Plant Extract Or Plant Material Of Undetermined Constitution Patents (Class 514/783)
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Patent number: 5935559Abstract: An emulsion comprising an oily phase dispersed in an aqueous phase with the aid of a silicone emulsifying agent, the oily phase comprising at least 50% by weight of silicone oil and the aqueous phase containing at least one polyol in a quantity which imparts a water activity value to the emulsion of .ltoreq.0.85.Type: GrantFiled: July 25, 1996Date of Patent: August 10, 1999Assignee: L'OrealInventors: Isabelle Afriat, Didier Gagnebien, Isabelle Pecile
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Patent number: 5932230Abstract: An analgesic cosmetic formulation in the form of an ointment, salve or cream which is applied to the skin, including the hands and feet for the treatment of such conditions as redness, swelling, itching and soreness of the skin. The cosmetic formulation contains ingredients including oranges, avocado, watermelon, banana, lemon, palm oil, coconut oil, petroleum jelly, beeswax, aloe vera, vitamin E, aspirin, ammonium sulfate, sodium bisulfate and quine sulfate.Type: GrantFiled: October 28, 1997Date of Patent: August 3, 1999Inventor: Frenchell DeGrate
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Patent number: 5910512Abstract: A water-based topical analgesic and method of application wherein the analgesic contains capsicum, capsicum oleoresin and/or capsaicin. This analgesic is applied to the skin to provide relief for rheumatoid arthritis, osteoarthritis, and the like.Type: GrantFiled: August 2, 1996Date of Patent: June 8, 1999Assignee: Healthline Laboratories, Inc.Inventor: Dale Conant
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Patent number: 5902796Abstract: A bioactive Factor produced, separated and isolated from either an aloe vera leaf or a product derived and processed from an aloe leaf, such as raw aloe vera gel, freeze-dried aloe vera gel extract, bulk acetylated mannan and bulk pharmaceutical mannan, utilizing different sizing processes, their processes or preparations, and their uses. The process of sizing can be accomplished by centrifugation, filtration, ultrafiltration, chromatography, dialysis, selective precipitation, pH adjustment, irradiation, homogenizing, or a combination of such processes. Compounding or mixing two or more different bioactive Factors from aloe at various concentration ratios, each Factor with its own specific bioactivity or bioactivities, to obtain a new bioactive Factor having desired optimal additive or synergistic effects.Type: GrantFiled: September 22, 1995Date of Patent: May 11, 1999Assignee: Carrington Laboratories, Inc.Inventors: David G. Shand, Kenneth Yates, D. Eric Moore, Bill H. McAnalley, Santiago Rodriguez
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Patent number: 5902606Abstract: Sparingly water-soluble active compounds, for example medicinal substances, are converted into the dissolved (molecularly disperse) state by dissolving them in a hydrophilic peptide having a molecular weight above 100 D, for example gelatin. The solubility both during storage and during use of the formulation by the user or patient is thereby ensured, without organic solvents or solubilizing agents which cause undesirable side effects being required.Type: GrantFiled: March 17, 1995Date of Patent: May 11, 1999Assignee: Alfatec-Pharma GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich
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Patent number: 5900251Abstract: An essentially herbal or herbal extract composition for the treatment and control of breath odors and aiding digestion, and method of treatment or control of breath odors and aiding digestion therewith. The preferred composition contains ginger, licorice, chamomile, parsley seed oil, and sunflower seed oil in a delivery system which is intended to be ingested and swallowed whole for delivery of the ingredients to the stomach and/or lower in the digestive tract.Type: GrantFiled: June 5, 1997Date of Patent: May 4, 1999Assignee: Breath Asure, Inc.Inventor: Anthony Raissen
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Patent number: 5891801Abstract: A liquid composition for the relief of discomfort, in particular, premenstrual and menstrual discomfort including, as active pharmaceutical agents, an effective amount of one or more of an analgesic, an antihistamine and a diuretic, said active agents being, or adapted to be, dissolved in a liquid vehicle, said composition preferably containing 5-25 percent by volume alcohol (or other effective liquid carrier such as glycerin, or even water) and being flavored with an active flavoring composition including (1) citrus and mint ingredients, (2) vanilla and mint ingredients, or (3) citrus, vanilla and mint ingredients, said active flavoring ingredients being present in an amount sufficient to mask the unpleasant taste of the pharmaceutically active agent(s).Type: GrantFiled: November 21, 1995Date of Patent: April 6, 1999Assignee: Calam and Associates, Inc.Inventors: Henry D. Calam, Hans A. Schaeffer
