Abstract: A method for treating podotrochlosis (navicular disease/navicular syndrome) in the foot of a horse is disclosed. The method comprises identifying the specific area(s) of the horse's foot affected by navicular disease and applying at least one extracorporeal shockwave to the affected area(s). In a preferred embodiment, a sonar-emitting device is used to identify the areas within the foot affected by podotrochlosis.

Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.

Abstract: There are disclosed compositions for oral administration of a novel pharmaceutical composition, which includes xanthine-based stimulants, various neurotransmitter precursors, minerals, nootropic herbs, and amino acids capable of augmenting the preparation. Also, embodied in these compositions are specific cerebral vasodilators and cognition enhancing neurosteroids.

Abstract: The present invention provides cytochrome P450 3A (CYP3A) inhibitors and enhancers. Examples of the CYP3A inhibitors include free bases or pharmacologically acceptable salts of at least one of the following compounds: &agr;-naphthoflavone, &bgr;-naphthoflavone, apigenin, baicalein, &bgr;-myrcene, catechin, 3-phenylpropyl acetate, formononetin, gallic acid, hesperetin, hesperidin, isoquercitrin, lauryl alcohol, luteolin, luteolin-7-glycoside, narigin, nordihydroguaiaretic acid, quercitrin, swertiamarin, terpineol, and trans-cinnamaldehyde. Examples of the CYP3A enhancers include free bases or pharmacologically acceptable salts of at least one of the following compounds: apigenin, formononetin, and luteolin-7-glycoside. The CYP3A inhibitors can be used, alone or co-administered with a drug, to improve the drug bioavailability.

Abstract: Nose ointment for the prophylaxis of inhalation allergic reactions comprising at least one mixture of saturated hydrocarbons characterized in that the at least one mixture of saturated hydrocarbons has a viscosity by the DIN 51 562 method of >6 mm2/s (100° C.).

Abstract: The present invention relates to methods of treating an individual with diabetes mellitus by administering to said individual an effective amount of copper chelators, hydrazine compounds, and/or substrate analogues. The invention also relates to methods of treating an individual with diabetes mellitus by lessening fructosamine odixase activity in said individual. Provided within is disclosure pertaining to treatment, pharmaceutical compositions, dosage ranges, and uses of fructosamine oxidase enzyme inhibitors to lessen fructosamine oxidase activity.

Abstract: The invention relates to the impregnation of wood by a solvent-free melt of modified natural resin which is solid at ambient temperature. Besides the modified natural resin, melts according to the invention may comprise wax and further additives. The melting point of the wax is preferably above 80° C. The addition of wax elevates the softening point and reduces the viscosity of the melt. Melts according to the invention do not tend to discolor even at the given temperatures of the loading treatment so that the wood treated with a melt of modified natural resin mainly retains its natural appearance.

Abstract: cis-Jasmone has been discovered to be useful as a semiochemical that changes the behaviour of insects and/or the physiology of plants. It has direct signalling roles with plant-feeding aphids, in attraction of aphid predators and parasitoids, and may act as an airborne signal inducing production of volatile plant semiochemicals, including the monoterpene (E)-&bgr;-ocimene, that stimulate foraging by parasitoids. It is an extremely benign compound having, to human beings, a pleasant aroma and gives a long-lasting effect after removal of the stimulus.

Abstract: The present invention relates to an extract of the Minari plant containing a component which prevents cancer and cancer metastasis. More particularly, the present invention relates to a Minari extract which is useful for the prevention of cancer and cancer metastasis induced by urethane (EC (ethylcarbamate)), which is a carcinogen present in fermented foods or alcoholic beverages, or by NNK[{(4-N-methyl-N-nitrosoamino)-1-(3-pyridyl)-1-buta none)}], which is a carcinogen present in cigarette smoke.

Abstract: Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an isoprenoid inhibitory compound such as a terpene to substantially inhibit the production of exotoxins by Gram positive bacteria.

Abstract: Stable, biocompatible cosmetic or dermatological oil-in-water emulsions (I), containing fatty acids and alcohols, glycerides, ethoxylated esters, non-polar lipids and consistency components, are new. Cosmetic or dermatological oil-in-water emulsion preparations (I) contain (by weight): (a) 0.1-5% 14-22 C fatty acid(s); (b) 0.2-10% fatty acid mono- and/or diglyceride(s); (c) 0.1-5% ethoxylated fatty acid ester(s); (d) 0.5-10% non-polar lipid(s); (e) 0.5-7.5% fatty alcohol(s); and (f) 0.5-7.5% lipophilic consistency source(s) having a melting point or drop point of at least 30 degrees C. The sum of the contents of (a)-(c) is at most 12% and the lipid phase optionally contains up to 40% (based on this phase) of polar lipids.

