Abstract: The present invention discloses high viscosity sustained release dental compositions, such as tooth bleaching or fluoride compositions, for treating tooth surfaces. For maximum results, an improved dental tray having reservoirs for holding the dental composition adjacent the desired tooth surfaces is preferably used in combination with the sustained release dental composition. The sustained release dental compositions include a high carboxypolymethylene concentration which results in very high viscosity. The high level of carboxypolymethylene makes dilution of the dental compositions from saliva difficult and time consuming so that the compositions stay within the tray reservoirs, thereby providing sustained release. The concentrated carboxypolymethylene adds a unique tackiness to the dental composition which helps retain and seal the soft tray material against the patient's teeth.

Abstract: The present invention provides, inter alia, formulations useful to ameliorate symptoms associated with mucosal abrasions, specifically those due to dental orthodontic brackets; oral surgery; periodontal surgery or other procedures. For instance, there is a formulation comprising: 65 to 75% microcrystalline wax; 5 to 15% non-ionic polymer; 15 to 25% topical anesthetic; and 1 to 5% surfactant, wherein the ratio of non-ionic polymer to microcrystalline wax is no greater than 0.2. Preferably, for solid topical anesthetics, the particle size is less than the apertures of a 100-mesh screen. However, the topical anesthetic may also be a liquid. Formulations wherein the mixture is a homogeneous matrix is preferred.

Abstract: The present invention provides a composition for preventing or treating periodontal diseases comprising an extract of Achyranthis radix, Ulmus cortex or a mixture thereof which inhibits the productions of superoxide, prostaglandin, and interleukin (IL-1.beta.) which are inducers for periodontal diseases and inhibits the enzyme activity of collagenase which decomposes collagen protein which is a substrate for the periodontal tissues, and at the same time promotes collagen protein synthesis, thereby treating periodontal diseases efficiently.

Abstract: Sticky dental compositions which include a sticky, glue-like matrix material for treating a variety of tooth or gum ailments and methods for using such compositions. For maximum comfort, an improved dental tray that is thin-walled, flexible and lightweight is used to hold the sticky dental composition adjacent the desired tooth surfaces. The sticky dental compositions include a sticky matrix material into which is dispersed an appropriate dental agent, such as a bleaching agent, a desensitizing agent, and an anticariogenic agent, an antimicrobial agent. The matrix material preferably includes carboxypolymethylene that has been partially neutralized with a base to reduce etching of the enamel. The carboxypolymethylene adds a unique stickiness to the dental composition which helps to adhere and retain the soft tray material against the person's teeth.

Abstract: The invention is directed to a novel pharmaceutical composition comprising one or more local anaesthetics in oil form, one or more surfactants, water and optionally a taste masking agent. The novel composition is advantageously used as a local anaesthetic for pain relief within the oral cavity.

Abstract: Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts.

Abstract: The invention relates to an oral composition for prevention of mycotic infections of the oral cavity comprising an antifungal compound embedded in a sustained release carrier such as a cellulosic polymer, and a method for the use of said composition in preventing microfungal infections in the oral cavity. The invention also provides for the supplementation of said oral composition with an adhesive and a plasticizer to increase antifungal effectiveness.

Abstract: Sticky dental compositions which include a sticky, glue-like matrix material for treating a variety of tooth or gum ailments, and methods for treating teeth using such compositions. For maximum comfort, an improved dental tray that is thin-walled, flexible and lightweight is used to hold the sticky dental composition adjacent the desired tooth surfaces. The sticky dental compositions include a sticky matrix material into which is dispersed an appropriate dental agent, such as a bleaching agent, a desensitizing agent, and an anticariogenic agent, an antimicrobial agent. The matrix material preferably includes carboxypolymethylene that has been partially neutralized with a base to reduce etching of the enamel. The carboxypolymethylene adds a unique stickiness to the dental composition which helps to adhere and retain the soft tray material against the person's teeth.

Abstract: Compositions and methods for treating periodontal disease and other related disorders utilizing a therapeutic treatment composition, including at lease one chemotherapeutic agent in combination with at least one carrier agent, are disclosed. Oral care products and a method preventing periodontal disease and related disorders are also provided.

Abstract: Antimicrobial compositions comprising at least two antimicrobial agents exhibit reduced MIC values relative to the MIC for the agents making up the combination when measured alone. The compositions are useful as therapeutic agents such as in oral hygiene products.

Abstract: The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.

