Abstract: Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Abstract: An improved method for suppressing xenograft rejection in a host subject is disclosed. The method includes administering an immunosuppressant drug, where the drug or the amount of drug administered is, by itself, ineffective to suppress xenograft rejection. Effective xenograft suppression is achieved by also administering an ethanolic extract of Triterygium wilfordii or a purified triptolide component thereof.

Abstract: Disclosed are methods to inhibit mammalian skin cell proliferation and, in particular, human keratinocyte proliferation by the topical administration of neutral gallium complexes.

Abstract: The invention provides a method for treating fungal dermatitis comprising administering an effective amount of 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno?2,3-b!?1,5!benzodiazepine to a patient in need thereof.

Abstract: A scalp and hair treatment method and composition wherein the composition comprises deionized water, a vasodilator (such as ethyl nicotinate and/or capsicum extract), a magnesium salt, and a hydrolyzed protein. The composition can be applied on a monthly or bi-monthly basis to the scalp and hair for about 30 minutes and rinsed away with water.

Abstract: A composition and method for treatment of skin. The composition comprises a pharmaceutically acceptable carrier containing a bilayer component having one or more polar terminus groups and one or more non-polar terminus groups separated from said polar terminus groups capable of penetrating the outer surface of the skin to form an aligned bilayer within the stratum corneum. The bilayer assists in the formation of bilayer lamellae that is believed to replicate the bilayer lamellae present in healthy skin. The composition is topically applied to the skin as often as is required.

Abstract: Cosmetic and/or dermatological active compound combinations comprisinga) an active amount of biotin and/or biotin esters,b) an active amount of one or more .alpha.-hydroxycarboxylic acids of the formulaR'(R")(OH)C COOHand/or an active amount of one or more .alpha.-ketocarboxylic acids of the formulaR'C(O) COOHor their physiologically acceptable salts or esters wherein R' and R" represent H-; branched or unbranched C.sub.1-25 -alkyl- or C.sub.1-25 -alkyl-substituted by one or more carboxyl groups and/or hydroxyl groups and/or a aldehyde groups and/or oxo groups (keto groups); phenyl- or phenyl substituted by one or more carboxyl groups and/or hydroxyl groups and/or branched and/or unbranched C.sub.1-25 -alkyl groups; or wherein the .alpha.-carbon atom of the .alpha.

Abstract: Non-greasy topical solutions, emulsion gels or lotions comprising as the active agent a compound of formula I ##STR1## and a lower alkanol, and if desired together with a solubilizing agent or an oil phase such as isopropyl myristate are useful delivery systems.

Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.

Abstract: Quercetin and/or naringenin in combination with either retinol or retinyl ester resulted in a synergistic inhibition of keratinocyte differentiation. The effects of the retinol or retinyl esters in combination with naringenin and/or quercetin were analogous to treatment with retinoic acid.

Abstract: A process of treatment against seborrhea and/or for the cicatrization of wounds and/or for stimulation of skin cell growth involving a topical application and/or an oral administration of any composition that contains zinc cysteate, wherein zinc cysteate is based on the following formula--O--SO.sub.2 --CH.sub.2 --CH(NH.sub.2)--CO--O--ZN--and wherein the zinc cysteate is in an anhydrous or a hydrated form. Zinc cysteate is dehydrated and based on the formulaC.sub.3 H.sub.5 O.sub.5 NSZSa, 2H.sub.2 O.

Abstract: A method for the preparation of Mycobacteria from any liquid, semi-solid or exotic source is described. The extracted Mycobacterial sample is suitable for detection by culture and amplification.

Abstract: The invention provides a composition for treating seborrheic dermatitis on the scalp, a method for treating seborrheic dermatitis and a method for making the composition of the invention. The composition of the invention, which is not a shampoo and does not contain any soap or detergent for cleaning hair, is a unique scalp medicament blend of ingredients. The composition comprises from about 0.5 to about 2.5 weight percent, based upon the weight of the composition, hydrocortisone; from about 2.5 to about 7.5 weight percent elemental sulfur; and from about 90 to about 97 weight percent of an active vehicle comprising a generally neutral hydrocarbon jelly, such as petrolatum or petroleum jelly, and gelled aqueous carboxypolymethylene.