Abstract: A topical composition comprising: (a) conjugated linoleic acid and/or derivatives thereof; (b) a phenolic compound or mixtures thereof; and (c) a dermatologically acceptable vehicle; with the proviso that the phenolic compound is not a sunscreen. The product is particularly useful for treating wrinkles and soothing sensitive skin.

Abstract: A synergistic insecticide is provided by the addition of sodium lauryl sulfate or lecithin to an essential oil, preferably an essential oil which has been deregulated by the Environmental Protection Agency, to enable independently inactive or relatively inactive materials to provide commercially acceptable insecticidal properties without the need for undesirable poisons that may be toxic to humans and pets.

Abstract: The present invention is based on a novel method for encapsulating in liposomes substantially water immiscible carotenoids. Therefore, there are provided by the present invention formulations comprising liposomes loaded with an amount of at least one water immiscible carotenoid, pharmaceutical compositions comprising such a formulation, and a method for preparing the liposomes loaded with said carotenoid.

Abstract: Methods of treating patients having susceptible viral infections, especially chronic hepatitis C infection by administering to said patient a therapeutically effective amount of a combination therapy of interferon-alfa and ribavirin for a time sufficient to lower HCV-RNA in association with a therapeutically effective amount of an antioxidant therapy comprising s-adenosyl methionine, preferably S-adenosyl L-methionine, for a time sufficient to ameliorate ribavirin-related hemolysis are disclosed.

Abstract: Disclosed are stabilized electrostatically-sprayable topical compositions and methods of treating the skin by electrostatic application of such compositions. The compositions comprise: a) from about 2% to about 90% of a liquid insulating material; b) from about 2% to about 90% of a conductive material; c) from about 0.1% to about 35% of a particulate material which is insoluble and immiscible in the composition; and d) from about 0.5% to about 30% of a thickener for stabilizing the composition. The liquid insulating materials and conductive materials present in the composition are sufficiently miscible or soluble in the composition such that they are in substantially one phase.

Abstract: Pesticidal compositions for the control of human body louse containing one or more plant essential oils. In addition, the present invention is directed to a method for controlling human body louse by applying a pesticidally-effective amount of the above pesticidal compositions to a locus where pest control is desired.

Abstract: A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammatory response in animals. The formulation comprises comprising an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.

Abstract: A food-grade insecticidal composition allowed for use in organic production which is effective in controlling insects, such as ants, aphids, mealy bugs, white flies, spider mites, leaf hoppers, cabbage loopers, leaf eating beetles and caterpillars, cockroaches, flies, wasps, mosquitoes, wood boring and eating insects, and body and head lice but which is non-toxic to humans, household animals, and farm animals includes an effective insect-controlling amount of D-limonene, a non-toxic emulsifying agent, and a non-toxic hydrophilic solvent.

Abstract: A new composition has been created which provide convenient solution for dry skin care needs. The composition is anhydrous and takes the form of a solid stick. The components of this product are: 5-50% of a wax; 10-80% of a hydrophobic liquid ingredient; 1-20% of a spreading agent; and optionally, 0-50% of a hydrophilic moisturizer.

Abstract: A composition in the form of a water-in-oil emulsion containing fibers, at least one silicone surfactant and-at least one wax. The composition obtained has very good stability and can in particular constitute a cosmetic composition. The invention also relates to the use of the said composition, in particular for caring for, treating, making up or cleansing the skin the lips, the eyelashes and/or the hair.

Abstract: Composition for impregnating porous materials, in which the composition contains at lease one component having preservative properties or which release a component having preservative properties on heating, the composition comprising an emulsion of water and oil containing a primary surfactant and an amphoteric additive, the pH of the emulsion being equal or approximately equal to the iso-electric point of the amphoteric additive. The compositions of the invention are particularly useful in the preservation of timber.

Abstract: A method of promoting the uptake of exogenous antimicrobial compounds by microbial cells is disclosed. In one embodiment, the method comprises the step of exposing the microbial cell to an amount of at least one sesquiterpenoid effective to enhance antimicrobial compound uptake in a microorganism and an antimicrobial compound. An antimicrobial composition comprising at least one sesquiterpenoid and an antimicrobial compound, the sesquiterpenoid being present in a concentration of between 0.1 mM and 50 mM, is also disclosed.

Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.

