Carbocyclic Patents (Class 514/763)
-
Publication number: 20010027216Abstract: The present invention provides a method for preventing the adverse effects which may be associated with the administration of at least one hormone to a subject without detectable cancer comprising administering to such subject at least one carotenoid. The invention further provides a method for preventing a variety of adverse effects associated with the administration of hormones, including, for example, an increased risk for developing cancer. The invention further provides a method for preventing adverse effects without inhibiting the beneficial activity of the hormone. The invention further provides a method for preventing the adverse effects associated with administration of estrogen and/or progestin in hormone replacement therapy without inhibiting the beneficial activity of such hormone. The invention further provides a method for preventing the adverse effects associated with the administration of phytoestrogens.Type: ApplicationFiled: March 5, 2001Publication date: October 4, 2001Inventors: Joseph Levy, Yoav Sharoni
-
Publication number: 20010025058Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula:Type: ApplicationFiled: February 2, 2001Publication date: September 27, 2001Inventors: Henryk Borowy-Borowski, Marianna Sikorska-Walker, P. Roy Walker
-
Patent number: 6290937Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.Type: GrantFiled: May 28, 1998Date of Patent: September 18, 2001Assignee: Applied Genetics Incorporated DermaticsInventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
-
Publication number: 20010019724Abstract: Carotenoid formulations comprising a mixture of &bgr;-carotene, lycopene and lutein, and the use thereof in human and animal foods, cosmetics and pharmaceuticals.Type: ApplicationFiled: March 20, 2001Publication date: September 6, 2001Inventors: Frank Runge, Jan Holm-Hansen, Birgit Michelsen
-
Patent number: 6262109Abstract: A method for preventing or treating high serum levels of cholesterol and lipids in a mammal, said method comprising orally administering an effective amount of natural lycopene to prevent or treat high serum levels of cholesterol or lipids to a mammal in need of such treatment. Also disclosed is an oral pharmaceutical composition in unit dosage form for oral administration for the prevention or treatment of high serum levels of cholesterol and/or lipids in a mammal, said composition comprising an effective amount of natural lycopene to prevent or treat high serum levels of cholesterol or lipids in a mammal and in a sufficient amount to achieve a level of serum cholesterol of less than 200 mg per deciliter over the course of treatment, and a pharmaceutically acceptable carrier therefor.Type: GrantFiled: August 22, 1997Date of Patent: July 17, 2001Assignee: Henkel CorporationInventors: James P. Clark, Manfred S. Dunker
-
Patent number: 6255356Abstract: Described is a method for inhibiting from feeding German cockroaches (Blattella germanica) from a surface or volume inhabited by said Blattella germanica consisting of the step of applying to said surface or said volume a Blattella germanica-anti-feedant quantity and concentration of a geraniol-containing mixture comprising: (i) from about 0 up to about 20% by weight of nerol; (ii) from about 20 up to about 40% by weight of citronellol; and (iii) from about 50 up to about 70% by weight of geraniol, which geraniol-containing mixture is defined according to specific GLC profiles set forth in FIGS. 4 and 5, described in the disclosure. Also described are compositions of matter defined according to the geraniol-containing compositions of FIGS. 4 and 5 which act as anti-feedants against the German cockroach species set forth above.Type: GrantFiled: March 30, 2000Date of Patent: July 3, 2001Assignees: International Flavors & Fragrances Inc., The University of FloridaInventor: Jerry F. Butler
-
Patent number: 6180681Abstract: The invention relates to 2-cyclopenten-1-one as an inducer of the heat shock protein HSP70 by activating the heat shock transcription factor HSF, and selectively inducing the transcription and translation of HSP70 in human cells. In particular, since a cytoprotective role of HSP70 during viral infection was previously shown, the invention refers to 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives as inducers of HSP70 with antiviral activity. Treatment with 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives causes a dose-dependent reduction of infectious virus yield during infection with vesicular stomatitis virus. The block of virus replication is due to inhibition of viral protein synthesis, associated with HSP70 synthesis.Type: GrantFiled: December 16, 1998Date of Patent: January 30, 2001Assignee: Consiglio Nazionale Delle RicercheInventors: Carla Amici, Giuliano Elia, Enrico Garaci, Antonio Rossi, Maria Gabriella Santoro
