C Of C-o- Group Is Nuclear C Of A Benzene Ring (e.g., Phenol, Phenolate, Etc.) Patents (Class 514/731)
  • Patent number: 10226498
    Abstract: The present invention relates to a phytocomplex or natural concentrate rich in polyphenolic compounds, such as hydroxytyrosol and 3,4-DHPA-EDA, derived from the vegetation waters of oil-bearing olives or from olive pomace resulting from the olive milling process for use in the treatment and prevention of angiogenesis and inflammation. In particular, the angiogenesis and inflammation to which reference is made is pathologic angiogenesis and inflammation, for example that which sustains the development and spread of a tumor or angiogenesis and inflammation tied to non-tumor pathologies. The present invention further relates to a beverage comprising the polyphenol concentrate and the use thereof in the treatment and prevention of angiogenesis and inflammation.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: March 12, 2019
    Assignee: FATTORIA LA VIALLA DI GIANNI, ANTONIO E BANDIDO LO FRANCO —SOCIETA' AGRICOLA SEMPLICE
    Inventors: Gianni Lo Franco, Adriana Albini, Massimo Pizzichini, Teresa Rossi, Antonino Bruno, Arianna Pagani
  • Patent number: 10143663
    Abstract: The invention relates to a food additive which includes at least one clay interspersed with volatile antimicrobial agents. Such an additive can be added to the feed of certain animals, in particular poultry and ruminants, in order to act as a growth promoter and to reduce the risks of infection, as well as the risks of intoxication by mycotoxins.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: December 4, 2018
    Assignee: ADNANE REMMAL
    Inventor: Ahmed Reda Chami
  • Patent number: 9901550
    Abstract: The invention relates to a food additive which includes at least one clay interspersed with volatile antimicrobial agents. Such an additive can be added to the feed of certain animals, in particular poultry and ruminants, in order to act as a growth promoter and to reduce the risks of infection, as well as the risks of intoxication by mycotoxins.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: February 27, 2018
    Inventor: Adnane Remmal
  • Patent number: 9872499
    Abstract: The invention provides a virus-inactivating composition with pH of 3.8 to 5.5, containing (A) 0.02 to 0.3 M arginine and (B) a component such as 0.01 to 10 mM flavonoid, polyphenol, or ascorbic acid derivative, 0.005 to 5 mass % of an arginine derivative, and 0.1 to 2.5 mass % of an extract solution of natural product.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: January 23, 2018
    Assignee: AJINOMOTO CO., INC.
    Inventors: Daisuke Ejima, Haruna Sato, Hajime Koyama, Tsutomu Arakawa
  • Patent number: 9724311
    Abstract: Curcumin compositions herein are described for improving muscle performance, endurance capacity and resistance to fatigue, when administered in effective amounts to a subject in need of such improvement. The compositions are comprised of curcumin and at least one pharmaceutically and/or nutraceutically acceptable excipient such as a hydrophilic carrier and exhibit enhanced bioavailability. More particularly methods are described and include use of curcumin compositions to increase exercise time, performance and capacity and to prevent muscle soreness, fatigue and injury. The compositions enhance mitochondrial biogenesis by modulating mitochondrial function, increasing mitochondrial mass and oxygen consumption, thus increasing mitochondrial aerobic capacity. The compositions reduce oxidative muscle stress, by decreasing inflammatory cytokines and inflammatory markers.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: August 8, 2017
    Assignee: OmniActive Health Technologies Limited
    Inventors: Jayant Deshpande, Vijaya Juturu
  • Patent number: 9532947
    Abstract: A formulation for oral transmucosal administration of at least one active principle with antispasmodic and/or analgesic effect, including the active principle in base form and/or in salt form, an aqueous alcohol solution titrating at least 35° alcohol by weight, the active principle being present in a state of stable and complete dissolution in the aqueous alcohol solution. Also, a method of preparing this formulation and its use for treating spastic crises.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: January 3, 2017
    Inventors: Philippe Perovitch, Marc Maury
  • Patent number: 9522194
    Abstract: Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand-drug conjugates were active in vitro and in vivo in inhibiting cell proliferation and are represented by the general structure of Lv-[(LU)0-1-(D)1-4]p wherein L- is Ligand unit; LU is a Linker unit (LU); v is 1; p is an number ranging from about 1 to about 20; and D is a drug moiety having the formula: wherein the moiety —N(R9)Z1 is a phenylalanine bioisostere, wherein Z1 is —CH(R10)Z2 so that the phenylalanine bioisostere has the structure of Formula A: and wherein the substituents R2-R10, X1 and Z2 are as defined.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: December 20, 2016
    Assignee: Seattle Genetics, Inc.
