Abstract: The present invention provides a pharmaceutical composition for the therapy of acne vulgaris which comprises a phosphoric diester compound of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and each represents hydrogen or methyl.

Abstract: Topical formulations comprising an anti-irritant amount of aqueous-soluble strontium (Sr.sup.2+) cation, and method for using the same to inhibit skin irritation are disclosed.

Abstract: A composition containing a dispersion of lipid vesicles with an aqueous core and/or of lipid vesicles with an oily core. At least one acidic compound is present in the dispersion in an amount which is sufficient to impart a pH of less than 5 to the composition. The lipid membrane of the vesicles with an aqueous core does not contain:(a) acidic amphiphilic lipids(b) or non-hydrogenated soya lecithin in the presence of glycerol in the dispersion.The composition is stable and may be stored for several months.

Abstract: Topical application to regions of tissue scarring of a composition comprising several ingredients commonly used in cosmetic products, such as benzoyl peroxide, leads to a reduction and a softening of scar tissue.

Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.

Abstract: The invention relates to water-soluble sugar retinoids (I) and to their preparation and the use thereof as medicaments and in the cosmetic sector, wherein X is a sugar radical attached at an oxygen atom, i.e. a mono-, di- or oligosaccharide, provided that X is not a glucose or galactose sugar residue attached at the oxygen atom in the respective 1-positions of the glucose or galactose residues.

Abstract: Compositions for treating acne that contain a peroxide and an antibiotic selected from the lincomycin family are disclosed. In particular, compositions containing benzoyl peroxide and clindamycin are disclosed along with methods of treating acne using these compositions.

Abstract: The present invention relates to the use of dihydroxybenzoic acid in or for the manufacture of a cosmetic or dermatological composition to stimulate the process of epidermal renewal. The invention also relates to a non-therapeutic skin treatment process for the treatment of wrinkles and/or fine lines and/or blemishes of the skin.

Abstract: A method for treating skin afflicted with blemishes or acne with a composition comprising distilled wool wax acids and at least one monoglycerol monocarboxylic acid monoester is presented.

Abstract: A method and composition for treating outbreaks of acne. Initially, the acne affected area is cleaned. A topical spray comprising about 1 to 20 grams niacinamide per 100 grams solution in an inert carrier is then applied to the area. A composition that includes lysine, selenium, chromium and zinc and any desired vitamins and minerals is then taken orally in the form of a capsule or tablet. Generally, at least two spray applications are made and two capsules are taken each day. For optimum skin cleaning, an exfoliation scrub such as a conventional apricot facial scrub is applied to the skin prior to application of the niacinamide topical spray.

Abstract: Topical formulations comprising an anti-irritant amount of aqueous-soluble lithium (Li.sup.+) or potassium (K.sup.+) cation, and methods for using the same to inhibit skin irritation, are disclosed.

Abstract: Disclosed are certain novel polyunsaturated dioic acids having between 8 and 16 carbon atoms (inclusive), excluding those compounds in the group consisting of: 2,5 octadienedioic acid; 1,7 octadienedioic acid; 2,4,6 octatrienedioic acid; and 1,3,5,7 nonatetraenedioic acid; 2,5,8 decatrienedioic acid; 3,6 dodecadienedioic acid; 3,13 hexadecadienedioic acid. Also disclosed are pharmaceutical or cosmetic compositions comprising unsaturated dioic acids and certain of their derivatives. Also disclosed are methods of treating human skin and a method of preparing unsaturated dioic acids.

Abstract: The present invention relates to compositions useful for treating hair or skin. These compositions comprise a topical vehicle containing panthenol and a polyalkyleneglycol having from 3 to about 12 repeating ethyleneglycol or propyleneglycol units.

Abstract: Disclosed are methods to inhibit mammalian skin cell proliferation and, in particular, human keratinocyte proliferation by the topical administration of neutral gallium complexes.

Abstract: The present invention relates to dual textured treatment pads comprising at least one paper pad layer laminated to at least one nonwoven, synthetic fiber pad layer. The invention also encompases treatment pads impregnated with a suitable medicated, cleansing, or cosmetic composition. The invention further encompasses a method of treating ache and skin wrinkling and/or atrophy with these medicated pads.

