Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.

Abstract: A homogenous, essentially nonaqueous adjuvant composition comprising a spray oil and a surfactant blend selected from the group consisting of sorbitan fatty acid ester, polyethoxylated derivative of a sorbitan fatty acid ester, fatty alkanolamides, peg esters, silicone surfactants, ethoxylated fatty acids, alkyl ethoxylates, alkylphenol ethoxylates, polypropylene glycols, and amine ethoxylates and a buffering agent selected from the group consisting of alkylaryl polyethoxy phosphate ester, C.sub.1 -C.sub.6 carboxylic acids, C.sub.1 -C.sub.6 dicarboxylic acids, phosphoric acid, citric acid, glutaric acid, gluconic acid, lactic acid, glycolic acid, acrylic acid, carboxylated alcohol ethoxylateR--O (CH.sub.2 CH.sub.2 O).times.HR=C-C.sub.25 carboxylic acid, andX=1-20 moles ethylene oxide in an amount sufficient to reduce the pH to below 7.

Abstract: A grooming composition includes by volume: 79.0%-91.0% water, 5.0-12.0% degreasifying agent (preferably, isoparaffinic hydrocarbon solvent), 0.5-3.5% conditioning and detangling agent (preferably, a silicone aqueous emulsion), 0.0-0.6% liquid vitamin E and 0.0-5.0% fragrance (preferably, vanilla flavoring).

Abstract: A method and composition for reducing evaporation of an aqueous layer from the surface of the eye. The method comprises applying a gel of oil and wax over the eye, preferably in the form of a meta-stable oil in water emulsion in a dosage not exceeding 100 microliters. The gel is formed by gelling a hydrocarbon oil with a wax, preferably dispersed in aqueous medium at a pH of at least about 8.0.

Abstract: The present invention provides a method of medical treatment for a medical condition in a mammal. In this method, a pharmacologically effective amount for treatment of the condition of a trioxolane or a diperoxide of a non-terpene unsaturated hydrocarbon is applied to the mammal. The invention also provides methods of modulating the immune system in a mammal, of treating inflammation of a tissue in a mammal, and of treating bacterial, fungal, protozoal and viral infections in a mammal.

Abstract: An indirect control of aphids is disclosed, comprising the use of relatively minute concentrations of the pheromone E-.beta.-farnesene, which prevents aphid-caused crop damage by warding off aphids and by attracting natural aphid predators and parasites.

Abstract: A therapeutic coolant for the local treatment of burn is provided wherein said coolant consisting of squalene, squalane, or mixtures thereof.A method of treating burn is provided wherein said method comprising :applying a therapeutic coolant cooled to a temperature range from -10 to -60.degree. C., said coolant selected from the group consisting essentially of squalene, squalane, or mixtures thereof.

Abstract: Compositions for topical treatment of lesions of human or animal skin which comprise dimethyl ether to freeze the tissue and an acid capable of dissolving the intercellular matrix of the lesion. The dimethyl ether and acid are present in the composition in amounts effective to remove the lesion in a single treatment by a combination of cryogenic and keratolytic action. Methods are provided for the topical treatment of lesions of the skin of human or animal subjects comprising direct spray or intermediate swab application of the present compositions to the lesions.

Abstract: The present invention provides a method of medical treatment for systemic disorders and oral pharyngeal conditions in a mammal. In this method, a pharmacologically effective amount for treatment of the disorder or condition of a trioxolane or a diperoxide of an unsaturated hydrocarbon, such as a terpene or non-terpene, is applied to the mammal. The invention also provides pharmaceutical compositions for use in these methods.

Abstract: The propagation of mouse population in a given area of actual or potential mice infestation is prevented as inhibited by treating such area with an effective amount of male mouse sesquiterpenic pheromone or a derivative thereof, wherein such pheromone has male mouse aversion signalling properties, and the pheromone is not used in the form of male mouse urine.

Abstract: A process for treating antigen solutions with an adjuvant is described, in which process a zinc hydroxide/calcium hydroxide gel and, where appropriate, additionally a lecithin and, where appropriate, additionally a polyalphaolefin is added to the antigen solution.