Abstract: The multi-purpose skin balm series is new to the art of skin healing, maintenance, and prevention in that each balm in the series is a compound of old products. Each ingredient in the series works to function in its own way but each action is enhanced when in combination. One will discover that indeed the whole is greater than the sum of its parts. In other words, 2+2=5. These products can offer much less healing time, greater pain control, and less cosmetic disfigurement in a wide range of conditions that affect the skin In and of itself the product is excellent, but when it is combined with the gold standard for each disease entity, injury, or surgical procedure it becomes a superb product. Skin Balm For Psoriasis is the flagship of this series. It was selected as such because of the millions of people world wide who afflicted by this chronic condition. Many have had little improvement in the past.

Abstract: The present invention relates to fuingicidally effective compositions containing at least one pentacyclic triterpene compound.

Abstract: A method of sensitizing tumor cells to radiation thereapy, chemotherapy and immunomodulatory thereapy, comprising the step of exposing the tumor cell to an effective amount of at least one monoterpene or sesquiterpene and treating the tumor cell is disclosed.

Abstract: Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.

Abstract: The present invention relates to fungicidally effective compositions containing at least one pentacyclic triterpene compound.

Abstract: The present invention relates to oral compositions and methods for inhibiting bone resoprtion in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of an isoprenoid compound.

Abstract: Nose ointment for the prophylaxis of inhalation allergic reactions comprising at least one mixture of saturated hydrocarbons characterized in that the at least one mixture of saturated hydrocarbons has a viscosity by the DIN 51 562 method of >6 mm2/s (100° C.).

Abstract: The present invention provides ethene containing solutions and the use thereof in methods of therapy and prophylaxis. Specifically provided are storage stable solutions comprising ethene solubilized in a suitable liquid. Methods of therapy and prophylaxis contemplated include direct and indirect action against disease and microorganisms, as well as methods for improving metabolic function and priming or causing a host to mount a protective response against disease or microorganisms.

Abstract: A composition for controlling harmful bio-organisms comprising (a) at least one imidazole compound represented by formula (I): wherein R represents a lower alkyl group or a lower alkoxy group; and n represents an integer of 1 to 5, as an active ingredient, and (b) at least one inorganic phosphorus compound and/or at least one fungicide for Phycomycetes as an active ingredient or (c) a spreader as an activity-enhancing ingredient, and a method for controlling harmful bio-organisms comprising applying the composition for controlling harmful bio-organisms onto harmful bio-organisms.

Abstract: The present invention provides an improved antimicrobial composition which includes at least one quaternary ammonium compound and nerolidol. The nerolidol component of the composition provides enhanced antimicrobial efficacy, even when used in small amounts. Further, the nerolidol component provides such enhanced antimicrobial efficacy that the quaternary ammonium compound may be used in reduced amounts as compared to the amounts used for antimicrobial effect in prior formulations. The enhanced antimicrobial composition of the present invention is especially useful in cleaning or disinfecting applications, such as the cleaning of hard surfaces.

Abstract: A method for preventing or treating high serum levels of cholesterol and lipids in a mammal, said method comprising orally administering an effective amount of natural lycopene to prevent or treat high serum levels of cholesterol or lipid to a mammal in need of such treatment. Also disclosed is an oral pharmaceutical composition in unit dosage form for oral administration for the prevention or treatment of high serum levels of cholesterol and/or lipids in a mammal, said composition comprising an effective amount of natural lycopene to prevent or treat high serum levels of cholesterol or lipid in a mammal and in a sufficient amount to achieve a level of serum cholesterol of less than 200 mg per deciliter over the course of treatment, and a pharmaceutically acceptable carrier therefor.

Abstract: Significant concentrations of naphthalene were detected in carton nests of Formosan subterranean termites, Coptotermes formosanus Shiraki, collected from Florida, Hawaii, and Louisiana. This is the first report of naphthalene being associated with termites or any other insects. Naphthalene and other compounds associated with termite carton nests may be used to increase termite bait acceptance. New attractant molecules include 2-phenoxyethanol. New feeding stimulants include ergosterol. A list of volatile compounds associated with termite nests is presented, compounds that may be used to detect termite nests.

Abstract: A method of treating, inhibiting, or preventing proliferative disease, particularly cancer, by administering an effective amount of the combination of lycopene and alpha-tocopherol.

Abstract: The present invention relates to methods of treating an individual with diabetes mellitus by administering to said individual an effective amount of copper chelators, hydrazine compounds, and/or substrate analogues. The invention also relates to methods of treating an individual with diabetes mellitus by lessening frictosamine odixase activity in said individual. Provided within is disclosure pertaining to treatment, pharmaceutical compositions, dosage ranges, and uses of frictosaminc oxidase enzyme inhibitors to lessen fructosamine oxidase activity.

Abstract: Process for treating psychosis such as schizophrenia using glycine-site full agonists or a precursor thereof.

Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.