Abstract: The invention refers to the treatment and prevention of lyso paf-mediated skin disorders with an effective amount of at least one antagonists against lyso paf receptors. Lyso paf or paf receptor antagonists were administered with or without an antagonist against production of ether phospholipids. Lyso paf antagonists are Ginkgoloides which are administered, for example, by food or topically.

Abstract: The invention relates to a method of skin treatment comprising the step of topically applying to skin affected by seborrheic dermatitis an amount of a composition comprising an excipient and from about 1% to 30% lithium ion, said amount being sufficient to reduce sebum production by said skin. The invention also relates to a method of skin treatment, which comprises the step of topically applying to skin affected by seborrheic dermatitis an amount of a composition comprising a topically acceptable excipient and an effective amount of a lithium salt.

Abstract: Methods and compositions are provided for the treatment of a host with a cellular proliferative disease, particularly a neoplasia. In the subject methods, a pharmaceutically acceptable, substantially anhydrous, injectable semi-solid composition which acts as a depot for a cytostatic agent, is administered to a lesion of the disease, particularly intralesionally. The subject compositions comprise a water immiscible, fatty acid ester matrix and a cytostatic agent.

Abstract: Methods for treating various autoimmune diseases and for providing immunorestoration, by administering, to a subject in need thereof, an effective amount of a composition having, as active ingredient, one or more rhamnolipids of formula (I) ##STR1## wherein R.sup.1 is H or .alpha.-L-rhamnopyranosyl;R.sup.2 is H or --CH(R.sup.4)--CH.sub.2 --COOH;R.sup.3 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl andR.sup.4 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl; are provided.

Abstract: The present invention relates to spironolactone contain compositions for application to an area of human skin afflicted with acne, seborrheic condition or hirsutism. N,N-dialkyl lauramides are used as permeation enhancers.

Abstract: Inhibitors of testosterone 5.alpha.-reductase activity, for example those of formula: ##STR1## wherein novel substituents are provided at the R.sup.4, R.sup.6, R.sup.7, R.sup.17.alpha. and/or R.sup.17.beta. positions are useful for the treatment of diseases whose progress is aided by activation of androgen receptors, e.g., prostate cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, androgenic alopecia and the like.

Abstract: An external skin treatment composition containing (I) vitamin A (retinol) and (II) as a stabilizer, a chelating agent/a polysaccharide, an oil, polyethylene (propylene) glycol, a hydroxy carboxylate, a neutral amino acid salt, an oil-soluble antioxidant/EDTA/a benzophenone compound, an oil-soluble antioxidant/an acid/a benzophenone compound, an inclusion compound of cyclodextrin including an antioxidant and/or an ultraviolet absorber, butanediol and/or an oil-soluble antioxidant, a water-soluble benzophenone compound, a basic amino acid and the salt thereof, an acidic amino acid and the salt thereof, a polar oil, a water-swellable clay mineral.

Abstract: A compound of general formula, in substantially pure form, wherein A is a cation. A method for preparation is also disclosed, together with compositions and methods of use thereof.

Abstract: The present invention relates to anti-acne compositions having good efficacy, low skin irritation, and good physical and chemical stability. These compositions comprise a benzoyl peroxide, a wetting agent, water, a non-volatile emollient component which is a liquid at 25.degree. C. and which has a weighted arithmetic mean solubility parameter of less than or equal to about 7, and a water soluble or dispersible gelling agent.

Abstract: Methods for treating various autoimmune diseases and for providing immunorestoration, by administering, to a subject in need thereof, an effective amount of a composition having, as active ingredient, one or more rhamnolipids of formula (I) ##STR1## wherein R.sup.1 is H or .alpha.-L-rhamnopyranosyl;R.sup.2 is H or --CH(R.sup.4)--CH.sub.2 --COOH;R.sup.3 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl andR.sup.4 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl;are provided.