Abstract: The invention provides a method for treating fungal dermatitis comprising administering an effective amount of 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno?2,3-b!?1,5!benzodiazepine to a patient in need thereof.

Abstract: Compositions and processes for medicating human skin disorders using hydrogen peroxide as an active antimicrobial agent. However, active agents other than hydrogen peroxide may be substituted. In the case of hydrogen peroxide, the agent is solubilized in carrier materials that are completely miscible with water and are nonvolatile. The use of such materials as carriers allows for a controlled release of nascent oxygen at a skin treatment site in the case of hydrogen peroxide.

Abstract: Compositions suitable for the treatment of acne by topical application comprise clindamycin and benzoyl peroxide. Kits for preparing the compositions include a solution of clindamycin in a first container and a gel suspension of benzoyl peroxide in a second container. Each component is stored at a pH which promotes stability, and the combination of the two components provides a final composition having a pH which promotes stability and enhances viscosity.

Abstract: An inhibitor of cholesterol synthesis is used for the treatment, alleviation or prevention of skin disorders.

Abstract: Pharmaceutical preparations are provided comprising antiandrogenically effective substances encapsulated in liposomes. These preparations are preferably used for topical treatment of androgen-dependent diseases.

Abstract: Staple, aqueous gel vehicles are provided for the topical application to the skin of irritating active ingredients such as retinoids, particularly tretinoin, with slow release of the active ingredient and minimal irritancy to the skin. The vehicles include a gelling agent effective to form a gel and hold the active ingredient in the aqueous medium for slow release on the skin, and an effective amount of an antioxidant to retard decomposition of the active ingredient. The vehicles and formulations are preferably aqueous emulsions which contain a solubilizing agent for the generally non-water soluble active ingredients, as well as usually an emulsifying agent and/or surfactant. Chelating agents, emollients, preservatives and other adjuvants and additives may also be included in the vehicles and formulations.

Abstract: Topical formulations comprising an anti-irritant amount of aqueous-soluble strontium (Sr.sup.2+) cation, and methods for using the same to inhibit skin irritation, are disclosed.

Abstract: The present invention relates to methods for treating acne and related pilosebaceous disorders with a safe and effective amount of salicylic acid and pantothenic acid or a pantothenic acid derivative. This combination of materials is found to be less irritating and drying to the skin than salicylic acid alone.

Abstract: A skin care composition in the form of a low pH aqueous gel. The compositions provide improved skinfeel and residue characteristics together with excellent moisturizing, emolliency, rub-in and absorption characteristics.

Abstract: Novel pharmaceutically/cosmetically-active dibenzofuran compounds have the structural formula (I): ##STR1## wherein A is a radical having one of the formulae (IIa), (IIb) or (IIc): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Abstract: A composition for topical application is provided which contains at least one water-sensitive active agent with a topical action and at least one polyol, the latter being present in a quantity which is effective for obtaining a water activity value of the composition of less than or equal to 0.85 with the aim of stabilizing the water-sensitive active agent, the composition containing at least one structuring agent chosen from polymers and oils. The water-sensitive active agent can, in particular, be an enzyme. The composition obtained can be used for cleansing and/or caring for and/or protecting the skin and/or keratinous fibers.

Abstract: A processed product for hair and skin treatment, having binary and tertiary fluid phase levels prior to remixing and therapeutic use is disclosed. The invention discloses defined amounts of admixed components including an Iodine complex having tincture of iodine solution and povidone-iodine compound, a diluting fluid complex having a water and mineral oil constituent, and a cod liver oil component, which, after admixing, are ambiently exposed to a photon-light-energy component from sunlight or substantially equivalent artificial light to produce a processed product having at least binary product reaction fluid levels and containing a nucleophically iodinated cod liver oil compound.

Abstract: Novel retinoic acid-containing topical compositions in the form of creams, lotions, gels, and the like, are disclosed. These compositions contain a urethane compound having a molecular weight of up to about 200,000, prepared by reacting approximately two moles of a hydroxy-terminated linear alkylene or polyalkylene glycol with approximately one mole of a monomeric organic diisocyanate. The presence of the urethane compound leads to decreased percutaneous transmission of the retinoic acid, resulting in reduced skin irritation but undiminished therapeutic effectiveness of the retinoic acid when compared to retinoic acid-containing topical formulations otherwise identical except for the absence of a urethane compound.