    Inventors: Svetlana O Doronina, Toni Beth Kline, Scott Jeffrey, Peter D Senter, Damon Meyer
  • Patent number: 9474701
    Abstract: The present invention relates to antimicrobial formulations containing carvacrol and at least one of the following 2-phenoxyethanol, caprylyl glycol and hexylene glycol.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: October 25, 2016
    Assignee: HYDROMER, INC.
    Inventors: Manfred F. Dyck, Silke von Dyck, Eric Becktel, Irina Grigorian
  • Patent number: 9422254
    Abstract: A pharmaceutical composition of fungicide including at least a compound represented by Formula (I). The pharmaceutical composition of fungicide can further include an emulsifier, a cosolvent, a stabilizer, and a solvent. The fungicide can prevent and treat powdery mildew, downy mildew, gray mold, brown spot, scab of vegetables and fruits, southern leaf blight of corn, rice false smut, citrus stem-end rot, and rape sclerotinia rot, with high efficiency, low toxicity, and relative environmental friendliness. A method of preparing the fungicide and a method of using thereof are also provided.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: August 23, 2016
    Assignee: Central China Normal University
    Inventors: Guangfu Yang, Peiliang Zhao, Wei Huang, Zuming Liu, Hualong Wu
  • Patent number: 9364002
    Abstract: The present invention provides compounds and compositions for attracting or repelling sap-sucking insects, such as whitefly, as well as methods for using such compositions.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: June 14, 2016
    Assignee: Keygene N.V.
    Inventors: Petronella Martina Bleeker, Kai Ament, Paul Johan Diergaarde, Michiel Theodoor Jan De Both, Robert Cornelis Schuurink
  • Patent number: 9357771
    Abstract: Foaming formulations including a quaternary ammonium compound and a foam stabilizer are disclosed. These foaming formulations are useful as leave-on liquid hand and surface sanitizers. The foaming formulations provide improved aesthetic properties and foaming appearance, while maintaining high antimicrobial capacity.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: June 7, 2016
    Assignee: KIMBERLY-CLARK WORLDWIDE, INC.
    Inventors: Jeffery Richard Seidling, Corey Thomas Cunningham
  • Patent number: 9358216
    Abstract: Methods and formulations for infusing bioavailable resveratrol tinctures into food, beverage, cosmetic or drug products with minimal effect on the alcohol by volume of the product is provided. A resveratrol tincture includes an amount of trans-resveratrol mixed with a solvent of pure, or majority by weight, ethanol. The tincture is added to various food and beverages to make a bioavailable amount of trans-resveratrol to be absorbed and metabolized by the body providing demonstrated health benefits.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: June 7, 2016
    Assignee: Heart Healthy Spirits, LLC
    Inventors: Jeffrey J Keaffaber, Kim A. Popejoy
  • Patent number: 9345733
    Abstract: A supplement composition for supporting telomere maintenance and protection, including effective amounts of extract of silybum marianum; N-acetylcysteine; Resveratrol; Extract of Panax ginseng; Extract of Ginkgo biloba; Puerarin; and L-arginine. Further disclosed is a method for supporting telomere maintenance and protection, comprising orally administering a supplement composition to a person one or twice daily, said supplement composition comprising in one dosage: from about 100 mg to about 300 mg of extract of silybum marianum, from about 400 mg to about 600 mg of N-acetylcysteine, from about 40 mg to about 60 mg of trans-resveratrol, from about 80 mg to about 120 mg of extract of Panax ginseng, from about 40 mg to about 60 mg of extract of ginkgo biloba, and from about 80 mg to about 120 mg of puerarin, and from about 400 mg to about 600 mg of L-arginine.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: May 24, 2016
    Assignee: CELLHEALTH TECHNOLOGIES LTD.