Abstract: An extemporaneous kit of pharmaceutical substance-containing fat emulsion which consists of a fat emulsion and (a) a pharmaceutical substance composition containing pharmaceutical substance and at least one solvent selected from the group consisting of water, liquid polyalkylene glycols, liquid alkylethanolamines, and liquid polyhydric alcohols, or (b) a pharmaceutical substance composition containing pharmaceutical substance and saccharides and/or 30 amino acids as an excipient, and a process for preparation of a pharmaceutical substance-containing fat emulsion therefrom.

Abstract: The present invention relates to an intravascular embolizing agent containing an angiogenesis-inhibiting substance and an intravascular embolizing substance. The agent strengthens the antitumor effect of an angiogenesis-inhibiting substance and serves to reduce the dose and undesirable side effects. And use of the agent in concert with an anti-neoplastic agent brings about further strong and long-lasting antitumor effects.

Abstract: The present invention arises from the discovery of an endogenous malignancy-associated catabolite characterized by (i) a molecular weight of about 135 daltons as determined by mass spectrum analysis; (ii) a UV absorption maximum at 237 nm; (iii) a 15 centimeter C18 HPLC column retention time of from about 1.00 to about 2.00 minutes as compared to a retention time at a 1 ml/minute flow rate of about 2.5 to about 3.0 minutes for an internal standard marker; (iv) containing no aromatic ring structures, containing one methyl group at the 1-position and one methyl group at the 6-position of an alpha carbon chain, and containing at least one nitrogen moiety as determined by nuclear magnetic resonance; and (v) being present in elevated amounts in the urine substantially exclusively of individuals suffering from malignant conditions.

Abstract: Methods are provided for inhibition of leaf rust infections of plants, especially wheat, using inhibitors which disrupt sulfhydryl bonds of the enzymes used by the leaf rust germ tube to ingest and metabolize components of epicuticular waxes.

Abstract: Ozonides of terpenes are disclosed. Terpenes which are believed to be pharmacologically active when prepared in accordance with the present invention include: limonene, citronella, alpha-carotene, beta-carotene, Vitamin A, linalool, linalyl acetate, or squalene. Other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include geraniol, limonene, alpha-pinene, loganin, cymene, farnesanes, eudesmanes, acoranes, cedranes, chamigranes, caryophyllanes, illudanes, humulenes, himachalenes, longifolanes, perhydroazulenes, quaianes, quaianolides, or germacranes. Still other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include labdanes, clerodanes, abietic acid, phyllocladene, giberellins, ophiobolin A, retigeranic acid, gasgardic acid, lanosterol, euphol, oleanane, ursane, lupeol, hydroxyhopanone, lupanes, or hopanes.

Abstract: Methods of treating systemic viral infections are disclosed comprising the parenteral administration of pharmacologically effective amounts of ozonides of terpenes in pharmaceutically acceptable carriers. Methods for treating viral lesions are also disclosed. In particular, a method for treating retroviral infections is disclosed. More particularly, a method for treating HIV infections is disclosed. In addition, methods for treating infections of non-retroviral viruses are disclosed. Further, methods for treating T-cell deficiencies are also disclosed. Moreover, a method of producing blood for medical products which is free of viral activity is disclosed.

Abstract: 5,9-Dimethylpentadecane (I) and 5,9-dimethylhexadecane (II) and their use in agents for the control of the white coffee-leaf miner, Perileucoptera coffeella, particularly by the confusion technique.

Abstract: Pharmaceutical formulations comprising aromatic polycyclic dione compounds useful for treating mammals suffering from diseases caused by retroviruses are disclosed herein. A method for treating mammals suffering from retrovirus infections is also disclosed.

Abstract: An insect repellent composition containing, as an active ingredient, 1-dodecene is described. When applied to an insect or a habitat thereof, the composition is effective in deterring insects.

Abstract: A method of enhancing the durability of an emollient material on a substrate by forming a mixture of an emollient material and an effective amount of an organosilicon compound, and applying the mixture to the substrate to be treated. The organosilicon compound is either an aminofunctional, amidofunctional, or carboxyfunctional, polysiloxane. A skin conditioning composition of enhanced durability is also disclosed which is a mixture of an emollient material and an effective amount of an organosilicon compound which is either an aminofunctional, amidofunctional, or carboxy functional, polysiloxane.

