaming formulations are useful as leave-on liquid hand and surface sanitizers. The foaming formulations provide improved aesthetic properties and foaming appearance, while maintaining high antimicrobial capacity.Type: GrantFiled: December 17, 2012Date of Patent: June 7, 2016Assignee: KIMBERLY-CLARK WORLDWIDE, INC.Inventors: Jeffery Richard Seidling, Corey Thomas Cunningham
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Patent number: 9345733Abstract: A supplement composition for supporting telomere maintenance and protection, including effective amounts of extract of silybum marianum; N-acetylcysteine; Resveratrol; Extract of Panax ginseng; Extract of Ginkgo biloba; Puerarin; and L-arginine. Further disclosed is a method for supporting telomere maintenance and protection, comprising orally administering a supplement composition to a person one or twice daily, said supplement composition comprising in one dosage: from about 100 mg to about 300 mg of extract of silybum marianum, from about 400 mg to about 600 mg of N-acetylcysteine, from about 40 mg to about 60 mg of trans-resveratrol, from about 80 mg to about 120 mg of extract of Panax ginseng, from about 40 mg to about 60 mg of extract of ginkgo biloba, and from about 80 mg to about 120 mg of puerarin, and from about 400 mg to about 600 mg of L-arginine.Type: GrantFiled: September 13, 2012Date of Patent: May 24, 2016Assignee: CELLHEALTH TECHNOLOGIES LTD.Inventors: Vincent C. Giampapa, David B. Cross
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Patent number: 9243009Abstract: Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y?C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.Type: GrantFiled: October 13, 2010Date of Patent: January 26, 2016Assignees: West China Hospital, Sichuan University, Yichang Humanwell Pharmaceutical Co., Ltd.Inventors: Wensheng Zhang, Jun Yang, Jin Liu
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Patent number: 9222055Abstract: The present invention relates to a high intensity fragrance composition for use in a cosmetic, toiletry, personal care, personal cleansing product or adsorbent article, which comprises by weight: a) 75% to 100% of at least 2 fragrance ingredients where each fragrance ingredients must contain only atoms of carbon, hydrogen, oxygen and nitrogen, comprise an ester functional group, an alcohol functional group or an aldehyde functional group, have boiling points between 100° C. and 300° C. at a pressure of 760 mm of mercury, have molecular weights within the range of 70 atomic mass units to 175 atomic mass units, and have ClogP values between 0.00 and 4.00; b) 0 to 25% of an essential oil; and c) 0 to 25% of a fragrance ingredient other than the fragrance ingredients in category a), wherein the sum of a), b) and c) equals 100%.Type: GrantFiled: March 3, 2010Date of Patent: December 29, 2015Assignee: TAKASAGO INTERNATIONAL CORPORATIONInventors: Stuart Fraser, Dominique Gindre, Jonathan Warr
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Patent number: 9155700Abstract: Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 ?m, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.Type: GrantFiled: December 21, 2011Date of Patent: October 13, 2015Assignee: CHIESI FARMACEUTICI S.p.A.Inventors: Celestino Ronchi, Giancarlo Ceschel
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Patent number: 9144577Abstract: The present invention relates to the field of viral disorders, and in particular to viral obesity. Compositions comprising nutraceutical agents are provided for treating viral obesity. Additionally, compositions comprising nutraceutical agents targeting adenoviruses are provided.Type: GrantFiled: May 30, 2014Date of Patent: September 29, 2015Assignee: LIFE SCIENCE NUTRITION ASInventors: Jan Remmereit, Ken Johnson
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Patent number: 9132090Abstract: The invention is a sterile pharmaceutical composition for parenteral administration comprised of an oil-in-water emulsion, in which Propofol is dissolved in a water-immiscible lipophilic agents, and surface stabilizing amphiphilic agent, and tonicity modifying water-soluble hydroxy group and preservative preferably, lipophilic organic compound (butylated hydroxytoluene, butylated hydroxyanisole) or its pharmaceutically acceptable salts thereof.Type: GrantFiled: November 17, 2009Date of Patent: September 15, 2015Inventors: Chetan Majmudar, Pradeep Chakravarty Mahadasyam, Minesh Suthar
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Publication number: 20150140127Abstract: Provided is a method for detecting injury to the brain comprising: a) determining the level of a tight junction (TJ) protein in exosomes isolated from a test sample from a subject, wherein the TJ protein is occludin, claudin-3, claudin-5, claudin-12, ZO-1, ZO-2, ZO-3, JAM-A, JAM-B or JAM-C, or any combination thereof; b) comparing the level of the TJ protein in the test sample to the level of the TJ protein in a control sample, wherein an elevated level of the TJ protein in the test sample relative to the level of the TJ protein in the control sample indicates that the subject has an injury to the brain.Type: ApplicationFiled: June 25, 2013Publication date: May 21, 2015Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONInventors: Servio H. Ramirez, Slava Rom, Yuri Persidsky
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Patent number: 9018237Abstract: The present disclosure relates to compositions for and methods of improving wound healing, including compositions for and methods of treating chronic wounds, and compositions for the inhibition and treatment of necrosis and extended quiescence that result in cellular necrosis instead of normal proliferation. The methods for wound healing administer one or more compositions including hydroxytyrosol and oleuropein with cells derived from umbilical cord blood.Type: GrantFiled: July 11, 2014Date of Patent: April 28, 2015Inventor: Darlene E. McCord