Abstract: Nodulocystic and conglobate acne in humans can be alleviated by the oral administration of 13-cis-retinoic acid or a derivative thereof. The active ingredient is administered in a dosage of from about 1.5 to about 3 mg/kg of body weight per day for a period of from about two to about four weeks.

Abstract: Cosmetic and/or dermatological compositions containing a non-photocatalytic metal oxide and tocopherol and, optionally, a metal-inactivating complexing agent are effective for inhibiting the light-induced peroxidation of lipids, and in particular lipids of sebaceous origin such as squalene.

Abstract: Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a hydrogen atom or various organic radicals, and the salts of the compounds of formula (I) when R.sub.1 is a carboxylic acid function.Use in human and veterinary medicine and in cosmetics.

Abstract: Novel sulfhydryl group-containing amides and disulfide group-containing bis-amides useful for treating or preventing an abnormal biological condition or a disease, and/or improving the texture or appearance of the skin, as well as compositions containing amides and bis-amides and methods for their use are described. Such types of abnormal biological conditions or diseases include skin atrophy, i.e., the thinning and/or general degradation of the dermis often characterized by a decrease in collagen and/or elastin as well as decreased number, size and doubling potential of fibroblast cells, and other maladies including, but are not limited to dry skin, severe dry skin, dandruff, acne, keratoses, psoriasis, eczema, skin flakiness, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, hyperkeratotic skin, inflammatory dermatoses, age-related skin changes and skin in need of cleansers.

Abstract: The subject invention relates to desquamation compositions comprising a combination of sulfhydryl compounds and zwitterionic surfactants. The subject invention further relates to methods of desquamation in mammalian skin and treating acne in mammalian skin.

Abstract: Compositions which comprise a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from antimicrobial agents, antiseptic agents, antibiotics, anti-inflammatory agents, anti-seborrhoeic agents, retinol and the derivatives thereof, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from keratolytic agents, protective agents, moisturizing agents and antioxidants, for treating these surface layers, are particularly effective for the treatment of acne.

Abstract: A topical medication for the treatment of skin pathology including acne is comprised of tetracycline, minocycline, clindamycin, erythromycin, or doxicycline and selenium sulfide or sulfur in a pharmaceutically acceptable carrier. The lotion, cream or ointment is applied to the lesions, left in place briefly and washed off. This is repeated twice daily. The lesions generally clear up within a week. Because the treatment is local, the serious side effects of systemic administration of drugs is avoided.

Abstract: A method of treating skin affected by acne or rosacea includes the steps of applying to affected skin a composition containing up to 50% by weight aluminum halide salt in a liquid carrier, allowing the composition to remain on the affected skin for an extended period of time which exceeds ten minutes, and washing off the composition. The composition is preferably applied to affected skin just prior to bedtime and is allowed to remain on the skin while the patient sleeps. Alternatively, liquid make-up compositions containing up to 50% by weight aluminum halide salt are applied as a part of a daily make-up routine and allowed to remain on affected skin all day long. The methods of treatment provide an improved treatment of acne and rosacea.

Abstract: The invention relates to the use of a salicylic acid derivative salified with a base, as a stabilizer for an oil-in-water emulsion. This salified derivative has the same properties as its acidic homologue, while at the same time having a less irritating nature. This salified derivative is, in particular, an n-alkanoyl-5-salicylic acid salified with an amphoteric base such as lysine or arginine. The present compositions are more especially intended for the cosmetic and dermatological fields.

Abstract: A composition for topical application to the skin for alleviation or prevention of dry flaky skin conditions, dandruff or ache comprising one or more stratum corneum trypsin-like enzymes. The composition may further comprise an additional enzyme selected from glycosidases, other proteases, lipases and mixtures thereof. Optional additional active ingredients include sunscreens, lipids, hydroxy carboxylic acids and ketocarboxylic acids.

Abstract: Quercetin and/or naringenin in combination with either retinol or retinyl ester resulted in a synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with naringenin and/or quercetin were analogous to treatment with retinoic acid.