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Patent number: 5888500Abstract: A biocarrier loaded with up to 60% by weight of a mixture including a biological control agent. The biocarrier is derived from the residual cell mass remaining after lipids and soluble proteins and sugars have at least in part been removed from crushed or ground oil seeds. The biological control agent is an agrochemical, biopesticide or mixtures thereof. When the product is formulated as a granule, tablet or briquette it has good hardness and produces substantially no dust, thereby reducing operator exposure to the biological control agent.Type: GrantFiled: September 26, 1996Date of Patent: March 30, 1999Inventor: Lucia G. I. Marshall
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Patent number: 5876729Abstract: The use of extracts of tamarind seeds enriched in xyloglycans as an active agent in a cosmetic and/or pharmaceutical product for topical usage for the skin and/or other exposed parts of the body. The extracts of tamarind seeds enriched in xyloglycans are present in the cosmetic and/or pharmaceutical product for topical use in a total weight fraction comprised between 0.05% and 100%, preferably between 1% and 25% by weight.Type: GrantFiled: January 3, 1996Date of Patent: March 2, 1999Assignee: Laboratoires Serobiologiques (SA)Inventor: Gilles Pauly
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Patent number: 5876762Abstract: The invention concerns fractions from echinoderms of the class Holothuroidea (sea cucumber) that can be used directly as active therapeutic agents or as raw materials in producing biologically active derivatives thereof. The fractions can be used alone or in combination and are derived from a) the epithelial layer, free of muscle and collagenous tissues, b) the isolated flower, or c) the whole body wall substantially free muscle, viscera and flower. The invention also concerns processes for obtaining these fractions that involve the use of thermal/mechanical and/or enzymatic means.Type: GrantFiled: August 5, 1996Date of Patent: March 2, 1999Assignee: Coastside Bio ResourcesInventor: Peter Donald Collin
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Patent number: 5876754Abstract: The invention relates to accurately meterable shaped articles, for example granules or pellets, containing hydrophilic macromolecules, active compounds and optionally further pharmaceutically acceptable structure-forming substances and auxiliaries, the active compound being present in a matrix in dissolved, suspended or emulsified form, and a novel process for the production of these shaped articles, the process being particularly economically and ecologically acceptable, and use of the shaped articles as medicaments, in which the bioavailability, shelf life and tolerability is increased. Using the shaped articles or mixtures according to the invention, intermediates or final products for pharmacy, cosmetics, diagnosis, analysis or dietetics (healthcare) can additionally be advantageously prepared.Type: GrantFiled: December 19, 1994Date of Patent: March 2, 1999Assignee: Alfatec-Pharma GmbHInventors: Jens-Christian Wunderlich, Ursula Schick, Jurgen Werry, Jurgen Freidenreich
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Patent number: 5872087Abstract: A herbal dry shampoo composition comprising from about 6-12% by weight of foaming accelerating agent, from about 6-12% by weight of pigment recreating agent, from about 6-12% by weight of foaming agent, from about 6-12% by weight of conditioning agent and from about 52-76% by weight of preservative and hair stimulating agent where said constituents are cleaned, dried and crushed to a mesh size of 200-300 sieve size and maintaining the pH at 6-9.Type: GrantFiled: December 3, 1997Date of Patent: February 16, 1999Assignee: GEM Energy Industry LimitedInventor: Kameswaran Neelakantan