Abstract: A male-produced aggregation pheromone was demonstrated in Carpophilus hemipterus (L.) (Coleoptera: Nitidulidae) using a wind-tunnel bioassay. The attractiveness of the pheromone is greatly enhanced by volatiles from a host plant, and combinations of pheromone and food volatiles typically attract 3-10 times more beetles than either source by itself. The pheromone consists of a series of 13-, 14-, and 15-carbon unsaturated hydrocarbons, the most abundant of which is 3,5,7-trimethyl-(E,E,E,E)-2,4,6,8-decatetraene.

Abstract: The invention provides insecticidal compositions for combatting aphids, which compositions contain an aphid insecticide in an amount lower than the minimum usual percentage for said insecticide in an aphicidal composition and an alarm pheromone for aphids. The compositions of the invention are less toxic because of the reduced insecticide content but they are not less effective than the insecticidal compositions which do not contain an alarm pheromone.

Abstract: According to the present invention, a skin therapeutic mixture is useful for the alleviation of certain skin disorders such as acne, psoriasis, burns, pimples, blackheads, and open sores, and such mixture comprises: the therapeutic agent being the extract from the dried leaves of the Aloe Vera plant; a preservative chosen from the group consisting of a sulfaderivative such as sulfathiazole and an alcohol amine; a skin softener such as an oil; and an oil soluble base. An inert pigment such as zinc oxide and a fragrance such as a perfume may be added. According to a specific illustrative embodiment of the present invention, the skin therapeutic mixture comprises about 7.4% by weight of the extract from the dried leaves of the Aloe Vera plant as the therapeutic agent; 5% by weight of sulfathiazole as the preservative; about 14.2% by weight of zinc oxide as the inert white pigment; and about 73.4% by weight of petrolatum.

Abstract: A composition comprising squalene and saturated normal aliphatic hydrocarbons which is very effective in the treatment of acne, minor skin irritations and minor skin wounds, burns, inflammation and soreness when applied topically to the skin. Basically, the product comprises from about 5 to 40 volume percent squalene and from about 5 to 25 volume percent n-decane, n-dodecane or mixtures thereof with the balance being normal aliphatic hydrocarbons with chain lengths in the C10 to C35 range or a water-polysorbate emulsion. If desired, certain other ingredients such as zinc oxide or a filler may be added to the mixture. The product may be applied as a spray, cream or gel.

Abstract: A composition is provided for suppressing formation of fat in animals comprising a blend of animal feed and polyterpenes of formula (C.sub.10 H.sub.16).sub.n, where n is an integer from 2 to 4. The polyterpenes may be generated in situ by the reaction of citrus essential oils with pharmaceutically acceptable acid or by direct synthesis. A method for suppressing body fat in both animals and humans is also disclosed comprising feeding or ingesting, respectively, polyterpenes prepared either by direct polymerization of neat terpenes or by the aforementioned in situ reaction.

Abstract: Complete dissolution of a wide range of drugs in chlorofluorocarbon aerosol propellents is achieved by the presence of glycerol phosphatides, preferably phosphatidylcholine.

Abstract: The healing of a number of skin disorders is effectively enhanced by prolonged continuous occlusion and/or hydration. Treating these disorders, e.g. psoriasis, is significantly facilitated by occluding affected skin areas with a suitable barrier for a prolonged and continuous period of time. Such occlusion is effective by itself, but is materially improved by concurrent topical administration of medicament useful for treating the disorder. In such cases the prolonged, continuous occlusion markedly increases hydration which has the further therapeutic benefit of tremendously facilitating penetration of medicament. The provided barrier is advantageously one with low vapor transmission or one which is water impermeable.

Abstract: The invention relates to topical antiinflammatory medicament formulations which also have analgesic activity and contain 2-(2-hydroxyethoxy)-ethyl N-(.alpha.,.alpha.,.alpha.,-trifluoro-m-tolyl) anthranilate as the active ingredient and an adjuvant which is preferably a triglyceride.

