Abstract: The present invention relates to the use of hydroxydiphenyl ether compounds as antimicrobially active substances, to certain new compounds of this type and to processes for the preparation of these compounds.

Abstract: Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.

Abstract: A hair-growing agent comprising, as active ingredients, one or more members selected from the group consisting of lysophosphatidic acids, and phosphatidic acids wherein the fatty acid residue moiety consists only of straight-chain fatty acid residues having an even number of carbon atoms.

Abstract: The present invention provides a topical drug delivery system which comprises: a therapeutically effective amount of an anti-alopecia agent; at least one dermal penetration enhancer, which is a safe skin-tolerant ester sunscreen ester; and a volatile liquid. The invention also provides a method for administering at least one systemic acting anti-alopecia agent to an animal which comprises applying an effective amount of the anti-alopecia agent in the form of the drug delivery system of the present invention.

Abstract: The invention relates to a therapeutic composition for broad spectrum dermal disease and in particular, to a composition comprising principal lipid components of skin, preferably having about 30 to 90% by weight of a carrier for applying to skin; 0.01 to 5.0% by weight of sphingolipid long-chain base; 0.001 to 1.0% by weight of lysophosphatidic acid; and 1 to 40% by weight of organic or inorganic additives. The composition is useful for the treatment and improvement of atopic dermatitis, psoriasis, acne, ichthyosis, infectious dermatitis, pruritus, erythema derived from pruritus, vulnus, chapping of skin and ulcer, etc.

Abstract: Cosmetic and dermatological preparations having at least one aqueous phase, comprising (I) one or more partially neutralized esters of monoglycerides and/or diglycerides of saturated fatty acids with citric acid, (II) one or more sorbitan monoesters, (III) one or more fatty alcohols, (IV) where at least one of the aqueous phases comprises one or more electrolytes in dissolved form.

Abstract: A cosmetic-pharmaceutical composition for topical use against human alopecia containing a pool of enzymes of the specific hydroxisteroido-dehydrogenase group in the presence of nicotinamido-adenine-dinucleotide coenzyme and a vasodilator, the whole being complexed with phospholipids in solution.

Abstract: A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5% by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10% by weight.

Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.

Abstract: The invention relates to the use of one or more antimicrobial metals, most preferably silver, preferably formed with atomic disorder, and preferably in a nanocrystalline form, for the treatment of inflammatory skin conditions. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.

Abstract: Emulsion treatment compositions comprise an aqueous continuous phase and a discontinuous phase in the form of an oil-in-oil emulsion. The oil-in-oil emulsion comprises a reactive component including a reactive agent and an internal oil, wherein the internal oil solubilizes the reactive agent, and a middle oil in which the reactive component is dispersed. The middle oil is immiscible with the internal oil, does not solubilize the reactive agent, is immiscible in the aqueous continuous phase, and includes a hydrophobic particulate thickener. Methods for treating hair comprise applying the emulsion treatment compositions to hair.

Abstract: Antidandruff composition for treating the hair and scalp, in a cosmetically acceptable medium, has at least one pyridinethione salt, one insoluble conditioner, and at least one acrylic terpolymer of: a monomer (a) selected from the group consisting of a C1-C6 alkyl acrylate and a C1-C6 alkyl methacrylate; a monomer (b) selected from the group consisting of a heterocyclic vinyl compound containing at least one nitrogen or sulphur atom, a (meth)acrylamide, a mono- or di(C1-C4)alkylamino(C1-C4)alkyl (meth)acrylate and a mono- or di(C1-C4) alkylamino(C1-C4) alkyl(meth)acrylamide; and a monomer (c) selected from the group consisting of a urethane produced by reaction between a monoethylenic unsaturated isocyanate and a nonionic surfactant, a copolymerizable ethylenic surfactant monomer, a surfactant monomer of urea type, an allyl ether containing alkylenoxy groups, and a nonionic monomer of urethane type.

Abstract: The invention relates to compositions such as body and hair cleansing products, in particular shampoos, comprising one or more antifungals inhibiting fungal ergosterol biosynthesis as a first active ingredient, a synthetic, amphotheric phospholipid acting both as a second active ingredient and as a surface active agent, and art-known body or hair cleansing product ingredients as a carrier.

Abstract: The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

Abstract: Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30° C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation.

Abstract: A liquid composition comprising an alcohol or mixture thereof in sufficient quantity to grow hair in an area of canine or feline skin wherein alopecia has occurred.