Abstract: A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant including a solvent and an emulsifier, wherein the solvent is a mixture of aliphatic hydrocarbons having a distillation range of about 520 to 600° F. and an aromatic content of about 1% or less, or the solvent is a single or combination of C6-C18 fatty alcohol(s); and (b) applying chlorothalonil to the crop previously to, simultaneously with, or subsequently to the application of the aqueous spray composition, wherein phytotoxicity associated with the application of chlorothalonil is reduced or eliminated.

Abstract: There is provided a cosmetic composition, preferably in the form of a lip gloss composition, that is smooth, glossy, and wear resistant. The composition has an oil or liquid ester and a gel, and optionally, one or more waxes, one or more pigments, and one or more emollients.

Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.

Abstract: A method for regulating the morphological transition of dimorphic Candida in a patient is described. The method comprises administering orally or by injection a compound to a patient suffering from an infection caused by dimorphic Candida selected from the group consisting of Candida albicans, Candida stellatoidea, Candida tropicalis, Candida grabrata, and Candida parapsilosis.

Abstract: A method for preventing or treating high serum levels of cholesterol and lipids in a mammal, said method comprising orally administering an effective amount of natural lycopene to prevent or treat high serum levels of cholesterol or lipids to a mammal in need of such treatment. Also disclosed is an oral pharmaceutical composition in unit dosage form for oral administration for the prevention or treatment of high serum levels of cholesterol and/or lipids in a mammal, said composition comprising an effective amount of natural lycopene to prevent or treat high serum levels of cholesterol or lipids in a mammal and in a sufficient amount to achieve a level of serum cholesterol of less than 200 mg per deciliter over the course of treatment, and a pharmaceutically acceptable carrier therefor.

Abstract: The first invention provides an external preparation for treating dermatoses comprising vitamin E and squalane, which has an efficacy at least equivalent to that of external preparations containing adrenocortical hormones as the active ingredient. The second invention provides an external preparation for treating dermatoses comprising an adrenocortical hormone, vitamin E and squalane, which is reduced in adrenocortical hormone content as compared with conventional preparations, is also reduced in side effects, and has high clinical efficacy. The third invention provides an external preparation for treating dermatoses comprising a nonsteroidal antiinflammatory agent, vitamin E and squalane and/or squalene, which is reduced in side effects and is highly efficacious. The fourth invention provides an external preparation for treating dermatoses comprising an antihistaminic agent, vitamin E and squalane and/or squalene, which is reduced in side effects and is highly efficacious like the above preparation.

Abstract: A liquid health supplement comprising: (i) from about 1% to about 99% of a combination of at least 150 different carotenoid compounds with structures having chemical formula I: wherein each R group is the same or different and is selected from the group consisting of hydrogen, straight chain or branched C1-8 alkyl, straight chain or branched C1-8 alkenyl, straight chain or branched C1-8 alkynyl, hydroxy, straight chain or branched C1-8 alkoxy, keto, carboxyl, cyano, nitro amino, amide, ester, ether, halogen, substituted acyclic, substituted or unsubstituted cyclic, aromatic and heteroaromatic; and, (ii) an oil in an amount sufficient to mask the smell of the carotenoid compounds selected from the group of natural plant oils obtained from plant matter.

Abstract: Compositions and methods for attracting, killing, and/or neutering populations of boll weevils and other insects which spend the winter in areas with thick vegetation are disclosed. With respect to boll weevils, certain plant compounds, when presented along with Grandlure, the synthetic pheromone of the cotton boll weevil (Anthonomus grandis Boh.), increase the capture of boll weevils by as much as 50% as compared to Grandlure alone. The compounds, beta-caryophyllene, eugenol and myrcene, are among those present in leaves in overwintering sites favored by boll weevils. With respect to controlling boll weevil populations, the compounds can be used alone, in combination with Grandlure, and/or in combination with compounds which are toxic to boll weevils or which inhibit their ability to develop normally or reproduce.

Abstract: A composition is disclosed for use in reducing the availability of undesired lipids, such as cholesterol, in the fluid media of the gastrointestinal tract prior to absorption of the lipids across the cells lining the tract. The composition is a nontoxic, substantially nondigestible polymer to which ligands are chemically bonded through biologically stable ether groups. The ligands scavenge the undesired lipids from the fluid media.

Abstract: A homogeneous, essentially nonaqueous adjuvant composition containing at least one spray oil selected from the group consisting of: (a) vegetable oils; (b) fatty acids and blends thereof; (c) esterified fatty acids or blends thereof; (d) saponified fatty acids or blends thereof; (e) N,N-dimethylamide of the formula RCON(CH3)2 (f) polybutenes of the following formula  a surfactant in an effective amount to emulsify said composition and a buffering agent in amount sufficient to reduce the pH to below about 7.