-
Patent number: 6130244Abstract: In its broadest aspect, the present invention is directed to the discovery of immunonutritional products that are useful in reducing the immunological system suppression that results from stress. The stress may be in the form of physical exertion, mental exhaustion, disease states and the like. In one embodiment, the invention relates to a nutritional composition comprising a structured glyceride component and an antioxidant system. This nutritional composition has been shown to be highly effective in reducing immune system down regulation or dysregulation as a result of stress.Type: GrantFiled: February 25, 1998Date of Patent: October 10, 2000Assignee: Abbott LaboratoriesInventors: Stephen J. DeMichele, Steven M. Wood
-
Patent number: 6130253Abstract: Pesticides for the extermination of terrestrial arthropods are disclosed which comprise formulations of a combination of terpenes in aqueous solutions which may be used together with citral. No resistance to the formulations of the invention has been seen. When used on the scalp or body for lice infestation no extended dwell time is required. The formulations do not have unpleasant odors. The formulations are directed towards providing topical preparations which may be used on the skin, scalp and hairy body parts of humans and animals, sprays for use directly against terrestrial arthropods, a dipping solution for combs and a laundry additive, amongst others.Type: GrantFiled: August 23, 1999Date of Patent: October 10, 2000Assignee: XiMed Group PLCInventors: Lanny Udell Franklin, Gary David Cunnington, David E. Young
-
Patent number: 6117872Abstract: NO precursors are administered at elevated levels in addition to the diet of the individual to enhance exercise performance. Particularly, L-arginine and L-lysine by enhancing endothelial NO production can provide for greater aerobic capacity and improved exercise performance.Type: GrantFiled: June 23, 1998Date of Patent: September 12, 2000Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Andrew J. Maxwell, John P. Cooke
-
Patent number: 6087402Abstract: The present invention relates to a foam composition for killing dust mites comprising an acaricidal agent, polymer, ether solvent, perfume, surfactant and water.Type: GrantFiled: September 26, 1997Date of Patent: July 11, 2000Assignee: Colgate Palmolive CompanyInventors: Germaine Zocchi, Pierre Fonsny
-
Patent number: 6080792Abstract: The present invention relates to a foam composition for killing dust mites comprising an acaricidal agent, polymer, ether solvent, perfume, surfactant and water.Type: GrantFiled: September 25, 1997Date of Patent: June 27, 2000Assignee: Colgate Palmolive CompanyInventors: Germaine Zocchi, Pierre Fonsny
-
Patent number: 6074634Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.Type: GrantFiled: October 5, 1998Date of Patent: June 13, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
-
Patent number: 6054490Abstract: The invention relates to the use of a sesquiterpene for inhibiting an oxidative enzyme, preferably a cytochrome P450 enzyme. The invention also relates to compositions comprising a sesquiterpene and a drug which exhibits instability in the presence of an oxidative enzyme.Type: GrantFiled: April 10, 1998Date of Patent: April 25, 2000Assignee: Zylepsis LimitedInventors: John Thomas Sime, Peter Samuel James Cheetham, Michelle Lorraine Gradley, Nigel Eric Banister
-
Patent number: 6028117Abstract: Disclosed herein are microemulsion insecticides that do not contain conventional actives. The microemulsion form permits insects to be killed by an oil/surfactant combination.Type: GrantFiled: December 18, 1996Date of Patent: February 22, 2000Assignee: S. C. Johnson & Son, Inc.Inventor: John D. Hagarty
-
Patent number: 6022897Abstract: In accordance with the present invention, there are provided a class of compounds which are capable of selectively modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-.gamma.). The identification of such compounds makes possible the selective intervention in PPAR-.gamma. mediated pathways, without exerting inadvertent effects on pathways mediated by other PPAR isoforms.Type: GrantFiled: June 5, 1995Date of Patent: February 8, 2000Assignee: The Salk Institute for Biological StudiesInventors: Ronald M. Evans, Barry M. Forman