Abstract: The present invention generally relates to a textile softening composition which comprises, as the softening agent, a quaternary ammonium salt which comprises a mixture of mono-, di- and tri-ester components, wherein the amount of diester quaternary is greater than about 50% by weight, and the amount of triester quaternary is less than about 25% by weight based on the total amount of quaternary ammonium salt. The invention also relates to a softening agent which comprises a high diester quaternary ammonium salt mixture comprising mono- and diester components derived for ether dialkanolamines. The invention also relates to processes for preparing said softening agents, and methods of use as a fabric softener and as a hair and skin conditioner.

Abstract: The invention concerns the use in a cosmetic composition or for preparing a pharmaceutical composition of at least a plant extract of the genus Chrysanthemum for stimulating skin and/or hair pigmentation. The invention also concerns a composition containing at least one active principle and an extract of at least a plant of the genus Chrysanthemum.

Abstract: Disclosed are propylene glycol hyaluronate esters having an esterification degree of 10-90% and a limiting viscosity of 3-35 dL/g as well as skin conditioning methods, moisturizing methods and emulsifying methods using said propylene glycol hyaluronate esters. Propylene glycol hyaluronate esters of the present invention are compounds showing excellent viscosity stability in low-pH systems and cation-containing systems and also showing high emulsifiability, hydration power and moisturizing effect.

Abstract: An aqueous shampoo composition comprising, in addition to water: i) at least one cleansing surfactant; ii) a cationic deposition polymer, and iii) a silicone component consisting of a blend of: (a) emulsified particles of an insoluble silicone, in which the emulsified particles of insoluble silicone are incorporated into the shampoo composition as a preformed aqueous emulsion having an average silicone particle size in the emulsion and in the shampoo composition of from 0.15 to 30 microns, and (b) microemulsified particles of an insoluble silicone, in which the microemulsified particles of insoluble silicone are incorporated into the shampoo composition as a preformed aqueous microemulsion having an average-silicone particle size in the microemulsion and in the shampoo composition of less than 0.10 microns.

Abstract: A cosmetic skin/hair darkening composition for topical application to skin and/or hair is provided that comprises for 0.1 to 10% by weight of a peptide having an isoelectric point ranging from 6 to 11.

Abstract: A composition, comprising, in a physiologically acceptable medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of caring for the skin, in particular of the face, and more especially for treating, that is to say decreasing, erasing and/or smoothing out, wrinkles and/or fine lines of the skin.

Abstract: Damaged or imperfect hair shafts are treated by: (a) hydrating hair shafts to open flaps of the cuticles layer, (b) applying to the hair shafts amino acids or peptides effective to nourish hair, and (c) compressing the hair shafts under heat by sandwiching the hair shafts between heated plates to cause the amino acids or peptides to penetrate through the cuticle layer and close the openings between the flaps. The penetrated amino acids or peptides nourish the cortex. The hair shafts may be subjected to hair styling treatment.

Abstract: The invention relates to hair compositions packaged in aerosol form and comprising, in a cosmetically acceptable medium, a polycondensate, such as a multiblock polymer, comprising at least one polyurethane and/or polyurea unit, at least one polyol, an organic solvent, and a propellant gas. The invention is also directed towards a process for shaping or maintaining the hairstyle, comprising the use of these compositions, as well as to their use for the manufacture of hair products, in order to maintain or shape the hairstyle.

Abstract: Ectoparasites, such as fleas, ticks, mites and lice, are removed from a human or animal host after applying a composition to the affected area that causes desiccation of the organism. In one embodiment, treatment is effected by applying a substantially anhydrous composition that has a strong affinity for water. As the composition hydrates, it desiccates the pests and facilitates their mechanical removal, such as by combing.

Abstract: A composition for treating hair includes an effective amount of a herbal extract extracted from Angelica and Astragali Radix. The herbal extract is prepared by adding water to these herbs in dried form, and heating the resulting liquid for 1 to 8 hours, at a temperature of about 90-200 degrees Celsius. An amine compound, preferably diethanol amine, or a combination of triethanol amine and dioctyl sodium sulfosuccinate, is added to the herbal extract. Benzoic acid, dissolved in ethanol, is also added to the herbal extract, together with water. The resulting solution is fermented between 12 to 24 hours, in an ultrasonic fermentation apparatus operating at about 15 KHz. A method for the treatment of hair loss includes applying to the scalp the above-described composition.

Abstract: A method of conditioning and oxidatively dyeing human hair includes applying an oxidative hair dyeing composition to the human hair in order to dye the human hair and, simultaneously or subsequently to the applying of the oxidative hair dyeing composition, applying a particular hair conditioning composition to the hair. This hair conditioning composition has a pH value of from 3.4 to 3.9, which corresponds to an isoelectric point of the human hair, and contains from 0.001 to 2.5% by weight of a cationic polymer, an optional pH buffer and preferably additional conditioning ingredients, such as a cationic surfactant and/or a fatty alcohol.