Abstract: A process is provided which is suitable for the preparation of herbal compositions for the treatment of skin disorders such as eczema and psoriasis. The process comprises preparing an extract or extracts of herbs which provide an anti-inflammatory agent, an adrenocortical stimulant and a cortisol protecting agent by steam distillation and decoction and then treating the extracts to reduce the polysaccharide and/or sugar content. This is achieved by fermentation or enzymic action or by extraction with a solvent having a polarity in the range E.degree. 0.4 to 0.95 or by precipitation with an inorganic compound and/or colloid or by a combination of two or more of the above. As a final concentration step, the material is further purified by extraction with a solvent having a polarity in the range mentioned above. The reduction of the sugar/polysaccharide content greatly improves the handling characteristics of the extract which can be dried to a free flowing powder.

Abstract: Dermatological conditions are treated by topically applying to the affected area an effective amount of a combination benzoyl peroxide and clindamycin composition.

Abstract: Autoimmune diseases are controlled by the administration of non-methylene interrupted fatty acids of the formula ##STR1## in which R is alkyl or alkenyl. A preferred compound within the scope of this formula is 5,11,14-eicosatrienoic acid.

Abstract: The invention relates to a pharmaceutical preparation comprising as an active ingredient at least one rhamnolipid or a pharmaceutically acceptable salt thereof, and a carrier and/or diluent, preferably comprising a rhamnolipid of the general formula: ##STR1## wherein R.sub.1 =H, alpha-L-rhamnopyranosyl; ##STR2## R.sub.3 =(C.sub.5 -C.sub.20)-saturated, -mono- of poly-unsaturated alkyl; R.sub.4 =(C.sub.5 -C.sub.

Abstract: The present invention relates to new polycyclic aromatic derivatives, to processes for their preparation and to their use in therapeutic and cosmetic formulations.

Abstract: The invention provides a composition for topical application to the skin comprising a mixture of Panthenol (B.sub.5), Cod Liver Oil, Alpha Tocopherol Acetate, Arginine, Isoleucine, Leucine, Methionine, Phenylalanine, Threonine, and Valine in admixture with a suitable carrier. These compositions are particularly useful for the treatment of burns, cuts, abrasions, insect bites, inflammation from sun and wind exposure, dry skin, psoriasis, seborrheic dermatitis, and eczema.

Abstract: Methods and products for promoting hair growth, preventing or minimizing hair loss, enhancing or restoring hair color or remelanization and treating other hair and skin afflictions are disclosed. The methods includes topical application of the products to the skin or hair follicles being treated. The product includes as an essential component a treatment agent in an amount effective for treating the affliction and selected from the class of chemicals consisting of anol, anethole, analogs of the above, polymers of the above and mixtures thereof. Various combinations of these chemicals may be found in herb families including umbelliferae, magnoliaceae, labiatae and rutaceae. The invention preferably contemplates selecting the treatment agent from the class of herbs consisting of Foeniculum vulgares (fennel seed), Pimpinella anisum (anise), Carum carvi (caraway seeds) and mixtures of the above herbs with each other and/or with other herbs.

Abstract: A dermatological pharmaceutical composition for stimulating hair growth and for the treatment of conditions of the skin selected from the group consisting of(a) benign moles, papillomas and seborrheic keratoses;(b) unsightly freckles, pimples and blemishes;(c) stasis dermatitis;(d) dermal ulcers; and(e) fungal nail infections; and(f) gingival and mucous membrane inflammations;the composition comprising an effective amount of tannic acid, a debriding agent and a pharmaceutically acceptable carrier therefore.

Abstract: A therapeutic composition for treatment of scalp disorders which comprises liquid castile soap, an aqueous extract from corncobs and aloe vera gel. The essential ingredients of the composition may be separately prepared and subsequently combined in relative proportionalities to produce a homogeneous liquid mixture having a consistency suitable for application as a shampoo to the hair and scalp. The shampoo composition can effectively eliminate dandruff in the hair, alleviate itching of the scalp, prevent hair loss and also accelerate hair growth.

Abstract: A skin care composition in the form of a substantially oil-free aqueous gel comprising a water-soluble humectant, a hydrophilic gelling agent, a specific silicone component and a specific cationic surfactant component. The compositions provide improved oil control along with improved skin feel and residue characteristics together with excellent moisturizing, emolliency, rub-in and absorption characteristics.