-
Patent number: 6020351Abstract: Selectively administering to humans, as a daily dosage, a combination of carotenoids, nicotinamide (or niacin or a precursor thereof) and a source of zinc, in excess of normal dietary levels, for improving resistance to DNA damage, enhancing DNA repair capacity, and stimulating immune function.Type: GrantFiled: August 11, 1998Date of Patent: February 1, 2000Assignee: OXiGENE, Inc.Inventor: Ronald W. Pero
-
Patent number: 6020333Abstract: The invention relates to the field of therapeutic chemistry and concerns novel antiviral pharmaceutical compositions for the local prevention of diseases of the genital and rectal mucus membranes. The compositions are characterized in that that the active ingredient used is riboflavin or one of the mineral or organic acid or FAD addition salts thereof. The active ingredient further comprises niacin or NAD or NADP. Vitamin factors can also be added such as carotene, flavonoids, acetyloenzyme A and vitamins A, E, C, B6, B8 or F. Fillers such as insoluble barium salts, titanium derivatives, alkaline-earth silicates, aluminium silicates, mineral or organic bismuth salts, insoluble zinc salts, rare earth derivatives, zirconium derivatives, can be added to said compositions to reinforce the mucus adhesiveness of said preparations. Vegetable extracts containing flavonoids or anthocyanosides can be further incorporated into the pharmaceutical compositions of the invention.Type: GrantFiled: December 18, 1995Date of Patent: February 1, 2000Inventor: Jean Berque
-
Patent number: 6001874Abstract: A non-toxic arthropod control composition is disclosed for application to foliage for plant protection. The composition includes behavior interfering compounds, agricultural oil and/or surface active compounds and diluents. The behavior interfering compounds may be any known conventional compound capable of interrupting or altering the normal behavioral sequences of the target. The agricultural oil can be a vegetable oil.Type: GrantFiled: June 20, 1997Date of Patent: December 14, 1999Inventor: Dan Veierov
-
Patent number: 5998484Abstract: A highly effective, broad spectrum, quick-acting, nonpoisonous insecticidal composition with synergistic kill ratio and kill time is provided when cornmint oil and sodium lauryl sulfate are combined as the essential active ingredients.Type: GrantFiled: April 15, 1998Date of Patent: December 7, 1999Assignee: Woodstream CorporationInventors: Karen A. Zobitne, Michael J. Gehret
-
Patent number: 5977186Abstract: Treatments are disclosed which comprise formulations of one or more terpenes in aqueous solutions. No resistance to the formulation of the invention has been seen. When used on the scalp or body no extended dwell time is required. The formulations do not have unpleasant odors associated with prior art shampoo treatments for lice and are preferable on grounds of safety to neurotoxins, which are the usual active ingredients associated with prior art treatments. The formulations are directed towards providing topical preparations which may be used on the scalp and hairy body parts, a spray for use on fabrics, a dipping solution for combs and a laundry additive.Type: GrantFiled: September 11, 1998Date of Patent: November 2, 1999Assignee: XiMed Group PLCInventor: Lanny Udell Franklin
-
Patent number: 5972985Abstract: Nutriceutical compositions useful as a dietary supplement which have antioxidant/free radical scavengers and also having a cytoprotective effect are disclosed. The compositions contain a cytoprotective and antioxidant/free radical scavenging amount of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof in combination with phytonutrients having antioxidant properties such as vitamin C, vitamin E, vitamin A and .beta.-carotene. The compositions can be prepared in capsule form, tablets, sustained release tablets, suspensions and oral rehydration solutions.Type: GrantFiled: November 3, 1997Date of Patent: October 26, 1999Assignee: Cytos Pharmaceuticals, LLCInventors: Peter G. Thomas, A. Michael Wade
-
Patent number: 5951992Abstract: Disclosed are novel methods for the use of pesticide formulations, containing d-limonene, directed against ants, termites, chinch bugs, sod web worms (Bacillus thuringiensis), weeds and the like.Type: GrantFiled: November 3, 1993Date of Patent: September 14, 1999Inventor: Joe Sam Wilkins, Jr.