Abstract: The method for promoting hair growth and/or reducing hair loss includes providing a certain agent for reducing hair loss and/or promoting hair growth, applying an effective amount of the agent to hair and scalp, after applying the agent massaging the scalp for one to five minutes and leaving the agent on the hair and the scalp for at least 24 hours. The agent includes a compound of the formulae (I), (II) and/or (III): or a physiologically compatible salt or salts thereof, as effective ingredient.

Abstract: The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (1) in which X is —O—, —S— or —NR3; R1 represents in particular a hydrogen atom or a C114 C40 alkyl radical; R2 represents in particular a hydrogen atom or an optionally substituted alkyl radical; R3 represents a hydrogen atom or an alkyl radical; R4 represents a hydrogen atom or a radical such as NH2, OH, SH, —CHOHCH3, —CONH2; n is a number greater than 1 such that the poly-aminoacid derivative molecular weight ranges between 200 and 200000. The invention also concerns the use of said derivatives for keratinous fibre strengthening and care.

Abstract: The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote hair growth and the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

Abstract: Hydrolyzed jojoba protein is provided which can be used in a variety of cosmetic formulations to enhance the desirable properties thereof. The preferred hydrolyzed jojoba protein is in the form of an aqueous dispersion containing a mixture of amino acids, peptides and/or protein fractions derived from the hydrolysis of naturally occurring jojoba protein. Cosmetic formulations such as shampoos, shampoo conditioners, hair styling gels, hair conditioners, hair reparatives, hair tonics, hair fixatives, hair mousses, bath and shower gels, liquid soaps, moisturizing sprays, makeup, pressed powder formulations, lip products, bath additives, sanitizing wipes, hand sanitizers, premoistened towelettes, skin lotions and creams, shaving creams, and sunscreens can be improved by incorporation of hydrolyzed jojoba protein therein.

Abstract: The invention provides methods and materials for improving or maintaining hair care. Such hair care compositions can contain a grape skin extract, a benzophenone, and/or an aryl benzotriazole. In addition, the hair care methods and materials can provide protection against sun exposure (e.g., exposure to ultraviolet radiation) and repeated chemical treatment.

Abstract: A composition for use in bleaching hair in combination with a liquid peroxide based oxidizing agent, said composition comprising an effective amount of at least one persulfate salt dispersed in a silicone oil base and a method for bleaching hair with said composition.

Abstract: A non-toxic, environmentally safe and easily employable insecticide and insect repellent is achieved by providing an aqueous composition incorporating ethanolamine based compounds, either independently or in combination with the ethanolamine based compounds being selected from both simple compounds and conjugated compounds. In one preferred embodiment, a highly effective composition is attained for safe, effective, direct topical application to humans and animals by employing between about 10% and 70% by volume of the entire composition of the ethanolamine-based compound. In alternate preferred embodiments, the insecticide is formulated for application to plants, trees, crops, and other vegetation to provide a composition which effectively controls bothersome insects, while being completely safe and non-injurious to the plant, tree, or crop, as well as to the flowers or fruit thereof.

Abstract: A cosmetic composition comprising, in a cosmetically acceptable medium, at least one cationic polymer containing at least one acrylamide unit or acrylamide derivative, and at least one nonionic associative polymer containing at least one fatty chain.

Abstract: The invention relates to aqueous hair-treatment compositions comprising one or more quaternary ammonium compounds which are sparingly soluble in water and which contain at least one long-chain alkyl or alkenyl group having at least 18 carbon atoms, one or more water-soluble quaternary ammonium compounds, one or more nonionic, amphoteric and/or zwitterionic solubility promoters and optionally one or more thickeners. The compositions according to the invention are distinguished by a clear and translucent appearance. In particular, the compositions are hair cures and hair rinses.

Abstract: Compositions containing at least one organic phospholipid capable of forming bilayers in aqueous solution; at least one amphoteric surfactant; and at least one nonionic surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; where the phospholipid and surfactants are present in a combined amount sufficient to allow at least one water-insoluble ingredient selected from waxes and unneutralized and partially neutralized water-insoluble polymers, resins, and latexes to be incorporated into an aqueous solution. A delivery system containing the composition and methods for styling hair and for treating keratinous substances are also disclosed.

Abstract: A method of enhancing hair growth or treating alopecia in a subject uses topically administered estrogen receptor antagonists. Pharmaceutical formulations comprising estrogen receptor antagonists are described.

