Abstract: A therapeutic material is contained in a water soluble glass having a dissolution rate that is distinctly pH sensitive, the ratio of dissolution rates between pH 2 and pH 6 being greater than 60 to 1. The glass incorporates phosphorus pentoxide as the glass former and an alkali metal oxide and one or more alkaline earth metal oxides as glass modifiers.

Abstract: A cosmetic make-up composition comprises, in combination, cosmetic make-up components and, as a binding agent therefor, an intimate mixture of from 5 to 95 percent by weight of said mixture of finely divided silica and about 95 to about 5 percent by weight of said mixture of finely divided polyethylene fibers having a fibrillar structure.

Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antitussive.

Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antinauseant.

Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antihistamine.

Abstract: The persistance of bendiocarb and propoxur deposited on both porous and non-porous surfaces is increased by the addition of silica to formulations, in which the insecticides are dissolved in organic solvent.

Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is a decongestant.

Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an appetite suppressant.

Abstract: A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antiasmatic.

Abstract: Dentifrice compositions are provided having an effervescent and cleansing action. The dentifrice compositions are formed from an essentially anhydrous dentifrice base medium and an inorganic oxide material containing an adsorbed gas. Upon contact of the dentifrice composition with water, an effervescent action occurs as the gas is desorbed from the inorganic oxide material.

Abstract: Self-warming personal care products such as lotions, creams and pastes can be prepared using Zeolite A that contains both sodium and potassium.

Abstract: Free flowing, substantially dust-free, dense granular amorphous precipitated silica having a principal particle size of between about 0.14 millimeters and about 0.84 millimeters are described. This material is particularly suitable as an inert carrier for water-soluble and fat soluble nutritional supplements, e.g., vitamins, which are added to feeds for livestock.

Abstract: Dry granulate pharmaceutical compositions containing 85 to 99 percent by weight of ibuprofen and 1 to 15 percent, by weight of Croscarmellose sodium, types A and/or B (cross-linked sodium carboxymethylcellose) are useful for making ibuprofen compressed tablet and filled capsule formulations containing from about 100 to about 1200 mg. of ibuprofen per dosage unit. They are particularly helpful for making compressed tablets containing from 800 to 1200 mg. of ibuprofen per tablet, which have bioavailability rates similar to those of presently known lower dosage strength ibuprofen tablets.

Abstract: A process is provided for the rapid wetting and dispersing of powders suitable for obtaining an essentially gas-free paste, particularly in the manufacture of toothpaste compositions. The process consists of charging a vacuum mixer with the appropriate liquids, and subjecting the liquids to a continuous vacuum that will draw the powders in at the bottom of the mixer in an area of high turbulence generated by a high speed mixing device. The turbulence caused by the expanding air entrained in the powder as it enters the vacuum and generated by the impeller of a high speed mixer, wets the powders very rapidly, inhibits the formation of undesirable lumps, and essentially minimizes loss of powders to the vacuum system. In addition, little or no air is entrained in the resulting paste.

Abstract: A device for the controlled release of an active material into an aqueous medium comprises a porous sintered body of a water soluble glass (11). The pores of the body are filled with a composition (12) consisting wholly or partially of an active material. The device may be provided with a low solubility coating (13). On immersion in an aqueous medium the glass (11) dissolves to become a sponge-like structure having a plurality of convoluted capillaries and from which the active material is released.

Abstract: Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at least about 6% CSD, have a MO/PIB of at least 1.0 and a viscosity of at least 1.5.times.10.sup.7 poises. Preferred systems for dispensing clonidine have a clonidine permeability of at least 1.0.times.10.sup.-4 .mu.g/cm sec and a MO/PIB of at least 1.2.

Abstract: A process is described which consists, in a first stage, in applying a composition based on a substance of vegetable or animal origin, a synthetic organic substance or a mineral substance, in suspension or in solution in a solvent and having a viscosity suitable for application to the hair, or as a powder, and making it possible to prevent or substantially to limit the passage of the dyestuffs and/or of the dyestuff precursors as far as the scalp, and, in a second stage, in dyeing the hair using one or more compositions, at least one of which contains either an oxidizable dyestuff or a direct dyestuff, the dyeing being followed, after an interval sufficient for coloring the hair, by rinsing and optionally by shampooing.

Abstract: A unit dose pharmaceutical composition suitable for oral administration which composition comprises a pharmaceutically acceptable carrier, a desiccant, amoxycillin trihydrate equivalent to 20 mg to 1500 mg of amoxycillin and potassium clavulanate equivalent to 20 mg to 500 mg of clavulanic acid, with the proviso that the weight ratio of amoxycillin to clavulanic acid is in the range 12:1 to 1:1; characterized in that the composition is in tablet form, wherein the desiccant is edible and incorporated within the tablets.

Abstract: A novel stable pituitous bicarbonate suspension in an aqueous/alcoholic medium having a high alcohol content and a low water content, with substantially no bicarbonate in solution, containing hydroxyethyl cellulose as the essential suspending agent, said alcohol content exceeding the upper solubility of hydroxyethyl cellulose in said alcohol and the water content being sufficient to prevent precipitation of said suspending agent and at least 5% by weight; having utility in deodorant products such as roll-ons, pumps and on substrates such as deodorant pads. The concentration of sodium or potassium bicarbonate is preferably high, about 10%, however 1-20% may be used. The alcohol utilized herein is monohydric such as ethanol, methyl or isopropyl alcohol, however, a polyhydric alcohol such as propylene glycol, glycerine and/or polypropylene glycols may be partially substituted for the monohydric alcohol.

Abstract: A cosmetically acceptable composition for topical application to human skin or hair in order to reduce greasiness comprises, at a concentration of from 0.0001M to 0.5M, a biotin antagonist which is capable of blocking the activity of the biotin dependent enzyme acetyl-SCoA-carboxylase implicated in sebum production; together with a carrier other than water as an aid to delivering the biotin antagonist to the sebaceous gland.

Abstract: A novel stable anhydrous paste or cream composition having superior ultradry characteristics when applied to the skin comprising an antiperspirant or deodorant agent and an oil absorbent material homogeneously dispersed in a vehicle comprising about 25-55% of a volatile silicone and a clay suspending/thickening agent in the form of a gel, preferably a bentonite gel. Additionally preferable ingredients are stability agents to prevent syneresis (oil separation) such as the fatty acid metal salts, more specifically zinc, aluminum, calcium, magnesium, and lithium stearates. Additional thickeners, binders, suspending agents, emollients and nonionic emulsifiers may be added as desired to further enhance the aesthetics of the cream product. The resultant dry-feel cream products spread easily, are not wet, oily or sticky, and vanish almost immediately on rub-in when applied to the skin.

Abstract: This invention relates to the preparation and use of glucuronide derivatives of anticholinergic compounds to render them safe for use in the control of human perspiration. These derivatives, which lack mydriatic potency in the eye, are applied to the axillae where they are rendered biologically active by the action of .beta.-glucuronidase occurring naturally on the skin.

Abstract: A powdered or granular solid pesticide composition comprising methyl isothiocyanate supported on natural or synthetic faujasite type zeolite particles having an effective micro-pore diameter of 3.5 to 6 angstrom. This pesticide composition can effectively control various plant parasitic nematodes and noxious soil organisms and can remarkably facilitate application work.