Abstract: Alendronate, a bisphosphonate can prevent tooth loss not necessarily associated with periodontal disease. Preferably, alendronate (or a pharmaceutically acceptable salt thereof) is given daily for an extended period of time.

Abstract: The invention relates to an anti-tartar composition comprising:(a) 0.5 to 5% by weight of at least one compound selected from among zirconium silicate and hydrated silica;(b) 0.5 to 5% by weight of at least one compound selected from among chlorhexidine digluconate and zinc digluconate;(c) 0.5 to 5% by weight of at least one compound selected from among potassium thiocyanate, glucose oxidase, lysozyme, and lactoperoxidase; and(d) 1 to 5% by weight of at least one acid compound selected from among vitamin C and citric acid.It also concerns the use thereof in combination with food supplements or chewable supports for animals as well as the food supplements and chewable articles thus obtained.The invention applies, in particular, to the control of the formation of tartar in domestic animals such as dogs.

Abstract: A method for reducing bone resorption at tooth extraction sites by topically applying a prostaglandin inhibitor, such as a non-steroidal anti-inflammatory drug (NSAID) to the affected area. The preferred NSAID is ketoprofen. The composition may also include a penetration enhancer such as vitamin E.

Abstract: The present invention discloses sticky dental compositions and methods for treating sensitive teeth. For maximum comfort, an improved dental tray that is thin-walled, flexible and lightweight is used to hold the dental composition adjacent the desired tooth surfaces. The dental compositions include a sticky matrix material into which is dispersed a desensitizing agent such as KNO.sub.3 and other optional dental agents. The matrix material preferably includes carboxypolymethylene that has been partially neutralized with a base to reduce etching of the enamel. The carboxypolymethylene adds a unique stickiness to the dental composition which helps to adhere and retain the soft tray material against the patient's teeth.

Abstract: Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

Abstract: The present invention discloses sustained release dental compositions, such as tooth bleaching or fluoride-containing compositions, having high viscosity and stickiness for treating tooth surfaces. For maximum results, an improved dental tray having reservoirs for holding the dental composition adjacent to the tooth surfaces being treated is preferably used in conjunction with the sustained release dental compositions. The sustained release dental compositions include carboxypolymethylene in a concentration in a range from about 3.5% to about 12% by weight of the dental composition, as well as a base so that the pH of the dental composition is in a range from about 5 to about 7, which results in a very high viscosity composition. The carboxypolymethylene also inhibits dilution of the dental compositions by saliva so that the compositions stay within the tray reservoirs over time, thereby providing sustained release, or prolonged delivery, of the active dental agent.

Abstract: An oral composition comprises an effective amount of an antibody obtained by immunizing an animal with an antigen comprised of at least one polysaccharide derived from the surface layer of periodontal disease associated bacteria. The at least one polysaccharide may be conjugated with polypeptides to further enhance the efficacy.

Abstract: Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

Abstract: The present invention discloses high viscosity sustained release dental compositions, such as tooth bleaching or fluoride compositions, for treating tooth surfaces. For maximum results, an improved dental tray having reservoirs for holding the dental composition adjacent the desired tooth surfaces is preferably used in combination with the sustained release dental composition. The sustained release dental compositions include a high carboxypolymethylene concentration which results in very high viscosity. The high level of carboxypolymethylene makes dilution of the dental compositions from saliva difficult and time consuming so that the compositions stay within the tray reservoirs, thereby providing sustained release. The concentrated carboxypolymethylene adds a unique tackiness to the dental composition which helps retain and seal the soft tray material against the patient's teeth.

Abstract: The present invention relates to unique interdental delivery devices, other than dental floss, which are suitable for cleaning, massaging, and/or treating surfaces of teeth and gums including interproximal and subgingival areas; wherein these devices contain ULTRAMULSION.TM. dispersions of high viscosity silicones dispersed in surfactants, these dispersions are released into the oral cavity from these devices during use wherein the dispersed silicone:a. is insoluble in the surfactant and oriented so as to form coatings in the oral cavity with enhanced substantivity,b. functions as a reservoir for various lipid soluble and/or liquid dispersible ingredients to be released onto oral cavity surfaces, andc. has a particle size from between about 0.1 and about 10 microns with from between about 80% and about 95% of the particles within this range.

Abstract: Oral compositions for use in the mouth are provided which contain a DNA-sodium salt obtained preferably from sturgeon milt. The compositions are useful, for example, as mouth wash and toothpaste formulations.