    Inventors: Vincent C. Giampapa, David B. Cross
  • Patent number: 9243009
    Abstract: Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y?C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: January 26, 2016
    Assignees: West China Hospital, Sichuan University, Yichang Humanwell Pharmaceutical Co., Ltd.
    Inventors: Wensheng Zhang, Jun Yang, Jin Liu
  • Patent number: 9222055
    Abstract: The present invention relates to a high intensity fragrance composition for use in a cosmetic, toiletry, personal care, personal cleansing product or adsorbent article, which comprises by weight: a) 75% to 100% of at least 2 fragrance ingredients where each fragrance ingredients must contain only atoms of carbon, hydrogen, oxygen and nitrogen, comprise an ester functional group, an alcohol functional group or an aldehyde functional group, have boiling points between 100° C. and 300° C. at a pressure of 760 mm of mercury, have molecular weights within the range of 70 atomic mass units to 175 atomic mass units, and have ClogP values between 0.00 and 4.00; b) 0 to 25% of an essential oil; and c) 0 to 25% of a fragrance ingredient other than the fragrance ingredients in category a), wherein the sum of a), b) and c) equals 100%.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: December 29, 2015
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Stuart Fraser, Dominique Gindre, Jonathan Warr
  • Patent number: 9155700
    Abstract: Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 ?m, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: October 13, 2015
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Celestino Ronchi, Giancarlo Ceschel
  • Patent number: 9144577
    Abstract: The present invention relates to the field of viral disorders, and in particular to viral obesity. Compositions comprising nutraceutical agents are provided for treating viral obesity. Additionally, compositions comprising nutraceutical agents targeting adenoviruses are provided.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: September 29, 2015
    Assignee: LIFE SCIENCE NUTRITION AS
    Inventors: Jan Remmereit, Ken Johnson
  • Patent number: 9132090
    Abstract: The invention is a sterile pharmaceutical composition for parenteral administration comprised of an oil-in-water emulsion, in which Propofol is dissolved in a water-immiscible lipophilic agents, and surface stabilizing amphiphilic agent, and tonicity modifying water-soluble hydroxy group and preservative preferably, lipophilic organic compound (butylated hydroxytoluene, butylated hydroxyanisole) or its pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: September 15, 2015
    Inventors: Chetan Majmudar, Pradeep Chakravarty Mahadasyam, Minesh Suthar
  • Publication number: 20150140127
    Abstract: Provided is a method for detecting injury to the brain comprising: a) determining the level of a tight junction (TJ) protein in exosomes isolated from a test sample from a subject, wherein the TJ protein is occludin, claudin-3, claudin-5, claudin-12, ZO-1, ZO-2, ZO-3, JAM-A, JAM-B or JAM-C, or any combination thereof; b) comparing the level of the TJ protein in the test sample to the level of the TJ protein in a control sample, wherein an elevated level of the TJ protein in the test sample relative to the level of the TJ protein in the control sample indicates that the subject has an injury to the brain.
    Type: Application
    Filed: June 25, 2013
    Publication date: May 21, 2015
    Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Servio H. Ramirez, Slava Rom, Yuri Persidsky
  • Patent number: 9018237
    Abstract: The present disclosure relates to compositions for and methods of improving wound healing, including compositions for and methods of treating chronic wounds, and compositions for the inhibition and treatment of necrosis and extended quiescence that result in cellular necrosis instead of normal proliferation. The methods for wound healing administer one or more compositions including hydroxytyrosol and oleuropein with cells derived from umbilical cord blood.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: April 28, 2015
    Inventor: Darlene E. McCord
  • Publication number: 20150111918
    Abstract: Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves proximate a vessel or duct of an immune system organ using an intravascularly or intraluminally positioned therapeutic element. One or more measurable physiological parameters corresponding to an immune system disorder, a condition associated with sympathetic activity in an immune system organ, or a condition associated with central sympathetic activity in the patient can thereby be reduced.