Abstract: The invention relates to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha anlagonist in a cosmetic, pharmaceutical or dermatological composition for treating sensitive skins. It relates especially to the use of a histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist for preventing and/or combating skin irritations and/or sores and/or erythema and/or dysaesthetic sensations and/or sensations of inflammation and/or pruritus and/or prickling and/or tingling and/or discomfort and/or tightness of the skin and/or mucosae. It also relates to a composition containing a histamine antagonist, an interleukin-1 anlagonist and/or a TNF alpha antagonist which limits or eliminates the irritant side-effects of certain products, and in particular of certain cosmetic, dermatological or pharmaceutical active agents.

Abstract: The invention relates to a water-in-oil emulsion containing retinol, an oil phase, an aqueous phase and an agent for emulsifying the aqueous phase in the oil phase, the oil phase containing at least one organic solvent for retinol which is liquid at room temperature, and the pH of the aqueous phase being basic, so as to stabilize the retinol for at least two months at 45.degree. C.This emulsion is for cosmetic or dermatological use.

Abstract: Abstract of the Disclosure: Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.

Abstract: A method for the topical treatment of skin affected with acne, rosacea, or a combination thereof. Sodium chloride in a substantially pure form is topically applied to the affected skin by gently gliding the sodium chloride over the affected skin in a manner insufficient to cause abrasion and debridement of the affected skin. A solid block of about 98% to about 100% by weight sodium chloride free of a carrier and/or free of other topical acne-treatment medicaments and/or free of other topical rosacea-treatment medicaments should be used. The applied sodium chloride is left on the skin. Preferably, the affected skin is pre-moistened with water from shaving, bathing, splashing water on the skin, and the like prior to gliding the sodium chloride thereon.

Abstract: The subject invention relates to desquamation compositions comprising a combination of salicylic acid and certain zwitterionic surfactants. The subject invention further relates to methods of desquamation in mammalian skin and treating acne in mammalian skin.

Abstract: Skin care compositions comprising a water-in-oil emulsion base containing retinoids and possessing good physical and chemical stability.

Abstract: Novel retinoic acid-containing topical compositions in the form of creams, lotions, gels, and the like, are disclosed. These compositions contain a urethane compound having a molecular weight of up to about 60,000, prepared by reacting approximately two moles of a hydroxy-terminated linear alkylene or polyalkylene glycol with approximately one mole of a monomeric organic diisocyanate. The presence of the urethane compound leads to decreased percutaneous transmission of the retinoic acid, resulting in reduced skin irritation but undiminished therapeutic effectiveness of the retinoic acid when compared to retinoic acid-containing topical formulations otherwise identical except for the absence of a urethane compound.

Abstract: This invention relates to aqueous gel retinoid compositions and their methods of use. More specifically, the aqueous gel retinoid compositions of the invention utilize micronized particles of retinoids, particularly tretinoin, to provide an aqueous gel for topical application of such retinoids to the skin which minimizes skin irritation while retaining drug efficacy.

Abstract: The use of a compound having the formula ##STR1## wherein R represents methyl or ethyl, for regulating the greasiness of the skin, particular novel physical forms of said compound, cosmetic compositions comprising said agent, processes for preparing said agent and compositions, and a method of reducing the greasiness of the skin.

Abstract: Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of axillary foul odor, foot malodor and other body odors, e.g. scalp, and skin, nail and follicular infections caused by microorganisms. The compositions are antimicrobial against several organisms that infect the skin and are specifically effective against P. acnes. The compositions are therapeutically effective against folliculitis and perifolliculitis and are useful for other skin lesions, nail and mucosal infections such as impetigo, seborrheic dermatitis, erythrasma and trichomycosis axillaris, associated with or caused by microorganisms. The therapeutic effect of the composition may be synergized or amplified by incorporating a cosmetic or dermatologic agent into the formulation for topical treatment of cosmetic and dermatologic indications.

Abstract: Dermatological compositions comprising nitrous oxide and at least one essential fatty acid or lower alkyl ester thereof in a dermatologically acceptable carrier medium is useful in the treatment of a variety of skin, muscle and joint disorders including psoriasis, shingles, fever blisters, chicken pox, ache, chilblains, eczema, chloasmas, alopecia, dermatitis, ringworm and burn wounds. The composition preferably also includes additional ingredients selected from coal tar, collagen, nicotinamide, nicotinic acid, lanolin, vitamin E, methyl salicylate, arnica, and H.sub.1 -antagonist antihistamines or combinations thereof.