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Patent number: 5869540Abstract: The invention provides herbal treatments for aged skin employing valerian extracts and other active herbal agents that are effective as relaxants. Surprisingly, mere ingestion of valerian tea on a daily basis is effective to reduce deep wrinkles. The treatments are particularly effective on persons afflicted by stress and are shown by clinical tests to reduce wrinkles and acne lesions and to improve skin texture and skin color without an increase in puffiness such as might be expected from mere hydration of the skin. The herbal agents can be administered either in a tea or a topical composition, and a combination of the two treatments is particularly effective. A preferred herbal agent is an aqueous valerian root extract. Other herbal agents include extracts of passion flower and mullein.Type: GrantFiled: March 29, 1996Date of Patent: February 9, 1999Inventor: Walter P. Smith
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Patent number: 5861439Abstract: An electrotransport composition comprises at least one C.sub.2 -C.sub.4 lower alcohol, unsaturated derivatives thereof, or mixtures thereof, and at least one C.sub.8 -C.sub.14 higher alcohol, unsaturated derivatives thereof, or mixtures thereof. An electrotransport device and a method of increasing transdermal electrotransport flux utilize the composition of the invention for delivering pharmaceutically-acceptable agents across a body surface such as skin.Type: GrantFiled: November 14, 1994Date of Patent: January 19, 1999Assignee: Alza CorporationInventors: J. Richard Gyory, Jane Yieh, James A. Huntington, Michel Cormier
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Patent number: 5853728Abstract: Cosmetics are herein disclosed which contain a polyphenol derived from the fruits of Rosaceae, and the polyphenol is obtainable by purifying a pressed juice or an extract of the unripe fruits of the Rosaceae, for example, apples, pears or peaches. The cosmetics have many useful functions such as an ultraviolet light absorbing activity and a free radical erasing activity.Type: GrantFiled: December 27, 1996Date of Patent: December 29, 1998Assignee: The Nikka Whisky Distilling Co., Ltd.Inventors: Masayuki Tanabe, Tomomasa Kanda, Akio Yanagida, Toshihiko Shoji
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Patent number: 5853732Abstract: The present invention provides pharmaceutical compositions comprising an effective amount of dermopharmaceutical active agent, kukui nut oil and a pharmaceutically acceptable base which comprises ingredients selected from the group consisting of propylene glycol, glycerin, xanthin gum, methyl paraben, propyl paraben, stearic acid, menthyl lactate, cetearyl alcohol (and) ceteareth 20, polyoxyl 40 stearate, glyceryl stearate (and) PEG-100 stearate, isopropyl myristate, isopropyl alcohol, oleyl alcohol, oleic acid, dimethicone, or C.sub.12 -C.sub.15 alcohols benzoate and purified water.The inclusion of kukui nut oil acts in synergy as an adjunct to the therapeutic agent to promote the alleviation of the medical condition being treated.Type: GrantFiled: October 27, 1997Date of Patent: December 29, 1998Assignee: Pharmacia & Upjohn CompanyInventor: James W. Munden
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Patent number: 5846544Abstract: The present invention concerns a method and composition for reducing blood sugar levels in diabetic human subjects. Practice of the invention requires ingestion of bilberry fruit and valerian root in timed relation to meals. Neither bilberry fruit nor valerian root alone achieve the lowering and regulation of blood sugar levels achieved by the combination. Practice of the invention requires ingestion of bilberry fruit with valerian root.Type: GrantFiled: July 11, 1997Date of Patent: December 8, 1998Inventor: Holly Christine Al-Dahir
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Patent number: 5843215Abstract: Coatings which comprise a water-based or water soluble resin and plant secondary compounds are described. The plant secondary compounds useful in the present invention consist of those compounds which have insecticidal characteristics. The coatings of the present invention have characteristics of insect repellence, antifeedance and oviposition deterrence.Type: GrantFiled: April 7, 1997Date of Patent: December 1, 1998Assignee: WARMM Sciences, LLCInventors: Mark E. Whalon, Gene E. Malloy
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Patent number: 5840329Abstract: A pulsatile drug delivery system comprising of a plurality of particles is able to deliver drug in any desired patterns. A plurality of particles with multi-layer core capable of short-pulse release interlaced with long-duration release is designed for delivery of multi-agents simultaneously or sequentially, or single agent, according to a pre-programmed profile.Type: GrantFiled: May 15, 1997Date of Patent: November 24, 1998Assignee: BioAdvances LLCInventor: Jane Pei-Fan Bai