-
Patent number: 5948823Abstract: A method of protecting a mammal from the detrimental effects of irradiation is disclosed. The method comprises administering an effective amount of a substantially crude Dunaliella algae preparation to the mammal.Type: GrantFiled: September 9, 1997Date of Patent: September 7, 1999Assignees: Hadasit Medical Research Services & Development Company Ltd., Nikken Sohonsha CorporationInventors: Ami Ben-Amotz, Zeev Weshler, Shaul Yatziv, Mordechai Sela
-
Patent number: 5906992Abstract: The present invention relates to a foam composition for killing dust mites comprising an acaricidal agent, polymer, ether solvent, perfume, surfactant and water.Type: GrantFiled: November 21, 1996Date of Patent: May 25, 1999Assignee: Colgate Palmolive CompanyInventors: Pierre Fonsny, Germaine Zocchi
-
Patent number: 5886053Abstract: The use of carotenoids for producing drugs for the treatment of inflammatory disorders not caused by the action of light or an infection with microorganisms.Type: GrantFiled: July 30, 1997Date of Patent: March 23, 1999Assignee: BASF AktiengesellschaftInventors: Wolfgang Schmutzler, Karl Kolter
-
Patent number: 5883136Abstract: This invention provides methods of inhibiting the growth of cells, of treating a subject having a disease characterized by an uncontrolled growth of cells and of blocking an immune response as well as related inflammatory responses in a subject which comprises administering a compound having the structure: ##STR1##Type: GrantFiled: June 7, 1995Date of Patent: March 16, 1999Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New YorkInventors: Ulrich Hammerling, Jochen Buck, Fadila Derguini, Koji Nakanishi
-
Patent number: 5874097Abstract: Significant concentrations of naphthalene were detected in carton nests of Formosan subterranean termites, Coptotermes formosanus Shiraki, collected from Florida, Hawaii, and Louisiana. This is the first report of naphthalene being associated with termites or any other insects. Naphthalene and other compounds associated with termite carton nests may be used to increase termite bait acceptance. New attractant molecules include 2-phenoxyethanol. New feeding stimulants include ergosterol. A list of volatile compounds associated with termite nests is presented, compounds that may be used to detect termite nests.Type: GrantFiled: December 11, 1997Date of Patent: February 23, 1999Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Gregg Henderson, Jian Chen, Roger A. Laine
-
Patent number: 5863953Abstract: Liquid, oil-miscible carotenoid preparations which, as double dispersion systems, comprise an aqueous-disperse phase which has a particle diameter of less than 100 .mu.m and in which particles, stabilized by protective colloid, of one or more carotenoids are present in disperse form, in an oil as a dispersion medium.Type: GrantFiled: November 18, 1997Date of Patent: January 26, 1999Assignee: BASF AktiengesellschaftInventors: Erik Luddecke, Angelika-Maria Pfeiffer, Joachim Meyer
-
Patent number: 5849787Abstract: A hypercholesterolemia therapeutic agent containing lycopene as an effective ingredient. The hypercholesterolemia therapeutic agent comprises a soft-capsulated drug, and the soft-capsulated drug comprises a soft capsule which comprises gelatin and glycerin, and contents which comprise lycopene, .beta.-carotene, .alpha.-carotene, d-.alpha. tocopherol and a mixture of a wheat germ oil and a vegetable oil, which contents are packed into the soft capsule.Type: GrantFiled: June 10, 1997Date of Patent: December 15, 1998Assignee: Mutsunori FujiwaraInventors: Mutsunori Fujiwara, Toru Hiyoshi, Shinzo Makita
-
Patent number: 5834445Abstract: Complexes of .beta. carotene with cyclodextrin are described, having reduced color intensity and a shift of color to tones more neutral than the deep red of uncomplexed .beta. carotene. When these complexes are added to topical compositions such as typical skin cream bases in amounts up to 1.0% .beta. carotene w/v, the result is a cream having a pinkish to beige color which is cosmetically acceptable, as opposed to the mustard orange to red color seen in creams containing like amounts of uncomplexed .beta. carotene.Type: GrantFiled: November 3, 1995Date of Patent: November 10, 1998Inventors: Christopher Sikorski, Joel L. Schwartz, Gerald Shklar