Abstract: The invention relates to acaricidal compositions for the control of ectoparasites of domesticated, warm blooded animals. Methods for application of the composition disclosed are also taught.

Abstract: Parasitic and viral diseases are treated with a pyrethroid preferably in the presence of alpha-pinene. Preferred compositions are extracts of pyrethrum with water, aqueous ethyl alcohol, or alpha-pinene.

Abstract: Parasitic and viral diseases are treated with a pyrethroid preferably in the presence of alpha-pinene. Preferred compositions are extracts of pyrethrum with water, aqueous ethyl alcohol, or alpha-pinene.

Abstract: A method for reducing the phytotoxicity of agricultural machine oil in its application to an agricultural or horticultural plant to exterminate noxious insects and acarines, characterized in that, prior to or at the same time as the application of the machine oil, a sucrose fatty acid ester is applied to the agricultural or horticultural plant in an amount of from 0.1 to 50 parts by weight per 100 parts by weight of the machine oil, in the form of an aqueous solution containing from 0.001 to 1 wt/v % of the ester.

Abstract: Method and pharmaceutical composition for topically treating skin inflammatory disorders by administering to the inflamed area a therapeutically effective amount of a substantially non-polar hydrocarbon fraction from beeswax comprising a mixture of (i) a major proportion of saturated straight chain C.sub.21 -C.sub.33 hydrocarbons and (ii) a minor proportion of mono-unsaturated long chain hydrocarbons.

Abstract: Two new compounds which are attractive to male fall cankerworm moths, Alsophila pometaria, in the field, are described. They are (Z,Z,Z,E)-3,6,9,11-nonadecatetraene and (Z,Z,Z,Z)-3,6,9,11-nonadecatetraene. These compounds, separately and together, and these two compounds together with a third, [(Z,Z,Z)3,6,9-nonadecatriene], act as attractants to male fall cankerworm moths and can be used to monitor, confuse or attempt to control, populations of the moths.

Abstract: A composition capable of promoting the skin permation or percutaneous absorption of a medicament, which comprises at least one adjuvant selected from the group consisting of a saturated hydrocarbon containing 5 to 20 carbon atoms which may be substituted by halogen, an alcohol ester of aliphatic carboxylic acid containing 12 to 18 carbon atoms, an ether, a dimethylpolysiloxane having a viscosity at 25.degree. C. of not more than 6 centistokes and a cyclic polydimethylsiloxane having a viscosity at 25.degree. C. of not more than 6 centistokes, and an imidazolidinone derivative represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each are a lower alkyl group; and pharmaceutical composition for external medication.

Abstract: A composition for reducing pest infestation of animals, such as domesticated animals, by topical application of the composition to the animal. The composition is effective in both reducing future infestation by acting as a pest repellent and also acting as a pesticide to aid in also reducing present infestation. The composition comprises a eucalyptus oil, present in an amount of 4% to about 22% by weight, a lower molecular weight, low carbon content alcohol, such as isopropyl alcohol which is miscible with water, present in an amount of about 9% to about 33% by weight, and water generally present in an amount of about 45% to about 85% by weight, all being based on the total fluid weight of the composition. The invention provides a method of reducing pest infestation by topically applying to an animal, on a periodic basis, a selected amount of the pest repellent composition.

Abstract: The invention is related to the use of liquid, branch-chained fatty acid esters or hydrocarbons with about 20 to 30 C-atoms in the entire molecule as a surface analgesic and antiphlogistic, as well as the use of triglycerides of saturated fatty acids having 8 to 14 carbon atoms for such purposes.

Abstract: A method for reducing the phytotoxicity of agricultural machine oil in its application to an agricultural or horticultural plant to exterminate noxious insects and acarines, characterized in that, prior to or at the same time as the application of the machine oil, a sucrose fatty acid ester is applied to the agricultural or horticultural plant in an amount of from 0.1 to 50 parts by weight per 100 parts by weight of the machine oil, in the form of an aqueous solution containing from 0.001 to 1 wt/v % of the ester.

Abstract: Insecticide composition comprising (E)-.beta.-farnesene as a contact insecticide against aphids, a process for preparing said composition and the use of the (E)-.beta.-farnesene for controlling aphids.