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Patent number: 5833968Abstract: The aqueous hair fixing composition is in the form of a highly viscous sprayable gel and contains 0.1 to 50 percent by weight of one or more disaccharides or a mixture of 2 to 37 percent by weight of one or more disaccharides and 63 to 98 percent by weight of one or more oligosaccharides, 0.05 to 30 percent by weight of one or more cationic polymers, and 0.05 to 10 percent by weight of at least one thickener selected from the group consisting of honopolymers of acrylic acid, acrylic acid/acrylamides copolymers and sclerotium gum, The composition of the invention necessarily does hot contain monovalent aliphatic alcohols having 1 to 4 carbon atoms and no inorganic salts of alkali metals or inorganic salts of bivalent or trivalent metals. Either the composition is sprayed with the aid of a mechanical spray device or, alternatively, a gaseous propellant is included in it and the composition and propellant is included under pressure in a dispensing container.Type: GrantFiled: January 20, 1995Date of Patent: November 10, 1998Assignee: Wella AktiengesellschaftInventors: Wolfgang Keil, Jurgen Schmenger, Bernd Stein
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Patent number: 5824345Abstract: Compositions useful in the delivery of fragrances and flavorant active agents, and particularly vaporous fragrances and flavorants, are provided. These compositions include a microsphere which includes (a) the active agent; and (b) (i) a proteinoid, (ii) a modified hydrolyzed vegetable protein wherein the protein is modified with an amino reactive agent, or (iii) a combination thereof. Also contemplated is a method for preparing these compositions wherein the active agent is mixed with the proteinoid of hydrolyzed vegetable protein solution and the proteinoid or modified hydrolyzed vegetable protein is precipitated out of the solution, thereby forming a microsphere containing the active agent. In a further embodiment, the active agent is applied to a substrate.Type: GrantFiled: June 7, 1995Date of Patent: October 20, 1998Assignee: Emisphere Technologies, Inc.Inventor: Sam J. Milstein
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Patent number: 5824312Abstract: Photoabsorptive compounds are disclosed which comprise a purified extract of a plant or plant part, wherein said plant is indigenous to an arid region of the world, especially where said arid region is located between 35.degree. north latitude and 35.degree. south latitude. The photoabsorptive compounds in many cases are capable of absorbing solar radiation from about 190 nm to about 500 nm, comprising ultraviolet A, ultraviolet B, and high energy visible light. In particular embodiments, the plant part is pollen, and the plant is mesquite, Prosopis juliflora; Mexican palo verde, Parkinsonia aculeata; blue palo verde, Cercidium floridum; or foothills palo verde, Cercidium microphyllum.Type: GrantFiled: December 15, 1995Date of Patent: October 20, 1998Assignee: ImaRx Pharmaceutical Corp.Inventors: Evan C. Unger, Thomas P. Mc Creery
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Patent number: 5821361Abstract: Methods for recovering isoflavones and derivatives thereof from soy molasses are disclosed. In a first embodiment, a method is disclosed in which isoflavones are recovered without any significant conversion of isoflavone conjugates to other forms. In a second embodiment, a method is disclosed whereby isoflavone conjugates are converted to glucosides while in the soy material prior to their recovery. In a third embodiment, a method is disclosed in which isoflavones are converted to their aglucone form while in the soy material and prior to their recovery. Also disclosed are various isoflavone enriched products obtained from soy molasses.Type: GrantFiled: June 11, 1996Date of Patent: October 13, 1998Assignee: Protein Technologies International, Inc.Inventors: Doyle Waggle, Barbara Bryan
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Patent number: 5811112Abstract: Cosmetic oil-in-water emulsions which are intended to be left on the skin after application (not rinsed off) the emulsions incorporating a stabilized protease. The cosmetic emulsions useful in treatment of dry, flaky, rough, aged, wrinkled or cellulotic skin.Type: GrantFiled: May 30, 1997Date of Patent: September 22, 1998Assignee: Chesebrough-Pond's USA Co., Division of Conopco Inc.Inventors: Prem Chandar, Norman Kramer Richardson, Alyse Battaglia, Karla Jean Cicciari, Kara Newell El-Kadi