-
Patent number: 5827904Abstract: A composition for the manufacture of a medical implant utilizing a solid polymeric material fashioned from stock or pressure molded from a powder base. A sufficient amount of a carotenoid is doped into powder base or stock solid polymeric material to produce a stable oxidation resistant matrix for use in medical implants, or alternatively doped into a solid, performed bulk polymeric material for use as medical implants.Type: GrantFiled: September 27, 1996Date of Patent: October 27, 1998Inventor: David Hahn
-
Patent number: 5817879Abstract: Compounds are provided which are crossreactive with peptides such as those bound by G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 or R.sub.6 comprises a chemical functional group which causes the compounds to be crossreactive with the peptide of interest.Type: GrantFiled: August 26, 1996Date of Patent: October 6, 1998Assignee: Trustees of the University of PennsylvaniaInventors: Ralph Hirschmann, Ellen Leahy, Paul Sprengeler
-
Patent number: 5814325Abstract: Closely related formulations of GRAS food additives serve as insect repellents, insecticides and larvicides. The ingredients of the repellent, insecticide and larvicide also exhibit useful disinfectant properties against vector-borne pathogenic micro-organisms.Type: GrantFiled: April 11, 1997Date of Patent: September 29, 1998Assignee: The Rod Family TrustInventor: Robert L. Rod
-
Patent number: 5798385Abstract: Described is a composition which is both an insect repellent and a perfume containing:Para-isopropylcyclohexanol;3,7-dimethyl-2,6-octadien-1-al;5,9-dimethyl-4,8-decadienal;p-mentha-1,8-diene;o-methyl-betaphenylethyl alcohol; and4-cyclooctenyl methyl carbonate.Also described is a method of using such formulation in order to repel insects.Type: GrantFiled: August 21, 1997Date of Patent: August 25, 1998Assignee: International Flavors & Fragrances Inc.Inventor: Anna Belle Marin
-
Patent number: 5728648Abstract: The present invention relates to an improved fertilizing composition of the type containing nitrogen, phosphorus and potassium, with the improvement being the addition of 1-methyl-4-(1-methylethenyl)cyclohexene (i.e., limonene) as an insecticide and fungicide.Type: GrantFiled: September 19, 1996Date of Patent: March 17, 1998Inventors: Virgil A. Delorme, Thomas Crisofulli, Madelyn Joy Warner
-
Patent number: 5712311Abstract: The invention relates to a cosmetic or dermatological composition with controlled release of active principle containing at least photoconvertible carotenoid, capable of being converted to retinol and retinoic acid or its isomers, of following formula (I): ##STR1## in which the R.sub.1 and R.sub.2 substituents denote one of the following groups: ##STR2## at least one of the R.sub.1 and R.sub.2 substituents denoting a .beta.-ionone group of formula (II), the R.sub.3 and R.sub.4 substituents denoting hydrogen, a hydroxyl, carboxyl or C.sub.1 -C.sub.4 alkoxy group or forming, with the carbon atom of the ring, a carbonyl group, in a cosmetically or dermatologically acceptable medium.Type: GrantFiled: June 14, 1996Date of Patent: January 27, 1998Assignee: L'OrealInventors: Etienne Soudant, Constantin Koulbanis
-
Patent number: 5709890Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 20, 1997Date of Patent: January 20, 1998Assignee: Donlar CorporationInventor: J. Larry Sanders
-
Patent number: 5705526Abstract: A hypercholesterolemia therapeutic agent containing lycopene as an effective ingredient. The hypercholesterolemia therapeutic agent comprises a soft-capsulated drug, and the soft-capsulated drug comprises a soft capsule which comprises gelatin and glycerin, and contents which comprise lycopene, .beta.-carotene, .alpha.-carotene, d-.alpha. tocopherol and a mixture of a wheat germ oil and a vegetable oil, which contents are packed into the soft capsule.Type: GrantFiled: February 20, 1996Date of Patent: January 6, 1998Assignee: Mutsunori FujiwaraInventors: Mutsunori Fujiwara, Toru Hiyoshi, Shinzo Makita
-