    Type: Application
    Filed: March 7, 2013
    Publication date: April 23, 2015
    Inventors: Paul Sobotka, Neil Barman
  • Patent number: 9006215
    Abstract: The invention relates to a pharmaceutical formulation that contains a complex of a propofol salt with a cyclodextrin. The invention makes it possible to provide propofol in a formulation that can be stored and that can be administered intravenously without problems.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: April 14, 2015
    Inventors: Norbert Roewer, Jens Broscheit
  • Patent number: 8999399
    Abstract: The invention relates to a novel combined disinfection and decontamination agent comprising at least one vitamin, at least one metal ion, at least one active-surface compound, and at least one further antimicrobial active substance. The agent according to the invention surprisingly shows nearly complete nucleic acid disintegration in addition to an improved disinfectant effect. The agent can be successfully used as a combined decontamination and disinfection agent for skin, mucous membranes, hands, wounds, and/or hair, and instruments and surfaces of all kinds.
    Type: Grant
    Filed: November 14, 2009
    Date of Patent: April 7, 2015
    Assignee: Bose Chemie GmbH
    Inventors: Thomas Lisowsky, Sven Eggerstedt, Richard Bloss, Christiane Ostermeyer, Karlheinz Esser, Frank Bürger, Barbara Krug, Yvonne Feil, Kai-Martin Mueller, Delphine Haase
  • Patent number: 9000049
    Abstract: The present invention relates to the cosmetic use, by the oral route, of a combination of lycopene, of vitamin C, of vitamin E and of at least one polyphenol compound derived from pine bark as active ingredient intended for maintaining and/or restoring the biomechanical properties of keratinous materials, and notably of the skin.
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: April 7, 2015
    Assignee: Laboratories Inneov SNC
    Inventors: Patricia Manissier, Christiane Montastier, Antoine Piccirilli
  • Publication number: 20150096067
    Abstract: A fish feed includes carvacrol and/or salvia extract (provided that where the fish feed comprises carvacrol and not salvia extract the lipid content of the fish feed is at least 15 wt %). The salvia extract may be selected from extract of Salvia officinalis and extract of Salvia lavandulifolia. The carvacrol may be synthetic or may be extracted from Origanum vulgare.
    Type: Application
    Filed: December 9, 2014
    Publication date: April 2, 2015
    Applicant: TROUW INTERNATIONAL B.V.
    Inventors: Wolfgang KOPPE, Alex OBACH, Ramon FONTANILLAS
  • Patent number: 8993636
    Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: March 31, 2015
    Assignee: Alcon Pharamceuticals, Ltd.
    Inventors: Gerald Cagle, Robert L. Abshire, David W. Stroman, John M. Yanni
  • Publication number: 20150086421
    Abstract: The present invention relates to a method of disinfecting a surface and to an antibacterial composition. Essential oils, which are used as antibacterial actives, are also known for their strong odour; using high amounts of these gives a strong smell to the product that is not always appreciated by the consumer. It is therefore an object of the invention to provide an antibacterial composition, having good anti-bacterial properties, at very low levels of essential oil actives. The present inventors have achieved this using a synergistic combination of select anti-bacterial actives, specific polymers and select hydrotropes.
    Type: Application
    Filed: November 19, 2012
    Publication date: March 26, 2015
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventors: Sujatha Jayaraman, Shanthi Appavoo, Sameer Keshav Barne, Maya Treesa Saji
  • Publication number: 20150087723
    Abstract: A synergistic microbicidal composition containing: (a) at least one microbicide selected from the group consisting of isopropyl methyl phenols and monosubstituted phenols and (b) at least antimicrobial alcohol is selected from the class consisting of acyclic terpene alcohols.