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Patent number: 5798342Abstract: The invention relates to the use of natural cyclodextrins and their derivatives for the solubilization of platelet anti-aggregating agents from the family of Ginkgolides.The cyclodextrins used comply with the formula: ##STR1## in which n is equal to 6, 7 or 8 and the R.sup.1, which can be the same or different, represent OH or SR.sup.2 with R.sup.2 representing a group derived from a monosaccharide or an oligosaccharide.The Ginkgolide is preferably Ginkgolide B.Type: GrantFiled: September 9, 1996Date of Patent: August 25, 1998Assignee: Commissariat a l'Energie AtomiqueInventors: Jacques Defaye, Valerie Laine, Florence Djedaini-Pilard, Bruno Perly
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Patent number: 5795574Abstract: The present invention relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium as substance P antagonist in a cosmetic composition or for the preparation of a pharmaceutical composition. The invention also relates to the use of at least one extract from at least one non-photosynthetic filamentous bacterium in a cosmetic composition or for the preparation of a pharmaceutical composition intended for the treatment of disorders associated with an excess in the synthesis and/or in the release of substance P. The invention additionally relates to various compositions containing an extract from at least one non-photosynthetic filamentous bacterium and to a cosmetic treatment process.Type: GrantFiled: September 9, 1996Date of Patent: August 18, 1998Assignee: Societe l'Oreal S.A.Inventors: Lionel Breton, Lucien Aubert, Jacques Leclaire, Richard Martin, Olivier De Lacharriere
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Patent number: 5792726Abstract: An anti-microbial herbal composition for living organisms and particularly as an herbal treatment for plant growth comprising a water solution of extracts of the type withdrawn at elevated temperature from Artemesia plants and the like, applicable to the root structure of plants and as an external spray.Type: GrantFiled: March 28, 1995Date of Patent: August 11, 1998Assignee: Allor FoundationInventors: Marianne Lorina, Robert H. Rines, Carol M. Rines, Justice C. Rines
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Patent number: 5780060Abstract: Microcapsules based on crosslinked plant polyphenols are described. These microcapsules are obtained by the interfacial crosslinking of plant polyphenols, particularly flavonoids. When incorporated in a composition such as a cosmetic, pharmaceutical, dietetic or food composition, these microcapsules make it possible to prevent any impairment of this composition, in particular any color modification, while at the same time preserving the activity, especially the anti-free radical and/or antioxidizing activity, of the plant polyphenols, particularly the flavonoids.Type: GrantFiled: September 27, 1995Date of Patent: July 14, 1998Assignee: Centre National de la Recherche ScientifiqueInventors: Marie-Christine Levy, Marie-Christine Andry
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Patent number: 5773004Abstract: Disclosed is the composition for treating or curing diabetes mellitus containing an ingredient or component suitable for treatment of diabetes mellitus from an extract obtained by immersing a plant belonging to genus Tithonia and/or Ludwigia in a pharmacologically acceptable solvent for a predetermined period of time, said plant belonging to genus Tithonia being Tithonia diversifolia (Hemsl.) A. Gray, Tithonia rotundifolia (Mill) Blake, Tithonia fruticosa Canby & Rose, Tithonia scaberrima Benth. or Tithonia longeradiata (Bertol) Brake; and said plant belonging to genus Ludwigia being Ludwigia octovalvis Raven or Ludwigia prostrata Roxb. or Ludwigia epilobioides Maxim. The composition administered in the form of tea or drink or other formulation to a diabetic patient by first applying a composition containing an extract from the plant belonging to genus Tithonia and thereafter applying a composition containing an extract from the plant belonging to genus Ludwigia.Type: GrantFiled: October 30, 1995Date of Patent: June 30, 1998Inventor: Masakiyo Takahashi