Abstract: A therapeutic agent for allergic diseases containing as an active ingredient an extract of Acanthopanax senticosus Harms. It became possible to provide a medicine enabling allergic diseases to be treated without causing almost no side effects.

Abstract: A series of dihydrophenanthreneones and tetrahydrophenanthreneones are useful as inhibitors of 5.alpha.-reductase, and a series of hexahydrophenanthreneones are useful as intermediates for preparing such pharmaceuticals.

Abstract: A method is provided for treating dermatological conditions by binding and blocking 5-a-dihydrotestosterone receptors comprising applying to the skin an effective amount of composition comprising:(a) from about 0.1% to about 2.0% by weight of mucopolysaccharides free of proteins and having a pH ranging from about 5 to 7.5 in aqueous solution, a rotary power between about to +15, and a sulfur content greater than 6%;(b) from about 1% to about 3% by weight of an aqueous extract of human umbilical cord free from sulfur and having a DH of from about 5 to about 7, a viscosity of 30.degree. C. of from 10 to 25 centistokes, a hyaluronic acid titre of from about 500 to about 700 mg/dl, and an ash content of less than about 0.5%;(c) from about 0.05 to about 0.08% by weight of tetrahydrofurfuryl nicotinate; and(d) pharmaceutically and cosmetically acceptable vehicles and excipients.

Abstract: An anhydrous, topically-effective composition that resists phase separation and exhibits improved properties comprising a topically-active compound, such as an astringent salt; an improved suspending agent comprising a finely-divided silica and a suspending wax composition; and a suitable volatile liquid carrier, such as a volatile silicone or a volatile hydrocarbon. The suspending wax composition comprises a wax, an ester including at least 10 to about 32 carbon atoms and a volatile liquid carrier. The anhydrous, topically-effective composition is useful in topical cosmetic and medicinal preparations, such as antiperspirants, sunscreens and topical drug products, and is especially useful in cosmetic and medicinal preparations wherein an insoluble topically-active compound is dispersed throughout a liquid phase.

Abstract: A pharmaceutical product to be used as an adjuvant treatment of seborrheic dermatitis even in HIV positive subjects is disclosed. The pharmaceutical product makes use of methionine, vitamin E and selenium as active principles which directly or indirectly provide a protective response to the damage caused by lipoperoxidation. The pharmaceutical product, in combination with a diet rich in PUFA-PL (polyunsaturated fatty acids of phospholipids), causes skin homeostasis to be restored and the symptoms of skin dermatitis to regress.

Abstract: Compositions containing 1.alpha.-hydroxyvitamin D homolog compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, dermal hydration and sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.

Abstract: This composition consists in an aqueous dispersion D, lamellar structure lipid vesicles encapsulating an aqueous phase E; it is characterised by the fact that the lipid phase forming the layers of the said vesicles is at least partly made up of a compound as formula (I): ##STR1## wherein R represents a linear saturated on unsaturated hydrocarbonated chain containing 9 to 17 carbon atoms. The compounds (I) have the advantage that they are easily biodegradable and of very low cytotoxicity.

Abstract: Therapeutic as well as preventative measures to improve the cosmetic conditions or to alleviate the symptoms of dermatologic disorders with phenyl alpha acyloxyalkanoic acids and derivatives is disclosed. The cosmetic conditions and dermatologic disorders in humans in which the compounds may be useful include brittle or soft nails; abnormally thin skin, mucous membranes or wound; friction blisters; brittle hairs; pruritus; acne; and diseased nails, skin or mucous membranes due to natural or unnatural causes including but not limited to in flammations or infections. The phenyl alpha acyloxyalkanoic acids and derivatives include, for example, diphenyl alpha acetoxyacetic acid, phenyl alpha acetoxyacetic acid, phenyl alpha methyl alpha acetoxyacetic acid and phenyl alpha acetoxypropanoic acid. The compositions containing the active ingredients are also useful for treatment of skin, nails and hair conditions or disorders in domestic animals.

Abstract: This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein X may represent sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-18 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen, in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.