Abstract: The present invention is directed to process for conditioning hair and skin in which the skin has applied to it a polypeptide having between 20 and 60 amino acids in a polypeptide, having cysteine as at least 10% of the amino acids units and proline as at least 5% of the amino acid units.

Abstract: The present application discloses a method of treating alopecia which is based on the use of a tellurium compound such as ammonium trichloro(dioxoethylene-O,O-tellurate).

Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45° C.; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.

Abstract: Cosmetic or dermatological compositions for washing and/or antidandruff treatment of hair and/or scalp comprising at least one antidandruff agent chosen from pyridinethione salts, at least 1% by weight of at least one hydroxy acid, and at least one amphoteric surface-active agent or nonionic surface-active agent of the alkyl(poly)glycoside type.

Abstract: The present invention relates to methods for treating alopecia and stimulating hair growth and pharmaceutical compositions using nonimmunosuppressive [&ggr;-hydroxy-methylleucine4] cyclosporin A having superior hair growth-promoting effect, wherein the hydroxyl group is added to the carbon position of No. 4 methylleucine of cyclosporin A by the microorganism.

Abstract: Damaged or imperfect hair shafts are treated by: (a) hydrating hair shafts to open flaps of the cuticles layer, (b) applying to the hair shafts amino acids or peptides effective to nourish hair, and (c) compressing the hair shafts under heat by sandwiching the hair shafts between heated plates to cause the amino acids or peptides to penetrate through the cuticle layer and close the openings between the flaps. The penetrated amino acids or peptides nourish the cortex. The hair shafts may be subjected to hair styling treatment.

Abstract: The invention relates to new s-triazine derivatives of the formula (I): in which R1 represents an —NH—F radical, wherein F is a screening chromophore; R2 represents an —NH—Z—W radical, wherein Z is a divalent radical providing the connection between —NH— and —W, and W is a silicone-containing radical; and R3 is R1, R2, a linear or branched C1-C20 alkyl radical, a linear or branched C2-C20 hydroxyalkyl radical, a linear or branched C1-C20 alkoxy radical, an NHR8 radical or an N(R8)2 radical, with R8 being a linear or branched C1-C20 alkyl radical. The compounds of the invention are useful as organic sunscreen agents in cosmetic compositions intended for the protection of the skin and the hair against ultraviolet radiation. The invention also relates to the use of the compounds in cosmetic applications and to cosmetic compositions with improved properties containing these compounds.

Abstract: The application of L-arginine and its derivatives to the skin causes beneficial effects of wound healing, increasing erectile function and increased growth of hair when applied in sufficient quantity to the skin. A hostile biophysical agent may be combined with the L-arginine to increase its absorption into the skin. The desired concentrations of the hostile biophysical agent is increased when concentration of L-arginine is less than 20% of the concentration of the substance applied to maximize its effect.

Abstract: A method for reducing the production of malodor in sulfur containing dermatological compositions by adjusting the pH of the composition to between about 6.5 to about 8.1. Also, sulfur containing dermatological compositions having a pH between about 6.5 and about 8.1.

Abstract: This application relates to a pharmaceutical composition for the prevention, treatment, and management of scalp conditions, such as dandruff, seborrheic dermatitis, psoriasis, folliculitis, and hair thinning including a therapeutically effective amount of an acidic component of a hydroxyacid or tannic acid, or a pharmaceutically acceptable salt thereof. A preferred anti-dandruff composition and method of managing dandruff includes a therapeutically effective amount of the acid component, a vitamin A component, and an anti-growth agent. A preferred anti-hair thinning composition and method of managing thinning hair includes a therapeutically effective amount of the acidic component, a niacin component present in an amount sufficient to locally increase blood circulation, and a 5-&agr; reductase inhibitor.

Abstract: Cosmetic compositions containing in a cosmetically acceptable medium, at least one fixing and/or conditioning polymer and at least one amphoteric polymer comprising from 1 to 20 mol % of at least one monomeric unit chosen from (meth)acrylate and (meth)acrylamide types having at least one fatty chain, the fatty chain having from 8 to 30 carbon atoms. This combination may provide markedly improved cosmetic properties (disentanglement, softness) compared with the properties obtained with either of the constituents used alone. These compositions are used for washing and/or conditioning keratinous materials such as the hair or the skin.

Abstract: The invention relates to aerosol devices comprising a container which contains, in a cosmetically acceptable medium, a multiblock polymer comprising at least one polyurethane and/or polyurea unit, these devices being suitable for obtaining an initial flow rate of aerosol composition of less than or equal to 0.75 gram per second. The invention is also directed towards a process for shaping or maintaining the hairstyle, comprising the use of these devices, as well as their use for the manufacture of a lacquer or an aerosol spray.