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Patent number: 5773014Abstract: Compositions for inhibiting the formation of unwanted skin pigmentation combine high tyrosinase blocking capabilities with stability in cosmetic preparations, absence of significant cytotoxic effects and synergy of action. The active components of the compositions include extracts of certain selected plants, namely, mulberry, saxifrage, grape and scutellaria root; and, preferably, ethylenediaminetetraacetic acid (EDTA). These ingredients are combined with various cosmetically acceptable carriers to produce cream and lotion formulations capable of whitening skin safely and effectively.Type: GrantFiled: October 7, 1996Date of Patent: June 30, 1998Assignee: Bioetica, Inc.Inventors: Eric Perrier, Delphine Rival
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Patent number: 5770206Abstract: Body oils of all natural ingredients are disclosed having a base oil, such as virgin olive oil, which serves as a carrier for flavoring(s) or fragrance(s), sensory material(s), and optionally a sweetener. Application of the oil provides sensory stimulation and is not harmful upon ingestion.Type: GrantFiled: December 19, 1996Date of Patent: June 23, 1998Assignee: C&D Master Enterprizes LtdInventor: Carlo Nicolicchia
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Patent number: 5762935Abstract: The uses of lignans of the sesamin family to treat infection and inflammation is disclosed. These lignans may be delivered enterally or parenterally and either in the form of sesame oil or in purified form. A total parenteral nutrition solution or dietary supplement are the preferred forms of administration.Type: GrantFiled: April 26, 1995Date of Patent: June 9, 1998Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: R. Armour Forse, Sambasiva Chavali
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Patent number: 5753266Abstract: Compositions of finely divided powder of safflower seed or its extract, and methods for the treatment of rheumatoid-based arthritic diseases and menopause.Type: GrantFiled: December 3, 1996Date of Patent: May 19, 1998Inventors: Parvin Youssefyeh, Homa Khot
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Patent number: 5747462Abstract: The present invention relates to the area of pharmacology; its objective is to solve the technical problem of inflammation, pain, pruritus and local hyperthermia in human beings and animal species. The composition and the subcompositions thereof are obtained from plants of the family Cactaceae, the main methodological steps being a set of processes: production, purification, physicochemical quantification, biotherapeutic evaluation, biopharmaceutical formulation and molecular identification. From the molecular identification a set of molecules is recognized, comprising carbohydrates and an aromatic amine, the general formulae of which are:C.sub.5 H.sub.10 O.sub.5 (RIBOSE),C.sub.6 H.sub.12 O.sub.5 (FUCOSE),C.sub.6 H.sub.12 O.sub.6 (GALACTOSE; MANNOSE; GLUCOSE),C.sub.8 H.sub.11 O.sub.2 N (1-HYDROXY-1-(4-HYDROXYPHENYL)-2-AMINOETHANE),C.sub.10 H.sub.18 O.sub.9 (RIBOFURANOSYLRIBOSE).Type: GrantFiled: August 16, 1995Date of Patent: May 5, 1998Assignee: Laboratorio CHile S.A.Inventor: Victoria M. Fuentes
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Patent number: 5741508Abstract: Livestock and poultry are fed with feed containing at least one spice chosen from among the families Myristicaceae, Cruciferae, Rutaceae, Compositae, Pedaliaceae, Piperaceae, Leguminosae, Umbelliferae, Myrtaceae, Solanaceae, Labiatae, Lauraceae, Liliaceae and Zingiberaceae, whereby the active ingredients of the spice taken into the bodies of the thus-fed livestock and poultry are transferred to their internal fat thereby to modify their meat and to improve the smell of their fat. Accordingly, the fatty smell of the meat and fat to be obtained from the thus-fed livestock and poultry is removed and the freshness-keeping power of the meat and fat is enhanced. As the spices may be added to feed, livestock and poultry may efficiently take the spices with ease.Type: GrantFiled: December 6, 1995Date of Patent: April 21, 1998Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Ikuo Katsumi, Yoshihide Fuse, Taizo Kawabe, Naoko Yasuhara, Yoji Hisada
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Patent number: 5728740Abstract: A method of treating bacterial infection is disclosed. The method comprises the step of applying to a plant having a bacterial infection a composition comprising a xylene source and a wood rosin source, wherein xylene and wood rosin from the xylene source and wood rosin source are present in amounts effective to treat bacterial infection in the plant.Type: GrantFiled: December 5, 1996Date of Patent: March 17, 1998Inventor: Mark William Barrett