Patent number: 5670549Abstract: A method for preventing acetaminophen toxicity in a mammal is provided. An acetaminophen toxicity inhibiting amount of beta-carotene is administered before, simultaneously with, after, or any combination thereof, administering acetaminophen to the mammal. Methods for reducing acetaminophen toxicity in a mammal in need of such treatment and for increasing the maximum amount of acetaminophen that can be administered to a mammal without the mammal exhibiting acetaminophen toxicity are also provided. Acetaminophen toxicity reducing amounts and acetaminophen toxicity preventing amounts, respectively, are administered. In another embodiment, a non-steroidal analgesic and anti-inflammatory composition of acetaminophen and an acetaminophen toxicity preventing amount of beta-carotene is provided.Type: GrantFiled: June 30, 1995Date of Patent: September 23, 1997Inventors: Steven Baranowitz, Paul F. Maderson
-
Patent number: 5661123Abstract: The present invention provides a method for providing nutrition to non-catabolic and moderately catabolic patients. Pursuant to the present invention, the enteral composition includes a peptide based protein source of hydrolyzed whey, a lipid source, and a carbohydrate source. Preferably, the protein source includes approximately 22% to about 27% of the total calories. The composition has a caloric density of approximately 1000 Kcal/L and a low osmolality of approximately 300 to 450 mOsm/Kg H.sub.2 O. Still further, the composition of the present invention also includes increased levels of certain vitamins and minerals.Type: GrantFiled: January 17, 1995Date of Patent: August 26, 1997Assignee: Nestec, Ltd.Inventors: Lance Stalker, Diana Twyman, Shen-Youn Chang, Veronique Jaussan
-
Patent number: 5653991Abstract: Closely related formulations of GRAS food additives serve as insect repellents, insecticides and larvicides. The ingredients of the repellent, insecticide and larvicide also exhibit useful disinfectant properties against vector-borne pathogenic microorganisms.Type: GrantFiled: May 9, 1995Date of Patent: August 5, 1997Assignee: The Rod Family TrustInventor: Robert L. Rod
-
Patent number: 5637324Abstract: A medical food having the below listed components is administered for several days as the sole source or as a substantial source of the daily caloric intake of a patient suffering from metabolic poisoning: 45 to 65% protein concentrate; 2.5 to 17.5% of grain syrup solids containing 50% dextran; 2.5 to 17.5% of grain syrup solids containing 50% of maltose; 3 to 12% of oil containing 20% of oleic acid, 1 to 11% medium chain triglycerides; magnesium ions; buffering agent; soluble calcium salt; ascorbic acid; 0.40 to 0.65% of .beta. carotene; D-.alpha.-tocopherol; chromium ions in the trivalent or hexavalent form, 0.008 to 0.022% glutathione, 0.08 to 0.22% N-acetylcysteine; L-lysine hydrochloride; 0.08 to 0.22% L-threonine, and 0.08 to 0.22% of L-cysteine.Type: GrantFiled: June 6, 1995Date of Patent: June 10, 1997Inventor: Jeffrey S. Bland
-
Patent number: 5635173Abstract: Described is (i) a method of repelling Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae for a finite period of time from a three-dimensional space inhabitable by Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae consisting essentially of the step of exposing a three-dimensional space to an effective Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae-repelling concentration and quantity of a geraniol-containing composition consisting essentially of 50-100% of geraniol with the remainder of the composition being a compound selected from the group consisting of citronellol and nerol and (ii) a method of attracting Musca domestica L.(Diptera:Muscidae) or Aedes aegyptae using lavender absolute, benzoin, dimethyl benzyl carbinyl acetate, jasmine absolute, racemic borneol, d-limonene and/or dihydrolinalool. The attractants taken alone or in combination find utility primarily as bait enhancers for acute toxins and/or trapping devices.Type: GrantFiled: May 25, 1995Date of Patent: June 3, 1997Assignees: International Flavors & Fragrances, The University of FloridaInventors: Craig B. Warren, Jerry F. Butler, Richard A. Wilson, Braja D. Mookherjee, Leslie C. Smith, Anna B. Marin
-