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Publication number: 20150111918Abstract: Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves proximate a vessel or duct of an immune system organ using an intravascularly or intraluminally positioned therapeutic element. One or more measurable physiological parameters corresponding to an immune system disorder, a condition associated with sympathetic activity in an immune system organ, or a condition associated with central sympathetic activity in the patient can thereby be reduced.Type: ApplicationFiled: March 7, 2013Publication date: April 23, 2015Inventors: Paul Sobotka, Neil Barman
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Patent number: 9006215Abstract: The invention relates to a pharmaceutical formulation that contains a complex of a propofol salt with a cyclodextrin. The invention makes it possible to provide propofol in a formulation that can be stored and that can be administered intravenously without problems.Type: GrantFiled: March 1, 2012Date of Patent: April 14, 2015Inventors: Norbert Roewer, Jens Broscheit
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Patent number: 9000049Abstract: The present invention relates to the cosmetic use, by the oral route, of a combination of lycopene, of vitamin C, of vitamin E and of at least one polyphenol compound derived from pine bark as active ingredient intended for maintaining and/or restoring the biomechanical properties of keratinous materials, and notably of the skin.Type: GrantFiled: December 3, 2009Date of Patent: April 7, 2015Assignee: Laboratories Inneov SNCInventors: Patricia Manissier, Christiane Montastier, Antoine Piccirilli
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Patent number: 8999399Abstract: The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds.Type: GrantFiled: November 14, 2009Date of Patent: April 7, 2015Assignee: Bose Chemie GmbHInventors: Thomas Lisowsky, Sven Eggerstedt, Richard Bloss, Christiane Ostermeyer, Karlheinz Esser, Frank Bürger, Barbara Krug, Yvonne Feil, Kai-Martin Mueller, Delphine Haase
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Publication number: 20150096067Abstract: A fish feed includes carvacrol and/or salvia extract (provided that where the fish feed comprises carvacrol and not salvia extract the lipid content of the fish feed is at least 15 wt %). The salvia extract may be selected from extract of Salvia officinalis and extract of Salvia lavandulifolia. The carvacrol may be synthetic or may be extracted from Origanum vulgare.Type: ApplicationFiled: December 9, 2014Publication date: April 2, 2015Applicant: TROUW INTERNATIONAL B.V.Inventors: Wolfgang KOPPE, Alex OBACH, Ramon FONTANILLAS
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Patent number: 8993636Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues.Type: GrantFiled: October 25, 2013Date of Patent: March 31, 2015Assignee: Alcon Pharamceuticals, Ltd.Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, John M. Yanni
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Publication number: 20150087723Abstract: A synergistic microbicidal composition containing: (a) at least one microbicide selected from the group consisting of isopropyl methyl phenols and monosubstituted phenols and (b) at least antimicrobial alcohol is selected from the class consisting of acyclic terpene alcohols.Type: ApplicationFiled: December 5, 2012Publication date: March 26, 2015Applicant: ROHM AND HAAS COMPANYInventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
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Publication number: 20150086421Abstract: The present invention relates to a method of disinfecting a surface and to an antibacterial composition. Essential oils, which are used as antibacterial actives, are also known for their strong odour; using high amounts of these gives a strong smell to the product that is not always appreciated by the consumer. It is therefore an object of the invention to provide an antibacterial composition, having good anti-bacterial properties, at very low levels of essential oil actives. The present inventors have achieved this using a synergistic combination of select anti-bacterial actives, specific polymers and select hydrotropes.Type: ApplicationFiled: November 19, 2012Publication date: March 26, 2015Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Sujatha Jayaraman, Shanthi Appavoo, Sameer Keshav Barne, Maya Treesa Saji
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Patent number: 8987335Abstract: In one aspect, the invention relates to substituted (E)-N?-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: August 15, 2012Date of Patent: March 24, 2015Assignee: University of Utah Research FoundationInventors: Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Bret Stephens, David J. Bearss, Sunil Sharma
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Publication number: 20150079182Abstract: A topical composition which includes a silica microspheres and an active ingredient in the amount of 0.01 to 15.0% w/w wherein the active ingredient is selected from adapalene, an antibiotic, tazarotene, tretinoin, a retinoid, or any combination thereof. The topical composition may also include benzoyl peroxide as an active ingredient. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.Type: ApplicationFiled: November 24, 2014Publication date: March 19, 2015Inventors: Marina Shevachman, Amira Ze' Evi, Eilon Asculai, Batella Binyaminovich, Nir Avram