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Patent number: 5710260Abstract: Sennosides A, B and Al of the formula: ##STR1## which are substantially free from sennosides C, D and Dl, and from aloe-emodin derivatives, are prepared by a process whereina) a sennoside mixture is reduced to rhein-9-anthrone-8-glucoside and aloe-emodin-9-anthrone-8-glucoside,b) a liquid-liquid partitioning of the compounds obtained is carried out between a polar organic solvent which is only partly miscible with water and an aqueous phase andc) the rhein-9-anthrone-8-glycosides contained after the partitioning in the aqueous phase is again oxidized to the corresponding sennosides and these are recovered.Type: GrantFiled: December 21, 1995Date of Patent: January 20, 1998Assignee: Madaus AGInventors: Alfons Carcasona, Wolf Grimminger, Pentti Hietala, Helga Zaeske, Klaus Witthohn
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Patent number: 5708038Abstract: The present invention provides a method for using Aloe vera as a biological vehicle for the delivery of drugs. In one embodiment Aloe vera is used as a biological vehicle to deliver the estrogen, .beta.-estradiol and the androgen, testosterone propionate. The present invention also provides a method of treating symptoms and diseases mediated by hormonal deficiencies or amenable to treatment by hormones using Aloe vera as a biological vehicle.Type: GrantFiled: June 13, 1996Date of Patent: January 13, 1998Assignee: Univera Pharmaceuticals, Inc.Inventor: Robert H. Davis
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Patent number: 5703041Abstract: A composition for topical application is provided which contains at least one water-sensitive active agent with a topical action and at least one polyol, the latter being present in a quantity which is effective for obtaining a water activity value of the composition of less than or equal to 0.85 with the aim of stabilizing the water-sensitive active agent, the composition containing at least one structuring agent chosen from polymers and oils. The water-sensitive active agent can, in particular, be an enzyme. The composition obtained can be used for cleansing and/or caring for and/or protecting the skin and/or keratinous fibers.Type: GrantFiled: July 24, 1996Date of Patent: December 30, 1997Assignee: L'OrealInventors: Isabelle Afriat, Didier Gagnebien
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Patent number: 5698524Abstract: A method of treating a patient suffering with a viral infection (such as HIV) by administering to the patient an effective anti-viral amount of a composite molecular active substance group, which is produced by the process comprising: (a) preparing lignin units by carrying out an extraction in an aqueous media under weakly acidic or alkaline conditions of wood or wood-like materials and/or plant-cell cultures and separating-off the resultant insoluble solids; (b) preparing lignoid units by carrying out an aqueous alkaline extraction at a pH of 7 to 14 of starting materials selected from the group consisting of wood-incarbonization products and bioconverted wood-like materials and separating-off the resultant alkali-insoluble solids; and (c) preparing a water-soluble mixed polymer by reacting the lignin units from step (a) with the lignoid units from step (b), under aqueous alkaline isolating by ultrafiltration a low molecular weight fraction having a molecular weight of no more than 3000 daltons of the mixedType: GrantFiled: June 5, 1995Date of Patent: December 16, 1997Inventors: Walter Mach, deceased, by Chantal Mach, legal representative
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Patent number: 5698200Abstract: A composition for controlling a plant disease caused by a plant pathogenic bacterium is disclosed. The composition comprises an activity for inhibiting the growth of the plant pathogenic bacterium and is extracted in an aqueous solvent from particles of malted cereal grain. The composition is used either in dry or wet form by application to plant parts, such as potato seed pieces, that are to be protected from the pathogenic bacteria.Type: GrantFiled: August 14, 1996Date of Patent: December 16, 1997Assignee: Lockheed Martin Idaho Technologies CompanyInventor: Karen B. Barrett
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Patent number: 5695763Abstract: Azadirachtin is effectively recovered from the seeds of the neem tree by crushing the seeds, extracting azadirachtin from the crushed seeds with water and then either extracting azadirachtin from the water using a non-aqueous solvent which is not miscible with water and has a higher solubility of azadirachtin than water or a surfactant having a turbidity temperature between 20.degree. and 80.degree. C. The concentrated azadirachtin is easily recovered from the second extraction solution and shows high activity as an insecticide.Type: GrantFiled: February 14, 1996Date of Patent: December 9, 1997Assignee: Trifolio-M GmbH, Herstellung Und VertriebInventor: Hubertus Kleeberg