Patent number: 5629023Abstract: A medical food having the below listed components is administered for several days as the sole source or as a substantial source of the daily caloric intake of a patient suffering from metabolic poisoning: 45 to 65% protein concentrate; 2.5 to 17.5% of grain syrup solids containing 50% dextran; 2.5 to 17.5% of grain syrup solids containing 50% of maltose; 3 to 12% of oil containing 20% of oleic acid, 1 to 11% medium chain triglycerides; magnesium ions; buffering agent; soluble calcium salt; ascorbic acid; 0.40 to 0.65% of .beta. carotene; D-.alpha.-tocopherol; chromium ions in the trivalent or hexavalent form, 0.008 to 0.022% glutathione, 0.08 to 0.22% N-acetylcysteine; L-lysine hydrochloride; 0.08 to 0.22% L-threonine, and 0.08 to 0.22% of L-cysteine.Type: GrantFiled: November 22, 1993Date of Patent: May 13, 1997Inventor: Jeffrey S. Bland
-
Patent number: 5614562Abstract: Organoselenones of the formulaR.sub.1 --Se(O.sub.2)--(CH.sub.2).sub.n --Xwherein R.sub.1 is selected from the group consisting of aryl, vinyl, acetylenyl, and aralkyl, n is an integer equal to 2 to 6 and X is a leaving group selected from the group consisting of halides, sulfonates and selenones; were surprisingly found to be useful as alkylating agents which possessed a high degree of selectivity for nitrogen nucleophiles without the usual increased preference for sulfur nucleophiles. This property allows the effective use of these compounds as anti-cancer alkylating agents suitable for use in drug-resistant cell lines which display either thiol mediated drug resistance or MER(+)-mediated drug resistance. Two methods of synthesizing these compounds are also provided.Type: GrantFiled: December 16, 1992Date of Patent: March 25, 1997Assignee: The University of Sourthern CaliforniaInventors: Colin P. Spears, Sang-Ihn Kang
-
Patent number: 5610200Abstract: This invention provides methods of inhibiting the growth of cells, of treating a subject having a disease characterized by an uncontrolled growth of cells and of blocking an immune response as well as related inflammatory responses in a subject which comprises administering a compound having the structure: ##STR1##Type: GrantFiled: April 10, 1995Date of Patent: March 11, 1997Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New YorkInventors: Ulrich Hammerling, Jochen Buck, Fadila Derguini, Koji Nakanishi
-
Patent number: 5610189Abstract: A disinfecting composition comprising stable aqueous solutions of (a) a blend of biocidally active terpenes, (b) one or more biocidally active surfactants, (c) one or more proton donor type biocides, and (d) a salt of mono, di or trihydroxy aliphatic or aromatic acid wherein the blend of biocidally active terpenes is tea tree oil.Type: GrantFiled: November 7, 1994Date of Patent: March 11, 1997Inventor: Reginald K. Whiteley
-
Patent number: 5521221Abstract: This invention provides a purified retro-retinoid compound characterized by a molecular mass of about 302 daltons. Also provided by this invention is a method of enhancing the growth of a cell in a vitamin A reduced environment which comprises contacting the cell with an effective growth enhancing amount of a compound having a structure: ##STR1## wherein the configuration of the C6, C8, C10 and C12 double bond independently is Z or E and the absolute configuration at C-14 is independently R or S; wherein R.sub.1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acid halide, amide, nitrile, or amine; and wherein R.sub.2 is hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R.sub.1 and R.sub.2 are replaced by a 14, 15-oxirane group; and wherein the retro structure is alpha or gamma.Type: GrantFiled: April 9, 1991Date of Patent: May 28, 1996Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New YorkInventors: Jochen Buck, Ulrich Hammerling, Fadila Derguini, Koji Nakanishi
-
Patent number: 5468770Abstract: A composition for preventing or limiting the attack and infestation of trees by pine bark beetles, by inhibiting the response of the beetles to their aggregation pheromones. The composition comprises a green leaf volatile selected from six carbon alcohols, aldehydes, their derivatives such as acetates, and mixtures thereof. The green leaf volatile may be employed alone or in combination with an additional, known inhibitor of the pheromone response of the beetle.Type: GrantFiled: December 17, 1993Date of Patent: November 21, 1995Assignees: The United States of America as represented by the Secretary of Agriculture, Texas A&M University SystemInventors: Joseph C. Dickens, Ronald F. Billings, Thomas L. Payne