Abstract: Disclosed are methods and compositions for inducing periodontal tissue morphogenesis in a mammal which include a therapeutically effective concentration of a morphogen. The methods and compositions are useful for integrating an implanted tooth in a tooth socket and for inhibiting tissue loss associated with periodontal disease or injury.

Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.

Abstract: The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the oral cavity or oropharynx, of an effective amount of an NSAID, especially a composition administering from about 0.001% to about 0.2% ketorolac to the oral cavity, alone or as an adjunct to surgery and/or radiation therapy.

Abstract: Methods of treating or preventing infection-induced oral tissue destruction or gingivitis in a mammal, comprising administering a therapeutically effective amount of a .beta.(1,3)-glucan, such as poly-.beta.(1-6)-glucotriosyl-.beta.(1-3)-glucopyranose glucan (PGG-glucan), are disclosed.

Abstract: The present invention provides compositions in the form of solutions, tablets and gels adapted for prophylaxis and treatment of oral lesions. The compositions are suitable for use as an oral lavage, and comprises water, a peroxide (preferably hydrogen peroxide) in a premixed aqueous form in the preparation mixture, with between about 0.01% and about 0.4% of a bicarbonate (preferably sodium bicarbonate). To produce such a composition adapted for the prophylaxis and treatment of oral lesions most preferably involves dissolving the peroxide and bicarbonate in an aqueous solution to produce a premixed preparation. Additionally, a method for prophylaxis and treatment of oral lesions incident the use of chemotherapeutic agents is included in the present invention.

Abstract: An ointment base useful for preparing topically applied medicament formulations. The base can be provided in the form of a stable emulsion including paraffin(s), polyol, beeswax, cetostearyl alcohol, a 4-hydroxy benzoic acid lower alkyl ester, a surface active agent and a dispersing agent. The base can be combined with large volumes containing a variety of medicaments to form stable, useful formulations.

Abstract: Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer of preferably, the dry microparticles and dispersed into the periodontal pocket whereby upon contact with the moist environment of the pocket, they hydrate, become tacky and adhere to one another and to the tissues surrounding the pocket so as to maintain intimate contact with the involved tissue so as to induce long term therapeutic benefits.

Abstract: The present invention relates to the use of Triclosan in the manufacture of a composition for the prevention, inhibition and/or reduction of aphthous ulcers. Preferably, the compositions are oral compostions such as toothpastes and mouthwashes. The oral composition is especially preferably in a gel form. Preferably the Triclosan is used together with a zinc salt such as zinc citrate, and or a polymer that enhances the delivery of the Triclosan.

Abstract: The present invention provides man-made saliva fluids which contain lysozyme chloride in such concentrations as may be able to suppress effectively the development of oral edema and which possess improved feeling of use and show lessened change in appearance and pH value as well as minimized reduction in enzymatic activity of lysozyme chloride after a prolonged period of storage.

Abstract: The present invention relates to methods and compositions for prevention or treatment of bone loss due to periodontal disease, oral osseous surgery, periodontal flap surgery, tooth extraction, dental implants, or scaling and root planing comprising topical administration, to mucosal tissues of the oral cavity, of a composition having from about 0.001% to about 0.2% ketorolac in the oral cavity.

Abstract: Composition for the treatment of gingivitis and other afflictions of the oral cavity, as well as for the reduction of dental plaque. These are in the form of gels, solutions or similar forms which comprise a therapeutically active agent in a polymeric carrier which contains a solvent. The nature of the preparation is such that when these are applied to an aqueous environment of the oral cavity, the polymer and the active agent precipitate and form a coating.

Abstract: Methods for aiding periodontal tissue regeneration with compositions containing bioresorbable polymers, leachable solvents, and bioavailable drug actives. The compositions useful for these methods are characterized by becoming harder upon contact with the periodontal tissue such that the composition is effective for aiding tissue regeneration and by releasing a therapeutically-effective amount of drug active agent.

Abstract: The invention relates methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.

Abstract: Binding between parts of living mineralized tissue such as between a tooth and the jaw bone is induced with a composition containing mammalian enamel matrix isolated from tooth germs and a carrier such as water, and optionally an adhesive containing fibrinogen, factor XIII and thrombin. The enamel matrix is a precursor to tooth enamel and induces binding by forming cementum tissue. The enamel matrix may be obtained from bovine or porcine species. The composition is particularly applicable in dental therapies including loosening of teeth due to periodontitis, transplantation of teeth or in reintroduction of teeth disconnected by accident. The composition may also be used for healing of artificial implants such as tooth implants and implants of skeletal replacements such as artificial hip joints. In the case of a dislocated tooth, the composition is applied to a surface of the tooth root and the tooth is put back into its alveolus and lightly fixed for some weeks.