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Patent number: 5674853Abstract: The present invention features saponin containing enteral formulations for treatment of infection and inflammation. These saponin containing formulations are particularly useful in conjunction with oils rich in .omega.3 polyunsaturated fatty acids such as fish oils and flax oil but also show benefits with .omega.6 rich oils such as borage oil, black currant seed oil, canola oil and rapeseed oil. These formulations may also contain a lignan from the sesamin family.Type: GrantFiled: March 7, 1995Date of Patent: October 7, 1997Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: R. Armour Forse, Sambasiva Chavali
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Patent number: 5670154Abstract: A tyrosinase inhibiting agent acts specifically on tyrosinase to inhibit it; the effective component of this action being an inhibitor of tyrosinase consisting of tea polyphenols.Type: GrantFiled: December 2, 1994Date of Patent: September 23, 1997Assignee: Mitsui Norin Co., Ltd.Inventors: Yukihiko Hara, Miwa Honda
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Patent number: 5667783Abstract: A method of lowering p24 (HIV) antigen to not more than 40 picograms/ml in an HIV positive subject by the administration of a therapeutically active composition is disclosed. The composition includes as an active pharmaceutical an extract of at least one plant of the Asphodelus genus and the tenuifolius species or the chemical equivalent thereof. The plant extract includes an aqueous extract of a woody stem, a root system, a plurality of loculicidal capsules, and a plurality of seeds. The plant extract is admixed with a pharmaceutically acceptable carrier such as water.Type: GrantFiled: December 13, 1993Date of Patent: September 16, 1997Assignees: Constantine Alen, Polexene AlenInventor: Stavros Papadakis
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Patent number: 5653983Abstract: The invention relates to the use of an extract of Marrubium vulgare for the preparation of a cosmetic or a pharmaceutical composition, especially dermatological composition, intended in particular for promoting the pigmentation of the skin, preventing or slowing down the appearance of white hair and treating pigmentation disorders.Type: GrantFiled: June 6, 1995Date of Patent: August 5, 1997Assignee: LVMH RechercheInventors: Alain Meybeck, Frederic Bonte, Marc Dumas
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Patent number: 5650149Abstract: A cosmetic composition containing triglyceride oleate and yeast extract and further, if desired, an L-cysteine hydrochloride as components for proliferating indigenous bacteria on the skin.Type: GrantFiled: August 4, 1995Date of Patent: July 22, 1997Assignee: Kabushiki Kaisya AdvanceInventor: Keiichiro Okabe
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Patent number: 5641489Abstract: Disclosed is a method for recovering maltol and water from naturally occurring plant material containing maltol and water. The maltol is extracted by utilizing a water-immiscible extractant while simultaneously stripping water from the plant material.Type: GrantFiled: August 22, 1995Date of Patent: June 24, 1997Assignee: Florasynth Inc.Inventor: Alexander Fleisher
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Patent number: 5635184Abstract: The present invention relates with a bacterial composition comprising an effective amount of an essential oil distilled from a resinous tree preferably Schinus Molle L. Pseudomonas aeruginosa and Staphylococcus aureus are killed by the composition.Type: GrantFiled: June 3, 1994Date of Patent: June 3, 1997Assignees: Eduardo Haim Pinto, Teodoro Poradosu HaidenvurcelInventor: Ricardo M. Camano
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Patent number: 5629350Abstract: Stable, concentrated aqueous suspensions of ortho-phenylphenol (OPP) which contribute minimal chemical oxygen demand and methods of preparing and using said suspensions in biocidal applications have been discovered. The formulations comprise from about 3 to about 70 weight percent of OPP suspended in about 30 to about 97 weight percent water in the presence of a suspending amount of a thixotrope that exhibits Ellis-Plastic behavior.Type: GrantFiled: March 20, 1996Date of Patent: May 13, 1997Assignee: The Dow Chemical CompanyInventor: Charles D. Gartner