    Type: Application
    Filed: December 5, 2012
    Publication date: March 26, 2015
    Applicant: ROHM AND HAAS COMPANY
    Inventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
  • Patent number: 8987335
    Abstract: In one aspect, the invention relates to substituted (E)-N?-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: March 24, 2015
    Assignee: University of Utah Research Foundation
    Inventors: Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Bret Stephens, David J. Bearss, Sunil Sharma
  • Publication number: 20150079182
    Abstract: A topical composition which includes a silica microspheres and an active ingredient in the amount of 0.01 to 15.0% w/w wherein the active ingredient is selected from adapalene, an antibiotic, tazarotene, tretinoin, a retinoid, or any combination thereof. The topical composition may also include benzoyl peroxide as an active ingredient. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 19, 2015
    Inventors: Marina Shevachman, Amira Ze' Evi, Eilon Asculai, Batella Binyaminovich, Nir Avram
  • Publication number: 20150072012
    Abstract: A highly bioavailable, water soluble, sustained release nanoformulation comprising a hydrophobic plant derived compound(s) in an emulsifier phase, and aqueous phase. The formulation provides sustained release of the hydrophobic plant derived compound(s) over a 24 hr time period. A process for preparation of the water soluble nanoformulation is described.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 12, 2015
    Inventors: Ravichandran SRIPATHY, Venkata Narasimha Siva Rama Raju MANDAPATI, Gopaal AJAY, Nirvanashetty SOMASHEKARA, Ramchand Nanappan CHANIYILPARAMPU, Rama Raju GOKARAJU, Ganga Raju GOKARAJU, Kiran BHUPATHIRAJU, Dwarakanath ANJANA
  • Publication number: 20150065945
    Abstract: Methods for treating a patient using therapeutic spinal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves of one or more targeted organs proximate one or more dorsal root ganglia, stellate ganglia, vertebral ganglia, or cervical ganglia of the nerves using an intravascularly-positioned therapeutic element. One or more measurable physiological parameters corresponding to at least one condition associated with sympathetic activity in the targeted organs and/or central sympathetic activity in the patient can thereby be reduced.
    Type: Application
    Filed: March 7, 2013
    Publication date: March 5, 2015
    Inventors: Denise Zarins, Sean Ward
  • Publication number: 20150064283
    Abstract: The invention comprises various aqueous PEG-carbohydrate-lipid based formulations of pharmaceutical active ingredients including compositions for intravenous injections. This invention relates to methods and compositions for improving solubility and the safety profile of pharmaceutical compounds. More particularly, the present invention relates to employing PEG-carbohydrate-lipid conjugates for formulating drug compositions having increased solubility or dispersivity and enhanced stability.