Abstract: Disclosed are several oral hygiene preparations including plaque disrupting and gingivitis control preparations in the form of chewing gums, wherein a chewing gum is coated with a plaque disrupting emulsion containing an ingestible surfactant and a polydimethyl siloxane emulsified therein, and wherein the emulsion coating can further contain a therapeutic substance such as the gingivitis control substance stannous fluoride.

Abstract: Described herein is an aqueous solution for application to an oral cavity generally as a mouthwash comprising an effective amount of echinacea, hydrastis canadensis, sanguinaria canadensis, quercus alba, grapefruit seed extract, aloe vera juice, water, vegetable glycerin, and peppermint oil.

Abstract: Methods are described for assisting the restoration of periodontal tissue in a periodontal pocket and for retarding migration of epithelial cells along the root surface of a tooth. The methods involve placement of an in-situ forming biodegradable barrier adjacent the surface of a tooth. The barrier is microporous and includes pores of defined size. The barrier can include a biologically active agent.

Abstract: Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.

Abstract: The subject invention relates to methods for prevention or treatment of gingivitis or periodontitis comprising topical administration, to gingival tissues of the oral cavity, of a composition comprising a safe and effective amount of a selective histamine-2 receptor antagonist compound, and oral care compositions used therefore.

Abstract: A method of treating damaged human tissues, especially mucosal and epithelial tissues, comprising topically administering to the damaged tissues a composition having an effective amount of misoprostol. The treatment is particularly effective against periodontal disease.

Abstract: The present invention provides a gel composition useful for the prevention or treatment of gingivitis, periodontal disease, and dental plaque which comprises ascorbic acid, copper sulfate, and essentially no added oxidizing agent, in concentrations sufficient for the prevention or treatment of gingivitis, periodontal disease, and dental plaque; and a gel carrier. The invention also provides a method for the prevention or treatment of gingivitis, periodontal disease, and dental plaque in the oral cavity of a subject which comprises applying for an effective period of time within the oral cavity of a subject an amount of the gel composition effective to prevent or treat gingivitis, periodontal disease, and dental plaque.

Abstract: The present invention relates to compositions and methods which are effective against alveolar bone resorption and enhance the ability of a tooth moved in orthodontic therapy to remain in its new position or to stay in its original position when adjacent teeth are moved.

Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula.

Abstract: A process for enhancing oral hygiene by reducing oral microflora and for inhibiting the formation of dental plaque by applying, to the oral cavity a composition containing (a)0.1 to 40 parts, by weight, of a higher acyl-N-betaine having the structure ##STR1## where R is a higher alkyl group of from 10 to 18 carbon atoms, or mixtures thereof, and (b) 0.

Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.

Abstract: This invention claims a method for treating periodontal disease in mammals, including humans, by administering an effective amount of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or a pharmaceutically acceptable salt including the monosodium salt tridydrate (alendronate) of the formula: ##STR1## The compounds are useful in the treatment of alveolar bone loss associated with peridontitis and periodontal disease.

Abstract: A method for treating Candida infections of surfaces and cavities of dentures, the oral and vaginal cavities is disclosed. The method includes contacting an antifungal formulation onto the surface or cavity which is infected with the Candida fungus. The antifungal formulation includes a humectant in a concentration from about 20% to about 80%, lytic activating agents including inorganic monovalent anions and detergents. The antifungal formulation is contacted to the infected surface or cavity by suitable carrier or dispenser. The method is preferably directed towards the treatment of denture stomatitis in the oral cavity. The method preferably includes forming a replica of the denture surface using a suitable fungal growth medium to determine the location and, then, contacting the infected denture surface and surface of the oral cavity with the antifungal formulation.

Abstract: The present invention provides novel methods for prevention or treatment of primary and recurring squamous cell carcinoma of the oral cavity or oropharynx comprising topical administration, to the oral cavity or oropharynx, of an effective amount of an NSAID, especially a composition administering from about 0.001% to about 0.2% ketorolac to the oral cavity, alone or as an adjunct to surgery and/or radiation therapy.