Abstract: A skin lotion and methods of use involving a skin lotion comprising effective amounts of allantoin, castor oil, oleic acid, calcium hydroxide powder and witch hazel water. The methods of use include as a keratoplastic and keratolytic for removing the "piled up" hyperkeratotic scales in seborrheic capitis and psoriasis vulgaris; to expedite the involution of the lesions of acute herpes simplex.

Abstract: A cosmetic composition comprises in solution in an appropriate vehicle at least one polymer having 50-100% of repeating units of the .beta.-alanine type having the formula ##STR1## and 0-50% of repeating units of the acrylamide type having the formula ##STR2## wherein R.sub.1 represents hydrogen or a member selected fromthe group consisting of (i) ##STR3## (ii) --CH.sub.2 OH, (iii) --(CH.sub.2).sub.n --CH.sub.3 wherein n is 0 or a whole number from1 to 11, (iv) ##STR4## wherein r' and r" each independently represent hydrogen or alkyl having 1-3 carbon atoms, (v) --CHOH--COOH, (vi) --CH.sub.2 --SO.sub.3 Na,(vii) ##STR5## and (viii) --(CH.sub.2 --CH.sub.2 --O).sub.m H wherein m ranges from 1 to 10, and R.sub.2 and R.sub.3 represent hydrogen or methyl.

Abstract: A skin- or hair-care composition containing silica additionally comprises a C.sub.2-4 alkyl ester of a di, tri- or tetrabasic carboxylic acid or hydroxy-carboxylic acid (optionally acetylated). The alkyl ester may be dissolved in an aqueous solvent system.

Abstract: Ozonides of terpenes are disclosed. Terpenes which are believed to be pharmacologically active when prepared in accordance with the present invention include: limonene, citronella, alpha-carotene, beta-carotene, Vitamin A, linalool, linalyl acetate, or squalene. Other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include geraniol, limonene, alpha-pinene, loganin, cymene, farnesanes, eudesmanes, acoranes, cedranes, chamigranes, caryophyllanes, illudanes, humulenes, himachalenes, longifolanes, perhydroazulenes, quaianes, quaianolides, or germacranes. Still other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include labdanes, clerodanes, abietic acid, phyllocladene, giberellins, ophiobolin A, retigeranic acid, gasgardic acid, lanosterol, euphol, oleanane, ursane, lupeol, hydroxyhopanone, lupanes, or hopanes.

Abstract: It has been discovered that 6-(substituted amino)purine cytokinins, such as kinetin, induce differentiation, and consequently reduce or eliminate the abnormally high rate of proliferation, of hyperproliferating cells associated with hyperproliferative skin diseases. Thus, the present invention provides methods and compositions for treating hyperproliferative skin diseases in mammals, particularly such diseases associated with hyperproliferating epidermal cells in humans, by administering to the hyperproliferating cells associated with such a disease, in the skin of a mammal suffering therefrom, a differentiation-inducing effective amount of a 6-(substituted amino)purine cytokinin.

Abstract: The compounds of this invention are bicyclic, tricyclic, azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; x is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group-consisting of a bicycloalkylamino, tricycloalkylamino, azabicycloalkyl, azatricycloalkyl, aszabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino, The compounds are useful as anti-inflammatory and anti-allergy agents.

Abstract: The present invention relates to a dermatological composition composed for cosmetics or medicines for external application to skin and to oral or nasal mucous-membrane. This composition can be applied in particular in the cosmetic or pharmaceutical field, especially in the dermatological cases to regenerate and to revitalize damaged cells by equilibrating electrochemical ion gradients across cell membrane and also by osmotic pressure on the inner face of the cell membrane. A composition based on a water phase in accordence with present invention comprises dextran, glucose, mutan lentinan, NaCl, KCl, and CaCl.sub.2, which are dissolved in the aqueous phase.

Abstract: A topical application composition for mitigating male pattern baldness and testosterone-induced acne contains, as essential active, androgen-reducing components (a) a testosterone-reducing amount of an ionizable sodium salt, and (b) an association of compounds for forming, androgen segregating cellular proliferation phospholipids. The association includes lecithin, soy oil, phosphoric acid, choline chloride and optionally inositol and a nonionic surfactant in an amount for solubilizing and/or dispersing components (a) and (b) in a cosmetically-compatible vehicle for topical application.