    Type: Application
    Filed: November 7, 2014
    Publication date: March 5, 2015
    Inventor: Nian Wu
  • Patent number: 8968755
    Abstract: The invention provides skin-protecting and penetrating, easy-to-administer base and active agent-containing compositions, such as those including hydrocortisone, for treating the skin of mammals for different dermatologic disorders. This is effected by topically administering effective amounts of the compositions thereto in forms that address the skin and mucosa of the mouth and lips, and the rest of the body. Additionally, an optional flavoring addition to these products affords significantly better tasting, and less bitter, compositions, allowing a more pleasant experience and better compliance by patients. The compositions include a unique formulation of FANCOL VB, Natunola Castor 1023, Finsolv TN, bees wax and, optionally, one or a plurality of plant or plant seed oils, fatty alcohols, fats and flavorings, in desirable weight percents thereof, in various forms, and preferably in a form of a solid roll-on stick in a variety of sizes and of a jar or pot.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: March 3, 2015
    Inventors: Joel Schlessinger, Daniel Isaac Schlessinger
  • Patent number: 8969407
    Abstract: At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected from among active agents for combating desquamative conditions of the scalp, plant extracts having propigmenting activity and active agents that slow hair loss and/or promote hair regrowth, are useful for preventing and/or limiting and/or stopping the development of canities.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 3, 2015
    Assignee: L'Oreal
    Inventor: Stephane Commo
  • Publication number: 20150056298
    Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
    Type: Application
    Filed: October 31, 2014
    Publication date: February 26, 2015
    Inventors: Bobak Robert Azamian, Scott Bradley Vafai
  • Patent number: 8962694
    Abstract: Compositions suitable for the control of pest amphibian species are described. More particularly, compositions for killing amphibians are described that comprise: (i) a xylenol compound or derivative according to formula (I) wherein R1, R2, R3, R4 and R5 are each independently selected from hydrogen, hydroxyl, halogen, —NH3 and C1-6 alkyl, and —R6—NH2, —R6—ONH2, —R6—NO2, and —R6—PO4, wherein R6 is C1-6 alkyl, and X is selected from hydrogen, halogen and C1-6 alkyl, or a salt thereof, and (ii) ethanol and optionally, (iii) methanol and/or at least one C3-6 alcohol. Methods for killing amphibians include contacting the amphibian with said compositions. Kits are described wherein said xylenol compounds and ethanol and optionally methanol and/or at least one C3-6 alcohol may be administered simultaneously or sequentially.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: February 24, 2015
    Assignee: Pestat Pty Ltd.
    Inventors: David James Dall, Joan Dawes
  • Patent number: 8962696
    Abstract: The invention provides a method and a composition for enhancing the dissolution and bioavailable properties of propofol (2, 6 diisopropyl phenol) for use as an intravenously administered anesthetic in mammals. The method produces a self-microemulsifyable emulsion base composition that is utilized in the production of a water-based microemulsion preparation. In a preferred two (2) component base composition, the base composition consists of: a surfactant, containing polyethylene glycol; and liquid propofol. The microemulsion is prepared by mixing the base composition with a carrier liquid, which results in the formation of a microemulsion containing concentrations of propofol of up to about 4% by weight of propofol to the volume of the microemulsion. In a four (4) component base composition, the base composition consists of: a surfactant, containing polyethylene glycol; liquid propofol; a water-immiscible solvent; and ethanol.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: February 24, 2015
    Assignee: Medos, Inc.
    Inventors: Steven B. Harris, Nick J. Huang
  • Publication number: 20150051297
    Abstract: The present invention relates to a method for disinfection involving an antimicrobial composition. It particularly relates to an antimicrobial method for personal cleaning, oral care or hard surface cleaning applications. It was found that compositions comprising thymol, acyclic terpene alcohols and a carrier provide synergistic antimicrobial action in a method for disinfection. In a preferred aspect the composition also comprises 1 to 80%-wt of one or more surfactants.
    Type: Application
    Filed: December 5, 2012
    Publication date: February 19, 2015
    Applicant: ROHM AND HAAS COMPANY
    Inventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
  • Publication number: 20150051298
    Abstract: A method for producing stable nanoemulsions having a desired droplet size and functional properties tailored for use in a specific application (which is referred to as substantially optimizing composition) that includes selecting an aqueous phase; the aqueous phase comprising at least one ingredient from water, surfactant, co-surfactant and co-solvent, the aqueous phase being selected such that a stable nanoemulsions having a desired droplet size and functional properties tailored for use in a specific application is obtained, and selecting an organic phase comprising at least two ingredients from lipophilic component, oil, surfactant, co-surfactant and cosolvent, the organic phase being selected such that a stable nanoemulsions having a desired droplet size and functional properties tailored for use in a specific application is obtained, a nanoemulsion being formed when the organic phase is mixed with the aqueous phase.
    Type: Application
    Filed: August 13, 2014
    Publication date: February 19, 2015
    Inventors: David J. McClements, Amir H. Saberi, Yuhua Chang, Lynne McLandsborough
  • Publication number: 20150050220
    Abstract: The present invention relates to an antimicrobial composition and a method for disinfection involving the antimicrobial composition. It particularly relates to an antimicrobial composition for personal cleaning, oral care or hard surface cleaning applications. It was found that compositions comprising thymol, p-menthene alcohols and a carrier provide synergistic antimicrobial action. In a preferred aspect the composition also comprises 1 to 80%-wt of one or more surfactants.
    Type: Application
    Filed: December 5, 2012
    Publication date: February 19, 2015
    Inventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
  • Patent number: 8952071
    Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: February 10, 2015
    Assignee: Edison Pharmaceuticals, Inc.
    Inventors: Andrew W. Hinman, Kieron E. Wesson
  • Publication number: 20150038576
    Abstract: A composition includes a liquid. The liquid aerosolizes for delivery to a user by an airway. The liquid includes an agent that activates a TRPV3 channel. The agent includes a terpenoid compound.
    Type: Application
    Filed: August 1, 2014
    Publication date: February 5, 2015
    Applicant: SENTIENS, LLC
    Inventors: Inna S. Timokhina, Reid von Borstel, Dennis Tan, John Siverling
  • Patent number: 8945596
    Abstract: The present invention relates to an antimicrobial composition. It particularly relates to an antimicrobial composition for cleansing or personal care. It is an object of the present invention to provide antimicrobial compositions that have relatively fast antimicrobial action. Present inventors have surprisingly found that compositions comprising selected ingredients, namely thymol and terpineol, in selective proportions provide relatively quick antimicrobial action.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: February 3, 2015
    Assignee: Conopco, Inc.
    Inventors: Amit Chakrabortty, Srilaxmi Venkata Medepalli
  • Publication number: 20150025152
    Abstract: A pharmaceutical formulation for treatment of shingles is provided. The formulation includes between 0.2 mg of menthol per 120 mL of the formulation and 1.0 mg of menthol per 120 mL of the formulation, camphor water, lime water, and a local anesthetic. The local anesthetic includes one of between 0.6 mL of phenol per 120 mL of the formulation and 2.0 mL of phenol per 120 mL of the formulation and between 0.25% concentration by weight of lidocaine and 5% concentration by weight of lidocaine.
    Type: Application
    Filed: July 16, 2014
    Publication date: January 22, 2015
    Inventors: Howard L. Wray, Aman Singh
  • Patent number: 8932584
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: January 13, 2015
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8932585
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: January 13, 2015
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Publication number: 20150004206
    Abstract: The invention relates to a process for preparing PCL-comprising microparticles, to microparticles obtainable by said process, to gel hence obtained and to several uses of the gel such as for the preparation of a medicament for treating a skin abnormality or disfigurement, and/or for controlling bladder function and/or controlling gastric reflux and/or for treating erectile dysfunction and/or for treating vocal cords. The gel may also be used for cosmetic applications.
    Type: Application
    Filed: July 1, 2014
    Publication date: January 1, 2015
    Inventors: Henderikus Supèr, Paul Willem Mijnen, Pieter Gerard Zijlstra, Dirk Wybe Grijpma
  • Publication number: 20150004216
    Abstract: A medicant composition is provided. The composition includes a film layer and a powder matrix layer. The powder matrix layer includes a medicant. The powder matrix layer is applied to the film layer by admixing particulate to form a powder matrix and by then applying the powder matrix to the film layer by any desired method. The composition of the powder matrix is varied to alter the dissolution rate of the medicant, the adhesion of the medicant composition, and other physical properties of the powder matrix. The powder matrix layer can be cured.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 1, 2015
    Inventor: Robert Steven Davidson
  • Publication number: 20140364391
    Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 11, 2014
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA, NORTHWESTERN UNIVERSITY
    Inventors: Ton That Hai, John-Bruce Devault Green, Timothy Michael Fulghum, Phillip Byron Messersmith, Tadas Stanislovas Sileika